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Targets

29

Compounds

Cat No. Product Name Synonyms Targets
T12728 RIP2 Kinase Inhibitor 3 Others , RIP kinase
RIP2 Kinase Inhibitor 3 is a potent and selective inhibitor of RIP2 with an IC50 of 1 nM.
T3537 GSK583 RIP kinase
GSK583 is a highly effective and specific RIP2 kinase inhibitor (IC50: 5 nM).
T7795 RIPA-56 RIP kinase
RIPA-56 is an inhibitor of RIP1
T9305 Necroptosis-IN-1 RIP kinase
Necroptosis-IN-1 is a potent necroptosis inhibitor of RIPK1. It is an analog of Necrostatin-1.
T6815 HS-1371 RIP kinase
HS-1371 is a novel kinase inhibitor of receptor-interacting protein kinase 3 (RIP3) with an IC50 of 20.8 nM.
T7151 GSK2982772 RIP kinase
GSK2982772 is an inhibitor of receptor interacting serine/threonine kinase 1 (RIPK1)with IC50 values of 16 nM and 20 nM for human and monkey RIP1, respectively.
T9702 Eclitasertib RIP kinase
Eclitasertib is a potent inhibitor of receptor-interacting protein kinase 1 (RIPK1, IC50 of <1 µΜ).
T15437 GSK3145095 RIP kinase
GSK3145095 is an orally active inhibitor of RIPK1 with IC50 of 5 nM, with potential immunomodulatory activities and antineoplastic.
T5054 GSK963 GSK963 (Racemate) RIP kinase
GSK963 (Racemate), a structurally distinct, potent and selective inhibitor of RIP1 kinase(IC50=29 nM).
T11501 GSK840 GSK'840 RIP kinase
GSK840 (GSK'840) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds the RIP3 kinase domain (IC50: 0.9 nM), and inhibits kinase activity (IC50: 0.3 nM).
T12493 PK68 Others , RIP kinase
PK68 is an effective and selective inhibitor of type II receptor-interacting kinase 1 (RIPK1, IC50 = 90 nM). PK68 can be used for research on the treatment of inflammatory disorders and cancer metastasis.
T11492 GSK2983559 free acid Others , RIP kinase
GSK2983559 free acid is an effective and selective inhibitor of receptor-interacting protein 2 (RIP2). GSK2983559 free acid shows excellent activity in blocking many proinflammatory cytokine responses in human inflammato...
T7397 GSK547 GSK'547 RIP kinase
GSK547 (GSK'547) is a highly selective and potent inhibitor of RIP1 kinase,inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer.
T6852 GSK481 GSK'481 RIP kinase
GSK481 (GSK'481) is a RIP1(Receptor Interacting Protein Kinase1) inhibitor. Inhibition of RIP1 has been shown to hinder cell necrotic death.
T12731 RIPK1-IN-7 RIP kinase
RIPK1-IN-7 is a potent and selective inhibitor of RIPK1(Kd of 4 nM and an enzymatic IC50 of 11 nM),andexhibits excellent antimetastasis activity in the experimental B16 melanoma lung metastasis model.
T40187 GNF2133 DYRK
GNF2133 is an effective and selective inhibitor of DYRK1A with IC50s of 6.2 nM. GNF2133 can be used in studies about type 1 diabetes.
T1847 Necrostatin-1 Nec-1,Necrostatin 1 Indoleamine 2,3-Dioxygenase (IDO) , Ferroptosis , Autophagy , RIP kinase
Necrostatin-1 (Nec-1) is a necrotic apoptosis inhibitor and RIP1 inhibitor with specificity. Necrostatin-1 inhibits TNF-α-induced necrotic apoptosis. Necrostatin-1 also inhibits IDO.
T4074 GSK-872 GSK872,GSK'872,GSK2399872A RIP kinase
GSK-872 (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity (IC50: 1.8 nM) and inhibits kinase activity (IC50: 1.3 nM).
T16753 RIP2 kinase inhibitor 2 Others
RIP2 kinase inhibitor 2 is a receptor-interacting protein-2 kinase inhibitor.
T39574 RIP2 Kinase Inhibitor 4
RIP2 Kinase Inhibitor 4 is a highly potent and selective RIPK2 PROTAC compound that efficiently degrades RIPK2 (with a pIC50 value of 8) and effectively inhibits the release of TNF-α.
T12727 RIP2 kinase inhibitor 1 Others
RIP2 kinase inhibitor 1 is a potent and selective receptor interacting inhibitor of protein 2 (RIP2) kinase(RIP2 FP with an IC50 of 0.03 μM ),and is used for autoinflammatory disorders.
T12725 RIP1 kinase inhibitor 1 Others
RIP1 kinase inhibitor 1 is an orally available and brain-penetrating inhibitor of RIP1 kinase with pKi of 9.04.
T9079 Apostatin-1 Apt-1 Others
Apostatin-1 (Apt-1) is a novel TRADD inhibitor. Apostatin-1 can bind to a pocket on the N-terminal TRAF2 binding domain of TRADD.
T9095 Necrostatin-34 2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4 RIP kinase
Necrostatin-34 (2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4) is a RIPK1 kinase inhibitor, stabilizing RIPK1 kinase in an inactive conformation by occupying a distinct binding pocket in the kinase domain.
T5401 GSK2983559 active metabolite GSK2983559,RIPK2 inhibitor 1,RIPK2-IN-1 RIP kinase
GSK2983559 active metabolite (RIPK2-IN-1) is a potent, selective receptor-interacting protein-2 (RIP2) kinase inhibitor.
T7504 Necrostatin 2 racemate Necrostatin-2 racemate RIP kinase
Necrostatin 2 racemate (Necrostatin-2 racemate) is an potent and specific inhibitor of RIPK1.
T8931L ICCB-19 hydrochloride ICCB-19 HCl(750621-52-4 free base) Apoptosis , Others , Autophagy , RIP kinase
ICCB-19 hydrochloride (ICCB-19 HCl) is an inhibitor of TRADD (TNFRSF1A Associated Via Death Domain). It binds to a pocket on the N-terminal TRAF2-binding domain of TRADD (TRADD-N), which interacts with the C-terminal dom...
T3997 WEHI-345 WEHI345 RIP kinase
WEHI-345 is a potent and selective RIPK2 inhibitor which shows NOD signalling events yet prevents inflammatory cytokine production.
T36243 PROTAC RIPK degrader-6
PROTAC RIPK degrader-6 (example 1) is a PROTAC targeting RIP Kinase degradation wherein the RIP2 kinase inhibitor is linked via a linker to a cereblon binder[1]. PROTACs is useful for the targeted degradation of proteins...

