neuropeptide y (human)

Neuropeptide Y (29-64), amide, human is a biologically active 36-amino acid peptide.

Neuropeptide Y (29-64), amide, human acetate is involved in Alzheimer's disease (AD) and protects rat cortical neurons against β-Amyloid toxicity.

[D-Arg25]-Neuropeptide Y (human) ([D-Arg25] NPY), a Y1 receptor selective agonist, plays a role in Alzheimer's disease (AD) and safeguards rat cortical neurons from β-Amyloid toxicity [1].

Neuropeptide Y (3-36) (human, rat) is a metabolite of neuropeptide Y (NPY) generated by dipeptidyl peptidase-4 (DPP4). Known as a selective Y2 receptor agonist, Neuropeptide Y (3-36) (human, rat) effectively reduces the release of norepinephrine via the Y2 receptor[1][2].

High affinity neuropeptide Y Y1 receptor agonist (Ki = 0.39 nM). Also shows affinity for Y4 and Y5 receptors.

Neuropeptide Y (1-24) (human) is a neuropeptide that inhibits the electrically stimulated twitch response in rat vas deferens and activates neurons in the rat CA3 region of the dorsal hippocampus in vivo following N-methyl-D-aspartate (NMDA) induction [1] [2].

Neuropeptide Y (13-36), amide, human is a neuropeptide Y receptor agonist.

Neuropeptide Y (NPY) (3-36) is a C-terminal fragment of NPY, a neuropeptide involved in controlling appetite, blood pressure, cardiac contractility, and intestinal secretion. NPY (3-36) is an endogenous peptide produced by cleavage of NPY by dipeptidyl peptidase 4 (DPP-4). It binds selectively to the NPY receptor Y2 (Ki = 0.41 nM in CHP 234 cells) over the Y1 receptor, where it does not bind at concentrations up to 1 μM. NPY (3-36) (0.1 nM) increases migration of human umbilical vein endothelial cells (HUVECs) by 80% after 12 hours in an in vitro wound closure assay. NPY (3-36) corresponds to residues 3-36 of the human and rat protein sequence.

[Leu31,Pro34]-Neuropeptide Y(human,rat) TFA acts as a specific agonist for the neuropeptide Y Y1 receptor, while also activating receptors Y4 and Y5. This compound is known to elevate blood pressure in anesthetized rats and enhance food intake [1] [2].

Neuropeptide Y (29-64), amide, human (TFA) is involved in Alzheimer's disease (AD) and protects rat cortical neurons against β-Amyloid toxicity.It is showed that Neuropeptide Y (29-64), amide, human (TFA) is able to protect cortical neurons from Aβ25-35 t

Neuropeptide Y (human) TFA, a compound implicated in Alzheimer's disease (AD), exhibits protective effects against β-Amyloid toxicity in rat cortical neurons.

[D-Trp34]-Neuropeptide Y Acetate is a potent and selective agonist of neuropeptide Y (NPY) Y5 receptor. [D-Trp34]-Neuropeptide acetate Y is a significantly less potent agonist at the NPY Y1, Y2, Y4, and y6 receptors. [D-Trp34]-Neuropeptide Y Acetate markedly increases food intake in rats.

Neuropeptide Y (scrambled) Acetate (Pro-Neuropeptide Y (scrambled) Acetate) is a scrambled peptide of Neuropeptide Y that has been implicated in Alzheimer's disease (AD) and may have neuroprotective effects.

Neuropeptide SF (human) aceate is a neuropeptide that augmented paraventricular CRH release and increased ACTH and corticosterone levels in the plasma.

Neuropeptide AF (human) acetate (Neuropeptide AF (human) acetate (192387-38-5 Free base)) is an anti-opioid neuropeptide, a Neuropeptide AF (human) derivative, which regulates adipocyte metabolism.

High affinity neuropeptide Y Y1 receptor agonist

'(Des-Bromo)-Neuropeptide B (1-23) (human)' is an agonist for orphan G-protein-coupled receptors, exhibiting a K i of 1.2 nM for GPR7 (NPBW1) and 341 nM for GPR8 (NPBW2) respectively [1].

