actinomycete

5'-Fluoro-5'-deoxyadenosine (5'-Fluoro-5'-deoxy-adenosine) is utilized commonly as a tool for studying the Actinomycete bacterium Streptomyces cattleya.

Fervenulin is isolated from a nematicidal actinomycete Streptomyces sp. CMU-MH021 with nematicidal activity. It also inhibits egg hatch and J2 mortality of M. incognita (MICs: 30 μg/mL and 120 μg/mL, respectively).

Erythromycin (E-Mycin) is a Macrolide and Macrolide Antimicrobial. The physiologic effect of erythromycin is by means of Decreased Sebaceous Gland Activity.

Oxytetracycline (Terramycin) is a TETRACYCLINE analog isolated from the actinomycete STREPTOMYCES rimosus and used in a wide variety of clinical conditions.

Nocarimidazole A, a white amorphous solid alkaloid exhibiting ultraviolet activity, can be isolated from the marine actinomycete Nocardiopsis [1] [2].

Luisol A, an aromatic tetraol and anthraquinone antibiotic analog, serves as a significant metabolite produced by an estuarine marine actinomycete from the genus Streptomyces. Additionally, it functions as an ADC (Antibody-Drug Conjugate) cytotoxin [1].

TPU-0037C is a metabolite of the marine actinomycete S. platensis that is structurally similar to lydicamycin . It is active against Gram-positive bacteria (MICs = 0.39-3.13 μg/ml), including methicillin-resistant S. aureus strains (MIC = 3.13 μg/ml), but is ineffective against Gram-negative bacteria (MICs = >50 μg/ml).

Saccharocarcin B was isolated from the fermentation broth of the actinomycete Saccharothrix aerocolongenes subsp.antibiotica SCC1886.

Friulimicin D, a lipopeptide antibiotic similar to Friulimicin B, is derived from the actinomycete Actinoplanes friuliensis [1].

K-252b, an indolocarbazole derived from the actinomycete Nocardiopsis, functions as a protein kinase C (PKC) inhibitor. It is effective in inhibiting extracellular kinases in cultured cells due to its inability to freely cross the cell membrane.

Wychimicin A, a spirotetronate polyketide isolated from the rare actinomycete Actinocrispum wychmicini strain MI503-AF4, exhibits potent antibacterial activity. Specifically, it demonstrates efficacy against methicillin-resistant Staphylococcus aureus (IC 50 = 0.125-0.5 μg/mL) and Enterococcus faecalis/faecium (IC 50 = 0.125-0.25 μg/mL) [1] [2].

IKD-8344 is a macrocyclic dilactone originally isolated from an actinomycete species and has diverse biological activities, including anticancer, antimicrobial, and anthelmintic properties.1,2,3 It is cytotoxic to L5178Y murine leukemia cells (IC50 = 0.54 ng/ml).1 IKD-8344 inhibits growth of the mycelial form of C. albicans (MIC = 6.25 μg/ml) and potentiates the activity of polymyxin B against the multidrug-resistant pathogenic bacterium B. cenocepacia.2,3 It is active against T. spiralis in vitro and in vivo.1 |1. Minami, Y., Yoshida, K., Azuma, R., et al. Structure of a novel macrodiolide antibiotic IKD-8344. Tetrahedron Lett. 33(48), 7373-7376 (1992).|2. Hwang, E.I., Yun, B.S., Yeo, W.H., et al. Compound IKD-8344, a selective growth inhibitor against the mycelial form of Candida albicans, isolated from Streptomyces sp. A6792. J. Microbiol. Biotechnol. 15(4), 909-912 (2005).|3. Loutet, S.A., El-Halfawy, O.M., Jassem, A.N., et al. Identification of synergists that potentiate the action of polymyxin B against Burkholderia cenocepacia. Int. J. Antimicrob. Agents 46(4), 376-380 (2015).

Lincomycin-B is a lincosamide antibiotic isolated from the actinomycete Streptomyces lincolnensis.

Wychimicin C, a spirotetronate polyketide isolated from the rare actinomycete, Actinocrispum wychmicini strain MI503-AF4, demonstrates potent antibacterial efficacy. Specifically, it exhibits significant activity against methicillin-resistant Staphylococcus aureus (IC 50 =0.125-0.5 μg/mL) and Enterococcus faecalis/faecium (IC 50 =0.125-0.25 μg/mL) [1] [2].

