T-cell surface glycoprotein CD3 epsilon chain, also known as CD3E, is a single-pass type I membrane protein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. The CD3 epsilon subunit of the T cell receptor (TCR) complex contains two defined signaling domains, a proline-rich sequence and an immune tyrosine activation motifs (ITAMs), and this complex undergoes a conformational change upon ligand binding that is thought to be important for the activation of T cells. T cell receptor-CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. This complex is critical for T-cell development and function, and represents one of the most complex transmembrane receptors. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. Homozygous mutations in CD3D and CD3E genes lead to a complete block in T-cell development and thus to an early-onset severe combined immunodeficiency phenotype.

CD3D & CD3E Heterodimer Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 77.5 kDa and the accession number is P04234-1&P07766-1.

CD3 epsilon/CD3e Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 12.3 kDa and the accession number is G7NCB9.

CD3D & CD3E Heterodimer Protein, Rhesus, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 76.7 kDa and the accession number is G7NCB9.

CD3 epsilon/CD3e Protein, Human, Recombinant (His) is expressed in CHO mammalian cells with His tag. The predicted molecular weight is 13.2 kDa and the accession number is P07766.

CD3D & CD3E Heterodimer Protein, Cynomolgus, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 76.63 kDa and the accession number is Q95LI8-1.

CD3 epsilon/CD3e Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 37.56 kDa and the accession number is Q95LI5-1.

CD3 epsilon/CD3e Protein, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 38.2 kDa and the accession number is P27597.

CD3 epsilon/CD3e Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 36.1 kDa and the accession number is A6J423.

CD3D Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 11 kDa and the accession number is B0YIY4.

CD3D & CD3E Heterodimer Protein, Mouse, Recombinant (Fc-Flag & Fc-His) is expressed in HEK293 mammalian cells with Fc-Flag, Fc-His tag. The predicted molecular weight is 76 kDa and the accession number is P04235&P22646.

CD3 epsilon/CD3e Protein, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 38 kDa and the accession number is G7NCB9.

CD3D Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 11 kDa and the accession number is Q95LI8.

CD3D Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 36.6 kDa and the accession number is Q95LI8.

CD3E & CD3G Heterodimer Protein, Human, Recombinant (Fc-Flag & mFc) is expressed in HEK293 mammalian cells with Fc-Flag, mFc tag. The predicted molecular weight is 76.9 kDa and the accession number is NP_000724.1&NP_000064.1.

CD3D Protein, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 36.2 kDa and the accession number is A0A8C0PNZ1.

CD3D & CD3E Heterodimer Protein, Human, Recombinant (Flag & His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31.05 kDa and the accession number is P04234&P07766.

CD3D Protein, Human, Recombinant (hFc & FLAG), Biotinylated is expressed in HEK293 mammalian cells with hFc and Flag tag. The predicted molecular weight is 37.8 kDa and the accession number is B0YIY4.

CD3D Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 36.4 kDa and the accession number is P04235.

CD3D & CD3E Heterodimer Protein, Rhesus, Recombinant (Fc-Flag & Fc-His) is expressed in HEK293 mammalian cells with Fc-Flag, Fc-His tag. The predicted molecular weight is 76.63 kDa and the accession number is F6WI60-1.

CD3D & CD3E Heterodimer Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 22.75 kDa.

CD3D & CD3E Heterodimer Protein, Human, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with Flag and His tag. The predicted molecular weight is 31.05 kDa and the accession number is P04234-1&P07766-1.

CD3E & CD3G Heterodimer Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 74.5 kDa and the accession number is NP_031674.1&NP_033980.1.

CD3 epsilon/CD3e Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 38.5 kDa and the accession number is P07766.

CD3E & CD3G Heterodimer Protein, Mouse, Recombinant (C-human IgG1-Fc & His & C-human IgG1-Fc) is expressed in HEK293 mammalian cells. The predicted molecular weight is 75.4 kDa and the accession number is NP_031674.1&NP_033980.1.

CD3 epsilon/CD3e Protein, Human, Recombinant (His), Biotinylated is expressed in CHO mammalian cells with His tag. The predicted molecular weight is 13.2 kDa and the accession number is P07766.

CD3E & CD3G Heterodimer Protein, Human, Recombinant (Fc) is expressed in HEK293 mammalian cells with Fc tag. The predicted molecular weight is 78.4 kDa and the accession number is NP_000724.1&NP_000064.1.

CD3E & CD3G Heterodimer Protein, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 75.4 kDa and the accession number is XP_014971302.1&NP_001253854.1.

CD3 epsilon/CD3e Protein, Human, Recombinant (HEK293,His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 13.2 kDa and the accession number is P07766.

CD3D & CD3E Heterodimer Protein, Mouse, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with Flag and His tag. The predicted molecular weight is 29.2 kDa and the accession number is P04235&P22646.

CD3E & CD3G Heterodimer Protein, Human, Recombinant (Fc-Flag & Fc-His) is expressed in HEK293 mammalian cells with Fc-Flag, Fc-His tag. The predicted molecular weight is 78.36 kDa and the accession number is NP_000724.1.

CD3D Protein, Human, Recombinant (hFc & FLAG) is expressed in HEK293 mammalian cells with hFc and Flag tag. The predicted molecular weight is 37.8 kDa and the accession number is B0YIY4.

CD3E & CD3G Heterodimer Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 74.9 kDa and the accession number is Q95LI5.2&NP_001270839.1.

CD3D & CD3E Heterodimer Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 75.4 kDa and the accession number is P04235&P22646.

The cell surface glycoprotein CD6 is expressed on leukocytes and mediates T cell trafficking across endothelial cell barriers. CD6 is a lymphocyte surface co-receptor physically associated with the T-cell receptor (TCR)/CD3 complex at the center of the immunological synapse.

T-Cell Surface Glycoprotein CD3 ε Chain (CD3ε) is a single-pass type I membrane protein. CD3ε contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3ε is a polypeptide encoded by the CD3E gene on chromosome 11 in humans. The T cell receptor-CD3 complex (TCR/CD3 complex) is involved in T-cell development and several intracellular signal-transduction pathways. This complex is critical for T-cell development and function, and represents one of the most complex transmembrane receptors. The T cell receptor-CD3 complex is unique in having ten cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs). TCR/CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways.

Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, ultimately leading to lymphokine production. LCK also contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP. Interacts with FYB2.

Butyrophilin-like 6 (BTNL6) is a member of the BTN/MOG Ig-superfamily and functions with BTNL1 as a regulator of immune cell proliferation. The Btnl6 gene is found only in mice. BTNL6 expression is coordinated as a heteromeric protein with BTNL1, and the presence of this complex is correlated with expansion of gamma δ T cells, especially those containing V gamma 7Vδ4 TCR. Btnl6 shows striking sequence similarity to Skint1; is also largely restricted to an epithelial tissue (the small intestine) replete with T cells. Our in-house studies showed BTNL6 co-inhibited anti-CD3 induced IL-2 secretion on CD3+ cells.

T-Cell Receptor-Associated Transmembrane Adapter 1 (TRAT1) is a single-pass type III membrane protein. TRAT1 exists as a disulfide-linked homodimer and is strongly expressed in the thymus, and to a lesser extent in the spleen, lymph node, and peripheral blood lymphocytes. TRAT1 is phosphorylated on tyrosines by LCK or FYN upon TCR activation. Its function is to stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells.