hep g2

Protein kinase G inhibitor-2 exhibits antibacterial, antiviral, and antitumor activities.

Compound 1059182-21-6 features a cyclic structure characterized by a nitrogen atom occupying an apex (corner) within the heterocycle. Its molecular scaffold integrates aromatic properties due to the presence of a conjugated system, while the inclusion of hydroxyl (-OH) groups confers reactive potential for subsequent modification. Additionally, a halogenated component, specifically a bromine atom, is attached to the aromatic ring, enhancing its propensity for undergoing further synthetic transformations.

FITC-εAhx-HHV-2 Envelope Glycoprotein G (561-578) is a fluorescein isothiocyanate (FITC)-labeled segment of the HHV-2 Envelope Glycoprotein G encompassing amino acids 561 to 578. This region is an immunodominant part of glycoprotein G (gG-2) and exhibits reactivity with all herpes simplex virus type 2 (HSV-2) sera [1].

4-Methyl-6,7,8,9-tetrahydro-2H-pyrano[3,2-g]quinolin-2-one is a useful organic compound for research related to life sciences and the catalog number is T66960.

2’-OMe-G(ibu) Phosphoramidite is a modified phosphoramidite monomer, which can be used for the oligonucleotide synthesis.

2'-MOE-G(iBu)-3'-phosphoramidite is a Nucleoside Phosphoramidite;Nucleoside Derivative - 2'-Modified nucleoside;.

Rev 2'-O-MOE-G(iBu)-5'-amidite is a Nucleoside Phosphoramidite.

HHV-2 Envelope Glycoprotein G (552-574), an immunodominant region within glycoprotein G (gG-2), demonstrates reactivity with all herpes simplex (HSV-2) sera [1].

2'-O-Propargyl G(iBu)-3'-phosphoramidite is a Nucleoside Phosphoramidite; Nucleoside Derivative - 2'-Modified nucleoside.

3'-O-MOE-G(iBu)-2'-phosphoramidite is a Nucleoside Phosphoramidite.

3'-O-Me-G(iBu)-2'-phosphoramidite is a Nucleoside Phosphoramidite.

Musk ketone can induce the growth repression and the apoptosis of cancer cells. Musk ketone increases activity of glutathione S-transferase and thus may prove to be useful cancer chemoprotectant.

Oleoside 11-methyl ester (Methyloleoside) is a natural product.

Camellianin A is a flavonoid series of compounds derived from A. nitida and tea that exhibits anticancer activity, inhibits angiotensin-converting enzyme (ACE) activity, and promotes apoptosis in Hep G2 and MCF-7 cells.Camellianin A prevents CCl4-induced liver injury by exerting anti-oxidative stress, anti-inflammatory, and anti-apoptotic properties.

Protoapigenone, an antineoplastic agent extracted from ferns, demonstrates notable inhibitory activity against various cancer cell lines, including Hep G2, Hep 3B, MCF-7, A549, and MDAMB-231. The respective IC50 values are 1.60, 0.23, 0.78, 3.88, and 0.27 μg/mL [1].

Torilin and torilolone show hepatoprotective effects on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells,the EC50 values are 20.6 +/- 1.86 and 3.6 +/- 0.1 microM, respectively; and silybin as a positive control shows an EC50 value of 69.0

EGFR/HER2/DHFR-IN-2 (Compound 4b) serves as an inhibitor for EGFR, HER2, and DHFR, with IC50 values of 0.248, 0.156, and 0.138 μM, respectively. It exhibits anticancer activity, displaying IC50 values of 9.14, 7.33, 14.18, 24.87, 20.07, and 6.16 μM in Hep G2, HeLa, HEp-2, HCT 116, PC-3, and MCF7 cancer cell lines, respectively. Additionally, EGFR/HER2/DHFR-IN-2 has been shown to reduce the growth of breast cancer tumors [1].

Alisol C can improve glucose uptake in Hep G2 cells, it may be one of the therapeutic material basis in hypoglycemic activities in A. orientalis. Alisol C,16,23-oxido-alisol B and alisol O in Zexie may cause nephrotoxicity.

Soyasaponin III is one of the main potentially bioactive saponins found in soy (Glycine max) and related products,and can induce apoptosis in Hep-G2 cells.

Gardenolic acid B shows promising hepatoprotective effects on nitrofurantoin-induced cytotoxicity in human liver-derived Hep G2 cells. Gardenolic acid B shows significant effects on terminating early pregnancy in rats.

Onitin shows super-oxide and DPPH free radical scavenging effects.It also exhibits hepatoprotective activity on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells.

Cudratricusxanthone A has potent anti-proliferative, antioxidative, and monoamine oxidase inhibitory effects, it also possesses anti-cancer activities and provide a basis for developing effective therapeutic agents to inhibit growth and metastasis of brea

O-Allylvanillin, an O-allylchalcone derivative, exhibits anti-cancer properties by inhibiting the growth of THP-1, HL60, Hep-G2, and MCF-7 cells with IC50 values of 74.76 μM, 63.52 μM, 90.99 μM, and 90.11 μM, respectively [1].

