camkk

HS-276 is a highly selective, orally active inhibitor of TAK1 (Ki: 2.5 nM). HS-276 significantly inhibits TAK1 (IC50: 8.25 nM), CLK2 (IC50: 29 nM), GCK (IC50: 22 nM), ULK2 (IC50: 63 nM), MAP4K5 (IC50. HS-276 can be used to study rheumatoid arthritis (RA).

Marein shows neuroprotective effect on PC12 cell damage induced by methylglyoxal, which is due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway, it may be a potent compound for preventing/counteracting diabetic e

TIM-063 is a selective, cell-permeable inhibitor of CaMKK that competes with ATP, directly targeting the catalytic domain of CaMKK. It exhibits K(i) values of 0.35 μM for CaMKKα and 0.2 μM for CaMKKβ, with respective IC(50) values of 0.63 μM and 0.96 μM.