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Neuroscience

Melanocortin Receptor

Neuropeptide Y Receptor

Serotonin Transporter

(47)

iGluR

(119)

Glutaminyl Cyclase

Glutaminyl Cyclase (QC) is an enzyme that catalyzes the conversion of N-terminal glutamine (Gln) or glutamic acid (Glu) residues into pyroglutamate (pGlu) through cyclization. This modification enhances the stability and bioactivity of proteins and peptides. QC plays a critical role in the formation of pyroglutamate-modified amyloid-β (pGlu-Aβ), which is implicated in Alzheimer's disease and other neurodegenerative disorders. It is considered a potential therapeutic target for diseases involving pGlu-modified peptides.

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PBD-150

T7905790663-33-1

PBD-150 is an inhibitor of human glutaminyl cyclase (hQC) Y115E-Y117E variant( ki : 490 nM)

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Glutaminyl Cyclase Inhibitor 1

T114242110449-60-8In house

Glutaminyl Cyclase Inhibitor 1, a glutaminyl cyclase inhibitor with an IC50 of 0.5 μM, can be utilized for studying neurological disorders.

$122

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Glutaminyl Cyclase Inhibitor 3

T114222092921-50-9

Glutaminyl Cyclase Inhibitor 3, a designed anti-Alzheimer’s compound, is a potent human Glutaminyl Cyclase (GC) inhibitor (IC50: 4.5 nM). It significantly reduced the brain concentrations of pyroform Aβ and total Aβ and restored cognitive functions.

$2,150

10-14 weeks

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SEN177

T610632117405-13-5

SEN177 shows the potential in the research of Huntington’s disease that is a potent inhibitor of glutaminyl cyclase (QPCT) with an IC 50 of 0.013μM for glutaminyl-peptide cyclotransferase-like (QPCTL). The Ki value of SEN177 for human glutaminyl cyclase (hQC) is 20 nM. SEN177 significantly reduces the early stages of mutant HTT oligomerisation and reduces the percentage of neurons with Q80 aggregates [1].

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Glutaminyl Cyclase Inhibitor 2

T114251884546-29-5

Glutaminyl Cyclase Inhibitor 2 is a glutaminyl cyclase inhibitor with an IC50 of 1.23 μM.

$1,520

6-8 weeks

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Glutaminyl Cyclase Inhibitor 5

T72136

Glutaminyl Cyclase Inhibitor 5 is a potent, selective inhibitor of human glutaminyl cyclase (hQC), demonstrating an inhibition concentration half-max (IC 50) of 3.2 nM.