T8306 |
Epiberberine chloride
|
889665-86-5
|
98%
|
|
Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor (IC50s: 1.07...
|
T3161 |
β-Secretase inhibitor-STA
|
350228-37-4
|
98%
|
|
BACE-IN-1 is amyloid precursor protein beta-secretase inhibitor
|
TN1472 |
Cassiaside
|
13709-03-0
|
98%
|
|
Cassiaside is a naphthyl ketone glycoside that inhibits BACE1 (IC50= 4.45 μM; Ki=9.85 μM).Cassiaside exhibits significant hepatoprotective effects against galact...
|
T3285L |
Eslicarbazepine
|
104746-04-5
|
98%
|
|
Eslicarbazepine can be used for adjunctive therapy for adults with partial-onset seizures.
|
T2639 |
LY2811376
|
1194044-20-6
|
98%
|
|
LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM). It has 10-fold selectivity...
|
TN2190 |
Scoulerine
|
6451-73-6
|
98%
|
|
Scoulerine shows significant cytotoxic effects against both two cancer cell lines (Caco-2 and Hep-G2 cancer cells), with IC50 values 6.44 ± 0.87 and 4.57 ± 0.42,...
|
T7011 |
Verubecestat
|
1286770-55-5
|
98%
|
|
Verubecestat (MK-8931) is an effective and specific β-secretase inhibitor and β-site APP-cleaving enzyme 1 inhibitor or BACE1 protein inhibitor.
|
T5S2361 |
Epiberberine
|
6873-09-2
|
98%
|
|
1. Epiberberine may be caused drug interactions based on CYP2D6 enzyme. 2. Epiberberine has anti-adipogenic effect is mediated by downregulation of the Raf/MEK1/...
|
T3285 |
Eslicarbazepine Acetate
|
236395-14-5
|
98%
|
|
Eslicarbazepine acetate (ESL) is an anticonvulsant medication approved for use in Europe, the United States and Canada as an adjunctive therapy for partial-onset...
|
T11175 |
Elenbecestat
|
1388651-30-6
|
98%
|
|
Elenbecestat is an effective oral bioutilization and CNS penetrating ACE-1 inhibitor for the treatment of Alzheimer's disease.
|
T2S1181 |
Aloenin
|
38412-46-3
|
98%
|
|
1. Aloenin and aloe-emodin are active principles for inhibition of c-ADH and c-ALDH activities in vitro.
|
T8179 |
Aloeresin D
|
105317-67-7
|
98%
|
|
Aloeresin D, a natural chromone glycoside, inhibits β-Secretase (BACE1) activity (IC50: 39 μM).
|
T3769 |
Tenuifolin
|
20183-47-5
|
98%
|
|
Tenuifolin has no inherent toxicity to either the transfected or wild type cells at the effective concentrations, it inhibits amyloid-β secretion in vitro.
|
T4398 |
LX2343
|
333745-53-2
|
98%
|
|
LX2343 is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM. LX2343 acts as a non-ATP competitive PI3K inhibitor with an IC50 of 15.99±3.23 μM. LX2343...
|
T6058 |
LY2886721
|
1262036-50-9
|
98%
|
|
LY2886721, a BACE inhibitor, is used for the therapy of Alzheimer's Disease.
|
T6772 |
AZD3839 free base
|
1227163-84-9
|
98%
|
|
AZD3839 is a potent and selective BACE1 inhibitor with Ki of 26.1 nM, about 14-fold selectivity over BACE2. Phase 1.
|
TN2217 |
Sophoflavescenol
|
216450-65-6
|
98%
|
|
Sophoflavescenol is a mixed inhibitor of PDE5 with a K(i) value of 0.005 microM. Sophoflavescenol has antioxidant, anti-inflammatory, and apoptotic effects , the...
|