delivery

DLin-KC2-DMA is a cationic/ionizable lipid. Which is used for siRNA delivery.

SM-102 is an ionizable amino lipid utilized in the synthesis of lipid nanoparticles (LNPs)[1]. It exhibits promise in the creation of LNPs dedicated to the transportation of mRNA-based vaccines[2].

D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.

Ethyl oleate, a fatty acid ester produced through the condensation of oleic acid and ethanol, serves as the liquid lipid component in nanostructured lipid carriers (NLCs). These NLCs represent a pioneering approach for the oral administration of trans-Ferulic acid (TFA), highlighting ethyl oleate's critical role in enabling effective drug delivery systems.

1. Glaucocalyxin A (Leukamenin F)-SBE-β-CD could be useful with a better solubility and sustained function in drug delivery. 2. Glaucocalyxin A activates caspase-3, decreases BAD phosphorylation, and reduces the expression of X-linked inhibitor of apoptosis protein. 3. Glaucocalyxin A inhibits Akt phosphorylation, suppresses proliferation, and promotes apoptosis in a dose-dependent manner, but not in normal glial cells. 4. Glaucocalyxin A inhibits collagen-stimulated tyrosine phosphorylation of Syk, LAT, and phospholipase Cγ2, the signaling events in collagen receptor GPⅥ pathway. 5. Glaucocalyxin A could potentially be developed as an antiplatelet and antithrombotic agent, can inhibit platelet p-selectin secretion and integrin activation by convulxin, is a GPVI selective ligand.

Casein is a milk protein with multiple roles in a novel drug delivery system that affects postprandial amino acid delivery in different ways through its intragastric coagulation properties.

L-Aspartic aicd sodium (Sodium L-aspartate) is an amino acid, a precursor active molecule for colon-specific active molecule delivery, that promotes Na+ efflux from rat forebrain membrane vesicles.

1,3,5-tris(pyridin-4-ylethynyl)benzene is a heterocyclic compound with a wide range of properties such as fluorescence and electrochemical activity with relatively low toxicity. It has been used as a building block for the synthesis of various materials such as polymers, nanomaterials and organic light emitting diodes (OLEDs). It is also a promising material for the development of novel drug delivery systems.

FFAGLDD amine salt is MMP9 selective cleavage peptides, which used for cytosolic delivery of Doxorubi-cin (DOX) and achieve temporally and spatially controlled slow drug delivery and release.

Fosphenytoin is a phosphate prodrug that can be used as an alternative to intravenous phenytoin for the acute intervention of seizures.Fosphenytoin is hydrolyzed to anticonvulsant phenytoin when administered parenterally.Fosphenytoin can be used in a variety of delivery modes such as intravenous and intraperitoneal.Fosphenytoin can be used in a variety of delivery modes such as intravenous and intraperitoneal.

Myristoyl Pentapeptide-17 Acetate is a small peptide. It promotes the delivery of key ingredients, thus effectively promoting the growth of eyelashes, lengthens and thickens the eyelashes, fortifies the hair, and noticeably intensifies eye expression.

N-(3-methoxyphenyl)prop-2-enamide is an acrylamide derivative that is utilized in the preparation of polymeric materials for drug delivery systems, such as nanoparticles, microparticles and hydrogels.

DLinDAP (D-LinDAP) is an ionizable cationic lipid used for SiRNA delivery.

Transdermal Peptide acetate(888486-23-5 free base) (TD 1 (peptide) acetate) is a 11-amino acid peptide, binds toNa+/K+-ATPase beta-subunit (ATP1B1), and mainly interacts with the C-terminus of ATP1B1. Transdermal Peptide can enhance the transdermal delivery of many macromolecules.Transdermal Peptide TD 1 Amide is novel peptide designed to enhance transdermal drug delivery.

1,4-Dipierazino-2,3,5,6-tetrafluorobenzene is a tetrafluorobenzene derivative with a unique structure that allows it to be used as a carrier for drugs, which can be released in a controlled manner, enabling its use in the development of targeted drug delivery systems.

eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) (387-394) [Multiple species](TFA) is Elongation factor 1 subunit.eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed in the brain, placenta, lung, liver, kidney, and pancreas, and the other isoform (alpha 2) is expressed in the brain, heart, and skeletal muscle. This isoform is identified as an autoantigen in 66% of patients with Felty syndrome. This gene has been found to have multiple copies on many chromosomes, some of which, if not all, represent different pseudogenes1.

Fmoc-Ala-Ala-Asn(Trt)-OH is a cleavable linker vital in ADC synthesis. Fmoc-Ala-Ala-Asn(Trt)-OH joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, optimizing ADC effectiveness.

ATX-002 is a property-tunable lipid for RNA drug delivery.

