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Fibroblast Growth Factor Receptors, FGFRs

The fibroblast growth factor receptors (FGFR) are receptors that bind to members of the fibroblast growth factor (FGF) family of proteins. The fibroblast growth factor receptors consist of an extracellular ligand domain composed of three immunoglobulin-like domains, a single transmembrane helix domain, and an intracellular domain with tyrosine kinase activity. The FGF/FGFR signalling pathway is involved in a variety of cancers.There are non-selective FGFR inhibitors that act on all of FGFR1-4 and other proteins, and some selective FGFR inhibitors for some/all of FGFR1-4. Selective FGFR inhibitors include AZD4547, BGJ398, JNJ42756493, and PD173074.

  • FGFR2IIIb Protein, Human, Recombinant (aa 22-378, hFc)
    TMPJ-00391
    FGFR2IIIb Protein, Human, Recombinant (aa 22-378, hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 85-120 KDa and the accession number is P21802-3.
    • $86
    7-10 days
    Size
    QTY
  • FGFR4 Protein, Human, Recombinant (His & Avi), Biotinylated
    TMPK-00381
    FGFR4 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 41.4 kDa and the accession number is P22455-1.
    • $814
    7-10 days
    Size
    QTY
  • FGFR4 Protein, Human, Recombinant (His & Avi)
    TMPK-00379
    FGFR4 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 41.4 kDa and the accession number is P22455-1.
    • $231
    7-10 days
    Size
    QTY
  • FGFR3 beta (IIIb) Protein, Human, Recombinant (His & Avi), Biotinylated
    TMPK-00391
    Four distinct genes encoding closely related FGF receptors, FGF R1-4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid‑box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain.FGFR3 is tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis.
    • $814
    7-10 days
    Size
    QTY
  • FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi)
    TMPK-00392
    Fibroblast growth factor receptor 1 (FGFR1) transmits signals through the plasma membrane regulating essential cellular processes like division, motility, metabolism, and death. Overexpression of FGFR1 is observed in numerous tumors and thus constitutes an attractive molecular target for selective cancer treatment. FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 25.23 kDa and the accession number is P11362-7.
    • $347
    7-10 days
    Size
    QTY
  • FGFR2 beta (IIIb) Domain Protein, Human, Recombinant (Avi)
    TMPK-00398
    FGFR2 beta (IIIb) Domain Protein, Human, Recombinant (Avi) is expressed in HEK293 mammalian cells with C-Avi tag. The predicted molecular weight is 15.49 kDa and the accession number is P21802-3.
    • $534
    7-10 days
    Size
    QTY
  • FGFR2 alpha (IIIb) Protein, Human, Recombinant (His & Avi), Biotinylated
    TMPK-00401
    Four distinct genes encoding closely related FGF receptors, FGF R1 - 4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid-box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain. Multiple forms of FGF R1 - 3 are generated by alternative splicing of the mRNAs.
    • $814
    7-10 days
    Size
    QTY
  • FGFR4 beta Protein, Human, Recombinant (His & Avi), Biotinylated
    TMPK-00380
    FGFR4 beta Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 26.90 kDa and the accession number is P22455-1.
    • $814
    7-10 days
    Size
    QTY
  • FGFR3 alpha (IIIc) Protein, Human, Recombinant (His & Avi)
    TMPK-00384
    FGFR3 alpha (IIIc) Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 41.1 kDa and the accession number is P22607.
    • $347
    7-10 days
    Size
    QTY
  • FGFR3 alpha (IIIb) Protein, Mouse, Recombinant (His)
    TMPK-00686
    FGFR3 alpha (IIIb) Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 37.09 kDa and the accession number is E9QNJ9.
    • $418
    7-10 days
    Size
    QTY
  • FGFR2 beta (IIIb) Protein, Mouse, Recombinant (His)
    TMPK-00847
    FGFR2 beta (IIIb) Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 26.3 kDa and the accession number is P21803-2.
    • $487
    7-10 days
    Size
    QTY
  • FGFR4 Protein, Mouse, Recombinant (His & hFc)
    TMPY-01019
    FGFR4 Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 67 kDa and the accession number is A0A0R4IZY3.
    • $600
    7-10 days
    Size
    QTY
  • FGFR4 Protein, Human, Recombinant (hFc)
    TMPY-00806
    FGFR4 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 66 kDa and the accession number is P22455-1.
    • $600
    7-10 days
    Size
    QTY
  • FGFR2 Protein, Mouse, Recombinant (His)
    TMPY-03389
    FGFR2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.5 kDa and the accession number is AAA39377.1.
    • $600
    7-10 days
    Size
    QTY
  • FGFR1 Protein, Human, Recombinant (beta (IIIb), His)
    TMPY-06034
    FGFR1 Protein, Human, Recombinant (beta (IIIb), His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 30.8 kDa and the accession number is H9FRD4.
    • $583
    In Stock
    Size
    QTY
  • FGFR1 Protein, Human, Recombinant (alpha (IIIb), His)
    TMPY-06036
    FGFR1 Protein, Human, Recombinant (alpha (IIIb), His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40.5 kDa and the accession number is P11362-7.
