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Porcupine

Porcupine (Porc) protein may be involved in secretion or ER transport, as Wingless is retained in the ER in porcupine mutant Drosophila embryos. In C. elegans, the porcupine homolog mom-1 has a similar function in promoting secretion of the Wnt protein Mom-2. Porcupine has some homology to a family of o-acyl transferases and may be involved in lipid modification of Wnt proteins. A special form of monounsaturated palmitoylation has been detected on a serine residue in the Wnt protein and could be mediated by porc as well. The human Porcupine gene is implicated in a genetic disease, Focal dermal hypoplasia. Porcupine, encodes a multipass transmembrane ER protein, which is required for normal distribution of Wg in embryos. Porc stimulates the processing of Wg when expressed in Drosophila cells in vitro and is also necessary for the localization of Drosophila Wnt-3 on the axon tracts of the embryonic central nervous system.
Cat No. product name
T2242 Wnt-C59 Wnt-C59(C59) is a highly effective and specific Wnt signaling antagonis with PORCN enzymatic activity.
T2702 IWP-2 IWP-2, an inhibitor of Wnt processing and secretion (IC50=27 nM) in a cell-free assay, selectively blocks Porcn-mediated Wnt palmitoylation.
T4043 ETC-159 ETC-159 is a potent, orally available PORCN inhibitor. It inhibits β-catenin reporter activity with an IC50 of 2.9 nM.
T5342 IWP-O1 IWP-O1 is a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM), effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.
T2683 IWP L6 IWP-L6 is an extremely effective Porcn inhibitor (EC50: 0.5 nM).
T2618 LGK974 LGK-974 is an effective and selective PORCN inhibitor and inhibits Wnt signaling (IC50: 0.4 nM) in TM3 cells. It has been used in trials studying the treatment o...
T4438 Porcn-IN-1 Porcupine-IN-1 is an effective porcupine inhibitor (IC50: 0.5±0.2 nM).
Wnt-C59
T2242
Wnt-C59(C59) is a highly effective and specific Wnt signaling antagonis with PORCN enzymatic activity.
IWP-2
T2702
IWP-2, an inhibitor of Wnt processing and secretion (IC50=27 nM) in a cell-free assay, selectively blocks Porcn-mediated Wnt palmitoylation.
ETC-159
T4043
ETC-159 is a potent, orally available PORCN inhibitor. It inhibits β-catenin reporter activity with an IC50 of 2.9 nM.
IWP-O1
T5342
IWP-O1 is a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM), effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.
IWP L6
T2683
IWP-L6 is an extremely effective Porcn inhibitor (EC50: 0.5 nM).
LGK974
T2618
LGK-974 is an effective and selective PORCN inhibitor and inhibits Wnt signaling (IC50: 0.4 nM) in TM3 cells. It has been used in trials studying the treatment o...
Porcn-IN-1
T4438
Porcupine-IN-1 is an effective porcupine inhibitor (IC50: 0.5±0.2 nM).