Compounds

RIP2 Kinase Inhibitor 3
T12728
Synonym:
Target: Others, RIP kinase
GSK583
T3537
Synonym:
Target: RIP kinase
RIPA-56
T7795
Synonym:
Target: RIP kinase
Necroptosis-IN-1
T9305
Synonym:
Target: RIP kinase
HS-1371
T6815
Synonym:
Target: RIP kinase
GSK2982772
T7151
Synonym:
Target: RIP kinase
Eclitasertib
T9702
Synonym:
Target: RIP kinase
GSK3145095
T15437
Synonym:
Target: RIP kinase
GSK963
T5054
Synonym: GSK963 (Racemate)
Target: RIP kinase
GSK840
T11501
Synonym: GSK'840
Target: RIP kinase
PK68
T12493
Synonym:
Target: Others, RIP kinase
GSK2983559 free acid
T11492
Synonym:
Target: Others, RIP kinase
GSK547
T7397
Synonym: GSK'547
Target: RIP kinase
GSK481
T6852
Synonym: GSK'481
Target: RIP kinase
RIPK1-IN-7
T12731
Synonym:
Target: RIP kinase
GNF2133
T40187
Synonym:
Target: DYRK
Necrostatin-1
T1847
Synonym: Nec-1,Necrostatin 1
Target: Indoleamine 2,3-Dioxygenase (IDO), Ferroptosis, Autophagy, RIP kinase
GSK-872
T4074
Synonym: GSK872,GSK'872,GSK2399872A
Target: RIP kinase
RIP2 kinase inhibitor 2
T16753
Synonym:
Target: Others
RIP2 Kinase Inhibitor 4
T39574
Synonym:
Target:
RIP2 kinase inhibitor 1
T12727
Synonym:
Target: Others
RIP1 kinase inhibitor 1
T12725
Synonym:
Target: Others
Apostatin-1
T9079
Synonym: Apt-1
Target: Others
Necrostatin-34
T9095
Synonym: 2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4
Target: RIP kinase
GSK2983559 active metabolite
T5401
Synonym: GSK2983559,RIPK2 inhibitor 1,RIPK2-IN-1
Target: RIP kinase
Necrostatin 2 racemate
T7504
Synonym: Necrostatin-2 racemate
Target: RIP kinase
ICCB-19 hydrochloride
T8931L
Synonym: ICCB-19 HCl(750621-52-4 free base)
Target: Apoptosis, Others, Autophagy, RIP kinase
WEHI-345
T3997
Synonym: WEHI345
Target: RIP kinase
PROTAC RIPK degrader-6
T36243
Synonym:
Target:
TargetMol