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GPCR/G Protein PAFR

PAFR

The platelet-activating factor receptor is a G-protein coupled receptor which binds platelet-activating factor. The PAF receptor shows structural characteristics of the rhodopsin (MIM 180380) gene family and binds platelet-activating factor (PAF). PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) that has been implicated as a mediator in diverse pathologic processes, such as allergy, asthma, septic shock, arterial thrombosis, and inflammatory processes.[supplied by OMIM][7] Its pathogenetic role in chronic kidney failure has also been reported recently.
Cat No. product name
T2751 Ginkgolide B Ginkgolide B is a PAFR antagonist(IC50=3.6 μM) isolated from Ginkgo biloba.
T6242 Rupatadine Fumarate Rupatadine Fumarate (UR-12592 Fumarate) is a potent dual PAF/H1 antagonist with Ki of 0.55/0.1 uM.
T3856 Tenuifoliside A Tenuifoliside A has anti-apoptotic , neuroprotective activity. And tenuifoliside A has anti-inflammatory effect, which is mediated by the inhibition of the NF...
TN1170 1-Cinnamoylpyrrolidine 1-Cinnamoylpyrrolidine shows inhibitory activity of platelet aggregation in vitro.
TN1254 3'-Methoxydaidzein 3'-Methoxydaidzein has antioxidant activity, it and geraldol have antiplatelet aggregation activity and appear to be specific against collagen€induce platele...
TN1271 4',5,6,7-Tetramethoxyflavone 4',5,6,7-Tetramethoxyflavone has a hemostatic effect.
TN1643 Ferulamide Ferulamide derivatives show potent inhibitory activity against arachidonic acid-induced platelet aggregation.
TN1715 Guaiacin (+)-Guaiacin has significant neuroprotective, and anti-inflammatory activities, it can inhibit cyclooxygenase (COX)-1 and COX-2.
TN1815 Kadsulignan L Kadsulignan L shows in vitro antiviral effects on hepatitis B virus. It also shows moderate platelet-activating factor (PAF) antagonistic activities with the IC...
TN1873 Lirinidine (+)-Lirinidine has antioxidative activity, and it can significantly inhibit the proliferation of melanoma cells; it also shows potent inhibition of melanogenesi...
TN2086 Piperlotine A Piperlotine A shows potent antiplatelet aggregation activity.
TN2087 Piperlotine C Piperlotine C shows potent antiplatelet aggregation activity.
TN2322 Yangambin Yangambin is a selective antagonist of the cardiovascular effects of platelet activating factor (PAF); it has hypotensive effect, which is probably due to a per...
TN2329 Zingiberen newsaponin Zingiberensis newsaponin I exhibits induction effect on platelet aggregation.
TN1654 Futoquinol Futoquinol is an anti-platelet activating factor principle from the stem part of Piper futokadsura (Piperaceae), the Chinese drug haifengteng.
T3P2855 Chamigrenal β-Chamigrenal has anti-inflammatory activity, it has inhibitory effects on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in RAW 264.7...
TL0014 Pinusolide Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, ...
TMA2418 1-Methoxyphaseollidin 1-Methoxyphaseollidin exhibits anti-Helicobacter pylori activity against the CLAR and AMOX-resistant strain as well as four CLAR (AMOX)-sensitive strains. 1-Met...
TN2763 2-Hydroxy-3-methoxybenzoic acid glucose ester 2-Hydroxy-3-methoxybenzoic acid glucose ester shows a potent antagonistic activity against platelet activating factor (PAF), it can prevent the mice from the PA...
TN3153 6-Acetyl-2,2-dimethylchroman-4-one 6-Acetyl-2,2-dimethylchroman-4-one and vanillin show anti-platelet aggregation activity induced by arachidonic acid in vitro.
TN3161 6-Deoxyjacareubin 6-Deoxyjacareubin possesses significant antioxidant activities, it also exhibits the cytotoxic activities against HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cel...
TN3348 Acuminatin (-)-Acuminatin exerts hepatoprotective activities, perhaps by serving as a potent antioxidant. (+)-trans-Acuminatin, and (+)-cis-acuminatin show weak activity a...
TN3443 Aristolactam AII Aristolactam AII has cytotoxic activity, it also shows platelet aggregation inhibitory activity.
TN3445 Aristolactam BIII Aristolactam BIII possesses anti-platelet aggregation activity in vitro, it also shows significant cytotoxic activity (IC50 values < 4 microg/mL) against P-388,...
TN3520 Bisdethiobis(methylthio)gliotoxin Bisdethiobis(methylthio)gliotoxin is a platelet activating factor (PAF) antagonist.
TN3723 Cryptomeridiol Cryptomeridiol is a potential skin-whitening agent, exhibits melanogenesis inhibitory activity on α-MSH-stimulated B16 melanoma cells. Cryptomeridiol has low a...
TN3740 Cyclocommunol Cyclocommunol exhibits cytotoxicity against hepatocellular carcinoma (SMMC-7721) and gastric carcinoma (BGC-823 and SGC-7901) cell lines. It also shows strong i...
