(S)-Laudanosine is the corresponding isomer of Laudanosine, which crosses the blood-brain barrier, causing euphoria and seizures, with potential systemic toxicity and analgesic effects. In the cardiovascular system, high plasma concentrations can lead to hypotension and bradycardia.Laudanosine interacts with γ-aminobutyric acid, opioid, and nicotinic acetylcholine receptors, and inhibits the low-affinity GABA receptor, as well as competitively binds to the opioid receptor Mu-1 receptor.
Armepavine (R-Armepavine) exerted both in vitro and in vivo antifibrotic effects in rats, with inhibition of NF-κB, JunD and C EBP pathways. It improves experimental autoimmune crescentic glomerulonephritis.