Drimentine C is a terpenylated diketopiperazine antibiotic originally isolated from Actinomycete bacteria. It inhibits proliferation of NS-1 murine β lymphocyte myeloma cells by 63 and 98% in vitro when used at concentrations of 12.5 and 100 μg/ml, respectively.

Erythromycin dihyrate dihydrate is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin dihyrate acts by binding to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid.

Propioxatin B is an enkephalinase B inhibitor isolated from actinomycete.

SF2312 ammonium is the ammonium salt of SF2312, a phosphonate antibiotic and enolase inhibitor derived from the actinomycete Micromonospora and active under anaerobic conditions. Notably, SF2312 exhibits selective toxicity against ENO1-deleted glioma cells [1].

Drimentine A is a terpenylated diketopiperazine antibiotic originally isolated from Actinomycete bacteria. It is active against Gram-positive and Gram-negative bacteria, fungi, and yeast and has anthelmintic properties.

Erythromycin thiocyanate acts by binding to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid .Erythromycin thiocyanate

Kibdelone A, a natural heterocyclic polyketide, was first isolated from the soil actinomycete Kibdelosporangium. It exhibits potent and selective cytotoxicity against various human tumor cell lines, in addition to showing significant antibacterial and nematocidal activity.

A 83016F, an antibiotic from an actinomycete designated A83016, exhibits weak antimicrobial activity.

Propioxatin A is an enkephalinase B inhibitor isolated from actinomycete.

Friulimicin A, a lipopeptide antibiotic analogous to Friulimicin B, is isolated from the actinomycete Actinoplanes friuliensis [1].

Luminamicin is active against anaerobic bacteria, especially Clostridium sp.; isolated from actinomycete strain OMR-59.

N,O-Diacetyltyramine, isolated from the actinomycete Pseudonocardia endophytica VUK-10, exhibits both antibacterial activity against Gram-positive and Gram-negative bacteria, alongside fungi, and demonstrates cytotoxicity towards MDA-MB-231, HeLa, MCF-7, and OAW-42 cells [1].

Elsamitrucin is a heterocyclic antineoplastic antibiotic isolated from the bacterium Actinomycete strain J907-21. Elsamitrucin intercalates into DNA at guanine-cytosine (G-C)-rich sequences and inhibits topoisomerase I and II, resulting in single-strand breaks and inhibition of DNA replication. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).

Salinosporamide C is a decarboxylated pyrrole analogue isolated from the marine Actinomycete Salinispora tropica.

Simaomicin alpha is an actinomycete metabolite isolated from an actinomycete strain.

Salinosporamide B is a deschloro analog isolated from the marine Actinomycete Salinispora tropica.

Drimentine B is a terpenylated diketopiperazine antibiotic originally isolated from Actinomycete bacteria. It is active against Gram-positive and Gram-negative bacteria, fungi, and yeast, and has anthelmintic properties. Drimentine B inhibits proliferation of NS-1 murine β lymphocyte myeloma cells by 41 and 59% in vitro when used at concentrations of 50 and 100 μg/ml, respectively.

Lincomycin is a lincosamide antibiotic that comes from the actinomycete Streptomyces lincolnensis. Although similar in structure, antibacterial spectrum, and mechanism of action to macrolides, lincomycin is also effective against other organisms including

Kibdelone C is a member of a family of natural heterocyclic polyketides first isolated from a soil actinomycete, Kibdelosporangium. Kibdelones have been described as having potent and selective cytotoxicity against a panel of human tumor cell lines, and kibdelone C has low nanomolar effectiveness in these assays. Kibdelone C disrupts the actin cytoskeleton without directly binding actin or affecting its polymerization in vitro.

Gilvocarcin V, a metabolite from Actinomycete DO-38, exhibits potent antibacterial, antifungal, and antiviral activity.

Resistoflavine is a metabolite of the marine actinomycete S. chibaensis. It slows the growth of and is cytotoxic to HMO2 and HepG2 cells with mean lethal concentrations (LC50) of 0.013 and 0.016 μg/ml, respectively.

N-Methylstreptothricin F is a streptothrycin isolated from actinomycete.

Toyocamycin (Vengicide) is an adenosine analog produced by Actinomycete, acts as an XBP1 inhibitor, inhibits IRE1α-induced ATP-dependent XBP1 mRNA cleavage (IC50: 80 nM). Toyocamycin induces apoptosis.