bicyclic

3-Carene（Delta-3-Carene） is a bicyclic monoterpene extracted from western larch and Douglas-fir that acts as a phytofungicide.3-Carene inhibits inflammatory infiltrates and COX-2 overexpression induced by nociceptive stimuli.3-Carene has anti-injury properties and promotes the activity and expression of alkaline phosphatase, an early marker of osteoblast differentiation.

(+)-BORNEOL (d-Borneol) is a natural bicyclic monoterpene used for analgesia and anesthesia in traditional Chinese medicine; enhances GABA receptor activity with an EC50 of 248 μM.

Camphor (2-Camphanone) is a bicyclic monoterpene ketone found widely in plants, especially CINNAMOMUM CAMPHORA. It is used topically as a skin antipruritic and as an anti-infective agent.

Indole has a bicyclic structure, consisting of a six-membered benzene ring fused to a five-membered nitrogen-containing pyrrole ring. It can be produced by bacteria as a degradation product of the amino acid tryptophan. It occurs naturally in human feces and has an intense fecal smell. At very low concentrations, however, it has a flowery smell, and is a constituent of many flower scents (such as orange blossoms) and perfumes.

Sabinene is a natural product that has antifungal and anti-inflammatory properties

Isobornyl acetate is a natural product derived from the essential oil of the lemongrass plant and is a bicyclic monoterpene. It is used in a variety of applications, including as a flavoring agent, a fragrance ingredient, and a pharmaceutical ingredient.

2-Carene is a naturally occurring bicyclic monoterpene found in many essential oils such as pine, cedar and cypress. It has been found to have anti-inflammatory, antifungal and antibacterial activities, as well as antioxidant, antitumor and antiallergic activities, and neuroprotective, cardioprotective and hepatoprotective effects.

Stenophyllol B (compound 4), a trimeric stilbene characterized by bicyclic and bridged tricyclic structures, was initially identified in the Dipterocarpaceae family, with occurrences in various species of the genera Hopea, Neobalanocarpus, Shorea, Stemonoporus, and Vateri [1].

(4R,4aS,5aS,6aR,6bS,7aR)-4-Hydroxy-3,6b-dimethyl-5-methylene-4,4a,5,5a,6,6a,7,7a-octahydrocyclopropa[2,3]indeno[5,6-b]furan-2(6bH)-one is a sesquiterpene lactone with a complex bicyclic structure [1].

Malformin C is a natural fungus-derived bicyclic pentapeptide that has antibacterial properties, particularly against species of Bacillus. Malformin C potently blocks the ability of bleomycin to induce G2 arrest in human T-cell leukemia-derived Jurkat cells (IC50 = 0.9 nM). It less potently abrogates colchicine-induced M phase arrest in Jurkat cells (IC50 = 24 nM). Malformin C inhibits cell growth dose-dependently in Colon 38 and HCT 115 cancer cells (IC50s = 0.27 and 0.18 μM, respectively) but has a low therapeutic index against cancer xenografts when tested in mice.

(-)-Isobicyclogermacrenal is a natural product. This sesquiterpene compound (C15H20O) is characterized by a bicyclic structure and is commonly found in various plants, often contributing to their aromatic properties. Its presence has been documented in essential oils and it is studied for its potential biological activities.

(±)-7-epi-Kadsurenone is a novel lignan characterized by a hydrobenzofuran structure and a bicyclic [3.2.1]octane moiety. [1]

Moroidin, a bicyclic octapeptide from the Urticaceae-type cyclopeptide family, acts as a tubulin polymerization inhibitor, demonstrating significant effects on purified tubulin polymerization. It exhibits cytotoxicity against various cancer cell lines and induces apoptosis in A549 human lung cancer cells [1].

(-)-Fenchone is a bicyclic monoterpenoid widely distributed in plants and can be extracted from Foeniculum vulgare and Peumus boldus. (-)-Fenchone has a wide range of biological activities including antioxidant, wound healing, antidiarrheal, antifungal, anti-injury sensory and bronchodilator activities. (-)-Fenchone is a potential anti-tumor compound.

Carabrone, a botanical bicyclic sesquiterpenic lactone, is a promising fungicidal agent that can effectively control G. tritici.