Home Tools
Log in
Cart

PAFR

The platelet-activating factor receptor is a G-protein coupled receptor which binds platelet-activating factor. The PAF receptor shows structural characteristics of the rhodopsin (MIM 180380) gene family and binds platelet-activating factor (PAF). PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) that has been implicated as a mediator in diverse pathologic processes, such as allergy, asthma, septic shock, arterial thrombosis, and inflammatory processes.[supplied by OMIM][7] Its pathogenetic role in chronic kidney failure has also been reported recently.
Cat No. product name
T6242 Rupatadine Fumarate Rupatadine Fumarate (UR-12592 Fumarate) is a potent dual PAF/H1 antagonist with Ki of 0.55/0.1 uM.
T2751 Ginkgolide B Ginkgolide B is a PAFR antagonist(IC50=3.6 μM) isolated from Ginkgo biloba.
TN1643 Ferulamide Ferulamide derivatives show potent inhibitory activity against arachidonic acid-induced platelet aggregation.
TN4660 Niranthin Niranthin is a potent anti-leishmanial agent, inhibits the relaxation activity of heterodimeric type IB topoisomerase of L. donovani and acts as a non-competitiv...
TN2322 Yangambin Yangambin is a selective antagonist of the cardiovascular effects of platelet activating factor (PAF); it has hypotensive effect, which is probably due to a peri...
TN2329 Zingiberen newsaponin Zingiberensis newsaponin I exhibits induction effect on platelet aggregation.
TN2087 Piperlotine C Piperlotine C shows potent antiplatelet aggregation activity.
TN2086 Piperlotine A Piperlotine A shows potent antiplatelet aggregation activity.
TN1815 Kadsulignan L Kadsulignan L shows in vitro antiviral effects on hepatitis B virus. It also shows moderate platelet-activating factor (PAF) antagonistic activities with the IC5...
TN1654 Futoquinol Futoquinol is an anti-platelet activating factor principle from the stem part of Piper futokadsura (Piperaceae), the Chinese drug haifengteng.
TN1715 Guaiacin (+)-Guaiacin has significant neuroprotective, and anti-inflammatory activities, it can inhibit cyclooxygenase (COX)-1 and COX-2.
TMA2418 1-Methoxyphaseollidin 1-Methoxyphaseollidin exhibits anti-Helicobacter pylori activity against the CLAR and AMOX-resistant strain as well as four CLAR (AMOX)-sensitive strains. 1-Meth...
TN1254 3'-Methoxydaidzein 3'-Methoxydaidzein has antioxidant activity, it and geraldol have antiplatelet aggregation activity and appear to be specific against collagen induce platelet a...
TN1271 Scutellarein tetramethyl ether Scutellarein tetramethyl ether 从暹罗草中提取,通过 NF-κB 途径表现出抗炎活性。
TN1170 1-Cinnamoylpyrrolidine 1-Cinnamoylpyrrolidine shows inhibitory activity of platelet aggregation in vitro.
TL0014 Pinusolide Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, a...
TN4600 Myrianthic acid Myrianthic acid shows anticancer activity, it shows inhibitory activities on foam cell formation in human monocyte-derived macrophages induced by acetylated low-...
TN4367 Kadsurin A Kadsurin A 具有抗血小板活化因子活性。
TN4181 Hancinone C Hancinone C shows inhibitory activity against the platelet aggregation caused by PAF.
TN4088 Futoenone Futoenone and a series of its derivatives have shown inhibitory activities against matrix metalloproteinases, the molecular modelings of these compounds indicate...
TN3740 Cyclocommunol Cyclocommunol exhibits cytotoxicity against hepatocellular carcinoma (SMMC-7721) and gastric carcinoma (BGC-823 and SGC-7901) cell lines. It also shows strong in...
TN3831 (-)-Denudatin B Denudatin B has nonspecific antiplatelet action at high concentration by inhibiting phosphoinositides breakdown induced by collagen and thrombin, it inhibits the...
TN3979 Epiyangambin Epiyangambin is a phytotoxic lignan, it shows inhibition of seed germination of Agrostis stolonifera cv. penncross (Poaceae) and inhibition of development of Lac...
TN2763 2-Hydroxy-3-methoxybenzoic acid glucose ester 2-Hydroxy-3-methoxybenzoic acid glucose ester shows a potent antagonistic activity against platelet activating factor (PAF), it can prevent the mice from the PAF...
