Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, cytochrome C, and cleaved-caspase-3 levels. Polyphyllin D has an anti-angiogenic effect. Polyphyllin D has toxicity in human RBCs as well as its underlying mechanism for the hemolysis and eryptosis/erythroptosis. Polyphyllin D has strong anticancer activity, can overcome drug resistance in R-HepG2 cells and elicit programmed cell death via mitochondrial dysfunction.
Formosanin C (Polyphyllin B) is a compound isolated from Rhizoma Paridis, showed pro-apoptosis and immunoregulation with antitumor activity in cultured cells and animal systems.
Pennogenin 3-O-beta-chacotrioside, isolated from *Paris polyphylla*, exhibits anti-colorectal cancer activity by modulating autophagy through increased expression of autophagy-related proteins LC3 and Beclin-1.
Polyphyllin H can be extracted from loblolly pine and rhizomes, has antitumor activity, and is used in studies of inflammation, fractures, and convulsions.
Polyphyllin F is a natural product of Paris, Liliaceae. The catalog number is TN4815 and the CAS number is 76296-74-7. Polyphyllin F can be used as a reference standard.
Dichotomin is a natural product of Paris, Liliaceae. The catalog number is TMA2055 and the CAS number is 53093-47-3. Dichotomin can be used as a reference standard.
Ergosta-7,22-dien-3-one is a lanosterane that can be isolated from the substrates of Ganoderma taiwanensis. It exhibits pro-inflammatory properties, stimulating nitric oxide production, inducing gene expression, and promoting the production of TLRs, cytokines, chemokines, and cellular adhesion molecules.
Polyphyllin G (Polyphyllin VII), the the main member of polyphyllin family, shows strong anticancer activity against several carcinomas, including lung cancer, breast cancer, colorectal cancer, cervical cancer, hepatocellular carcinoma and osteosarcoma.
Parisyunnanoside B is a natural product of Paris, Liliaceae. The catalog number is TMA2053 and the CAS number is 945865-37-2. Parisyunnanoside B can be used as a reference standard.