wilfordii

Cynandione A, an acetophenone derived from Cynanchum wilfordii, has anti-inflammatory activity and significantly reduces pro-inflammatory cytokine overexpression via macrophage α7 nAChR activation and subsequent IL-10 expression.

Wilforol A is a natural product from Tripterygium wilfordii Hook. f.

Demethylzeylasteral (T-96), isolated from Tripterygium wilfordii, has anti-inflammatory, immunosuppressive and anti-tumor activities. It inhibits the invasion of triple-negative breast cancer by blocking the TGF-β signaling pathway, and it can significantly reduce atherosclerosis.

Triptonoditerpenic acid is an aromatic pimarane diterpenoid that can be isolated from Tripterygium wilfordii. It exhibits cytotoxicity against HepG2, Hep3B, and Bcap37 cell lines, with IC50 values of 42.53 μM, 29.74 μM, and 37.63 μM, respectively.

Triptonoterpene Me ether (compound 5), a rosinane-type diterpenoid, is derived from the traditional Chinese medicinal plant, Tripterygium wilfordii Hook. f [1].

Triptonoterpene is a natural product found in Tripterygium wilfordii and Tripterygium doianum. Triptonoterpene is an abietane diterpenoid.

Triptonodiol is a natural product from Tripterygium wilfordii Hook.f.

Triptoquinonide is a natural product from Tripterygium wilfordii.

Triptonoterpenol (Compound 6) is a secondary metabolite derived from Tripterygium wilfordii [1].

Triptophenolide (Hypolide) is a compound isolated from Tripterygium wilfordii Hook with anti-inflammatory activity.

Wilforine, a sesquiterpene pyridine alkaloid, is an important bioactive compound in T. wilfordii plants and is effective in treating idiopathic pulmonary fibrosis. Wilforine exhibits an anti-inflammatory effect, which might be mediated by the down-regulation of inflammatory factors TNF-α, IL-6, and NO. Additionally, it has insecticidal activity by inhibiting the Na+-K+-ATPase in the central nervous system.

Triptotriterpenic acid C, an ursolic-type compound, can be isolated from the total glycosides extracted from the root of Tripterygium wilfordii Hook.f [1].

Peritassine A, an alkaloid derived from Tripterygium wilfordii Hook. f., exhibits anti-HIV properties.

Wilforlide A (3-Epiabruslactone A) is a natural product, separated from the ethanolic extract of tripterygium wilfordii. High-dose wilforlide A has obvious anti-inflammatory effect, but has no significant immune suppressive activity.

1. Triptonide (PG 492) is effective in the treatment of autoimmune diseases and has potent antileukemic and antitumor activities. 2. Triptonide possesses anti-inflammatory activity, upregulate the expression of IL-37, and this expression was suppressed by ERK1 2 and p38 MAPK inhibitors.

Triptotriterpenic acid A, a natural product isolated from *Tripterygium wilfordii*,