TN3831 Denudatin B Denudatin B has nonspecific antiplatelet action at high concentration by inhibiting phosphoinositides breakdown induced by collagen and thrombin, it inhibits th...
TN3979 Epiyangambin Epiyangambin is a phytotoxic lignan, it shows inhibition of seed germination of Agrostis stolonifera cv. penncross (Poaceae) and inhibition of development of La...
TN4088 Futoenone Futoenone and a series of its derivatives have shown inhibitory activities against matrix metalloproteinases, the molecular modelings of these compounds indicat...
TN4181 Hancinone C Hancinone C shows inhibitory activity against the platelet aggregation caused by PAF.
TN4367 Kadsurin A Kadsurin A and Kadsurin B have anti-platelet activating factor activities.
TN4600 Myrianthic acid Myrianthic acid shows anticancer activity, it shows inhibitory activities on foam cell formation in human monocyte-derived macrophages induced by acetylated low...
TN4660 Niranthin Niranthin is a potent anti-leishmanial agent, inhibits the relaxation activity of heterodimeric type IB topoisomerase of L. donovani and acts as a non-competiti...
TN4794 Pinusolidic acid Pinusolidic acid shows a potent inhibitory effect on platelet activating factor (PAF) binding to rabbit platelets (IC50 = 2.3 x 10(-5) M, 7.48 +/- 2.11 microgra...
TN4795 Piperenone Piperenone is an insect antifeeding substance. It has anti-platelet-activating factor(PAF) activities, is a PAF-acether antagonist.
TN4796 Piperlotine D Piperlotine D shows potent antiplatelet aggregation activity.
TN4797 Piperolactam C Piperolactam C possesses anti-platelet aggregation activity in vitro. It can inhibit the growth of the fungi Cladosporium sphaerospermum and C. cladosporioides.
TN4821 Pregomisin Pregomisin shows platelet-activating factor (PAF) antagonistic activity and the IC 50 value is 4.8x10(-5) M.
TN5045 Spiradine F Spiradine F can significantly inhibit platelet-activating factor(PAF)-induced platelet aggregation in a concentration-dependent manner.
Ginkgolide B
T2751CAS 15291-77-7
Ginkgolide B is a PAFR antagonist(IC50=3.6 μM) isolated from Ginkgo biloba.
Rupatadine Fumarate
T6242CAS 182349-12-8
Rupatadine Fumarate (UR-12592 Fumarate) is a potent dual PAF/H1 antagonist with Ki of 0.55/0.1 uM.
Tenuifoliside A
T3856CAS 139726-35-5
Tenuifoliside A has anti-apoptotic , neuroprotective activity. And tenuifoliside A has anti-inflammatory effect, which is mediated by the inhibition of the NF...
1-Cinnamoylpyrrolidine
TN1170CAS 52438-21-8
1-Cinnamoylpyrrolidine shows inhibitory activity of platelet aggregation in vitro.
3'-Methoxydaidzein
TN1254CAS 21913-98-4
3'-Methoxydaidzein has antioxidant activity, it and geraldol have antiplatelet aggregation activity and appear to be specific against collagen€induce platele...
4',5,6,7-Tetramethoxyflavone
TN1271CAS 1168-42-9
4',5,6,7-Tetramethoxyflavone has a hemostatic effect.
Ferulamide
TN1643CAS 61012-31-5
Ferulamide derivatives show potent inhibitory activity against arachidonic acid-induced platelet aggregation.
Guaiacin
TN1715CAS 36531-08-5
(+)-Guaiacin has significant neuroprotective, and anti-inflammatory activities, it can inhibit cyclooxygenase (COX)-1 and COX-2.
Kadsulignan L
TN1815CAS 163660-06-8
Kadsulignan L shows in vitro antiviral effects on hepatitis B virus. It also shows moderate platelet-activating factor (PAF) antagonistic activities with the IC...
Lirinidine
TN1873CAS 54383-28-7
(+)-Lirinidine has antioxidative activity, and it can significantly inhibit the proliferation of melanoma cells; it also shows potent inhibition of melanogenesi...
Piperlotine A
TN2086CAS 389572-70-7
Piperlotine A shows potent antiplatelet aggregation activity.
Piperlotine C
TN2087CAS 886989-88-4
Piperlotine C shows potent antiplatelet aggregation activity.
Yangambin
TN2322CAS 13060-14-5
Yangambin is a selective antagonist of the cardiovascular effects of platelet activating factor (PAF); it has hypotensive effect, which is probably due to a per...
Zingiberen newsaponin
TN2329CAS 91653-50-8
Zingiberensis newsaponin I exhibits induction effect on platelet aggregation.
Futoquinol
TN1654CAS 28178-92-9
Futoquinol is an anti-platelet activating factor principle from the stem part of Piper futokadsura (Piperaceae), the Chinese drug haifengteng.
