mspeg12boc

Ms-PEG12-Boc, a PEG-based linker for PROTACs, connects two essential ligands necessary for creating PROTAC molecules, facilitating selective protein degradation via the ubiquitin-proteasome system within cells.

Boc-12-Ado-OH can be used as a PROTAC linker in the synthesis of PROTACs. Boc-12-Ado-OH is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.