DNA-PK

The DNA-dependent protein kinase (DNA-PK) is a serine/threonine protein kinase consisting of a catalytic subunit (DNA-PKcs) and a Ku heterodimer that is made up of the Ku70 and Ku80 subunits. DNA-PK was accidentally discovered after researchers studying translation found that double-stranded DNA (dsDNA) contaminated their preparations, leading to the phosphorylation of specific proteins.

Cat. No.	Product name	CAS No.	Purity
T12672	(Rac)-Nedisertib	1637542-34-7	98%
T12672	(Rac)-Nedisertib is a racemate of Nedisertib, a potent inhibitor of DNA-PK(IC50 of <3 nM).
T8637	DMNB	20357-25-9	98%
T8637	6-Nitroveratraldehyde is DNA-dependent protein kinase (DNA-PK) inhibitor with IC50 of 15 μM, an enzyme involved in the non-homologous end-joining (NHEJ) pathway ...
T2433	NU 7026	154447-35-5	98%
T2433	NU7026 is an effective DNA-PK inhibitor (IC50: 0.23 μM, in cell-free assays), 60-fold selective for DNA-PK than PI3K and no inhibition against both ATM and ATR.
T11067	VX-984	1476074-39-1	98%
T11067	VX-984 is an oral, selective DNA-PK inhibitor that can cross the blood-brain barrier. VX-984 inhibited the conjugation of non-homologous terminal NHEJ and acted ...
T1826	PI3K-IN-1	1349796-36-6	98%
T1826	Voxtalisib (SAR245409, XL765)Analogue is a dual inhibitor of mTOR/PI3K, mostly for p110γ , also inhibits DNA-PK and mTOR.
T7122	AZD-7648	2230820-11-6	98%
T7122	AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.
T6319	OSI-027	936890-98-1	98%
T6319	OSI-027 is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, and more than 100-fold selectivity observed for mTOR than PI3...
T2083	PI-3065	955977-50-1	98%
T2083	PI-3065 is a novel potent and selective PI3K p110δ inhibitor.
T2287	PIK-75 hydrochloride	372196-77-5	98%
T2287	PIK-75 Hydrochloride is a p110α inhibitor with IC50 of 5.8 nM (200-fold more potently than p110β), isoform-specific mutants at Ser773, and also potently inhibits...
T3986	SF2523	1174428-47-7	98%
T3986	SF2523 is a highly selective and potent inhibitor.
T25399	ETP-45658	1198357-79-7	98%
T25399	ETP-45658 is an inhibitor of PI3-kinase, also inhibiting DNA-PK and mTOR.
T13017	STL127705	1326852-06-5	98%
T13017	STL127705 is a inhibitor of Ku 70/80 heterodimer protein(Ku70/80-DNA interaction, with an IC50 of 3.5 μM). STL127705 also inhibits Ku-dependent activation of DNA...
T6557	KU-0060648	881375-00-4	98%
T6557	KU-0060648 is a dual inhibitor of DNA-PK and PI3Kα, PI3Kβ, PI3Kδ with IC50 of 8.6 nM and 4 nM, 0.5 nM, 0.1 nM respectively, less inhibition of PI3Kγ with IC50 of...
T3541	CC-115	1228013-15-7	98%
T3541	CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM).
T6143	PI-103	371935-74-9	98%
T6143	PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members (IC50s: 2/3/3/15/30/23 nM for p110α/β/δ/γ, mTOR, and DNA-PK).
T9498	BAY-8400	T9498	98%
T9498	BAY-8400 is an orally active, potent and selective DNA-dependent protein kinase ( DNA-PK ) inhibitor ( IC 50 =81 nM) which shows synergistic efficacy in combinat...
T9760	IC 86621	404009-40-1	98%
T9760	IC 86621 is a selective and reversible ATP-competitive inhibitor of DNA-PK with an IC50 of 120 nM. IC 86621 increases DNA double-strand break(DSB)-induced antitu...
T7014	Voxtalisib	934493-76-2	98%
T7014	Voxtalisib (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.
T6045	Torin 1	1222998-36-8	98%
T6045	Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold selectivity for mTOR than PI3K.
T4339	YU238259	1943733-16-1	98%
T4339	YU238259 is a novel inhibitor of homology-dependent DNA repair(HDR), but does not inhibit non-homologous end-joining (NHEJ), in cell-based GFP reporter assays.