motivational

BP 897 (2-Naphthalenecarboxamide, N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-) is a potent and selective dopamine D3 receptor agonist, and a weak dopamine D2 receptor antagonist, with Kis of 0.92 nM and 61 nM for D3 and D2 receptors, and shows low affinities at D1 and D4 receptors (Kis, 3 and 0.3 μM, respectively).

BP 897 is a potent and selective agonist of dopamine D3 receptor and it is a weak dopamine D2 receptor antagonist, with Kis of 0.92 nM and 61 nM for D3 and D2 receptors. Which shows low affinities at D1 and D4 receptors (Kis, 3 and 0.3 μM, respectively).

GS 39783 is a positive allosteric modulator (PAM) of GABABR, which reduces the motivational properties of alcohol and the conditioned reinforcement and conditional reward of psychostimulants.

(S)-CE-123 is an innovative and highly selective atypical dopamine transporter (DAT) inhibitor, exhibiting an EC 50 of 2.76 μM in uptake inhibition assays performed in HEK293 cells with stable expression of human DAT isoforms. As a Modafinil analogue, (S)-CE-123 can cross the blood–brain barrier and enhances cognitive and motivational functions in experimental animals [1] [2].