DNA-PK

The DNA-dependent protein kinase (DNA-PK) is a serine/threonine protein kinase consisting of a catalytic subunit (DNA-PKcs) and a Ku heterodimer that is made up of the Ku70 and Ku80 subunits. DNA-PK was accidentally discovered after researchers studying translation found that double-stranded DNA (dsDNA) contaminated their preparations, leading to the phosphorylation of specific proteins.

Cat. No.	Product name	CAS No.	Purity
T78645	ZL-2201	2865115-39-3	98%
T78645	ZL-2201 is a potent inhibitor of DNA-PK, demonstrating an IC50 value of 1 nM (WO2021104277A1, compound 5) [1].
T79165	DNA-PK-IN-10	2919315-89-0	98%
T79165	DNA-PK-IN-10 is a DNA-PK inhibitor utilized in the research of breast cancer and non-small cell lung cancer [1].
T12672	(Rac)-Nedisertib	1637542-34-7	98%
T12672	(Rac)-Nedisertib is a racemate of Nedisertib, a potent inhibitor of DNA-PK(IC50 of <3 nM).
T5166	Leniolisib	1354690-24-6	99.97%
T5166	Leniolisib (CDZ173) (CDZ173) is a potent and selective PI3Kδ inhibitor (IC50: 11 nM).
T6087	AZD 6482	1173900-33-8	99.95%
T6087	AZD 6482 (AZD6482) is a potent and selective p110β inhibitor with IC50 of 0.69 nM and a PI3Kβ inhibitor with IC50 of 10 nM.
T15789	LTURM34	1879887-96-3	99.91%
T15789	LTURM34 is an inhibitor of DNA-PK with IC50 of 34 nM. LTURM34 displays effective antiproliferative activity in a wide range of tumor cell lines. LTURM34 shows 17...
T2667	PIK-75	372196-67-3	99.88%
T2667	PIK-75, a DNA-PK and PI3K inhibitor, suppresses DNA-PK(IC50=2 nM), p110α(IC50=5.8 nM) and p110γ(IC50=76 nM).
T6612	NU6027	220036-08-8	99.85%
T6612	NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-aminopurin...
T2616	PIK-93	593960-11-3	99.83%
T2616	PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.
T3586	Compound 401	168425-64-7	99.76%
T3586	Compound 401 (2-morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one) is a synthetic DNA-PK inhibitor (IC50 = 0.28 μM) that also targets mTOR but not PI3K.
T2008	LY294002	154447-36-6	99.76%
T2008	LY294002 (SF 1101) is a broad-spectrum inhibitor of PI3K, inhibiting PI3Kα, PI3Kδ, and PI3Kβ (IC50=0.5/0.57/0.97 μM). LY294002 is also an inhibitor of DNA-PK (IC...
T11381	Pictilisib dimethanesulfonate	957054-33-0	99.69%
T11381	Pictilisib dimethanesulfonate (GDC-0941 2 MeSO3H salt) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p1...
T6883	Samotolisib	1386874-06-1	99.61%
T6883	Samotolisib (LY3023414) is an oral ATP competitive inhibitor of the class I PI3K isoforms, DNA-PK, and mTOR. Samotolisib (LY3023414) has been used in trials stud...
T13448	(R)-(-)-Rolipram	85416-75-7	99.6%
T13448	(R)-(-)-Rolipram ((-)-Rolipram) is an R-enantiomer of Rolipram which is a PDE4 inhibitor.
T2084	ETP-46464	1345675-02-6	99.56%
T2084	ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM).
T6100	Torin 2	1223001-51-1	99.47%
T6100	Torin 2(IC50=0.25 nM), a specific and effective mTOR inhibitor, is the 800-fold greater specific activity for mTOR than PI3K and improves pharmacokinetic propert...
T2377	Pilaralisib analogue	956958-53-5	99.46%
T2377	Pilaralisib analogue (XL147 analogue) is a selective and reversible class I PI3K inhibitor for PI3Kα/δ/γ.
T4339	YU238259	1943733-16-1	99.43%
T4339	YU238259 is a novel inhibitor of homology-dependent DNA repair(HDR), but does not inhibit non-homologous end-joining (NHEJ), in cell-based GFP reporter assays.
T3351	Onatasertib	1228013-30-6	99.41%
T3351	Onatasertib (CC223) is an orally available mTOR inhibitor with potential antitumor activity. Onatasertib inhibits the activity of mTOR, which may result in the i...
T6045	Torin 1	1222998-36-8	99.38%
T6045	Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold selectivity for mTOR than PI3K.