nicotinamide-adenine

β-Nicotinamide adenine dinucleotide reduced dipotassium is an orally active, reduced coenzyme that functions as a donor of ADP-ribose units in ADP-ribosylation reactions and as a precursor of cyclic ADP-ribose. It also serves as a regenerative electron donor in essential cellular energy metabolism processes, including glycolysis, β-oxidation, and the tricarboxylic acid (TCA) cycle [1].

8-Bromo NAD+ serves as a prodrug for the cyclic ADP-ribose (cADPR) inhibitor, 8-bromo cADPR, undergoing conversion to its active form by the enzyme CD38. At a concentration of 1 mM, it effectively inhibits the rise in intracellular calcium levels and chemotaxis triggered by N-formyl-Met-Leu-Phe (fMLP) in mouse bone marrow-derived neutrophils. Furthermore, when applied at 100 µM, this compound reduces LPS-induced nitrite production and decreases the secretion of TNF-α and IL-2 in mouse primary microglial cells.

Niacin (Nicotinic acid) is a water-soluble vitamin belonging to the vitamin B family, which occurs in many animal and plant tissues, with antihyperlipidemic activity. Niacin is converted to its active form niacinamide, which is a component of the coenzymes nicotinamide adenine dinucleotide (NAD) and its phosphate form, NADP.

Nicotinamide riboside chloride, also known as NR and SRT647, is a pyridine-nucleoside form of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide or NAD+.

NADP disodium salt (Disodium NADP) is a nicotinamide adenine dinucleotide. NADP disodium salt is a key redox cofactor for electron transfer in the metabolism, serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH).

Nicotinamide N-oxide (Nicotinamide 1-oxide) is recognized as an in vivo metabolite of nicotinamide which is a precurser of nicotinamide-adenine dinucleotide (NAD+) in animals. The enzyme that catalyzes the reduction of nicotinamide N-oxide to nicotinamide in the liver is xanthine oxidase.

NADPH tetrasodium salt is the reduced form of the electron acceptor nicotinamide adenine dinucleotide phosphate, which acts as an electron donor in a variety of biological reactions. NADPH tetrasodium salt is also an endogenous inhibitor of ferroptosis.

NADH disodium salt (Disodium NADH) hydrate is the reduced form of nicotinamide adenine dinucleotide (NAD) that can donate electrons in a reducing reaction, becoming oxidized to produce NAD+. Various enzymes utilize NADH disodium salt hydrate plus H+ to reduce substrates, generating NAD+ and the reduced product.

Keto-pantoyllactone (Dihydro-4,4-dimethyl-2,3-furandione) is assayed by the ketopantoyl lactone-dependent oxidation of nicotinamide adenine dinucleotide phosphate.

Ac9-25 acetate is an annexin AI peptide and activates the neutrophil reduced nicotinamide adenine dinucleotide phosphate oxidase through FPR but not through FPRL1.

LmNADK1-IN-1 (compound MC1) is an inhibitor of nicotinamide adenine dinucleotide kinases (NADK1) from L. monocytogenes, with a K_i value of 54 nM, and can be used for bacterial infection research [1].

RV01 is a novel quinoline-substituted analogue of resveratrol that inhibits DNA damage, reduces ethanol-induced acetaldehyde dehydrogenase (ALDH2) mRNA expression, and has hydroxyl radical scavenging activity. rV01 reduces iNOS expression and has anti-neuroinflammatory effects. rV01 reduces tumor necrosis factor-a (TNF-a) and interleukin-6 (IL-6) mRNA levels and secretion. RV01 reduced tumor necrosis factor-a (TNF-a) and interleukin-6 (IL-6) mRNA levels and secretion, inhibited lps-induced ROS production and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activation, decreased toll-like receptor 4 (TLR4) protein expression, and inhibited lps-induced activation of mitogen-activated protein kinase (MAPK) and nuclear transcription factor-кB (NF-кB) signaling pathways.

NAAD sodium salt (NAAD Na salt) is a substrate of nicotinamide adenine dinucleotide synthase and can be used in studies about the specificity and kinetics of the substrate.

Adenosine 5'-diphosphoribose sodium (ADP ribose sodium) is a metabolite of nicotinamide adenine nucleotide (NAD+), which is widely present in organisms.Adenosine 5'-diphosphoribose sodium (ADP ribose sodium) is a potent intracellular Ca2+-permeable cation TRPM2 channel activator. Adenosine 5'-diphosphoribose sodium (ADP ribose sodium) is a potent intracellular Ca2+ permeable cation TRPM2 channel activator that also induces autophagy.)

The P7C3 class of neuroprotective aminopropyl carbazoles has been shown to block neuronal cell death in models of neurodegeneration. We now show that P7C3 molecules additionally preserve axonal integrity after injury, before neuronal cell death occurs, in

Glyceraldehyde phosphate dehydrogenase, targeted by anti-thymocyte and anti-apoptotic agents, catalyzes the oxidation of reduced nicotinamide adenine dinucleotide (NADH) by perhydroxyl radicals [1] [2].

NAD sodium (β-Nicotinamide Adenine Dinucleotide sodium) is an analogue of NAD that can be reduced to β-nicotinamide adenine dinucleotide (NADH) through reactions that oxidize organic substrates. Furthermore, NAD sodium can be converted to NADH, which then moves into the mitochondria to indirectly produce ATP [1].

NADP+ is the oxidized form of the electron donor nicotinamide adenine dinucleotide phosphate . It serves as a cofactor in various biological reactions. In addition, the balance between these reduced and oxidized forms plays key roles in diverse cellular functions, including cell survival, the maintenance of redox status, and intracellular signaling. For example, binding of NADP+ to β-subunits of Kv channels activates ion transport, whereas NADPH stabilizes channel inactivation. NADP+ is biosynthesized from NAD+ by NAD kinase, with ATP as the phosphoryl donor.

(2S)-2',5,6',7-Tetrahydroxyflavanone can inhibit the lipid peroxide formation induced by adenosine diphosphate and reduced nicotinamide adenine dinucleotide phosphate in rat liver homogenate.

Phytic acid dipotassium salt is an endogenous metabolite that inhibits β-secretase 1 (BACE1).

GPP78 is a potent inhibitor of Nampt (IC50: 3.0 nM for nicotinamide adenine dinucleotide (NAD) depletion). GPP78 is cytotoxic to neuroblastoma cell line SH-SY5Y cells (IC50: 3.8 nM by inducing autophagy). GPP78 has anti-cancer and anti-inflammatory effect

NOX2-IN-1 (compound 10) is an inhibitor of nicotinamide adenine dinucleotide phosphate oxidase isoform 2 (NOX2), disrupting the p47phox-p22phox protein-protein interaction with high binding affinities and potent activity in cellular assays [1].

N-terminal peptide of Annexin I (AI/Lipocortin I) that inhibits leukocyte extravasation. Acts as a formyl peptide receptor 1 (FPR1) ligand and stimulates neutrophil NADPH oxidase activation.