Biotinyl-neuropeptide W-23 (human) is a biotinylated form of neuropeptide W-23 (human), which functions as an agonist for the NPBW1 (GPR7) and NPBW2 (GPR8) receptors [1] [2].

Potent neuropeptide Y (NPY) Y5 receptor agonist (pEC50 values are 7.82, 6.28, 6.44 and > 6 at rat Y5, Y4, Y1 and Y2 receptors respectively) that displays > 26-fold, > 1000-fold and > 1000-fold selectivity over Y1, Y2 and Y4 receptors respectively. Induces

Neuropeptide Y (NPY) is a 36-amino acid neuropeptide that exerts its activity via G-protein-coupled receptors. NPY is widely distributed in the peripheral and central nervous systems. It modulates a variety of physiological processes, e.g. the central reg

Neuropeptide W-23(human) (NPW-23) is an endogenous ligand for NPBW1 and NPBW2.

Neuropeptide W-23 (human) (NPW-23) TFA, representing the active form of Neuropeptide W, functions as an endogenous agonist for both NPBW1 (GPR7) and NPBW2 (GPR8) receptors [1].

Neuropeptide AF (93-110), Human is an endogenous antiopioid peptide.

Neuropeptide SF (human) considerably increases the amplitude of the sustained current of heterologously expressed ASIC3 (12-fold vs. 19- and nine-fold for FMRFamide and NPFF, respectively) with an EC50 of ~50 μM.

Neuropeptide Y (2-36) (porcine) is a pig-sourced peptide closely resembling its rat and human counterparts with 97.14% homology. It acts as an agonist for rat neuropeptide receptors Y5, Y2, and Y1, demonstrating EC50 values of 1.2, 1.6, and 3.4 nM, respectively. This compound is utilized in research on obesity and eating disorders [1].

Neuropeptide Y(29-64) is a 36 amino acid peptide, a fragment of Neuropeptide Y.

Neuropeptide S human (TFA) is a potent endogenous neuropeptide S receptor agonist (EC50=9.4 nM).

Neuropeptide Y (18-36) (porcine) acts as a competitive antagonist of the neuropeptide Y (NPY) cardiac receptor, effectively blocking the attachment of I-NPY to cardiac ventricular membranes. Its action is concentration-dependent, exhibiting an IC50 value of 158 nM and a Ki value of 140 nM. This compound is utilized in the study of congestive heart failure [1].

Neuropeptide Y (22-36), a 15 amino acid peptide, is a fragment of Neuropeptide Y.Neuropeptide Y (NPY) is a 36 amino-acid neuropeptide that is involved in various physiological and homeostatic processes in both the central and peripheral nervous systems. N

Neuropeptide Y (porcine), a peptide found in the porcine brain, effectively inhibits secretin-stimulated pancreatic secretion [1].

[D-Trp34]-Neuropeptide Y TFA acts as a potent and selective agonist for the neuropeptide Y (NPY) Y5 receptor, demonstrating significantly lower potency at the NPY Y1, Y2, Y4, and Y6 receptors. It has been observed to significantly increase food intake in rats [1] [2].

Galanin (1-13)-Neuropeptide Y (25-36) amide exhibits high-affinity binding to galanin receptors, similar to that of galanin itself [1].

Neuropeptide Y (NPY), a neuropeptide, plays roles in regulating appetite, vasoconstriction, cardiac contractility, and intestinal secretion, acting as an agonist for NPY receptors Y1, Y2, and Y5. Expressed ubiquitously, NPY modulates cellular responses by selectively inhibiting forskolin-induced cAMP accumulation in L-M(TK-) cells expressing rat Y1 or Y2 and in HEK293 cells expressing rat Y5, more so than in cells expressing rat Y4 receptors (EC50s = 0.15, 2.7, 0.66, and >1,000 nM, respectively). Additionally, it elevates perfusion pressure in isolated guinea pig hearts (EC30 = 1.3 nM) and, when administered intracerebroventricularly at 300 pmol/animal, it notably increases food intake in rats.

Neuropeptide Y (3-36) (porcine) acts as an agonist for the Y2 subtype of the neuropeptide Y (NPY) receptor, effectively stimulating feeding behavior in rats. This compound exhibits high selectivity for the Y2 receptor compared to the non-selective Y1/Y2 receptor ligand, Neuropeptide Y 1-36 [1] [2] [3].

