Home Tools
Log in
Cart

PAFR

The platelet-activating factor receptor is a G-protein coupled receptor which binds platelet-activating factor. The PAF receptor shows structural characteristics of the rhodopsin (MIM 180380) gene family and binds platelet-activating factor (PAF). PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) that has been implicated as a mediator in diverse pathologic processes, such as allergy, asthma, septic shock, arterial thrombosis, and inflammatory processes.[supplied by OMIM][7] Its pathogenetic role in chronic kidney failure has also been reported recently.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T3P2855 Chamigrenal 19912-84-6
Chamigrenal
β-Chamigrenal has anti-inflammatory activity, it has inhibitory effects on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in RAW 264.7 m...
TN4795 Piperenone 57625-31-7 98%
Piperenone
Piperenone is an insect antifeeding substance. It has anti-platelet-activating factor(PAF) activities, is a PAF-acether antagonist.
TN4797 Piperolactam C 116064-76-7 98%
Piperolactam C
Piperolactam C possesses anti-platelet aggregation activity in vitro. It can inhibit the growth of the fungi Cladosporium sphaerospermum and C. cladosporioides.
TN4796 Piperlotine D 958296-13-4 98%
Piperlotine D
Piperlotine D shows potent antiplatelet aggregation activity.
TN4794 Pinusolidic acid 40433-82-7 98%
Pinusolidic acid
Pinusolidic acid shows a potent inhibitory effect on platelet activating factor (PAF) binding to rabbit platelets (IC50 = 2.3 x 10(-5) M, 7.48 +/- 2.11 microgram...
TN3348 (+)-Acuminatin 41744-39-2 98%
(+)-Acuminatin
(+)-Acuminatin exerts hepatoprotective activities, perhaps by serving as a potent antioxidant. (+)-trans-Acuminatin, and (+)-cis-acuminatin show weak activity ag...
TN2763 2-Hydroxy-3-methoxybenzoic acid glucose ester 172377-87-6 98%
2-Hydroxy-3-methoxybenzoic acid glucose ester
2-Hydroxy-3-methoxybenzoic acid glucose ester shows a potent antagonistic activity against platelet activating factor (PAF), it can prevent the mice from the PAF...
TN3153 6-Acetyl-2,2-dimethylchroman-4-one 68799-41-7 98%
6-Acetyl-2,2-dimethylchroman-4-one
6-Acetyl-2,2-dimethylchroman-4-one and vanillin show anti-platelet aggregation activity induced by arachidonic acid in vitro.
TN1654 Futoquinol 28178-92-9 98%
Futoquinol
Futoquinol is an anti-platelet activating factor principle from the stem part of Piper futokadsura (Piperaceae), the Chinese drug haifengteng.
TN3445 Aristolactam BIII 53948-10-0 98%
Aristolactam BIII
Aristolactam BIII possesses anti-platelet aggregation activity in vitro, it also shows significant cytotoxic activity (IC50 values < 4 microg/mL) against P-388, ...
TN3723 Cryptomeridiol 4666-84-6 98%
Cryptomeridiol
Cryptomeridiol is a potential skin-whitening agent, exhibits melanogenesis inhibitory activity on α-MSH-stimulated B16 melanoma cells. Cryptomeridiol has low act...
TL0014 Pinusolide 31685-80-0 98%
Pinusolide
Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, a...
TN3161 6-Deoxyjacareubin 16265-56-8 98%
6-Deoxyjacareubin
6-Deoxyjacareubin exhibits potent antioxidant and antifungal activities. 6-Deoxyjacareubin inhibits platelet activating factor (PAF) receptor with an IC50 of 29....
TMA2418 1-Methoxyphaseollidin 65428-13-9 98%
1-Methoxyphaseollidin
1-Methoxyphaseollidin exhibits anti-Helicobacter pylori activity against the CLAR and AMOX-resistant strain as well as four CLAR (AMOX)-sensitive strains. 1-Meth...
TN4600 Myrianthic acid 89786-84-5 98%
Myrianthic acid
Myrianthic acid shows anticancer activity, it shows inhibitory activities on foam cell formation in human monocyte-derived macrophages induced by acetylated low-...
TN4821 Pregomisin 66280-26-0 98%
Pregomisin
Pregomisin shows platelet-activating factor (PAF) antagonistic activity and the IC 50 value is 4.8x10(-5) M.
