Beta-Secretase

Beta-secretase is a protein family that includes in humans Beta-secretase 1 and Beta-secretase 2. Beta-secretase 1, also known as beta-site amyloid precursor protein cleaving enzyme 1, beta-site APP cleaving enzyme 1 (BACE1), membrane-associated aspartic protease 2, memapsin-2, aspartyl protease 2, and ASP2, is an enzyme that in humans is encoded by the BACE1 gene. Expression of BACE1 is observed mainly in neurons. BACE1 is an aspartic acid protease important in the formation of myelin sheaths in peripheral nerve cells: in mice the expression of BACE1 is high in the postnatal stages, when myelination occurs. The transmembrane protein contains two active site aspartate residues in its extracellular protein domain and may function as a dimer, its cytoplasmic tail is required for the correct maturation and an efficient intracellular trafficking, but doesn't affect the activity. It is produced as a pro-enzyme, the endoproteolitc removal occurs after BACE leaves Endoplasmic reticulum, in the Golgi apparatus. In addition the pro-peptide receives additional sugars to increase the molecular mass. and the tail became a palmitoylated. Beta-secretase 2 (also known as Memapsin-1) is an enzyme that cleaves Glu-Val-Asn-Leu!Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein. BACE2 is a close homolog of BACE1.

Cat. No.	Product name	CAS No.	Purity
T3161	β-Secretase inhibitor-STA	350228-37-4	98%
T3161	BACE-IN-1 is amyloid precursor protein beta-secretase inhibitor
T8306	Epiberberine chloride	889665-86-5	98%
T8306	Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor (IC50s: 1.07...
T2S1181	Aloenin	38412-46-3	98%
T2S1181	1. Aloenin and aloe-emodin are active principles for inhibition of c-ADH and c-ALDH activities in vitro.
T3285L	Eslicarbazepine	104746-04-5	98%
T3285L	Eslicarbazepine can be used for adjunctive therapy for adults with partial-onset seizures.
T2639	LY2811376	1194044-20-6	99.01%
T2639	LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM). It has 10-fold selectivity...
TN2190	Scoulerine	6451-73-6	99.22%
TN2190	Scoulerine shows significant cytotoxic effects against both two cancer cell lines (Caco-2 and Hep-G2 cancer cells), with IC50 values 6.44 ± 0.87 and 4.57 ± 0.42,...
T7011	Verubecestat	1286770-55-5	99.49%
T7011	Verubecestat (MK-8931) is an effective and specific β-secretase inhibitor and β-site APP-cleaving enzyme 1 inhibitor or BACE1 protein inhibitor.
T5S2361	Epiberberine	6873-09-2	99.58%
T5S2361	1. Epiberberine may be caused drug interactions based on CYP2D6 enzyme. 2. Epiberberine has anti-adipogenic effect is mediated by downregulation of the Raf/MEK1/...
T3285	Eslicarbazepine Acetate	236395-14-5	99.59%
T3285	Eslicarbazepine acetate (ESL) is an anticonvulsant medication approved for use in Europe, the United States and Canada as an adjunctive therapy for partial-onset...
T11175	Elenbecestat	1388651-30-6	99.67%
T11175	Elenbecestat is an effective oral bioutilization and CNS penetrating ACE-1 inhibitor for the treatment of Alzheimer's disease.
T8179	Aloeresin D	105317-67-7	99.84%
T8179	Aloeresin D, a natural chromone glycoside, inhibits β-Secretase (BACE1) activity (IC50: 39 μM).
T3769	Tenuifolin	20183-47-5	99.9%
T3769	Tenuifolin has no inherent toxicity to either the transfected or wild type cells at the effective concentrations, it inhibits amyloid-β secretion in vitro.
T4398	LX2343	333745-53-2	99.92%
T4398	LX2343 is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM. LX2343 acts as a non-ATP competitive PI3K inhibitor with an IC50 of 15.99±3.23 μM. LX2343...
T6058	LY2886721	1262036-50-9	99.94%
T6058	LY2886721, a BACE inhibitor, is used for the therapy of Alzheimer's Disease.
T6772	AZD3839 free base	1227163-84-9	99.96%
T6772	AZD3839 is a potent and selective BACE1 inhibitor with Ki of 26.1 nM, about 14-fold selectivity over BACE2. Phase 1.
TN2217	Sophoflavescenol	216450-65-6
TN2217	Sophoflavescenol is a mixed inhibitor of PDE5 with a K(i) value of 0.005 microM. Sophoflavescenol has antioxidant, anti-inflammatory, and apoptotic effects , the...