laxative

Docusate sodium (Aerosol OT) is an orally available, over-the-counter laxative and stool softener used to treat or prevent constipation. Docusate has not been linked to serum enzyme elevations during therapy or to clinically apparent liver injury with jaundice.

Casanthranol is a concentrated mixture of anthranol glycosides derived from the dried bark of Rhamnus p., commonly known as cascara sagrada. This compound serves as a stimulant laxative that is primarily administered to alleviate constipation and other medical conditions. By exerting its effects on the intestinal wall, casanthranol promotes increased muscle contractions, thereby facilitating bowel movements.

Sennoside A (NSC-112929), a kind of irritant laxative isolated from rhei rhizome, causes purgative actions in the intestine.

D-Sorbitol (Sorbitol) is a polyhydric alcohol with about half the sweetness of sucrose. D-Sorbitol occurs naturally and is also produced synthetically from glucose. It was formerly used as a diuretic and may still be used as a laxative and in irrigating solutions for some surgical procedures. It is also used in many manufacturing processes, as a pharmaceutical aid, and in several research applications.

Chenodeoxycholic acid (CDCA) is a bile acid, usually conjugated with either glycine or taurine. It acts as a detergent to solubilize fats for intestinal absorption and is reabsorbed by the small intestine. It is used as cholagogue, a choleretic laxative, and to prevent or dissolve gallstones.

Bisoxatin can be used in the analytical study for the detection of laxative abuse by urine analysis with HPLC and diode array detection. Bisoxatin is also a medicine for Laxatives.

Aloe emodin anthrone is a stimulant-laxative which has been shown to enhance colonic membrane permeability of water-soluble and poorly permeable compounds.

Bisoxatin acetate is a contact laxative in pearl form.

Multiflorin A, an active compound extracted from Pruni semen, exhibits laxative properties and hinders intestinal glucose absorption while facilitating bacterial metabolism [1].

Sulisatin disodium salt is a laxative.

Strictinin, a phenolic compound extracted from Pu'er teas, exhibits antiviral, antibacterial, and laxative properties. Its mode of action involves speeding up intestinal transit without promoting gastric emptying, boosting food consumption, or triggering diarrhea in rats.

Sulisatin is a laxative drug. It is hydrolyzed in the large intestine by the intestinal flora to its diphenyl derivative, BHMI, which is responsible for the laxative activity of the drug.

Phenolphthalol is estrogenically active which is also a laxative in drug preparations [1].

Castor oil (Xenaderm) is a vegetable oil pressed from the seeds of the castor bean, Ricinus communis, used as a laxative and as an excipient in medicinally.

Dolcanatide, an orally active guanylate cyclase-C (GC-C) agonist, exhibits laxative, anti-nociceptive, and anti-inflammatory properties. It is utilized in research concerning inflammatory bowel disease [1] [2].

Sennoside C is an anthraquinone glycoside extracted from leaves and pods of Senna and has an auxiliary effect on the laxative effect of mice.

Oxyphenisatine (Oxyphenisatin), along with related bisacodyl, sodium picosulfate, and phenolphthalein, isa precursor of oxyphenisatine, which has anticancer activity. Oxyphenisatine is often used as a laxative and can cause liver damage when used long-term.

Aloe-emodin-glucoside is a stimulant-laxative which has been shown to enhance colonic membrane permeability of water-soluble and poorly permeable compounds.

Dichlorophen (DDM) is a nontoxic laxative vermicide of chlorinated phenol compound. Dichlorophen is used as a veterinary fungicide, anthelmintic, and anti-protozoan, as well as an ingredient in antimicrobial soaps and shampoos. This agent probably acts by increasing the clearing of intestinal contents, thereby eradicating tapeworm infections from the intestines.

Desacetyl bisacodyl, the active metabolite of the laxative bisacodyl, evokes epithelial Cl(-) secretion in the rat colon and rectum, in addition to increasing mucus and chloride secretion [1].

Bisacodyl (Fenilaxan) is a diphenylmethane stimulant laxative used for the treatment of constipation and for bowel evacuation.

Physcion (Physcione) (Parietin) is an anthraquinone isolated from traditional Chinese medicine Radix et Rhizoma Rhei, acts as an inhibitor of 6-phosphogluconate dehydrogenase, with an IC50 and a Kd of 38.5 μM and 26.0 μM, respectively. Physcion (Parietin) exhibits laxative, hepatoprotective, anti-inflammatory, anti-microbial, anti-proliferative and anti-tumor effects.

2-(Hydroxymethyl)pyridine (Piconol) is used as an organic synthesis and medicinal chemistry intermediate for the synthesis of the stimulant laxative bisacodyl, and as a pyridinol with hypoglycemic activity.