phosphoryl

Ethyl 2-(bis(2,2,2-trifluoroethoxy)phosphoryl)acetate is a useful organic compound for research related to life sciences. The catalog number is T66317 and the CAS number is 124755-24-4.

(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl ditetradecanoate (DMPE) is a phosphatidylethanolamine (PE or GPEtn), a glycerophospholipid with a phosphorylethanolamine moiety at a glycerol substitution site. DMPE comprises two myristic acid chains at the C-1 and C-2 positions, derived from nutmeg and butter. Phospholipids are ubiquitous in nature, key components of the cell lipid bilayer, and play roles in metabolism and signaling.

(S)-2-Ethylbutyl 2-(((S)-(4-nitrophenoxy)(phenoxy)phosphoryl)amino)propanoate is a useful organic compound for research related to life sciences. The catalog number is T64602 and the CAS number is 1354823-36-1.

2-Ethylbutyl ((S)-(perfluorophenoxy)(phenoxy)phosphoryl)-L-alaninate is a useful organic compound for research related to life sciences. The catalog number is T64609 and the CAS number is 1911578-98-7.

(S)-Isopropyl 2-(((S)-(perfluorophenoxy)(phenoxy)phosphoryl)amino)propanoate is a useful organic compound for research related to life sciences. The catalog number is T66528 and the CAS number is 1334513-02-8.

The compound [10-(diethoxy-phosphoryl)-decyl]-phosphonic acid is a suitable alkyl chain-based PROTAC linker for the synthesis of PROTACs [1].

(2S,3R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(((benzyloxy)(hydroxy)phosphoryl)oxy)butanoic acid is a useful organic compound for research related to life sciences. The catalog number is T65807 and the CAS number is 175291-56-2.

Phosphorylcholine chloride calcium salt tetrahydrate (Phosphocholine chloride calcium salt tet) is a small haptenic molecule, is found in a wide variety of organisms. Human hepatic tumors undergo an elevation in the concentration of phosphorylcholine as the principal metabolic change is observed (PMID: 11076016 ). Phosphorylcholine chloride calcium salt tetrahydrate is the precursor metabolite of choline in the glycine, serine and threonine metabolism pathways (KEGG, map00260) and in intermediate between choline and cytidine-diphosphate choline in the glycerophospholipid metabolism pathway (KEGG, map00564).

1,2-Distearoyl-sn-glycero-3-phosphorylcholine (L-ALPHA-PHOSPHATIDYLCHOLINE, DISTEAROYL) is a cylindrical-shaped lipid used to synthesize liposomes. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine (L-ALPHA-PHOSPHATIDYLCHOLINE, DISTEAROYL) is the lipid component in the lipid nanoparticle (LNP) system.

1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine (1,2-DSPE) is a phosphatidylethanolamine (PE or GPEtn). The stearic acid moieties are derived from animal fats, cocoa butter, and sesame oil. Phospholipids are ubiquitous in nature and are key components of the lipid bilayer of cells, as well as being involved in metabolism and signaling.

Phosphorylethanolamine (O-Phosphorylethanolamine) is a phosphomonoester metabolite of the phospholipid metabolism. Phosphorylethanolamine is a precursor of phospholipid synthesis and a product of phospholipid breakdown. Phosphomonoesters are present at much higher levels in the brain than in other organs. In developing the brain, phosphomonoesters are normally elevated during the period of neuritic proliferation. This also coincides with the occurrence of normal programmed cell death and synaptic pruning in developing the brain. These findings are consistent with the role of phosphomonoesters in membrane biosynthesis. Phosphorylethanolamine shows a strong structural similarity to the inhibitory neurotransmitter, GABA, and the GABAB receptor partial agonist, 3-amino-propylphosphonic acid. Phosphorylethanolamine is a phosphomonoester which is decreased in post-mortem Alzheimer's disease (AD) brain.

pp60 c-src (521-533) (phosphorylated) acetate is a regulator of focal adhesion formation and cell spreading. pp60 c-src (521-533) (phosphorylated) acetate also regulates cell motility and is a key component in the signaling pathway triggered by the motogenic hyaluronan receptor RHAMM.

Glycogen phosphorylase-IN-1 is a selective and potent inhibitor of human hepatic glycogen phosphorylase (hlGPa) with inhibitory effects on hlGPa activity and on hepatocyte glycogen-derived glucose production, and can be used in the study of type 2 diabetes mellitus and canine lupus.

Cytidine 5'-diphosphate trisodium salt (CDP) catalyzes the production of Cytidine triphosphate (CTP) for DNA and RNA synthesis by transferring a phosphoryl group from ATP to cytidine monophosphate (CMP) through the action of uridine monophosphate kinase (UMPK).

Phosphorylcholine chloride, an antigenic component found on the surface of numerous commensal and pathogenic bacteria inhabiting the upper airway, is integral to bacterial cell surfaces.

CDK2 acetate is a member of the eukaryotic S T protein kinase family and its function is to catalyze the phosphoryl transfer of ATP γ-phosphate to serine or threonine hydroxyl (denoted as S0 T0) in a protein substrate.

