Search Result

Search Results for " peroxynitrite "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T8408	GKT136901	AK120765	NADPH-oxidase , NADPH
	GKT136901 (AK120765) is an inhibitor of NOX1/4.It acts as Selective and Direct Scavenger of Peroxynitrite		NADPH-oxidase , NADPH
T21967	MEG hemisulfate	Mercaptoethylguanidine hemisulfate	NOS
	MEG hemisulfate (Mercaptoethylguanidine hemisulfate) acts as a highly potent and selective suppressor of inducible NO synthase (iNOS), demonstrating EC50 values of 11.5 μM for iNOS, 110 μM for ecNOS, and 60 μM for bNOS i...		NOS
T38164	MnTBAP chloride	Mn(III)TBAP
	MnTBAP chloride (Mn(III)TBAP) is a cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger that reduces the doubling time of SOD-E. coli by a factor of 2. MnTBAP chloride exhibits anti-inflammatory ...
T38324	Coumarin Boronic Acid
	Coumarin boronic acid (CBA) is a fluorescent probe that can be used to detect peroxynitrite , hypochlorous acid, and hydrogen peroxide.It reacts with peroxynitrite at an exponentially faster rate (k = 1.1 μM/s) than hydr...
T35996	FeTPPS
	Peroxynitrite is a highly reactive nitrogen species formed from the reaction of nitric oxide (NO) and superoxide.[1] FeTPPS is a ferric porphyrin complex that causes the decomposition of peroxynitrite by catalytic isomer...
T27314	Fe-TMPyP
	Fe-TMPyP binds to the prion protein PrP and inhibits misfolding. Fe-TMPyP is also a peroxynitrite decomposition catalyst.
T38325	Coumarin Boronic Acid pinacolate ester
	Coumarin boronic acid pinacolate ester (CBE) is a more soluble form of coumarin boronic acid that can be used to detect peroxynitrite , hypochlorous acid, and hydrogen peroxide. Peroxynitrite oxidizes CBE into the fluore...
T38933	HKYellow-AM (6/12-mixture)
	HKYellow-AM (6/12-mixture) is a fluorogenic probe, which can be used for sensitive and specific detection of peroxynitrite.
T60530	Mercaptoethylguanidine (MEG) (dihydrobromide)
	Mercaptoethylguanidine (MEG) dihydrobromide is a selective inducible nitric oxide synthase inhibitor and peroxynitrite scavenger with potential for inflammatory bowel diseases research.
T35966	Mn(III)TMPyP
	Mn(III)TMPyP is a manganese-porphyrin which acts as a superoxide dismutase (SOD) mimetic and peroxynitrite decomposition catalyst. SOD mimetics described to date are unstable and are capable of catalyzing undesired side-...
T38646	GKT136901 hydrochloride	GKT136901 hydrochloride
	GKT136901 hydrochloride is a powerful, selective, and orally active inhibitor of NADPH oxidase (NOX1/4). It exhibits K i values of 160 nM and 165 nM against NOX1 and NOX4, respectively. Additionally, GKT136901 hydrochlor...
T78346	Superoxide dismutase	SOD
	Superoxide dismutase (SOD), an exclusive antioxidant enzyme, catalyzes the dismutation of the superoxide anion into oxygen and hydrogen peroxide, averting peroxynitrite formation and subsequent harm. It is extensively st...
T37270	9(E),11(E)-12-nitro Conjugated Linoleic Acid
	9(E),11(E)-12-nitro Conjugated linoleic acid (9(E),11(E)-12-nitro CLA) is a nitrated fatty acid. It is formed from 9(Z),11(E)-CLA upon exposure to acidified nitrite, peroxynitrite, gaseous nitrogen dioxide, or a combinat...
T38071	HPF
	The biology of highly reactive oxygen radical species is of great interest in many biomedical research disciplines, including neurodegeneration, aging, cancer, and infectious diseases.[1] There are a number of fluorescen...
T75074	6-Methoxypurine-9-β-D-5’(R)-C-methylriboside
	6-Methoxypurine-9-β-D-5’(R)-C-methylriboside, an analog of hypoxanthine—a purine base predominantly found in muscle tissue and a metabolite generated when purine oxidase acts on xanthine—displays anti-inflammatory proper...
T36830	9-Nitrooleate
	Nitrated unsaturated fatty acids, such as 10- and 12-nitrolinoleate , cholesteryl nitrolinoleate, and nitrohydroxylinoleate, represent a new class of endogenous lipid-derived signalling molecules. LNO2 isomers serve as p...

