PDK

In the field of biochemistry, PDPK1 refers to the protein 3-phosphoinositide-dependent protein kinase-1, an enzyme which is encoded by the PDPK1 gene in humans. It is implicated in the development and progression of melanomas.PDPK1 is a master kinase, which is crucial for the activation of AKT/PKB and many other AGC kinases including PKC, S6K, SGK. An important role for PDPK1 is in the signalling pathways activated by several growth factors and hormones including insulin signaling.

Cat. No.	Product name	CAS No.	Purity
T12566	PS10	1564265-82-2	98%
T12566	PS10 is a ATP-competitive inhibitor of pan-PDK(PDK2, PDK4, PDK1, and PDK3 with IC50 of 0.8 μM, 0.76 μM, 2.1 μM and 21.3 μM , respectively).
T16450	PDK1-IN-RS2	1643958-89-7	98%
T16450	PDK1-IN-RS2 inhibits the activation of the downstream kinases S6K1 by PDK1. PDK1-IN-RS2 is a mimic of the peptide docking motif (PIFtide) and is a substrate-sele...
T19783	Dehydroabiethylamine	1446-61-3	98%
T19783	Dehydroabiethylamine is an inducer of hepatic CYP2B activity. Dehydroabiethylamine inhibits pyruvate dehydrogenase kinases (PDKs) and intracellular cholesterol t...
TMA2474	δ-Tocotrienol	25612-59-3	98%
TMA2474	Delta-tocotrienol is a potential angiogenic inhibitor, it (2.5-5 microM) can significantly suppress human colorectal adenocarcinoma cells (DLD-1-CM) -induced tub...
T12412L	PDK4-IN-1 hydrochloride	2310262-11-2	98%
T12412L	PDK4-IN-1 hydrochloride is an anthraquinone derivative and a potent and orally active inhibitor of pyruvate dehydrogenase kinase 4 (PDK4)(IC50 value of 84 nM)
T4046	BX517	850717-64-5	98%
T4046	BX-517 is a potent and selective inhibitor of PDK1.
T3163	PS 48	1180676-32-7	98%
T3163	PS 48 has been shown to be a PKB Kinase (PDK1) activator (Kd: 10.3 μM). This compound selectively binds to the PIF-binding pocket of PKB Kinase (PDK1).
T11765	KPLH1130	906669-07-6	98.43%
T11765	KPLH1130 improves glucose tolerance in HFD-fed mice. KPLH1130 is a specific pyruvate dehydrogenase kinase (PDK) inhibitor, blocks macrophage polarization and att...
T24677	PS47	1180676-33-8	98.61%
T24677	PS-47 is an inactive E-isomer of PS48. PS48 is an activator of PDK1.
T2348	GSK2334470	1227911-45-6	98.65%
T2348	GSK2334470 is a novel PDK1 inhibitor (IC50: ~10 nM, in a cell-free assay), with no inhibitory at other close related AGC-kinases.
T17224	VER-246608	1684386-71-7	98.88%
T17224	VER-246608 is an effective and ATP-competitive inhibitor of pyruvate dehydrogenase kinase (IC50s: 35 nM, 40 nM, 84 nM, and 91 nM for PDK-1, PDK-3, PDK-2, and PDK...
T2466	Osu03012	742112-33-0	99.22%
T2466	AR-12 is an orally bioavailable, small-molecule, celecoxib-derived inhibitor of phosphoinositide-dependent kinase-1 (PDK1) with potential antineoplastic activity...
T1837	BX-912	702674-56-4	99.34%
T1837	BX-912 is a specific inhibitor of 3-Phosphoinositide-dependent Kinase-1 (PDK1, IC50: 12 nM). The selectivity of BX-912 is more 10 fold than C-Kit, EGFR, PKA, PKC...
T3895	Polyphyllin I	50773-41-6	99.36%
T3895	Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, c...
T12398	MP7	1001409-50-2	99.45%
T12398	MP7 is a inhibitor of phosphoinositide-dependent kinase-1 (PDK1).
T1830	BX795	702675-74-9	99.57%
T1830	BX795 is an effective and selective PDK1 inhibitor (IC50: 6 nM), and its selectivity is 140- and 1600-fold for PDK1 over PKA and PKC in cell-free assays, respect...
T6084	Rabusertib	911222-45-2	99.63%
T6084	Rabusertib is an inhibitor of the cell cycle checkpoint kinase 1 (chk1) with potential chemopotentiating activity. Rabusertib has been used in trials studying th...
T16670	PS210	1221962-86-2	99.65%
T16670	PS210 is inactive against other protein kinases, including PDK1 downstream signaling components such as S6K, PKB/Akt, or GSK3. PS210 is a potent and selective PD...
T22350	JX06	729-46-4	99.66%
T22350	JX06, a potent, selective and covalent PDK inhibitor, inhibits PDK1, PDK2 and PDK3 with IC50 of 49 nM, 101 nM and 313 nM respectively.
T2420	PHT-427	1191951-57-1	99.77%
T2420	PHT-427 is a dual Akt (Ki: 2.7 μM) and PDPK1 (Ki: 5.2 μM) inhibitor (high-affinity binding for the PH domains of Akt and PDPK1).