Filaminast (UNII-CDD69JC61J) is an analog of a phosphodiesterase 4 inhibitor (PDE4 inhibitor) and roliplam, which is used as an anti-asthma drug.

cis-PDA (cis PDA) is a general ionotropic receptor antagonist. cis-PDA acts by blocking NMDA, AMPA, and kainate-mediated responses.

BPDA2 is a selective and potent SHP2 inhibitor with IC50 values of 92.0 nM, 33.39 μM, and 40.71 μM for SHP2, SHP1, and SHP1B, respectively.DBDA2 possesses anticancer and antitumor activity and inhibits anchorage-independent growth of breast cancer cells and cancer stem cell properties in a concentration-dependent manner.BPDA2 can be used to study of breast cancer.

h-NTPDase-IN-3 is an h-NTPDase inhibitor that inhibits h-NTPDase1, h-NTPDase2, h-NTPDase3 and h-NTPDase8.

h-NTPDase-IN-2 is a broad-spectrum NTPDase inhibitor that inhibits multiple h-NTPDas isoforms.

h-NTPDase8-IN-1 is a specific aminosulfonylbenzamide inhibitor of h-NTPDases8 (IC 50 = 0.28 ± 0.07 μM). h-NTPDase8-IN-1 can be used to study diseases brought about by aberrant h -NTPDase expression.

12-Oxo phytodienoic acid (12-oxo PDA) is an endogenous signal converter that increases alkaloid biosynthesis in E. californica cell cultures, increases b. dioica tendril curls, And inhibited jasmonic acid-induced programmed cell death in conditioned A. fru mutants.

h-NTPDase-IN-4 is a pan-inhibitor of NTPDase, which can inhibit h-NTPDase1, 1h-NTPDase2, h-NTPDase3, h-NTPDase8. The IC50 values were 3.58 μM, 10.21 μM, 0.13 μM and 13.57 μM, respectively.

PDAT is a noncompetitive Indolethylamine N-methyltransferase inhibitor.

NTPDase-IN-1 (compound 5a) is a selective inhibitor of NTPDase enzymes. It shows inhibitory activity against h-NTPDase-1, h-NTPDase-2, and h-NTPDase-8 with IC50 values of 0.05 μM, 0.23 μM, and 0.54 μM, respectively. NTPDase-IN-1 exerts non-competitive inhibition on h-NTPDase-1 and h-NTPDase-2, with a K m value of 21 μM for h-NTPDase-1. This compound is useful for investigating various conditions like cancer, immunologic disorders, and bacterial infections [1].

NTPDase-IN-2 (compound 5g) selectively inhibits NTPDase-2 and NTPDase-8 with IC50 values of 0.04 µM and 2.27 µM, respectively, and exhibits non-competitive inhibition towards h-NTPDase-1 and h-NTPDase-2, with a Km of 74 µM for h-NTPDase-2. This compound is applicable in researching cancer, immunological disorders, and bacterial infections [1].

CPDA is a new potent inhibitor of SH2 domain-containing inositol phosphatase 2 (SHIP2).

CMPDA is a positive allosteric modulator of AMPA receptors (EC50s: 45.4 nM/63.4 nM for GluA2i/GluA2o receptor).

h-NTPDase-IN-5 (compound 3b) serves as a pan-inhibitor of NTPDase, exhibiting inhibitory concentration 50 (IC50) values of 1.10 μM (h-NTPDase1), 44.73 μM (h-NTPDase2), 26.14 μM (h-NTPDase3), and 0.32 μM (h-NTPDase8).

h-NTPDase-IN-1 (Compound 3i) is an inhibitor of human NTPDase (h-NTPDase) with IC50 values of 2.88 μM for h-NTPDase1 and 0.72 μM for h-NTPDase3, indicating its potential utility for thrombosis, inflammation, diabetes, and cancer research [1].

NTPDase-IN-3 (Compound 5e), an inhibitor of NTPDase, exhibits IC50 values of 0.38 μM (NTPDase3), 0.05 μM (NTPDase8), 0.21 μM (NTPDase1), and 1.07 μM (NTPDase2). It is utilized in cancer and thrombosis research [1].

Subtype-selective NMDA receptor antagonist

Mycro 3 is potent and selective for c-Myc in whole cell assays.

Brincidofovir (HDP-CDV) is an orally active, lipophilic form of cidofovir. It has enhanced activity compared to CDV against certain adenoviruses, herpesviruses, and orthopoxviruses.

RX-RA 69 is a pyrimido-pyrimidine derivative and PDA-inhibitor which inhibits tumor cell induced platelet aggregation in vitro.

13-epi-12-oxo Phytodienoic acid (13-epi-12-oxo PDA) is a lipoxygenase metabolite of α-linolenic acid in the leaves of green plants such as corn. ω-3 and ω-6 polyunsaturated fatty acids in plants are substrates for plant lipoxygenases. 12-oxo PDA is one of the best studied end metabolites of this enzymatic pathway. While the initial enzymatic product and major isomer of 12-oxo PDA contains side chains in the cis position, both being β to the ring, the upper side chain attached at C-13, can and frequently does, isomerize when 12-oxo PDA is extracted, isolated, or stored. 13-epi-12-oxo PDA is the product of this isomerization.