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DNA-PK

The DNA-dependent protein kinase (DNA-PK) is a serine/threonine protein kinase consisting of a catalytic subunit (DNA-PKcs) and a Ku heterodimer that is made up of the Ku70 and Ku80 subunits. DNA-PK was accidentally discovered after researchers studying translation found that double-stranded DNA (dsDNA) contaminated their preparations, leading to the phosphorylation of specific proteins.
Cat No. product name
T6087 AZD 6482 AZD 6482 is a potent and selective p110β inhibitor with IC50 of 0.69 nM and a PI3Kβ inhibitor with IC50 of 10 nM.
T2287 PIK-75 hydrochloride PIK-75 Hydrochloride is a p110α inhibitor with IC50 of 5.8 nM (200-fold more potently than p110β), isoform-specific mutants at Ser773, and also potently inhibits...
T25399 ETP-45658 ETP-45658 is an inhibitor of PI3-kinase, also inhibiting DNA-PK and mTOR.
T9498 BAY-8400 BAY-8400 is an orally active, potent and selective inhibitor of DNA-dependent protein kinase (DNA-PK) with an IC50 of 81 nM.
T6276 KU-57788 NU7441 (KU-57788) is a highly effective and specific DNA-PK inhibitor (IC50: 14 nM).
T6143 PI-103 PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members (IC50s: 2/3/3/15/30/23 nM for p110α/β/δ/γ, mTOR, and DNA-PK).
T2616 PIK-93 PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.
T3351 Onatasertib CC-223 is an orally available mTOR inhibitor with potential antitumor activity. CC-223 inhibits the activity of mTOR, which may result in the induction of tumor ...
T6283 Wortmannin Wortmannin is the first described PI3K inhibitor with IC50 of 3 nM, with little selectivity within the PI3K family. Also blocks autophagosome formation and poten...
T6100 Torin 2 Torin 2(IC50=0.25 nM), a specific and effective mTOR inhibitor, is the 800-fold greater specific activity for mTOR than PI3K and improves pharmacokinetic propert...
T2685 KU-55933 KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor.
T7014 Voxtalisib Voxtalisib (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.
T8637 DMNB 6-Nitroveratraldehyde is DNA-dependent protein kinase (DNA-PK) inhibitor with IC50 of 15 μM, an enzyme involved in the non-homologous end-joining (NHEJ) pathway ...
T6045 Torin 1 Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold selectivity for mTOR than PI3K.
T2008 LY294002 LY294002 is an inhibitor of PI3K (IC50s: 0.5/0.57/0.97 μM for PI3Kα/δ/β in cell-free assays). It also blocks autophagosome formation.
T2377 Pilaralisib analogue XL147 analogue is a selective and reversible class I PI3K inhibitor for PI3Kα/δ/γ.
T13017 STL127705 STL127705 is a inhibitor of Ku 70/80 heterodimer protein(Ku70/80-DNA interaction, with an IC50 of 3.5 μM). STL127705 also inhibits Ku-dependent activation of DNA...
T11381 Pictilisib dimethanesulfonate Pictilisib dimethanesulfonate is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p110γ (25-fold).
T6557 KU-0060648 KU-0060648 is a dual inhibitor of DNA-PK and PI3Kα, PI3Kβ, PI3Kδ with IC50 of 8.6 nM and 4 nM, 0.5 nM, 0.1 nM respectively, less inhibition of PI3Kγ with IC50 of...
T4339 YU238259 YU238259 is a novel inhibitor of homology-dependent DNA repair(HDR), but does not inhibit non-homologous end-joining (NHEJ), in cell-based GFP reporter assays.
T2433 NU 7026 NU7026 is an effective DNA-PK inhibitor (IC50: 0.23 μM, in cell-free assays), 60-fold selective for DNA-PK than PI3K and no inhibition against both ATM and ATR.
T6883 Samotolisib LY3023414 is an oral ATP competitive inhibitor of the class I PI3K isoforms, DNA-PK, and mTOR. LY3023414 has been used in trials studying the treatment of Neopla...
T6319 OSI-027 OSI-027 is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, and more than 100-fold selectivity observed for mTOR than PI3...
T2667 PIK-75 PIK-75, a DNA-PK and PI3K inhibitor, suppresses DNA-PK(IC50=2 nM), p110α(IC50=5.8 nM) and p110γ(IC50=76 nM).
T2083 PI-3065 PI-3065 is a novel potent and selective PI3K p110δ inhibitor.
T2084 ETP-46464 ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM).
T1826 PI3K-IN-1 Voxtalisib (SAR245409, XL765)Analogue is a dual inhibitor of mTOR/PI3K, mostly for p110γ , also inhibits DNA-PK and mTOR.
T2461 PIK-90 PIK-90, a DNA-PK and PI3K inhibitor, suppresses p110α( IC50=11 nM), p110γ(IC50=18 nM) and DNA-PK(IC50=13 nM) .
T7122 AZD-7648 AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.
T5166 Leniolisib Leniolisib (CDZ173) is a potent and selective PI3Kδ inhibitor (IC50: 11 nM).
T6612 NU6027 NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-aminopurin...
T3586 Compound 401 Compound 401 is a synthetic DNA-PK inhibitor (IC50 = 0.28 μM) that also targets mTOR but not PI3K.
T3541 CC-115 CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM).
T3986 SF2523 SF2523 is a highly selective and potent inhibitor.
T15789 LTURM34 LTURM34 is an inhibitor of DNA-PK with IC50 of 34 nM. LTURM34 displays effective antiproliferative activity in a wide range of tumor cell lines. LTURM34 shows 17...
