antitumor agent 4

Antitumor agent-4 is a butenylphenyl phosphate derivative, is an agent of mammary cancer and anovulatory sterility.

Anti-Influenza agent 4 is a potent and selective inhibitor of the influenza virus, effectively inhibiting the A Parma and A Roma strains with EC50s of 62 nM and 150 nM, respectively.

Antitumor agent-2 has anti-inflammatory and anti-tumor activity and can be used to study cancer.

(2E)-3-(3,5-dimethoxyphenyl)-1-(2-methoxyphenyl)prop-2-en-1-one is also known as DMPVP.It is a novel synthetic compound belonging to the class of cathinones that is psychoactive.

Antitumor agent-19 is a modulator of tumor-associated macrophages with EC50s of 17.18 μM and 18.87 μM in the RAW 264.7 cells and the BMDM cells.

Antitumor agent-87 is a potent compound exhibiting high antitumoral activity, with a Ki value of 0.23 µM for CYP1A1. It demonstrates antiproliferative effects and induces cell cycle arrest at the G2 M phase, underscoring its effectiveness as an antitumor agent.

2-({[2-(4-ethoxy-3-methoxyphenyl)-1,3-thiazol-4-yl]methyl}sulfanyl)pyrimidine-4,6-diamine can be used in the development of new deoxycytidine kinase (dCK) inhibitors.

Antimycobacterial agent-4 (4-nitro-N-[4-(2-pyridyl)thiazol-2-yl]benzamide) has antibacterial activity against Mycobacterium tuberculosis.

Antitumor agent-66 (Compound 4) is a derivative of (-)-cleistenolide, exhibiting potential as a research tool for cancer diseases [1].

Antitumor agent-77 inhibits the growth and migration of cancer cells and has anticancer effects. antitumor agent-77 inhibits GPx-4 and enhances COX2-induced iron sagging. antitumor agent-77 activates the intrinsic apoptotic pathway (Bax-Bcl-2-caspase-3) in tumor cells and prevents tumor cell epithelialization. Antitumor agent-77 activates the tumour cell intrinsic apoptotic pathway (Bax-Bcl-2-caspase-3) and blocks the epithelial mesenchymal transition (EMT) process.

Antitumor agent-78 inhibits GPx-4 and elevates COX2, leading to ferroptosis. antitumor agent-78 activates the tumor cell intrinsic apoptotic pathway (Bax-Bcl-2-caspase-3) and inhibits the epithelial mesenchymal transition (EMT) process in tumor cells. Antitumor agent-78 exhibits antitumor effects and inhibits the growth and migration of cancer cells.

Antitumor agent-89 (Compd OTS-5), a naturally occurring compound, exhibits weak inhibitory activity against fMLP-induced superoxide generation [1].

Antitumor Agent-100 (compound A6) is a molecular gel and apoptosis inducer targeting PDE3A-SLFN12 with an IC50 of 0.3 μM, demonstrating potent antitumor activity. This orally available agent binds to the PDE3A enzyme pocket, recruiting and stabilizing SLFN12 which disrupts protein translation and induces apoptosis [1].

Compound Ir5 (Antitumor agent-145) serves as a tumor inhibitor characterized by significant fluorescence and mitochondrial targeting. It promotes anti-cancer activity by inducing necroptosis and stimulating the necroptosis-related immune response [1].

Compound 2 (Antioxidant agent-4) is a potent antioxidant with notable antilipid peroxidative properties [1].

Compound 24a, also known as Neuroprotective agent 4, is a novel and effective small molecule antioxidant with neuroprotective effects. It is utilized in the study of ischemic stroke and related diseases [1].

Antitumor agent-62 is an NO-releasing antitumor agent that exhibits antiproliferative effects on cancer cells, activates the mitochondrial apoptosis pathway, and is capable of blocking the cell cycle to G2/M phase.