Sulbactum Sodium (5'-CDP) is synthesized from cytidine monophosphate (CMP) or uridine monophosphate (UMP) by the transfer of phosphoryl group, catalyzed by the enzyme uridylate kinase (UMPK)

Latanoprost, the isopropyl ester of 17-phenyl-13,14-dihydro prostaglandin F2α, serves as a prodrug for the free acid form, a potent FP receptor agonist in the eye. Isopropyl 5-(diphenylphosphoryl)pentanoate may exist as a potential trace impurity in commercial latanoprost preparations.

Phosphorylcholine is widely present in the biological world, which is a phospholipid present in the eukaryotic biofilm, and also in the symbiotic bacteria or pathogens associated with eukaryotes. Phosphorylcholine has immunomodulatory properties and can be used to study atherosclerosis.

H1-7 (histone H1 phosphorylation site), a synthetic polypeptide, serves as a PKA substrate and demonstrates utility in various PKA substrate applications [1] [2].

Diethoxy-phosphorylethyl-PEG5-ethylphosphonic acid is a polyethylene glycol (PEG) derived linker used in PROTAC synthesis [1].

Maltose phosphorylase, a dimerase belonging to family 65 of the glycoside hydrolases [1], catalyzes the conversion of maltose and inorganic phosphate into β-D-glucose-1-phosphate and glucose.

p-Nitrophenylphosphorylcholine is a chromogenic substrate that is used to measure phospholipase C (PLC) activity. Hydrolysis of p-nitrophenylphosphorylcholine by PLC results in the liberation of p-nitrophenol, which can be measured at 405 nm at pH 7.2-7.5.

The pp60 (v-SRC) Autophosphorylation Site, Phosphorylated is a phosphorylated peptide derived from an EGFR substrate, used as a critical tool for quantifying phosphorylated substrates in the screening of EGFR Kinase inhibitors.

1,2-Diheptadecanoyl-sn-glycero-3-phosphorylcholine (DHPC) is a biologically active derivative of phosphatidylcholine (PC) that functions as a phospholipid compound [1].

4-Aminophenylphosphorylcholine, when conjugated to sepharose, serves as an effective adsorbent for affinity precipitation experiments. This compound functions as a probe facilitating selective binding and isolation processes in biochemical studies.

(4R,5R,6S)-4-Nitrobenzyl 3-((diphenoxyphosphoryl)oxy)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate is a useful organic compound for research related to life sciences. The catalog number is T66253 and the CAS number is 90776-59-3.

Monophosphoryl lipid A (MPLA), also known as Glucopyranosyl lipid A, is an agonist of toll-like receptor 4. Derived from the cell wall of nonpathogenic Salmonella, MPLA is a valuable compound for research on immunization and vaccine development.

Glycerophosphorylethanolamine is an active phosphodiester metabolite of phosphatidylethanolamine.1,2It promotes aggregation of amyloid-β (1-40) (Aβ40)in vitro, and levels of glycerophosphorylethanolamine are elevated in postmortem brains isolated from patients with Alzheimer’s disease. 1.Klunk, W.E., Xu, C.J., McClure, R.J., et al.Aggregation of β-amyloid peptide is promoted by membrane phospholipid metabolites elevated in Alzheimer’s disease brainJ. Neurochem.69(1)266-272(1997) 2.Blusztajn, J.K., Lopez Gonzalez-Coviella, I., Logue, M., et al.Levels of phospholipid catabolic intermediates, glycerophosphocholine and glycerophosphoethanolamine, are elevated in brains of Alzheimer’s disease but not of Down’s syndrome patientsBrain Res.536(1-2)240-244(1990)

PPARγ phosphorylation inhibitor 1 (Compound 10) is a potent PPARγ binding agent (IC50: 24 nM) with antidiabetic effects, inhibiting CDK5-mediated PPARγ Ser273 phosphorylation (IC50: 160 nM) and displaying minimal PPARγ agonism.

UDP-sugar pyrophosphorylase (BlUSP) is an enzyme that activates glucose-1-phosphate (Glc-1-P) to UDP-glucose (UDP-Glc) and catalyzes the reversible transfer of the uridyl group from UTP to sugar-1-phosphate, yielding UDP-sugar and pyrophosphate (PPi) [1].

Phosphorylated p60c-src substrate II is a pentapeptide and a phosphorylated polypeptide form of p60c-src substrate II. Phosphorylation is a critical post-translational modification (post-translationmodification) vital for biological regulatory processes [1].

Sucrose phosphorylase, a bacterial transglucosidase, catalyzes the conversion of sucrose and phosphate into α-D-glucose-1-phosphate and D-fructose. This enzyme can also hydrolyze glucosylated sucrose into α-D-glucose or transfer the glucosyl group to a receptor's hydroxyl group, resulting in new α-D-glucoside products. Its enzymatic activity towards the base, substrate, and product is weak [1].