Antioxidant agent-15 (Compound 4) demonstrates potent antioxidant inhibition activity, exhibiting an IC50 value of 15.44 nM. Furthermore, it effectively inhibits tumor cell growth in Hela, Hep G2, and Caco-2 cells, with respective IC50 values of 395.26 nM, 400.4 nM, and 24.6 nM [1].

CPT-Se3, a camptothecin (CPT) seleno-derivative, exhibits enhanced anticancer efficacy by effectively killing cancer cells and hindering tumor proliferation. This compound diminishes the GSH/GSSG ratio and total thiols while increasing ROS levels, ultimately triggering apoptosis in Hep G2 cells. Furthermore, CPT-Se3 demonstrates significant cytotoxicity against HeLa, Hep G2, A549, and SMMC-7721 cell lines with IC50 values ranging from 2.19 to 4.7 μM [1].

2,3-O-Isopropylidenyl euscaphic acid shows good hepatoprotective effect,the EC50 value of 88.36±3.25 uM in Hep G2 cells.

Mestranol (Devocin), a semisynthetic estrogen, is used as an estrogen receptor agonist and must be demethylated to be biologically active.

Cochliodone A, a bioactive compound isolated from the deep-sea fungus Chaetomium sp., exhibits both antibacterial and anticancer properties. This substance demonstrates toxicity against multiple bacterial strains, as evidenced by its minimum inhibitory concentrations (MICs) of 15.3 μg/mL for V. vulnificus, 32.7 μg/mL for V. rotiferianus, 15.9 μg/mL for S. aureus ATCC 43300, and 16.3 μg/mL for S. aureus CGMCC 1.12409. Additionally, Cochliodone A effectively inhibits several cancer cell lines, with half-maximal inhibitory concentrations (IC50s) recorded at 28.1 μM for A549, 20.7 μM for HeLa, and 23.2 μM for Hep G2 [1].

Topoisomerase II inhibitor 9 is a Topo II inhibitor (IC50: 0.97 μM) and DNA embedding agent (IC50: 43.51 μM) that blocks the Hep G-2 cell cycle in the G2/M phase and induces apoptosis.

Hepatitis B Virus Receptor Binding Fragment (hepatitis B peptide 4980), a synthetic peptide analog, specifically binds to Hep G2 cells and is a potential immunogen anticipated to induce protective antibodies through the attachment blockade pathway of virus neutralization [1] [2].

GLS-1-IN-1 (compound 1d) is a GLS-1 inhibitor that inhibits Hep G2, MCF 7 and MCF 10A cells.

CPT-Se4, a seleno-derivative of Camptothecin (CPT), exhibits enhanced efficacy in cancer cell eradication and tumor suppression. It reduces the GSH/GSSG balance and total thiol content while increasing ROS concentrations in Hep G2 cells, leading to the induction of cancer cell apoptosis. Furthermore, CPT-Se4 demonstrates cytotoxicity towards a range of cell lines including HeLa, Hep G2, A549, and SMMC-7721, with IC50 values ranging from 2.54 to 6.4 μM [1].

KDM1/CDK1-IN-1 (compound 4) is a potent inhibitor of KDM1 (IC50: 0.096 μM) and CDK1 (IC50: 0.078 μM). kDM1/CDK1-IN-1 blocks the cell cycle of HOP-92 cells in G2/M phase and induces apoptosis. KDM1/CDK1-IN-1 is highly cytotoxic to CCRF-CEM cells (IC50: 16.34 μM), HOP-92 cells (IC50: 3.45 μM) and Hep-G2 cells (IC50: 7.79 μM).

Docosylferulate is a biochemical that has been studied for its inhibition on Hep G2 cells and anti-tumor activities.

Pterisolic acid A shows moderate activity against HCT-116,Hep G2 and BGC-823 cell lines.

Soyasapogenol B has anti-cancer, hypocholesterolemic, anticomplementary, hepatoprotective effects, it inhibits proliferation of cultured Hep-G2.

Anticancer Agent 157 (compound 15) is a nitric oxide (NO) inhibitor with IC50 values of 0.62 μg/mL, exhibiting both anti-inflammatory and anticancer effects. It interacts with inducible NO synthase (iNOS) and caspase 8, which facilitates apoptosis through nuclear fragmentation and chromatin condensation. Additionally, Anticancer Agent 157 effectively inhibits HT29 colon cancer cells (IC50 =2.45 μg/mL), Hep-G2 liver cancer cells (IC50 =3.25 μg/mL), and B16-F10 murine melanoma cells (IC50 =3.84 μg/mL) [1].

Cudraxanthone L shows the significant hepatoprotective effect on nitrofurantoin-induced cytotoxicity in human liver-derived Hep G2 cells.

AR 12465 is a trapidil derivative which may affect LDL receptor mediated uptake and degradation of 125 I-LDL by human skin fibroblasts (HSF) and human hepatic cells (HEP G2).