T13448 (R)-(-)-Rolipram (R)-(-)-Rolipram 是一种 PDE4 抑制剂 Rolipram 的 R-对映异构体。
AZD 6482
T6087
AZD 6482 is a potent and selective p110β inhibitor with IC50 of 0.69 nM and a PI3Kβ inhibitor with IC50 of 10 nM.
PIK-75 hydrochloride
T2287
PIK-75 Hydrochloride is a p110α inhibitor with IC50 of 5.8 nM (200-fold more potently than p110β), isoform-specific mutants at Ser773, and also potently inhibi...
ETP-45658
T25399
ETP-45658 is an inhibitor of PI3-kinase, also inhibiting DNA-PK and mTOR.
BAY-8400
T9498
BAY-8400 is an orally active, potent and selective inhibitor of DNA-dependent protein kinase (DNA-PK) with an IC50 of 81 nM.
KU-57788
T6276
NU7441 (KU-57788) is a highly effective and specific DNA-PK inhibitor (IC50: 14 nM).
PI-103
T6143
PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members (IC50s: 2/3/3/15/30/23 nM for p110α/β/δ/γ, mTOR, and DNA-PK).
PIK-93
T2616
PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.
Onatasertib
T3351
CC-223 is an orally available mTOR inhibitor with potential antitumor activity. CC-223 inhibits the activity of mTOR, which may result in the induction of tumor ...
Wortmannin
T6283
Wortmannin is the first described PI3K inhibitor with IC50 of 3 nM, with little selectivity within the PI3K family. Also blocks autophagosome formation and poten...
Torin 2
T6100
Torin 2(IC50=0.25 nM), a specific and effective mTOR inhibitor, is the 800-fold greater specific activity for mTOR than PI3K and improves pharmacokinetic propert...
KU-55933
T2685
KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor.
Voxtalisib
T7014
Voxtalisib (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.
DMNB
T8637
6-Nitroveratraldehyde is DNA-dependent protein kinase (DNA-PK) inhibitor with IC50 of 15 μM, an enzyme involved in the non-homologous end-joining (NHEJ) pathway...
Torin 1
T6045
Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold selectivity for mTOR than PI3K.
LY294002
T2008
LY294002 is an inhibitor of PI3K (IC50s: 0.5/0.57/0.97 μM for PI3Kα/δ/β in cell-free assays). It also blocks autophagosome formation.
Pilaralisib analogue
T2377
XL147 analogue is a selective and reversible class I PI3K inhibitor for PI3Kα/δ/γ.
STL127705
T13017
STL127705 is a inhibitor of Ku 70/80 heterodimer protein(Ku70/80-DNA interaction, with an IC50 of 3.5 μM). STL127705 also inhibits Ku-dependent activation of DN...
Pictilisib dimethanesulfonate
T11381
Pictilisib dimethanesulfonate is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p110γ (25-fold).
KU-0060648
T6557
KU-0060648 is a dual inhibitor of DNA-PK and PI3Kα, PI3Kβ, PI3Kδ with IC50 of 8.6 nM and 4 nM, 0.5 nM, 0.1 nM respectively, less inhibition of PI3Kγ with IC5...
YU238259
T4339
YU238259 is a novel inhibitor of homology-dependent DNA repair(HDR), but does not inhibit non-homologous end-joining (NHEJ), in cell-based GFP reporter assays.
NU 7026
T2433
NU7026 is an effective DNA-PK inhibitor (IC50: 0.23 μM, in cell-free assays), 60-fold selective for DNA-PK than PI3K and no inhibition against both ATM and ATR....
Samotolisib
T6883
LY3023414 is an oral ATP competitive inhibitor of the class I PI3K isoforms, DNA-PK, and mTOR. LY3023414 has been used in trials studying the treatment of Neopla...
OSI-027
T6319
OSI-027 is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, and more than 100-fold selectivity observed for mTOR than PI3...
PIK-75
T2667
PIK-75, a DNA-PK and PI3K inhibitor, suppresses DNA-PK(IC50=2 nM), p110α(IC50=5.8 nM) and p110γ(IC50=76 nM).
PI-3065
T2083
PI-3065 is a novel potent and selective PI3K p110δ inhibitor.
ETP-46464
T2084
ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM).
PI3K-IN-1
T1826
Voxtalisib (SAR245409, XL765)Analogue is a dual inhibitor of mTOR/PI3K, mostly for p110γ , also inhibits DNA-PK and mTOR.
PIK-90
T2461
PIK-90, a DNA-PK and PI3K inhibitor, suppresses p110α( IC50=11 nM), p110γ(IC50=18 nM) and DNA-PK(IC50=13 nM) .
AZD-7648
T7122
AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.
Leniolisib
T5166
Leniolisib (CDZ173) is a potent and selective PI3Kδ inhibitor (IC50: 11 nM).
NU6027
T6612
NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-aminop...
Compound 401
T3586
Compound 401 is a synthetic DNA-PK inhibitor (IC50 = 0.28 μM) that also targets mTOR but not PI3K.
CC-115
T3541
CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM).
SF2523
T3986
SF2523 is a highly selective and potent inhibitor.
LTURM34
T15789
LTURM34 is an inhibitor of DNA-PK with IC50 of 34 nM. LTURM34 displays effective antiproliferative activity in a wide range of tumor cell lines. LTURM34 shows 17...
(R)-(-)-Rolipram
T13448
(R)-(-)-Rolipram 是一种 PDE4 抑制剂 Rolipram 的 R-对映异构体。