Purine Nucleoside Phosphorylase, an essential enzyme in purine metabolism, plays a critical role in the purine salvage pathway. Its deficiency impairs T cell function. With inorganic orthophosphate as a co-substrate, this enzyme catalyzes the cleavage of the glycosidic bond linking ribose and deoxyribonucleoside, resulting in the production of a purine base and ribose (deoxyribose)-1-phosphate [1].

benzyl 2-diethoxyphosphorylacetate is a useful organic compound for research related to life sciences. The catalog number is T66318 and the CAS number is 7396-44-3.

N-(5-((Diphenylphosphoryl)methyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide is a useful organic compound for research related to life sciences. The catalog number is T66148 and the CAS number is 289042-10-0.

Sphingosine phosphorylcholine is a wound healing agent.

D-galactosyl-β1-3-N-acetyl-D-hexosamine phosphorylase (BiGalHexNAcP), a member of the CAZy glycoside hydrolase family GH112, plays a pivotal role in biochemical research by catalyzing the phosphorolysis of lacto-n-biose and galacto-n-biose, yielding Gal-1-P and the corresponding N-acetyl-D-hexosamine [1].

1-O-Hexadecyl-2-O-docosahexaenoyl-sn-glycero-3-phosphorylcholine, an endogenous metabolite found in urine, has applications in obesity research [1][2].

Myristoylated Alanine-Rich C Kinase Substrate peptide (151-175) is a high affinity Protein Kinase C substrate.

Peptide corresponding to the pp60c-src carboxy terminal regulatory domain; phosphorylated at Tyr527. Binds to pp60c-src and pp60v-src at the SH2 domain, suppressing their tyrosine kinase activity and transforming potential.

Phosphorylase Kinase β-Subunit Fragment (420-436) is a peptide fragment (430-436) derived from the β-Subunit of phosphorylase kinase. Phosphorylase kinase, a serine threonine-specific protein kinase, plays a crucial role in activating glycogen phosphorylase for the release of glucose-1-phosphate from glycogen [1].

1-Palmitoyl-2-succinyl-sn-glycerophosphorylcholine, a glycerophosphorylcholine derivative, comprises glycerol phosphate, choline, and palmitic acid and accumulates at oxidative stress sites in vivo. It potentially acts as a ligand for scavenger receptors class B, akin to oxidized phospholipids oxPC(CD36), which are established potent ligands for receptors CD36 and SR-BI. These oxidized phospholipids also play a pivotal role in promoting tumor apoptosis and may present in higher concentrations within malignant biliary strictures [1] [2].

N-Acetylglucosamine kinase (EcNagK), a key enzyme in GlcNAc metabolism, catalyzes the transfer of the gamma-phosphoryl group from ATP to the hydroxyl group at the C-6 position of GlcNAc, producing GlcNAc-6-P [1].

2'-Deoxyadenosine-5'-monophosphate (D-AMP) is a nucleoside comprised of adenine attached to a ribose (ribofuranose) moiety via a -N9-glycosidic bond. Deoxyadenosine monophosphate is a derivative of the common nucleic acid ATP, or adenosine triphosphate, in which the -OH (hydroxyl) group on the 2' carbon on the nucleotide's pentose has been removed (hence the deoxy- part of the name). Additionally, the monophosphate of the name indicates that two of the phosphoryl groups of GTP have been removed, most likely by hydrolysis. Deoxyadenosine monophosphate is abbreviated dAMP.

NADP+ is the oxidized form of the electron donor nicotinamide adenine dinucleotide phosphate . It serves as a cofactor in various biological reactions. In addition, the balance between these reduced and oxidized forms plays key roles in diverse cellular functions, including cell survival, the maintenance of redox status, and intracellular signaling. For example, binding of NADP+ to β-subunits of Kv channels activates ion transport, whereas NADPH stabilizes channel inactivation. NADP+ is biosynthesized from NAD+ by NAD kinase, with ATP as the phosphoryl donor.

PptT-IN-2 (compound 5k) is a highly effective inhibitor of phosphopantetheinyl phosphoryl transferase (PptT), with an IC50 of 2.5 μM. PptT is an indispensable enzyme crucial for synthesizing cellular lipids and virulence factors in Mycobacterium tuberculosis. Therefore, PptT-IN-2 holds great promise for further investigations into tuberculosis research [1].

CDK2, a eukaryotic S/T protein kinase family member, catalyzes the phosphoryl transfer from ATP γ-phosphate to the hydroxyl of serine or threonine (denoted as S0/T0) in a protein substrate.

PptT-IN-3 (compound 5p) is a powerful inhibitor (IC50 = 3.5 μM) of phosphopantetheinyl phosphoryl transferase (PptT), an indispensable enzyme involved in the synthesis of cellular lipids and virulence factors in Mycobacterium tuberculosis. This compound holds promise for tuberculosis research [1].

PptT-IN-1 (compound 5j) is a highly potent inhibitor (IC50: 2.8 μM) of phosphopantetheinyl phosphoryl transferase (PptT), an essential enzyme in the biosynthesis of cellular lipids and virulence factors in Mycobacterium tuberculosis, demonstrating considerable potential for tuberculosis research [1].