TN3161 6-Deoxyjacareubin 6-Deoxyjacareubin possesses significant antioxidant activities, it also exhibits the cytotoxic activities against HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell...
TN3153 6-Acetyl-2,2-dimethylchroman-4-one 6-Acetyl-2,2-dimethylchroman-4-one and vanillin show anti-platelet aggregation activity induced by arachidonic acid in vitro.
TN3520 Bisdethiobis(methylthio)gliotoxin Bisdethiobis(methylthio)gliotoxin is a platelet activating factor (PAF) antagonist.
TN3723 Cryptomeridiol Cryptomeridiol is a potential skin-whitening agent, exhibits melanogenesis inhibitory activity on α-MSH-stimulated B16 melanoma cells. Cryptomeridiol has low act...
TN3348 (+)-Acuminatin (-)-Acuminatin exerts hepatoprotective activities, perhaps by serving as a potent antioxidant. (+)-trans-Acuminatin, and (+)-cis-acuminatin show weak activity ag...
TN3445 Aristolactam BIII Aristolactam BIII possesses anti-platelet aggregation activity in vitro, it also shows significant cytotoxic activity (IC50 values < 4 microg/mL) against P-388, ...
TN3443 Aristolactam AII Aristolactam AII has cytotoxic activity, it also shows platelet aggregation inhibitory activity.
TN4821 Pregomisin Pregomisin shows platelet-activating factor (PAF) antagonistic activity and the IC 50 value is 4.8x10(-5) M.
TN4796 Piperlotine D Piperlotine D shows potent antiplatelet aggregation activity.
TN4795 Piperenone Piperenone is an insect antifeeding substance. It has anti-platelet-activating factor(PAF) activities, is a PAF-acether antagonist.
TN4794 Pinusolidic acid Pinusolidic acid shows a potent inhibitory effect on platelet activating factor (PAF) binding to rabbit platelets (IC50 = 2.3 x 10(-5) M, 7.48 +/- 2.11 microgram...
TN4797 Piperolactam C Piperolactam C possesses anti-platelet aggregation activity in vitro. It can inhibit the growth of the fungi Cladosporium sphaerospermum and C. cladosporioides.
TN5045 Spiradine F Spiradine F can significantly inhibit platelet-activating factor(PAF)-induced platelet aggregation in a concentration-dependent manner.
T3P2855 Chamigrenal β-Chamigrenal has anti-inflammatory activity, it has inhibitory effects on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in RAW 264.7 m...
Rupatadine Fumarate
T6242
Rupatadine Fumarate (UR-12592 Fumarate) is a potent dual PAF/H1 antagonist with Ki of 0.55/0.1 uM.
Ginkgolide B
T2751
Ginkgolide B is a PAFR antagonist(IC50=3.6 μM) isolated from Ginkgo biloba.
Ferulamide
TN1643
Ferulamide derivatives show potent inhibitory activity against arachidonic acid-induced platelet aggregation.
Niranthin
TN4660
Niranthin is a potent anti-leishmanial agent, inhibits the relaxation activity of heterodimeric type IB topoisomerase of L. donovani and acts as a non-competitiv...
Yangambin
TN2322
Yangambin is a selective antagonist of the cardiovascular effects of platelet activating factor (PAF); it has hypotensive effect, which is probably due to a peri...
Zingiberen newsaponin
TN2329
Zingiberensis newsaponin I exhibits induction effect on platelet aggregation.
Piperlotine C
TN2087
Piperlotine C shows potent antiplatelet aggregation activity.
Piperlotine A
TN2086
Piperlotine A shows potent antiplatelet aggregation activity.
Kadsulignan L
TN1815
Kadsulignan L shows in vitro antiviral effects on hepatitis B virus. It also shows moderate platelet-activating factor (PAF) antagonistic activities with the IC5...
Futoquinol
TN1654
Futoquinol is an anti-platelet activating factor principle from the stem part of Piper futokadsura (Piperaceae), the Chinese drug haifengteng.
Guaiacin
TN1715
(+)-Guaiacin has significant neuroprotective, and anti-inflammatory activities, it can inhibit cyclooxygenase (COX)-1 and COX-2.
1-Methoxyphaseollidin
TMA2418
1-Methoxyphaseollidin exhibits anti-Helicobacter pylori activity against the CLAR and AMOX-resistant strain as well as four CLAR (AMOX)-sensitive strains. 1-Meth...
