β estradiol 6 one 6 (o carboxymethyloxime)

β-Estradiol-6-one 6-(O-carboxymethyloxime) is an alkyl chain-based PROTAC linker used for PROTAC synthesis [1].

6-Maleimidocapronic acid, an alkyl chain-based PROTAC linker, is utilized in the synthesis of PROTACs (proteolysis-targeting chimeras).

1-Bromo-6-chlorohexane (Hexane, 1-bromo-6-chloro-) is used as PROTAC linker.

Potent and selective cereblon degrader (DC50 = 1.5 nM). Induces complete degradation of cereblon in MM1S cells. Comprises a cereblon E3 ligase ligand joined by a linker to a ligand for the E3 ligase VHL. Cell-permeable. Steinebach et al (2019) PROTAC-mediated crosstalk between E3 ligases. Chem.Commun.(Camb) 55 1821 PMID:30672516

PROTAC CDK9 degrader-6 is a specific PROTAC targeting CDK9 for degradation via the proteasome pathway, effectively degrading CDK9 with DC50 values of 0.10 μM and 0.14 μM for the CDK9 42 and CDK9 55 isoforms, respectively [1].

K-Ras ligand-Linker Conjugate 6 is a chemical compound that combines a ligand for the K-Ras recruiting moiety and a PROTAC linker. It can recruit E3 ligases, including VHL, CRBN, MDM2, and IAP. K-Ras ligand-Linker Conjugate 6 is particularly useful in synthesizing PROTAC K-Ras Degrader-1, which achieves ≥70% degradation efficacy in SW1573 cells[1].

PROTAC IRAK4 degrader-6 is a potent Cereblon-based compound designed to degrade [interleukin-1 receptor-associated kinase 4 (IRAK4)].

β-Estradiol-6-CMO-PEG3-biotin serves as a cleavable 3-unit PEG ADC linker for the synthesis of antibody-drug conjugates (ADCs) [1].

2-(2-(6-Chlorohexyloxy)ethoxy)ethanamine hydrochloride [catalog number: T64585] is a valuable organic compound for life sciences research.

Pomalidomide-6-OH, a Pomalidomide-derived cereblon (CRBN) ligand, facilitates the recruitment of CRBN protein. This compound can be tethered to a protein ligand through a linker to create a proteolysis-targeting chimeric molecule (PROTAC [1]).

6-Bromohexylphosphonic acid, an alkyl chain-based linker, is commonly used in the synthesis of PROTACs (proteolysis targeting chimeras) [1].

Lenalidomide-6-F is a derivative of Lenalidomide that serves as a cereblon (CRBN) ligand facilitating the recruitment of CRBN protein. With the addition of a linker, Lenalidomide-6-F can be conjugated to the ligand for the protein, enabling the formation of PROTAC.

PROTAC BRD9 Degrader-6, with an IC50 value of 0.13 nM, is a potent degrader of BRD9 suitable for research on BAF complex-related disorders [1].

6-Maleimidocaproic acid-PFP ester is a hydrocarbon-based PROTAC linker suitable for synthesizing PROTACs [1].

HEMTAC CDK4 6 degrader 1 is a PROTAC connected by ligands for HSP90 and CDK4 6 with a ( K_d ) value of 35.7 μM. It induces CDK4 6 degradation in B16F10 melanoma cells, arrests the cell cycle at the G0 G1 phase, and induces apoptosis. HEMTAC CDK4 6 degrader 1 can be used in cancer research [1].

4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenol is an alkyl chain-derived PROTAC linker used in the synthesis of PROTACs[1].

Boc-6-aminohexanoic acid, an alkyl ether-based linker, is utilized in PROTAC synthesis.

Pomalidomide-6-O-CH3 is a Pomalidomide-derived ligand for cereblon (CRBN), which serves as a linkage agent to recruit the CRBN protein. This ligand, when connected to a protein via a linker, enables the formation of PROTAC.

PROTAC RIPK degrader-6 (example 1) is a PROTAC engineered for RIP Kinase degradation, comprising a RIP2 kinase inhibitor linked to a cereblon binder[1].

PROTAC BTK Degrader-6 (Compound 15), with a DC50 of 3.18 nM, exhibits anti-inflammatory properties by inhibiting NF-κB activation and suppressing the expression of pro-inflammatory cytokines such as IL-1β and IL-6 [1].

6-Maleimidocaproic acid sulfo-NHS serves as an alkyl/ether-based PROTAC linker, facilitating the synthesis of PROTACs.

BET-IN-6, a ligand with potent and high affinity for inhibiting BRD2/BRD4, plays a crucial role in the synthesis of PROTAC BRD2/BRD4 degrader-1 [1], targeting the protein BRD2/4.

PROTAC EGFR degrader 6 is a potent PROTAC EGFR degrader that effectively reduces EGFR Del19 levels in HCC827 cells, exhibiting a DC50 of 45.2 nM. It notably promotes apoptosis and induces G1 phase arrest in HCC827 cells [1].

cIAP1 Ligand-Linker Conjugates 6 hydrochloride combines an IAP ligand for the E3 ubiquitin ligase with a PROTAC linker, and is utilized for designing SNIPERs[1].

m-PEG6-(CH2)6-Phosphonic acid functions as a PEG-based PROTAC linker for PROTAC synthesis [1].

6-O-2-Propyn-1-yl-D-galactose functions as an irreversible glycolinker, facilitating the attachment of cytotoxic drugs for applications in antibody-drug conjugation (ADC).

m-PEG4-(CH2)6-Phosphonic acid is a polyethylene glycol-based linker compound designed for synthesizing proteolysis targeting chimeras (PROTACs)[1].