Antitumor agent-100 hydrochloride (compound A6), serving as both an apoptosis inducer and molecular glue, exhibits superior anti-tumor activity [1].

Antitumor agent-112 (compound 3a) is a potent antitumor compound that induces apoptosis and exhibits cytotoxic activity on A549 cells, with an IC50 value of 91.35 μM [1].

Antitumor agent-93 (compound 7D) effectively inhibits the proliferation of multiple tumor cell lines, including MDA-MB-231 and HCT-116 [1].

Antitumor agent-120 (compound 1), a flavonoid derived from Kudzu root, exhibits negligible inhibitory effects on LNCaP and PC3 cancer cells, with IC50 values exceeding 50 μM [1].

Antitumor Agent-106 (Compound 42) is a potent anticancer compound, demonstrating significant inhibitory activity (IC50 = 4.2-6.6 µM) against lung and colon cancer cell lines [1].

Antitumor agent-60 is a potent antitumor agent that targets the RAS-RAF signaling pathway and binds to CRAF (Kd: 721.3 nM). antitumor agent-60 increases p53 and ROS levels in cancer cells, resulting in oval and irregular nuclei. antitumor agent-60 is sufficient to block the cell cycle in G2/M phase and induce apoptosis. Antitumor agent-60 is sufficient to block the cell cycle in G2/M phase and induce apoptosis. In the A549 tumor transplantation model, Antitumor agent-60 has the ability to inhibit tumor growth.

Antitumor agent-55 (compound 5q) is a potent antitumor compound that inhibits PC3 with an IC50 of 0.91 μM. It blocks the G1 S phase of the PC3 cell cycle, induces apoptosis, inhibits cell migration, and prevents PC3 formation.

Antitumor Agent-71 is an antitumor compound that exhibits an inhibitory effect on tubulin aggregation. antitumor Agent-71 possesses an anti-proliferative effect with IC50 values ranging from 3.98-15.70 μM against tumor cell lines.

Antitumor agent-83 acts as a BAX pro-apoptotic protein activator, significantly inhibiting tumor cell proliferation and mediating cell apoptosis through BAX's conformational activation. It also impedes the A549 cell cycle, demonstrating robust metabolic stability and an in vitro CYPs spectrum.

Antitumor Agent-84, a G-quadruplex (G4)-ligand, stabilizes various G4-DNA structures, demonstrating highly effective antitumor properties.

Antitumor agent-46 is an anti-tumor agent. Antitumor agent-46 demonstrates markedly higher antiproliferative activity on MCF-7 cells with an IC 50 value of 2.08 µM .

Antitumor agent-47 is a silibinin derivative with an antitumor activity. Antitumor agent-47 shows cytotoxic activity against NCI-H1299 and HT29 cells with IC 50 values of 8.07 µM and 6.27 µM, respectively .

Anti-Trypanosoma cruzi Agent-4 is a Trypanosoma cruzi inhibitor utilized for the investigation of infections caused by this parasite.

Anti-MRSA agent 4 (compound 7a), a selective and potent inhibitor of Gram-positive Methicillin-resistant Staphylococcus aureus (MRSA) growth, demonstrates a minimum inhibitory concentration (MIC) of ≤ 0.26 µM and exhibits neither cytotoxic nor hemolytic activity in HEK293 cells [1].

Antitumor agent-86 (compound 5a) demonstrates efficacy against MCF-7 breast cancer cells with an inhibitory concentration (IC 50) of 2.62 µM, promoting apoptosis and cell cycle arrest by disrupting the RAS PI3K Akt JNK signaling pathways [1].

Antiproliferative agent-4 showed good anti-proliferative effects on some cancer cells. antiproliferative agent-4 inhibited tumour growth in nude mice and showed low toxicity. antiproliferative agent-4 reduced the mitochondrial membrane potential of EC109 cells and increased Antiproliferative agent-4 reduced the mitochondrial membrane potential of EC109 cells and increased the apoptosis rate and ROS level.