TN2087 Piperlotine C 886989-88-4 98%
Piperlotine C
Piperlotine C shows potent antiplatelet aggregation activity.
TN3740 Cyclocommunol 145643-96-5 98%
Cyclocommunol
Cyclocommunol exhibits cytotoxicity against hepatocellular carcinoma (SMMC-7721) and gastric carcinoma (BGC-823 and SGC-7901) cell lines. It also shows strong in...
TN4367 Kadsurin A 99340-07-5 98%
Kadsurin A
Kadsurin A has anti-platelet activating factor activities.
TN3979 Epiyangambin 24192-64-1 98%
Epiyangambin
Epiyangambin is a phytotoxic lignan, it shows inhibition of seed germination of Agrostis stolonifera cv. penncross (Poaceae) and inhibition of development of Lac...
Chamigrenal
T3P2855
β-Chamigrenal has anti-inflammatory activity, it has inhibitory effects on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in RAW 264.7 m...
Piperenone
TN4795
Piperenone is an insect antifeeding substance. It has anti-platelet-activating factor(PAF) activities, is a PAF-acether antagonist.
Piperolactam C
TN4797
Piperolactam C possesses anti-platelet aggregation activity in vitro. It can inhibit the growth of the fungi Cladosporium sphaerospermum and C. cladosporioides.
Piperlotine D
TN4796
Piperlotine D shows potent antiplatelet aggregation activity.
Pinusolidic acid
TN4794
Pinusolidic acid shows a potent inhibitory effect on platelet activating factor (PAF) binding to rabbit platelets (IC50 = 2.3 x 10(-5) M, 7.48 +/- 2.11 microgram...
(+)-Acuminatin
TN3348
(+)-Acuminatin exerts hepatoprotective activities, perhaps by serving as a potent antioxidant. (+)-trans-Acuminatin, and (+)-cis-acuminatin show weak activity ag...
2-Hydroxy-3-methoxybenzoic acid glucose ester
TN2763
2-Hydroxy-3-methoxybenzoic acid glucose ester shows a potent antagonistic activity against platelet activating factor (PAF), it can prevent the mice from the PAF...
6-Acetyl-2,2-dimethylchroman-4-one
TN3153
6-Acetyl-2,2-dimethylchroman-4-one and vanillin show anti-platelet aggregation activity induced by arachidonic acid in vitro.
Futoquinol
TN1654
Futoquinol is an anti-platelet activating factor principle from the stem part of Piper futokadsura (Piperaceae), the Chinese drug haifengteng.
Aristolactam BIII
TN3445
Aristolactam BIII possesses anti-platelet aggregation activity in vitro, it also shows significant cytotoxic activity (IC50 values < 4 microg/mL) against P-388, ...
Cryptomeridiol
TN3723
Cryptomeridiol is a potential skin-whitening agent, exhibits melanogenesis inhibitory activity on α-MSH-stimulated B16 melanoma cells. Cryptomeridiol has low act...
Pinusolide
TL0014
Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, a...
6-Deoxyjacareubin
TN3161
6-Deoxyjacareubin exhibits potent antioxidant and antifungal activities. 6-Deoxyjacareubin inhibits platelet activating factor (PAF) receptor with an IC50 of 29....
1-Methoxyphaseollidin
TMA2418
1-Methoxyphaseollidin exhibits anti-Helicobacter pylori activity against the CLAR and AMOX-resistant strain as well as four CLAR (AMOX)-sensitive strains. 1-Meth...
Myrianthic acid
TN4600
Myrianthic acid shows anticancer activity, it shows inhibitory activities on foam cell formation in human monocyte-derived macrophages induced by acetylated low-...
Pregomisin
TN4821
Pregomisin shows platelet-activating factor (PAF) antagonistic activity and the IC 50 value is 4.8x10(-5) M.
Piperlotine C
TN2087
Piperlotine C shows potent antiplatelet aggregation activity.
Cyclocommunol
TN3740
Cyclocommunol exhibits cytotoxicity against hepatocellular carcinoma (SMMC-7721) and gastric carcinoma (BGC-823 and SGC-7901) cell lines. It also shows strong in...
Kadsurin A
TN4367
Kadsurin A has anti-platelet activating factor activities.
Epiyangambin
TN3979
Epiyangambin is a phytotoxic lignan, it shows inhibition of seed germination of Agrostis stolonifera cv. penncross (Poaceae) and inhibition of development of Lac...
1 2
TargetMol