3'-Methoxydaidzein
TN1254
3'-Methoxydaidzein has antioxidant activity, it and geraldol have antiplatelet aggregation activity and appear to be specific against collagen induce platelet a...
Scutellarein tetramethyl ether
TN1271
Scutellarein tetramethyl ether 从暹罗草中提取,通过 NF-κB 途径表现出抗炎活性。
1-Cinnamoylpyrrolidine
TN1170
1-Cinnamoylpyrrolidine shows inhibitory activity of platelet aggregation in vitro.
Pinusolide
TL0014
Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, a...
Myrianthic acid
TN4600
Myrianthic acid shows anticancer activity, it shows inhibitory activities on foam cell formation in human monocyte-derived macrophages induced by acetylated low-...
Kadsurin A
TN4367
Kadsurin A 具有抗血小板活化因子活性。
Hancinone C
TN4181
Hancinone C shows inhibitory activity against the platelet aggregation caused by PAF.
Futoenone
TN4088
Futoenone and a series of its derivatives have shown inhibitory activities against matrix metalloproteinases, the molecular modelings of these compounds indicate...
Cyclocommunol
TN3740
Cyclocommunol exhibits cytotoxicity against hepatocellular carcinoma (SMMC-7721) and gastric carcinoma (BGC-823 and SGC-7901) cell lines. It also shows strong in...
(-)-Denudatin B
TN3831
Denudatin B has nonspecific antiplatelet action at high concentration by inhibiting phosphoinositides breakdown induced by collagen and thrombin, it inhibits the...
Epiyangambin
TN3979
Epiyangambin is a phytotoxic lignan, it shows inhibition of seed germination of Agrostis stolonifera cv. penncross (Poaceae) and inhibition of development of Lac...
2-Hydroxy-3-methoxybenzoic acid glucose ester
TN2763
2-Hydroxy-3-methoxybenzoic acid glucose ester shows a potent antagonistic activity against platelet activating factor (PAF), it can prevent the mice from the PAF...
6-Deoxyjacareubin
TN3161
6-Deoxyjacareubin possesses significant antioxidant activities, it also exhibits the cytotoxic activities against HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell...
6-Acetyl-2,2-dimethylchroman-4-one
TN3153
6-Acetyl-2,2-dimethylchroman-4-one and vanillin show anti-platelet aggregation activity induced by arachidonic acid in vitro.
Bisdethiobis(methylthio)gliotoxin
TN3520
Bisdethiobis(methylthio)gliotoxin is a platelet activating factor (PAF) antagonist.
Cryptomeridiol
TN3723
Cryptomeridiol is a potential skin-whitening agent, exhibits melanogenesis inhibitory activity on α-MSH-stimulated B16 melanoma cells. Cryptomeridiol has low ac...
(+)-Acuminatin
TN3348
(-)-Acuminatin exerts hepatoprotective activities, perhaps by serving as a potent antioxidant. (+)-trans-Acuminatin, and (+)-cis-acuminatin show weak activity ag...
Aristolactam BIII
TN3445
Aristolactam BIII possesses anti-platelet aggregation activity in vitro, it also shows significant cytotoxic activity (IC50 values < 4 microg/mL) against P-388, ...
Aristolactam AII
TN3443
Aristolactam AII has cytotoxic activity, it also shows platelet aggregation inhibitory activity.
Pregomisin
TN4821
Pregomisin shows platelet-activating factor (PAF) antagonistic activity and the IC 50 value is 4.8x10(-5) M.
Piperlotine D
TN4796
Piperlotine D shows potent antiplatelet aggregation activity.
Piperenone
TN4795
Piperenone is an insect antifeeding substance. It has anti-platelet-activating factor(PAF) activities, is a PAF-acether antagonist.
Pinusolidic acid
TN4794
Pinusolidic acid shows a potent inhibitory effect on platelet activating factor (PAF) binding to rabbit platelets (IC50 = 2.3 x 10(-5) M, 7.48 +/- 2.11 microgram...
Piperolactam C
TN4797
Piperolactam C possesses anti-platelet aggregation activity in vitro. It can inhibit the growth of the fungi Cladosporium sphaerospermum and C. cladosporioides.
Spiradine F
TN5045
Spiradine F can significantly inhibit platelet-activating factor(PAF)-induced platelet aggregation in a concentration-dependent manner.
Chamigrenal
T3P2855
β-Chamigrenal has anti-inflammatory activity, it has inhibitory effects on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in RAW 264.7 ...