Potent endogenous neuropeptide S receptor agonist (EC50 = 9.4 nM). Increases locomotor activity and wakefulness in mice. Also reduces anxiety-like behavior in mice.

Neuropeptide Y, porcine TFA, a peptide found in the pig's brain, effectively inhibits secretin-stimulated pancreatic secretion [1].

Pancreatic Polypeptide (human) acetate is a C-terminally amidated 36 amino acid peptide, which acts as a neuropeptide Y (NPY) Y4/Y5 receptor agonist.

Peptide YY (PYY) (3-36), human (Peptide YY (3-36)) is a gut hormone peptide. Peptide YY (PYY) (3-36), human acts as a Y2 receptor agonist to reduce appetite.

α-Melanocyte-stimulating hormone (α-MSH) is a 13-amino acid peptide hormone produced by post-translational processing of proopiomelanocortin (POMC) in the pituitary gland, as well as in keratinocytes, astrocytes, monocytes, and gastrointestinal cells.1It is an agonist of melanocortin receptor 3 (MC3R) and MC4R that induces cAMP production in Hepa cells expressing the human receptors (EC50s = 0.16 and 56 nM, respectively).2α-MSH (100 pM) reducesS. aureuscolony formation andC. albicansgerm tube formationin vitro.3It inhibits endotoxin-, ceramide-, TNF-α-, or okadaic acid-induced activation of NF-κB in U937 cells.1α-MSH reduces IL-6- or TNF-α-induced ear edema in mice.4It also prevents the development of adjuvant-induced arthritis in rats and increases survival in a mouse model of septic shock. Increased plasma levels of α-MSH are positively correlated with delayed disease progression and reduced death in patients with HIV.1 1.Catania, A., Airaghi, L., Colombo, G., et al.α-melanocyte-stimulating hormone in normal human physiology and disease statesTrends Endocrinol. Metab.11(8)304-308(2000) 2.Miwa, H., Gantz, I., Konda, Y., et al.Structural determinants of the melanocortin peptides required for activation of melanocortin-3 and melanocortin-4 receptorsJ. Pharmacol. Exp. Ther.273(1)367-372(1995) 3.Cutuli, M., Cristiani, S., Lipton, J.M., et al.Antimicrobial effects of a-MSH peptidesJ. Leukoc. Biol.67(2)233-239(2000) 4.Lipton, J.M., Ceriani, G., Macaluso, A., et al.Antiiinflammatory effect of the neuropeptide a-MSH in acute, chronic, and systemic inflammationAnn. N.Y. Acad. Sci.25(741)137-148(1994)

GR231118 TFA, a neuropeptide Y C-terminus analogue, acts as a potent, competitive, and relatively selective antagonist at the human neuropeptide YY receptor, exhibiting a pKi of 10.4. It serves as a strong agonist at the human neuropeptide YY4 receptor with a pEC50 of 8.6 and a pKi of 9.6, while demonstrating weak agonistic activity at both human and rat neuropeptide YY2 and YY5 receptors. Additionally, this compound shows high affinity for the mouse neuropeptide YY6 receptor, with a pKi value of 8.8 [1].

Potent, selective peptide agonist for the neuropeptide Y Y5 receptor (IC50 values for inhibition of NPY binding to human Y5, Y1, Y2 and Y4 receptors are 0.24, 530, > 500, and 51 nM respectively, Ki at Y5 = 0.1 - 0.15 nM). Stimulates food intake in vivo.

(Pro34)-Peptide YY (human) is a highly Y 1 -selective full agonist of Peptide YY /neuropeptide Y receptors [1] .

CART(55-102)(human) TFA, a human satiety factor, exhibits strong appetite-suppressing activity. It is closely linked with leptin and neuropeptide Y [1] [2].

CART (1-39), Human, Rat is a neuropeptide comprising the first 39 residues of the CART peptide. This compound serves as a rat satiety factor, possessing significant appetite-suppressing effects, and demonstrates a close association with leptin and neuropeptide Y. It effectively inhibits regular and starvation-induced feeding and has the capacity to induce anxiety and stress-related behaviors [1].