Compounds

GKT136901

T8408

Synonym: AK120765

Target: NADPH-oxidase, NADPH

MEG hemisulfate

T21967

Synonym: Mercaptoethylguanidine hemisulfate

Coumarin Boronic Acid

Coumarin Boronic Acid pinacolate ester

T38325

Synonym:

Target:

HKYellow-AM (6/12-mixture)

T38933

Synonym:

Target:

Mercaptoethylguanidine (MEG) (dihydrobromide)

GKT136901 hydrochloride

T38646

Synonym: GKT136901 hydrochloride

9(E),11(E)-12-nitro Conjugated Linoleic Acid

6-Methoxypurine-9-β-D-5’(R)-C-methylriboside

Cat No.	Product Name	Synonyms	Targets
T0626	Uric Acid	2,6,8-Trioxopurine,2,6,8-Trioxypurine,2,6,8-Trihydroxypurine,Lithic acid,Urate	Reactive Oxygen Species , Endogenous Metabolite , Phosphorylase
	Uric Acid (Lithic acid) is an oxidation product of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE ...
T4890	3-Nitro-L-tyrosine	3-Nitrotyrosine	Endogenous Metabolite
	3-Nitro-L-tyrosine (3-Nitrotyrosine) is the major product from the spontaneous reaction of peroxynitrite with tyrosine. Formation of nitrotyrosine can indicate the formation of peroxynitrite by a nitric oxide (NO)-depend...		Endogenous Metabolite
T3778	3'-Hydroxypuerarin	Pueraria glycoside,3'-hydroxy Puerarin	Others
	3'-Hydroxypuerarin (Pueraria glycoside) shows marked peroxynitrite.		Others
T41242	Uric acid sodium		Reactive Oxygen Species
	Uric acid sodium, scavengers of oxygen radicals, is a potent and common antioxidant that helps maintain stable blood pressure and resist oxidative stress. Uric acid sodium, which removes reactive oxygen species (ROS) suc...		Reactive Oxygen Species
T2924	Phloretin	Dihydronaringenin,NSC 407292,RJC 02792	SGLT , transporter , Endogenous Metabolite
	Phloretin (NSC-407292) is a well-known inhibitor of eukaryotic urea transporters, blocks VacA-mediated urea and ion transport. Phloretin is a dihydrochalcone, a type of natural phenols. It can be found in apple tree leav...		SGLT , transporter , Endogenous Metabolite
TN1796	Brassicin	Isorhamnetin 7-O-glucoside	Others
	Isorhamnetin 7-O-glucoside has antioxidant activity, it showed the peroxynitrite and DPPH scavenging activities with IC50 values of 2.07 /- 0.17 and 13.3 microM, respectively.		Others
TN6608	Cyanidin-3-O-arabinoside chloride
	Cyanidin-3-O-arabinoside chloride has antioxidant activity. It reduces the peroxynitrite-induced suppression of mitochondrial respiration, DNA damage, PARS activation and vascular dysfunction in HUVECs.
TN2545	1-Hydroxypinoresinol 1-O-glucoside		ROS
	(+)-1-Hydroxypinoresinol 1-O-beta-D-glucoside exhibits peroxynitrite, total ROS and DPPH radical scavenging activities with IC50 values of 3.23 +/- 0.04, 2.26 +/- 0.07 and 32.3 +/- 0.13 microM, respectively.		ROS
TN1834	Kobusin		Others , NOS , NF-κB
	Kobusin, a Calmodulin inhibitor, shows mild antiplasmodial,anti-inflammatory, and cytotoxic activities; it may be beneficial for the treatment of neuro-inflammatory diseases through the inhibition of iNOS expression and ...		Others , NOS , NF-κB

Natural Products

Uric Acid

T0626

Synonym: 2,6,8-Trioxopurine,2,6,8-Trioxypurine,2,6,8-Trihydroxypurine,Lithic acid,Urate

Target: Reactive Oxygen Species, Endogenous Metabolite, Phosphorylase

3-Nitro-L-tyrosine

T4890

Synonym: 3-Nitrotyrosine

Target: Endogenous Metabolite

3'-Hydroxypuerarin

T3778

Synonym: Pueraria glycoside,3'-hydroxy Puerarin

Target: Reactive Oxygen Species

Phloretin

T2924

Synonym: Dihydronaringenin,NSC 407292,RJC 02792

Target: SGLT, transporter, Endogenous Metabolite

Brassicin

TN1796

Synonym: Isorhamnetin 7-O-glucoside

Target: Others

Cyanidin-3-O-arabinoside chloride

TN6608

Synonym:

Target:

1-Hydroxypinoresinol 1-O-glucoside

Target: Others, NOS, NF-κB

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPJ-00933	PRDX5 Protein, Human, Recombinant (His)	Human	Human Cells
	Peroxisomes are essential organelles that participate in multiple important metabolic processes, including the β-oxidation of fatty acids, plasmalogen synthesis, and the metabolism of reactive oxygen species (ROS). Perox...

PRDX5 Protein, Human, Recombinant (His)

TMPJ-00933

Species: Human

Expression System: Human Cells