7-Chlorokynurenic acid (7-chloro-4-hydroxy-2-carboxyquinoline) is an effecitve and selective antagonist of NMDA receptor with IC50 of 0.56 μM for the glycine B coagonist site. 7-Chlorokynurenic acid inhibits the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM and shows antinociceptive actions after neuraxial delivery.

JHU395 is an orally-bioavailable prodrug of a lipophilic glutamine antagonist (GA), 6-diazo-5-oxo-L-norleucine (DON). It demonstrates delivery of DON to malignant peripheral nerve sheath tumor (MPNST) both in vitro and in vivo, resulting in significant antitumor activity in MPNST. Additionally, JHU395 exhibits plasma stability.

Estredox (E2 CDS) is a redox-based estradiol (E2) chemical delivery system.E2-CDS provides sustained and brain-selective delivery of estradiol.

Chlorin E6 (CE6) is a second-generation photosensitizer with antitumor activity when used in combination with irradiation. In a mouse model of implanted fibrosarcoma, Chlorin E6 (2.5-10 mg/kg, i.v., 50-200 J/cm2 irradiation) resulted in complete tumor disappearance after varying degrees of irradiation. Agents including Chlorin E6 were tested in a Phase I clinical study in patients with early superficial squamous cell carcinoma of bronchial origin with favorable results (40 mg/m2, IV, 100 J/cm2 laser irradiation). In a Phase II clinical trial in patients with early stage lung cancer, the same mode of administration resulted in a complete response in 82.9% of patients. Chlorin E6 has been investigated as a nanotechnology drug delivery tool.

Coumarin 6 (Coumarin VI) is a fluorescent dye frequently used to facilitate the traceability of drug delivery systems in vitro.

L-DOPA (Levodopa) is an amino acid precursor of dopamine with antiparkinsonian properties. Levodopa is a prodrug that is converted to dopamine by DOPA decarboxylase and can cross the blood-brain barrier. When in the brain, levodopa is decarboxylated to dopamine and stimulates the dopaminergic receptors, thereby compensating for the depleted supply of endogenous dopamine seen in Parkinson's disease. To assure that adequate concentrations of levodopa reach the central nervous system, it is administered with carbidopa, a decarboxylase inhibitor that does not cross the blood-brain barrier, thereby diminishing the decarboxylation and inactivation of levodopa in peripheral tissues and increasing the delivery of dopamine to the CNS.

DL-Borneol ((endo)-Borneol) is a small molecule extracted from traditional Chinese medicine (TCM). It is an orally bioadjuvant that improves drug delivery to the brain and is commonly used as an adjuvant ingredient in TCM for the treatment of cardio-cerebral vascular diseases.

Cholesterylamine, a cationic lipid, can be incorporated into PLGA to create particles with a charged surface, facilitating its use in drug delivery systems and in the research of autoimmune diseases and allergies [1].

16:0 TAP, a lipid compound, is utilized in the preparation of giant unilamellar vesicles for agent delivery [1].

Paclitaxel-SMCC is a paclitaxel derivative with a SMCC linker. (Succinimidyl-4-( N -maleimidomethyl)cyclohexane-1-carboxylate). Paclitaxel-SMCC can be used to synthesize Paclitaxel bioconjugates with enzymes, antobodies, antigens and other biopolymers. Pa

(2-Pyridyldithio)-PEG4 acid is a four-unit cleavable polyethylene glycol (PEG) linker specifically designed for the synthesis of antibody-drug conjugates (ADCs)[1]. It serves as a crucial component in the conjugation of antibodies and drugs, enabling targeted drug delivery and enhanced therapeutic efficacy. This linker possesses a (2-pyridyldithio) group at one end, facilitating the attachment of the linker to the specific site on the antibody molecule. The PEG4 chain provides the necessary flexibility and biocompatibility for optimal drug release while maintaining stability throughout the circulation in the body. Ultimately, (2-Pyridyldithio)-PEG4 acid is instrumental in the development and advancement of ADCs, a promising approach in cancer therapy.

MPS-Gαi3, a cell-penetrating peptide, facilitates drug delivery [1].

L-Diguluronic acid, a linear polysaccharide copolymer consisting of two L-guluronic acid (G) units, serves as a precursor for Alginate[1], a categorically unbranched polyanionic polysaccharide. Alginate finds application in the development of antifungal agent delivery carriers[2].

Iso5-2DC18, a lipid, is utilized in the synthesis of amine-containing lipids, which are instrumental in mRNA delivery, activation of the stimulator of interferon genes (STING) pathway, and demonstration of anti-tumor immunity [1].

C8 PEG-Ceramide, a lipid product, possesses the capability to synthesize lipid bilayer carriers, making it applicable for drug delivery [1] [2].

