(R)-Reticuline is a natural alkaloid that can be catalyzed by the microsomal P-450 system in plants and animals for conversion to Salutaridine, which is involved in endogenous morphine synthesis. The isomer of (R)-Reticuline is Reticuline. Reticuline inhibits the JAK2 STAT3 and NF-κB signaling pathways, and also inhibits the mRNA expression of TNF-α and IL-6, with anti-inflammatory effects.