PAFR

The platelet-activating factor receptor is a G-protein coupled receptor which binds platelet-activating factor. The PAF receptor shows structural characteristics of the rhodopsin (MIM 180380) gene family and binds platelet-activating factor (PAF). PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) that has been implicated as a mediator in diverse pathologic processes, such as allergy, asthma, septic shock, arterial thrombosis, and inflammatory processes.[supplied by OMIM][7] Its pathogenetic role in chronic kidney failure has also been reported recently.

Cat No.	product name
T2751	Ginkgolide B	Ginkgolide B is a PAFR antagonist(IC50=3.6 μM) isolated from Ginkgo biloba.
T6242	Rupatadine Fumarate	Rupatadine Fumarate (UR-12592 Fumarate) is a potent dual PAF/H1 antagonist with Ki of 0.55/0.1 uM.
T3856	Tenuifoliside A
TN1170	1-Cinnamoylpyrrolidine	1-Cinnamoylpyrrolidine shows inhibitory activity of platelet aggregation in vitro.
TN1254	3'-Methoxydaidzein	3'-Methoxydaidzein has antioxidant activity, it and geraldol have antiplatelet aggregation activity and appear to be specific against collageninduce platele...
TN1271	4',5,6,7-Tetramethoxyflavone	4',5,6,7-Tetramethoxyflavone has a hemostatic effect.
TN1643	Ferulamide	Ferulamide derivatives show potent inhibitory activity against arachidonic acid-induced platelet aggregation.
TN1715	Guaiacin	(+)-Guaiacin has significant neuroprotective, and anti-inflammatory activities, it can inhibit cyclooxygenase (COX)-1 and COX-2.
TN1815	Kadsulignan L	Kadsulignan L shows in vitro antiviral effects on hepatitis B virus. It also shows moderate platelet-activating factor (PAF) antagonistic activities with the IC...
TN1873	Lirinidine	(+)-Lirinidine has antioxidative activity, and it can significantly inhibit the proliferation of melanoma cells; it also shows potent inhibition of melanogenesi...
TN2086	Piperlotine A	Piperlotine A shows potent antiplatelet aggregation activity.
TN2087	Piperlotine C	Piperlotine C shows potent antiplatelet aggregation activity.
TN2322	Yangambin	Yangambin is a selective antagonist of the cardiovascular effects of platelet activating factor (PAF); it has hypotensive effect, which is probably due to a per...
TN2329	Zingiberen newsaponin	Zingiberensis newsaponin I exhibits induction effect on platelet aggregation.
TN1654	Futoquinol	Futoquinol is an anti-platelet activating factor principle from the stem part of Piper futokadsura (Piperaceae), the Chinese drug haifengteng.
T3P2855	Chamigrenal	β-Chamigrenal has anti-inflammatory activity, it has inhibitory effects on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in RAW 264.7...
TL0014	Pinusolide	Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, ...
TMA2418	1-Methoxyphaseollidin	1-Methoxyphaseollidin exhibits anti-Helicobacter pylori activity against the CLAR and AMOX-resistant strain as well as four CLAR (AMOX)-sensitive strains. 1-Met...
TN2763	2-Hydroxy-3-methoxybenzoic acid glucose ester	2-Hydroxy-3-methoxybenzoic acid glucose ester shows a potent antagonistic activity against platelet activating factor (PAF), it can prevent the mice from the PA...
TN3153	6-Acetyl-2,2-dimethylchroman-4-one	6-Acetyl-2,2-dimethylchroman-4-one and vanillin show anti-platelet aggregation activity induced by arachidonic acid in vitro.
TN3161	6-Deoxyjacareubin	6-Deoxyjacareubin possesses significant antioxidant activities, it also exhibits the cytotoxic activities against HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cel...
TN3348	Acuminatin	(-)-Acuminatin exerts hepatoprotective activities, perhaps by serving as a potent antioxidant. (+)-trans-Acuminatin, and (+)-cis-acuminatin show weak activity a...
TN3443	Aristolactam AII	Aristolactam AII has cytotoxic activity, it also shows platelet aggregation inhibitory activity.
TN3445	Aristolactam BIII	Aristolactam BIII possesses anti-platelet aggregation activity in vitro, it also shows significant cytotoxic activity (IC50 values < 4 microg/mL) against P-388,...
TN3520	Bisdethiobis(methylthio)gliotoxin	Bisdethiobis(methylthio)gliotoxin is a platelet activating factor (PAF) antagonist.
TN3723	Cryptomeridiol	Cryptomeridiol is a potential skin-whitening agent, exhibits melanogenesis inhibitory activity on α-MSH-stimulated B16 melanoma cells. Cryptomeridiol has low a...
TN3740	Cyclocommunol	Cyclocommunol exhibits cytotoxicity against hepatocellular carcinoma (SMMC-7721) and gastric carcinoma (BGC-823 and SGC-7901) cell lines. It also shows strong i...
TN3831	Denudatin B	Denudatin B has nonspecific antiplatelet action at high concentration by inhibiting phosphoinositides breakdown induced by collagen and thrombin, it inhibits th...
TN3979	Epiyangambin	Epiyangambin is a phytotoxic lignan, it shows inhibition of seed germination of Agrostis stolonifera cv. penncross (Poaceae) and inhibition of development of La...
TN4088	Futoenone	Futoenone and a series of its derivatives have shown inhibitory activities against matrix metalloproteinases, the molecular modelings of these compounds indicat...
TN4181	Hancinone C	Hancinone C shows inhibitory activity against the platelet aggregation caused by PAF.
TN4367	Kadsurin A	Kadsurin A and Kadsurin B have anti-platelet activating factor activities.
TN4600	Myrianthic acid	Myrianthic acid shows anticancer activity, it shows inhibitory activities on foam cell formation in human monocyte-derived macrophages induced by acetylated low...
TN4660	Niranthin	Niranthin is a potent anti-leishmanial agent, inhibits the relaxation activity of heterodimeric type IB topoisomerase of L. donovani and acts as a non-competiti...
TN4794	Pinusolidic acid	Pinusolidic acid shows a potent inhibitory effect on platelet activating factor (PAF) binding to rabbit platelets (IC50 = 2.3 x 10(-5) M, 7.48 +/- 2.11 microgra...
TN4795	Piperenone	Piperenone is an insect antifeeding substance. It has anti-platelet-activating factor(PAF) activities, is a PAF-acether antagonist.
TN4796	Piperlotine D	Piperlotine D shows potent antiplatelet aggregation activity.
TN4797	Piperolactam C	Piperolactam C possesses anti-platelet aggregation activity in vitro. It can inhibit the growth of the fungi Cladosporium sphaerospermum and C. cladosporioides.
TN4821	Pregomisin	Pregomisin shows platelet-activating factor (PAF) antagonistic activity and the IC 50 value is 4.8x10(-5) M.
TN5045	Spiradine F	Spiradine F can significantly inhibit platelet-activating factor(PAF)-induced platelet aggregation in a concentration-dependent manner.