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Porcupine

Porcupine (Porc) protein may be involved in secretion or ER transport, as Wingless is retained in the ER in porcupine mutant Drosophila embryos. In C. elegans, the porcupine homolog mom-1 has a similar function in promoting secretion of the Wnt protein Mom-2. Porcupine has some homology to a family of o-acyl transferases and may be involved in lipid modification of Wnt proteins. A special form of monounsaturated palmitoylation has been detected on a serine residue in the Wnt protein and could be mediated by porc as well. The human Porcupine gene is implicated in a genetic disease, Focal dermal hypoplasia. Porcupine, encodes a multipass transmembrane ER protein, which is required for normal distribution of Wg in embryos. Porc stimulates the processing of Wg when expressed in Drosophila cells in vitro and is also necessary for the localization of Drosophila Wnt-3 on the axon tracts of the embryonic central nervous system.
Cat. No. Product name CAS No. Purity Chemical Structure
T5342 IWP-O1 2074607-48-8 98%
IWP-O1 is a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM), effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.
T2618 LGK974 1243244-14-5 98%
LGK-974 is an effective and selective PORCN inhibitor and inhibits Wnt signaling (IC50: 0.4 nM) in TM3 cells. It has been used in trials studying the treatment o...
T2683 IWP L6 1427782-89-5 98%
IWP-L6 is an extremely effective Porcn inhibitor (EC50: 0.5 nM).
T4438 Porcn-IN-1 2036044-77-4 98%
Porcupine-IN-1 is an effective porcupine inhibitor (IC50: 0.5±0.2 nM).
T2242 Wnt-C59 1243243-89-1 98%
Wnt-C59(C59) is a highly effective and specific Wnt signaling antagonis with PORCN enzymatic activity.
T11444 GNF-6231 1243245-18-2 98%
GNF-6231 is a potent, selective, and orally bioavailable Porcupine inhibitor that blocks Wnt signaling.
T2702 IWP-2 686770-61-6 98%
IWP-2, an inhibitor of Wnt processing and secretion (IC50=27 nM) in a cell-free assay, selectively blocks Porcn-mediated Wnt palmitoylation.
T4043 ETC-159 1638250-96-0 98%
ETC-159 is a potent, orally available PORCN inhibitor. It inhibits β-catenin reporter activity with an IC50 of 2.9 nM.
IWP-O1
T5342
IWP-O1 is a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM), effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.
LGK974
T2618
LGK-974 is an effective and selective PORCN inhibitor and inhibits Wnt signaling (IC50: 0.4 nM) in TM3 cells. It has been used in trials studying the treatment o...
IWP L6
T2683
IWP-L6 is an extremely effective Porcn inhibitor (EC50: 0.5 nM).
Porcn-IN-1
T4438
Porcupine-IN-1 is an effective porcupine inhibitor (IC50: 0.5±0.2 nM).
Wnt-C59
T2242
Wnt-C59(C59) is a highly effective and specific Wnt signaling antagonis with PORCN enzymatic activity.
GNF-6231
T11444
GNF-6231 is a potent, selective, and orally bioavailable Porcupine inhibitor that blocks Wnt signaling.
IWP-2
T2702
IWP-2, an inhibitor of Wnt processing and secretion (IC50=27 nM) in a cell-free assay, selectively blocks Porcn-mediated Wnt palmitoylation.
ETC-159
T4043
ETC-159 is a potent, orally available PORCN inhibitor. It inhibits β-catenin reporter activity with an IC50 of 2.9 nM.