GlyT

Glycine transporters (GlyTs) are plasmalemmal neurotransmitter transporters. They serve to terminate the signaling of glycine by mediating its reuptake from the synaptic cleft back into the presynaptic neurons. There are two glycine transporters: glycine transporter 1 (GlyT1) and glycine transporter 2 (GlyT2).

Cat. No.	Product name	CAS No.	Purity
T14198	ALX-1393	949164-09-4	98%
T14198	ALX-1393 is a selective GlyT2 inhibitor that effectively reduces neuronal action potential activity in a concentration-dependent manner and inhibits the activity...
T14334	ASP2535	374886-51-8	98%
T14334	ASP2535 is a potent, selective, orally bioavailable, brain permeable and centrally-active glycine transporter-1 (GlyT1) inhibitor.ASP2535 can improve cognitive i...
T17096	Tilapertin	1000690-85-6	98%
T17096	Tilapertin is an oral glycine transporter type-1 inhibitor.
T10552	Bitopertin (R enantiomer)	845614-12-2	98%
T10552	Bitopertin R enantiomer (RG1678 R enantiomer) is the R-enantiomer of Bitopertin. Bitopertin is a noncompetitive glycine reuptake inhibitor and inhibits glycine u...
T16399	Opiranserin	1441000-45-8	98%
T16399	Opiranserin is a development as an injectable agent for the treatment of postoperative pain. Opiranserin is a non-opioid and non-NSAID analgesic candidate and is...
T11908	LY2365109 hydrochloride	1779796-27-8	98%
T11908	LY2365109 hydrochloride is a potent and selective GlyT1 inhibitor, with an IC50 of 15.8 nM for glycine uptake in cells over-expressing hGlyT1a.
T22126	Org 25543 hydrochloride	495076-64-7	98%
T22126	Org 25543 hydrochloride is a potent and selective glycine transporter type 2 (GlyT2) inhibitor (IC50 = 16 nM for hGlyT2). Displays no activity at GlyT1 or 56 oth...
T1568	Amoxapine	14028-44-5	98%
T1568	Amoxapine exerts its antidepressant effect by inhibiting the re-uptake of norepinephrine and, to a lesser degree, of serotonin, at adrenergic nerve endings and b...
T6788	Bitopertin	845614-11-1	98%
T6788	Bitopertin (RG1678, RO-4917838) is a potent inhibitor of glycine transporter 1 (GlyT1), with Ki of 8.1 nM for human hGlyT1b and IC50 of 22-25 nM in Chinese hamst...
T61564	PF-03463275	1173239-39-8	98%
T61564	PF-03463275 is an orally active and selective reversible inhibitor of competitive glycine transporter protein-1 (GlyT1) with a Ki of 11.6 nM.PF-03463275 has CNS ...
T6975	Sarcosine	107-97-1	98%
T6975	Sarcosine is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist.
T9833	Opiranserin hydrochloride	1440796-75-7	98%
T9833	Opiranserin (VVZ-149) hydrochloride is a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A), with IC50s of 0.86 and 1.3 μM, ...