Antitumor agent-58 is an antitumour agent that effectively inhibits colony formation and cell migration in MGC-803 cells and induces mitochondrial dysfunction in MGC-803 cells. Antitumor agent-58 exhibited potent inhibitory activity against tumour growth in xenograft models carrying MGC-803 cells.

Antitumor agent-44 (Compound 5n) elicits potent antitumor effects by disrupting mitochondrial homeostasis, inducing cell cycle arrest, and triggering apoptosis in human adenocarcinoma cells. Additionally, Antitumor agent-44 demonstrates significant anti-tumor activity in a lung cancer cell xenograft mice model [1].

Antitumor agent-128 (compound 1a) induces cell cycle arrest in the G2 M and S phases, leading to apoptosis in A549 cells [1].

Antitumor agent-96 (Compound D34) is a potent MRE11 inhibitor that down-regulates the homologous recombination (HR) pathway by binding to and suppressing the endonuclease functions of MRE11, thereby inducing apoptosis in CM cells [1].

Antitumor Agent-114, a potent STING (stimulator of interferon genes) agonist, activates immune responses and diminishes tumor size in mouse breast cancer models, demonstrating potential applications in immunity and cancer research [1].

Antitumor Agent-104 (Compound 9) serves as an antineoplastic by impeding DNA repair mechanisms in tumor cells, primarily through the inhibition of PARP1 enzyme activity and reduction of PAR protein levels. Additionally, it suppresses CDK12 expression [1].

Antitumor agent-97 (compound 42), an anticancer agent, effectively inhibits proliferation and autophagy in MGC 803 cells, induces apoptosis, and enhances ROS accumulation, proving useful in cancer research [1].

Antitumor Agent-113 exhibits cytotoxicity in A549 cells, with an IC50 of 46.60 μM, and induces apoptosis, making it applicable for research in non-small cell lung cancer [1].

Antitumor Agent-110 (Compound 13), an imidazotetrazine anticancer agent, exhibits excellent permeability. It halts the cell cycle at the G2/M phase and induces apoptosis [1].

Antitumor Agent-111 (Compound 46), a c-Met kinase inhibitor (IC50 = 46 nM), exhibits both antitumor and antiproliferative effects. It impedes the cell cycle at the G0/G1 phase and induces apoptosis [1].

Antitumor agent-115 (SS-12) is a potent anti-tumor compound with an IC50 range of 0.34 μM-24.14 μM against the 4T1 mouse breast cancer cell line. It impedes the cell cycle, diminishes mitochondrial membrane potential, and triggers apoptosis, with an IC50 for cell viability spanning 8-25 μmol L. This compound is applicable in breast cancer research [1].

Antitumor agent-67 (compound 3), a potent antitumor agent, exhibits highly selective toxicity toward cancer cells while sparing normal cells. This compound can be activated by NQO1 to effectively release podophyllotoxin, thereby killing tumor cells. In HepG2 xenograft models, Antitumor agent-67 significantly inhibits cancer growth with minimal toxicity [1].

Antitumor agent-119 (compound 13K), a 2-benzoxazolyl hydrazone derivative, exhibits anticancer capabilities by impeding the proliferation of Burkitt, CCRF-CEM, HeLa, and HT-29 cells, with respective IC50 values of 30 nM, 140 nM, 100 nM, and 40 nM [1].

GABAA receptor agent 4 (compound 1e) is a potent antagonist of γ-GABAAR, exhibiting a Ki of 0.18 µM, and demonstrates immunomodulatory potential by effectively rescuing the inhibition of T cell proliferation [1].

Antitumor agent-54 (Compound C11) is a 14-3-3η protein inhibitor (KD: 35 μM). antitumor agent-54 inhibits several typical human hepatocellular carcinoma cell lines. antitumor agent-54 blocks the cell cycle in the G1-S phase and induces apoptosis, showing good metabolic stability. It exhibits good metabolic stability.