Chamigrenal
T3P2855CAS 19912-84-6
β-Chamigrenal has anti-inflammatory activity, it has inhibitory effects on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in RAW 264.7...
Pinusolide
TL0014CAS 31685-80-0
Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, ...
1-Methoxyphaseollidin
TMA2418CAS 65428-13-9
1-Methoxyphaseollidin exhibits anti-Helicobacter pylori activity against the CLAR and AMOX-resistant strain as well as four CLAR (AMOX)-sensitive strains. 1-Met...
2-Hydroxy-3-methoxybenzoic acid glucose ester
TN2763CAS 172377-87-6
2-Hydroxy-3-methoxybenzoic acid glucose ester shows a potent antagonistic activity against platelet activating factor (PAF), it can prevent the mice from the PA...
6-Acetyl-2,2-dimethylchroman-4-one
TN3153CAS 68799-41-7
6-Acetyl-2,2-dimethylchroman-4-one and vanillin show anti-platelet aggregation activity induced by arachidonic acid in vitro.
6-Deoxyjacareubin
TN3161CAS 16265-56-8
6-Deoxyjacareubin possesses significant antioxidant activities, it also exhibits the cytotoxic activities against HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cel...
Acuminatin
TN3348CAS 41744-39-2
(-)-Acuminatin exerts hepatoprotective activities, perhaps by serving as a potent antioxidant. (+)-trans-Acuminatin, and (+)-cis-acuminatin show weak activity a...
Aristolactam AII
TN3443CAS 53948-07-5
Aristolactam AII has cytotoxic activity, it also shows platelet aggregation inhibitory activity.
Aristolactam BIII
TN3445CAS 53948-10-0
Aristolactam BIII possesses anti-platelet aggregation activity in vitro, it also shows significant cytotoxic activity (IC50 values < 4 microg/mL) against P-388,...
Bisdethiobis(methylthio)gliotoxin
TN3520CAS 74149-38-5
Bisdethiobis(methylthio)gliotoxin is a platelet activating factor (PAF) antagonist.
Cryptomeridiol
TN3723CAS 4666-84-6
Cryptomeridiol is a potential skin-whitening agent, exhibits melanogenesis inhibitory activity on α-MSH-stimulated B16 melanoma cells. Cryptomeridiol has low a...
Cyclocommunol
TN3740CAS 145643-96-5
Cyclocommunol exhibits cytotoxicity against hepatocellular carcinoma (SMMC-7721) and gastric carcinoma (BGC-823 and SGC-7901) cell lines. It also shows strong i...
Denudatin B
TN3831CAS 87402-88-8
Denudatin B has nonspecific antiplatelet action at high concentration by inhibiting phosphoinositides breakdown induced by collagen and thrombin, it inhibits th...
Epiyangambin
TN3979CAS 24192-64-1
Epiyangambin is a phytotoxic lignan, it shows inhibition of seed germination of Agrostis stolonifera cv. penncross (Poaceae) and inhibition of development of La...
Futoenone
TN4088CAS 19913-01-0
Futoenone and a series of its derivatives have shown inhibitory activities against matrix metalloproteinases, the molecular modelings of these compounds indicat...
Hancinone C
TN4181CAS 111843-10-8
Hancinone C shows inhibitory activity against the platelet aggregation caused by PAF.
Kadsurin A
TN4367CAS 99340-07-5
Kadsurin A and Kadsurin B have anti-platelet activating factor activities.
Myrianthic acid
TN4600CAS 89786-84-5
Myrianthic acid shows anticancer activity, it shows inhibitory activities on foam cell formation in human monocyte-derived macrophages induced by acetylated low...
Niranthin
TN4660CAS 50656-77-4
Niranthin is a potent anti-leishmanial agent, inhibits the relaxation activity of heterodimeric type IB topoisomerase of L. donovani and acts as a non-competiti...
Pinusolidic acid
TN4794CAS 40433-82-7
Pinusolidic acid shows a potent inhibitory effect on platelet activating factor (PAF) binding to rabbit platelets (IC50 = 2.3 x 10(-5) M, 7.48 +/- 2.11 microgra...
Piperenone
TN4795CAS 57625-31-7
Piperenone is an insect antifeeding substance. It has anti-platelet-activating factor(PAF) activities, is a PAF-acether antagonist.
Piperlotine D
TN4796CAS 958296-13-4
Piperlotine D shows potent antiplatelet aggregation activity.
Piperolactam C
TN4797CAS 116064-76-7
Piperolactam C possesses anti-platelet aggregation activity in vitro. It can inhibit the growth of the fungi Cladosporium sphaerospermum and C. cladosporioides.
Pregomisin
TN4821CAS 66280-26-0
Pregomisin shows platelet-activating factor (PAF) antagonistic activity and the IC 50 value is 4.8x10(-5) M.
Spiradine F
TN5045CAS 21040-64-2
Spiradine F can significantly inhibit platelet-activating factor(PAF)-induced platelet aggregation in a concentration-dependent manner.