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PTEN

Phosphatase and tensin homolog (PTEN) is a protein that, in humans, is encoded by the PTEN gene. Mutations of this gene are a step in the development of many cancers. Genes corresponding to PTEN (orthologs) have been identified in most mammals for which complete genome data are available. PTEN acts as a tumor suppressor gene through the action of its phosphatase protein product. This phosphatase is involved in the regulation of the cell cycle, preventing cells from growing and dividing too rapidly. It is a target of many anticancer drugs.
Cat No. product name
T3404 Cucurbitacin B Cucurbitacin B has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation through up-re...
T6667 SF1670 SF1670 is a specific PTEN inhibitor with IC50 of 2 μM.
T7012 VO-Ohpic trihydrate VO-Ohpic is a potent inhibitor of PTEN (phosphatase and tensin homolog) with IC50 of 35 nM.
T7953 bpV (HOpic) bpV (HOpic) is a potent inhibitor of PTEN (IC50 of 14 nM). 
T10594 bpV(phen) bpV(phen) is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor (IC50s: 343 nM, 920 nM, and 38 nM for PTP-β, PTP-1B, and PTEN).
Cucurbitacin B
T3404CAS 6199-67-3
Cucurbitacin B has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation through up-re...
SF1670
T6667CAS 345630-40-2
SF1670 is a specific PTEN inhibitor with IC50 of 2 μM.
VO-Ohpic trihydrate
T7012CAS 476310-60-8
VO-Ohpic is a potent inhibitor of PTEN (phosphatase and tensin homolog) with IC50 of 35 nM.
bpV (HOpic)
T7953CAS 722494-26-0
bpV (HOpic) is a potent inhibitor of PTEN (IC50 of 14 nM). 
bpV(phen)
T10594CAS 42494-73-5
bpV(phen) is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor (IC50s: 343 nM, 920 nM, and 38 nM for PTP-β, PTP-1B, and PTEN).