aggressiveness

BMS-1 (PD-1/PD-L1 inhibitor 1) is an inhibitor of the PD1-PD-L1 protein-protein interaction. It also acts as an immunomodulator. Programmed death ligand 1 (PD-L1) is a protein in humans that is encoded by the CD274 gene and the upregulation of PD-L1 allows Ys to evade the host immune system. High tumor expression of PD-L1 was associated with increased tumor aggressiveness and a 4.5-fold increased risk of death.

Evenamide (NW-3509) is a sodium channel blocker. Which shows efficacy in a broad spectrum of rodent models of psychosis, mania, depression, and aggressiveness.

Geissoschizine methyl ether, a major indole alkaloid found in Uncaria hook, is a key active component of Yokukansan with psychotropic effects. It is a potent serotonin A receptor agonist and a candidate for ameliorating aggressiveness and sociality by Yokukansan.

PI-55 (6-(2-hydroxy-3-methylbenzylamino)purine) is a cytokinin receptor inhibitor that exhibits structural similarity to 6-benzylaminopurine (BAP). It competitively inhibits BAP binding on the specific Arabidopsis receptors CRE1 AHK4 and AHK3. Furthermore, PI-55 effectively suppresses cytokinins-induced haustorium formation and enhances parasite aggressiveness [1].

Ac-VLPE-FMK, a tetrapeptidyl mono-fluoromethyl ketone (m-FMK), inhibits Cathepsin B (Cat-B) and Cathepsin L (Cat-L) and is used in cancer aggressiveness research [1] [2].