sulfone

Toltrazuril sulfone (Ponazuril) is an antiprotozoal agent that acts upon Coccidia parasites.

Bis-sulfone-PEG4-DBCO is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Fenbendazole sulfone is a minor metabolite of the anthelmintic fenbendazole . Fenbendazole undergoes oxidation to form oxfendazole, which is further oxidized to form fenbendazole sulfone.

Active-mono-sulfone-PEG8-acid is a polyethylene glycol (PEG) derivative serving as a linker for PROTAC synthesis[1].

SB 203580 sulfone, an analog of the p38 MAP kinase inhibitor SB 203580, inhibits IL-1 production in monocytes and binds competitively with CSAID binding proteins (CSBP), inhibiting stress response signaling. It exhibits an IC50 of 0.2 μM for IL-1 inhibition and 0.03 μM for CSBP-mediated signaling inhibition [1].

Bis-sulfone-PEG3-Azide, a cleavable ADC linker, finds application in the synthesis of antibody-drug conjugates (ADCs).

m-PEG3-Sulfone-PEG4-propargyl is a polyethylene glycol (PEG)-based prodrug-induced degradation (PROTAC) linker. It is utilized in the efficient synthesis of PROTACs, a class of heterobifunctional molecules designed to selectively target and degrade specific protein targets[1].

Leukotriene F-4 sulfone induces vascular permeability changes.

5-hydroxylansoprazole is an in vitro metabolism-dependent CYP2C19 inhibitor.

Propargyl-PEG4-Sulfone-PEG4-acid serves as a PEG-based PROTAC linker for the synthesis of PROTACs[1].

Cenicriviroc Sulfone is a derivative of Cenicriviroc which is an experimental drug candidate for the treatment of HIV infection. It is an inhibitor of CCR2 and CCR5 receptors allowing it to function as an entry inhibitor which prevents the virus from entering into a human cell.

Albendazole sulfone, a metabolite of Albendazole, is an antibiotic, anthelmintic, and antiparisitic.

m-PEG3-Sulfone-PEG3-acid is a polyethylene glycol (PEG)-based protein degradation utilizing targeted chimera (PROTAC) linker [1].

Boc-PEG4-sulfone-PEG4-Boc is a polyethylene glycol (PEG)-derived linker specifically designed for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

Toltrazuril sulfone-d3 is a deuterated compound of Toltrazuril sulfone. Toltrazuril sulfone has a CAS number of 69004-04-2. Toltrazuril sulfone is an antiprotozoal agent that acts upon Coccidia parasites.

m-PEG3-Sulfone-PEG3-Boc is a polyethylene glycol (PEG)-derived proteolysis-targeting chimera (PROTAC) linker employed for the synthesis of PROTACs[1].

m-PEG3-Sulfone-PEG3-azide is a polyethylene glycol (PEG)-based linker widely employed in the synthesis of PROTACs, which stands for Proteolysis Targeting Chimeras[1].

Propargyl-PEG3-sulfone-PEG3-propargyl is a polyethylene glycol (PEG)-based linker specifically designed for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

m-PEG3-Sulfone-PEG3 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Lansoprazole sulfone is a metabolite of the gastric pump inhibitor Lansoprazole.

Propargyl-PEG4-Sulfone-PEG4-Boc is a polyethylene glycol (PEG)-based linker molecule for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

Pantoprazole sulfone is a metabolite of the gastric H+/K+ ATPase pump inhibitor pantoprazole . Pantoprazole is metabolized by the cytochrome P450 (CYP) isoforms CYP2C19 and CYP3A4 to form pantoprazole sulfone.

5'-Methyl-Thioadenosine-sulfone is a useful organic compound for research related to life sciences and the catalog number is T124301.

Leukotriene E-4 sulfone is a synthetic leukotriene.

Dimethyl sulfone exists in all living organisms, ranging from bacteria to humans. It derives from dietary sources, from intestinal bacterial metabolism and from human endogenous methanethiol metabolism. Dimethyl sulfone is a metabolite occurring in plasma and CSF of normal human.

Sulfone-Bis-PEG4-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Azido-PEG3-Sulfone-PEG4-acid is a polyethylene glycol (PEG) derivative frequently employed as a linker in the construction of proteolysis targeting chimeras (PROTACs)[1].

Chlorpromazine Sulfone Hydrochloride is a metabolite of Chlorpromazine -- an anti-emetic and anti-psychotic agent. It may also be used as a potential N-methyltransferase inhibitor.

Azido-PEG3-Sulfone-PEG4-Boc is a polyethylene glycol (PEG)-based PROTAC linker, utilized for the synthesis of PROTACs[1].

Biotin sulfone is isolated as a natural metabolite of biotin.

Rabeprazole sulfone, a metabolite of the proton pump inhibitor rabeprazole, is produced via the cytochrome P450 (CYP) isoform CYP3A. Additionally, it has been identified as an impurity in bulk rabeprazole preparations.

Dipropyl sulfone may function as an enhancer of heparin absorption in the intestine.

Fipronil sulfone is an insecticide fipronil. Its metabolite fipronil sulphone is an inhibitor of rat ɑ1β2γ2L GABA(A) receptor.

Vamidothion sulfone is a biochemical.

Azide-PEG3-Sulfone-PEG3-azide is a polyethylene glycol (PEG)-based bifunctional molecule, specifically designed as a PROTAC linker for the synthesis of PROTACs[1].

Fulvestrant sulfone is a synthetic estrogen receptor antagonist.

Aldicarb sulfone is a cholinesterase inhibitor .

Sulindac sulfone is a metabolite of the nonsteroidal anti-inflammatory drug sulindac.

Omeprazole sulfone is a metabolite of Omeprazole that inhibits the proton pump.

Albendazole sulfone-d3 is a deuterated compound of Albendazole sulfone.

Ilaprazole sulfone, primarily metabolized by CYP3A4/5, constitutes the chief metabolite of Ilaprazole (IY-81149), an orally active proton pump inhibitor [1].

Sulfalene (SMP2), a long-acting sulfonamide antibiotic, is used for the therapy of chronic bronchitis, urinary tract infections, and malaria.

Exisulind (CP248) induces apoptosis through the activation of protein kinase G (PKG). Exisulind exhibits antineoplastic activity in solid tumour and haematological cancer cell lines and is an inhibitor of tumour growth in rodent models of colon, prostate, bladder, mammary and lung cancer.

Dapsone (Sulphadione) has activity against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae.

Acediasulfone is an antibiotic. It is used to treat ear infections.

Fluensulfone (MCW-2) is a new nematicide of the fluoroalkenyl thioether group that has significantly reduced environmental impact with low toxicity to non-target insects and mammals.

Pyroxasulfone is an inhibitor of very-long-chain fatty acid biosynthesis. Pyroxasulfone is used to control grass weed species in pre-emergence in major field crops.

3,4,5,6-Tetrabromophenolsulfonephthalein is a useful organic compound for research related to life sciences. The catalog number is T66319 and the CAS number is 77172-72-6.

WRN Inhibitor 4 (Example 107), a cyclic vinyl sulfone-based compound, serves as an inhibitor of the Werner Syndrome ATP-dependent helicase enzyme (WRN). This inhibitor is applicable in cancer research [1].

WRR139, a peptide vinyl sulfone, plays a role in disease processes including inflammation and cancer, and acts as an inhibitor of cytosolic enzyme N-glycanase 1 (NGLY1) and Nrf1. Moreover, WRR139 amplifies the cytotoxic effects of Carfilzomib on cancer cells [1].