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Metabolism CETP

CETP

Cholesteryl ester transfer protein (CETP), also called plasma lipid transfer protein, is a plasma protein that facilitates the transport of cholesteryl esters and triglycerides between the lipoproteins. It collects triglycerides from very-low-density (VLDL) or low-density lipoproteins (LDL) and exchanges them for cholesteryl esters from high-density lipoproteins (HDL), and vice versa. Most of the time, however, CETP does a heteroexchange, trading a triglyceride for a cholesteryl ester or a cholesteryl ester for a triglyceride.
Cat No. product name
T1928 Anacetrapib Anacetrapib (MK0859) is an effective, specific, reversible rhCETP and mutant CETP(C13S) inhibitor (IC50: 7.9 nM and 11.8 nM). Anacetrapib reduces the transfer o...
T2499 Torcetrapib Torcetrapib is a cholesteryl ester transfer protein (CETP) inhibitor that reduces the heterotypic transfer of cholesteryl ester from HDL to LDL and/or VLDL. Tor...
T2545 Lomitapide Mesylate Lomitapide Mesylate is a methanesulfonic acid form of lomitapide, a small molecule inhibitor of microsomal triglyceride transfer protein.
T6048 Dalcetrapib Dalcetrapib, a rhCETP inhibitor (IC50=0.2 μM), increases the plasma HDL cholesterol.
T6262 Evacetrapib Evacetrapib (LY2484595) is a potent and selective inhibitor of CETP with IC50 of 5.5 nM, elevates HDL cholesterol without increases in aldosterone or blood pres...
T6267 Lomitapide Lomitapide is a small molecule inhibitor of microsomal triglyceride transfer protein (MTP), an enzyme located in the lumen of the endoplasmic reticulum responsi...
T15004 CP-532623 CP-532623, a close structural analog of Torcetrapib, is a CETP inhibitor with highly lipophilic properties. It elevates high-density lipoprotein cholesterol.
T13079 TAP311 TAP311 is an inhibitor of cholesteryl ester transfer protein (CETP)(IC50 of 62 nM).
T15570 Implitapide Implitapide is an inhibitor of microsomal triglyceride transfer protein (MTP).
T13423 (1R,2R)-2-PCCA(hydrochloride) (1R,2R)-2-PCCA hydrochloride is a diastereomer of 2-PCCA, and is a potent agonist of GPR88 receptor(EC50 of 3 nM and 603 nM in cell-free assay and in cell assay...
T16266 NAMI-A NAMI-A is a ruthenium-based drug characterized by the selective activity against tumor metastases. NAMI-A inhibits adhesion and migration.
T4S2157 Campesterol Campesterol is a plant sterol with cholesterol lowering and anticarcinogenic effects, it and other plant sterols often decrease LDL cholesterol levels overall. ...
Anacetrapib
T1928CAS 875446-37-0
Anacetrapib (MK0859) is an effective, specific, reversible rhCETP and mutant CETP(C13S) inhibitor (IC50: 7.9 nM and 11.8 nM). Anacetrapib reduces the transfer o...
Torcetrapib
T2499CAS 262352-17-0
Torcetrapib is a cholesteryl ester transfer protein (CETP) inhibitor that reduces the heterotypic transfer of cholesteryl ester from HDL to LDL and/or VLDL. Tor...
Lomitapide Mesylate
T2545CAS 202914-84-9
Lomitapide Mesylate is a methanesulfonic acid form of lomitapide, a small molecule inhibitor of microsomal triglyceride transfer protein.
Dalcetrapib
T6048CAS 211513-37-0
Dalcetrapib, a rhCETP inhibitor (IC50=0.2 μM), increases the plasma HDL cholesterol.
Evacetrapib
T6262CAS 1186486-62-3
Evacetrapib (LY2484595) is a potent and selective inhibitor of CETP with IC50 of 5.5 nM, elevates HDL cholesterol without increases in aldosterone or blood pres...
Lomitapide
T6267CAS 182431-12-5
Lomitapide is a small molecule inhibitor of microsomal triglyceride transfer protein (MTP), an enzyme located in the lumen of the endoplasmic reticulum responsi...
CP-532623
T15004CAS 261947-38-0
CP-532623, a close structural analog of Torcetrapib, is a CETP inhibitor with highly lipophilic properties. It elevates high-density lipoprotein cholesterol.
TAP311
T13079CAS
TAP311 is an inhibitor of cholesteryl ester transfer protein (CETP)(IC50 of 62 nM).
Implitapide
T15570CAS 177469-96-4
Implitapide is an inhibitor of microsomal triglyceride transfer protein (MTP).
(1R,2R)-2-PCCA(hydrochloride)
T13423CAS 1609563-71-4
(1R,2R)-2-PCCA hydrochloride is a diastereomer of 2-PCCA, and is a potent agonist of GPR88 receptor(EC50 of 3 nM and 603 nM in cell-free assay and in cell assay...
NAMI-A
T16266CAS 201653-76-1
NAMI-A is a ruthenium-based drug characterized by the selective activity against tumor metastases. NAMI-A inhibits adhesion and migration.
Campesterol
T4S2157CAS 474-62-4
Campesterol is a plant sterol with cholesterol lowering and anticarcinogenic effects, it and other plant sterols often decrease LDL cholesterol levels overall. ...