PAFR

The platelet-activating factor receptor is a G-protein coupled receptor which binds platelet-activating factor. The PAF receptor shows structural characteristics of the rhodopsin (MIM 180380) gene family and binds platelet-activating factor (PAF). PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) that has been implicated as a mediator in diverse pathologic processes, such as allergy, asthma, septic shock, arterial thrombosis, and inflammatory processes.[supplied by OMIM][7] Its pathogenetic role in chronic kidney failure has also been reported recently.

Cat No.	product name
T6242	Rupatadine Fumarate	Rupatadine Fumarate (UR-12592 Fumarate) is a potent dual PAF/H1 antagonist with Ki of 0.55/0.1 uM.
T2751	Ginkgolide B	Ginkgolide B is a PAFR antagonist(IC50=3.6 μM) isolated from Ginkgo biloba.
TN1643	Ferulamide	Ferulamide derivatives show potent inhibitory activity against arachidonic acid-induced platelet aggregation.
TN4660	Niranthin	Niranthin is a potent anti-leishmanial agent, inhibits the relaxation activity of heterodimeric type IB topoisomerase of L. donovani and acts as a non-competitiv...
TN2322	Yangambin	Yangambin is a selective antagonist of the cardiovascular effects of platelet activating factor (PAF); it has hypotensive effect, which is probably due to a peri...
TN2329	Zingiberen newsaponin	Zingiberensis newsaponin I exhibits induction effect on platelet aggregation.
TN2087	Piperlotine C	Piperlotine C shows potent antiplatelet aggregation activity.
TN2086	Piperlotine A	Piperlotine A shows potent antiplatelet aggregation activity.
TN1815	Kadsulignan L	Kadsulignan L shows in vitro antiviral effects on hepatitis B virus. It also shows moderate platelet-activating factor (PAF) antagonistic activities with the IC5...
TN1654	Futoquinol	Futoquinol is an anti-platelet activating factor principle from the stem part of Piper futokadsura (Piperaceae), the Chinese drug haifengteng.
TN1715	Guaiacin	(+)-Guaiacin has significant neuroprotective, and anti-inflammatory activities, it can inhibit cyclooxygenase (COX)-1 and COX-2.
TMA2418	1-Methoxyphaseollidin	1-Methoxyphaseollidin exhibits anti-Helicobacter pylori activity against the CLAR and AMOX-resistant strain as well as four CLAR (AMOX)-sensitive strains. 1-Meth...
TN1254	3'-Methoxydaidzein	3'-Methoxydaidzein has antioxidant activity, it and geraldol have antiplatelet aggregation activity and appear to be specific against collagen induce platelet a...
TN1271	Scutellarein tetramethyl ether	Scutellarein tetramethyl ether 从暹罗草中提取，通过 NF-κB 途径表现出抗炎活性。
TN1170	1-Cinnamoylpyrrolidine	1-Cinnamoylpyrrolidine shows inhibitory activity of platelet aggregation in vitro.
TL0014	Pinusolide	Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, a...
TN4600	Myrianthic acid	Myrianthic acid shows anticancer activity, it shows inhibitory activities on foam cell formation in human monocyte-derived macrophages induced by acetylated low-...
TN4367	Kadsurin A	Kadsurin A 具有抗血小板活化因子活性。
TN4181	Hancinone C	Hancinone C shows inhibitory activity against the platelet aggregation caused by PAF.
TN4088	Futoenone	Futoenone and a series of its derivatives have shown inhibitory activities against matrix metalloproteinases, the molecular modelings of these compounds indicate...
TN3740	Cyclocommunol	Cyclocommunol exhibits cytotoxicity against hepatocellular carcinoma (SMMC-7721) and gastric carcinoma (BGC-823 and SGC-7901) cell lines. It also shows strong in...
TN3831	(-)-Denudatin B	Denudatin B has nonspecific antiplatelet action at high concentration by inhibiting phosphoinositides breakdown induced by collagen and thrombin, it inhibits the...
TN3979	Epiyangambin	Epiyangambin is a phytotoxic lignan, it shows inhibition of seed germination of Agrostis stolonifera cv. penncross (Poaceae) and inhibition of development of Lac...
TN2763	2-Hydroxy-3-methoxybenzoic acid glucose ester	2-Hydroxy-3-methoxybenzoic acid glucose ester shows a potent antagonistic activity against platelet activating factor (PAF), it can prevent the mice from the PAF...
TN3161	6-Deoxyjacareubin	6-Deoxyjacareubin possesses significant antioxidant activities, it also exhibits the cytotoxic activities against HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell...
TN3153	6-Acetyl-2,2-dimethylchroman-4-one	6-Acetyl-2,2-dimethylchroman-4-one and vanillin show anti-platelet aggregation activity induced by arachidonic acid in vitro.
TN3520	Bisdethiobis(methylthio)gliotoxin	Bisdethiobis(methylthio)gliotoxin is a platelet activating factor (PAF) antagonist.
TN3723	Cryptomeridiol	Cryptomeridiol is a potential skin-whitening agent, exhibits melanogenesis inhibitory activity on α-MSH-stimulated B16 melanoma cells. Cryptomeridiol has low act...
TN3348	(+)-Acuminatin	(-)-Acuminatin exerts hepatoprotective activities, perhaps by serving as a potent antioxidant. (+)-trans-Acuminatin, and (+)-cis-acuminatin show weak activity ag...
TN3445	Aristolactam BIII	Aristolactam BIII possesses anti-platelet aggregation activity in vitro, it also shows significant cytotoxic activity (IC50 values < 4 microg/mL) against P-388, ...
TN3443	Aristolactam AII	Aristolactam AII has cytotoxic activity, it also shows platelet aggregation inhibitory activity.
TN4821	Pregomisin	Pregomisin shows platelet-activating factor (PAF) antagonistic activity and the IC 50 value is 4.8x10(-5) M.
TN4796	Piperlotine D	Piperlotine D shows potent antiplatelet aggregation activity.
TN4795	Piperenone	Piperenone is an insect antifeeding substance. It has anti-platelet-activating factor(PAF) activities, is a PAF-acether antagonist.
TN4794	Pinusolidic acid	Pinusolidic acid shows a potent inhibitory effect on platelet activating factor (PAF) binding to rabbit platelets (IC50 = 2.3 x 10(-5) M, 7.48 +/- 2.11 microgram...
TN4797	Piperolactam C	Piperolactam C possesses anti-platelet aggregation activity in vitro. It can inhibit the growth of the fungi Cladosporium sphaerospermum and C. cladosporioides.
TN5045	Spiradine F	Spiradine F can significantly inhibit platelet-activating factor(PAF)-induced platelet aggregation in a concentration-dependent manner.
T3P2855	Chamigrenal	β-Chamigrenal has anti-inflammatory activity, it has inhibitory effects on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in RAW 264.7 m...