MC-VC-PAB-NH2 is a cleavable linker vital in ADC synthesis. MC-VC-PAB-NH2 joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, optimizing ADC effectiveness.

m-PEG8-Amine is a cleavable linker vital in ADC synthesis. m-PEG8-Amine joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, optimizing ADC effectiveness.

Boc-Val-Ala-PAB-PNP is an ADC linker employed for the synthesis of antibody-drug conjugates (ADCs)[1]. This cleavable compound efficiently facilitates the attachment of drugs to antibodies, allowing for targeted delivery and release of therapeutic agents within the body, making it an important component in ADC development.

Cyclo(Gly-His) is a cyclic dipeptide encompassed within liposomes, exhibiting antimicrobial and anticancer properties with cytotoxic effects on HeLa and MCF-7 cells, demonstrating IC50 values of 1.699 mM and 0.358 mM, respectively. This compound is relevant for drug delivery system research [1].

SWELYYPLRANL-NH2 is a dual antagonist of E-cadherin and N-cadherin, effectively inhibiting the binding of phage clones to both E-cad/Fc and N-cad/Fc chimeric proteins with IC50 values of 0.7 μM and 0.09 μM, respectively. This compound also impedes cell aggregation and has potential applications in enhancing drug delivery by increasing epithelial and endothelial permeability barriers [1].

Fluorescent DOTAP, a cationic lipid, facilitates research in nucleic acid and protein delivery [1].

DSPE-PEG-Maleimide, a compound comprised of DSPE phospholipid and maleimide, is utilized for preparing nanostructured lipid carriers, enhancing both blood circulation time and stability of encapsulated agents [1] [2]. The variant DSPE-PEG5000-Mal includes PEG5000, further contributing to its utility in drug delivery systems.

Hydrogenated soya phosphatidylcholines, a natural compound, enhances the controlled release of water-soluble drugs in oral drug delivery systems by improving drug loading and solubility [1].

MC-VAL-CIT-PAB-VX765 or MC-VAL-CIT-PABC-VX765 is a VX765 derivative that can be conjugated to antibodies, proteins, or polymers for targeted drug delivery. MC-Val- CIT -PAB is a cathepsin cleavable ADC connector, which has been widely used in the preparat

FAP Ligand 1 (FL), a high-affinity small molecule targeting fibroblast activation protein (FAP), facilitates the delivery of conjugated therapeutics to FAP-expressing fibroblasts and enables radiographic imaging of select tumors [1].

2,3-Diphosphoglyceric acid (2,3-DPG), an intermediate of the glycolytic pathway, allosterically binds to deoxygenated hemoglobin, stabilizing it and facilitating oxygen release at tissue sites. This binding decreases hemoglobin's oxygen affinity, promoting oxygen delivery to tissues [1] [2].

Cyclo(RGDyC), a cyclic pentapeptide, exhibits anti-angiogenic properties and has been investigated in conjunction with liposomal delivery systems for the study of ocular neovascular diseases and cancer [1] [2].

Paclitaxel-Succinic acid (paclitaxel-succinate , paclitaxel-semisucinic acid)is a paclitaxel derivative with a succinic acid linker. Paclitaxel-Succinic acid can be used to prepare paclitaxel conjugates for drug delivery and nanomedicine research.

Sulfo-PDBA-DM4 is a drug-linker conjugate for antibody-drug conjugate (ADC) applications, combining the potent tubulin inhibitor DM4 with the gluthatione-cleavable linker Sulfo-PDBA. This configuration harnesses DM4's cytotoxic potential through Sulfo-PDBA's targeted delivery mechanism.

N,N'-Dicyclohexylurea (AURORA KA-3582) is a soluble epoxide hydrolase (sEH) inhibitor.

Palbociclib-Succinic acid is a Palbociclib- derivative with a succinic acid linker. The carboxy group of Palbociclib-Succinic acid can be used to conjugate with other molecules such as peptides, proteins, or polymers. Palbociclib-Succinic acid is a useful

Caspase-3 activator 1 (compound 4b), a Ru(III) metal complex, effectively inhibits gastric tumor growth and metastasis by mediating caspase-3 cleavage. This cleavage enables Caspase-3 to process gasdermin E (GSDME), which results in the production of the GSDME-N terminus, leading to perforation of the gastric tumor cell membrane. Furthermore, compound 4b induces pyroptosis and subsequent immune responses. It can be incorporated with decitabine (DCT) into the 4b-DCT-Lip lipid delivery system [1].

DL-Dopa is a phenylalanine beta-hydroxylated derivative.

Levodopa is the naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can be taken orally and crosses the blood-brain barrier, and rapidly taken up by dopaminergic neurons and converted to D