    • $228
    In Stock
    Size
    QTY
  • FGFR2IIIc Protein, Human, Recombinant (hFc)
    TMPJ-00388
    FGFR2IIIc Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 85-120 KDa and the accession number is P21802.
    • $86
    7-10 days
    Size
    QTY
  • FGFR3 beta (IIIb) Protein, Human, Recombinant (His & Avi)
    TMPK-00389
    FGFR3 beta (IIIb) Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 30.5 kDa and the accession number is P22607-2.
    • $418
    7-10 days
    Size
    QTY
  • FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated
    TMPK-00394
    Fibroblast growth factor receptor 1 (FGFR1) transmits signals through the plasma membrane regulating essential cellular processes like division, motility, metabolism, and death. Overexpression of FGFR1 is observed in numerous tumors and thus constitutes an attractive molecular target for selective cancer treatment. FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 25.23 kDa and the accession number is P11362-7.
    • $814
    7-10 days
    Size
    QTY
  • FGFR3 alpha (IIIb) Protein, Human, Recombinant (His & Avi)
    TMPK-00388
    FGFR3 alpha (IIIb) Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 41.4 kDa and the accession number is P22607-2.
    • $347
    7-10 days
    Size
    QTY
  • FGFR3 beta (IIIc) Protein, Human, Recombinant (His & Avi)
    TMPK-00385
    FGFR3 beta (IIIc) Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 30.1 kDa and the accession number is P22607-1.
    • $418
    7-10 days
    Size
    QTY
  • FGFR3 alpha (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated
    TMPK-00386
    FGFR3 alpha (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 41.1 kDa and the accession number is P22607.
    • $814
    7-10 days
    Size
    QTY
  • FGFRL1 Protein, Human, Recombinant (His)
    TMPJ-01224
    Fibroblast Growth Factor Receptor-Like 1 (FGFRL1) is a single-pass type I membrane protein that belongs to the FGF receptor family. The mature human FGFRL1 consists of a 354 amino acid extracellular domain (ECD) with 3 Ig-like C2-type domains, a 21 amino acid transmembrane segment, and a 134 amino acid cytoplasmic domain. FGFR1 expressed in various tissues, preferentially in cartilaginous tissues and pancreas. It highly expressed in the liver, kidney, heart, brain and skeletal muscle, weakly expressed in the lung, small intestine and spleen. FGFRL1 has a negative effect on cell proliferation.
    • $85
    7-10 days
    Size
    QTY
  • FGFR1 Protein, Human, Recombinant (Yeast, His)
    TMPH-01337
    FGFR1 Protein, Human, Recombinant (Yeast, His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 41.4 kDa and the accession number is P11362.
    • $231
    20 days
    Size
    QTY
  • FGFR2 Protein, Human, Recombinant (beta IIIc, His)
    TMPY-00351
    FGFR2 Protein, Human, Recombinant (beta IIIc, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31.2 kDa and the accession number is P21802-21.
    • $904
    7-10 days
    Size
    QTY
  • FGFR3 Protein, Human, Recombinant (alpha IIIb, hFc)
    TMPY-00389
    FGFR3 Protein, Human, Recombinant (alpha IIIb, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 65.3 kDa and the accession number is P22607-2.
    • $904
    7-10 days
    Size
    QTY
  • FGFR2 Protein, Human, Recombinant (alpha IIIb, hFc)
    TMPY-00423
    FGFR2 Protein, Human, Recombinant (alpha IIIb, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 66.3 kDa and the accession number is P21802-17.
    • $583
    In Stock
    Size
    QTY
  • FGFR2 Protein, Human, Recombinant (His & hFc)
    TMPY-00972
    FGFR2 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 67.6 kDa and the accession number is P21802-1.
    • $386
    In Stock
    Size
    QTY
  • FGFR4 Protein, Mouse, Recombinant (His)
    TMPY-00974
    FGFR4 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40 kDa and the accession number is A0A0R4IZY3.
    • $700
    7-10 days
    Size
    QTY
  • FGFR4 Protein, Human, Recombinant (His)
    TMPY-02112
    FGFR4 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40 kDa and the accession number is P22455-1.
    • $255
    In Stock
    Size
    QTY
  • FGFR1 Protein, Human, Recombinant (beta (IIIb), hFc)
    TMPY-06033
    FGFR1 Protein, Human, Recombinant (beta (IIIb), hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 56 kDa and the accession number is H9FRD4.
    • $904
    7-10 days
    Size
    QTY
  • FGFR2IIIb Protein, Human, Recombinant (hFc)
    TMPJ-00390
    FGFR2IIIb Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 70-90 KDa and the accession number is P21802-3.
    • $86
    7-10 days
    Size
    QTY
  • FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi)
    TMPK-00393
    FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 42 kDa and the accession number is P11362-7.
    • $231
    7-10 days
    Size
    QTY
  • FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated
    TMPK-00395
    FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 42 kDa and the accession number is P11362-7.
    • $814
    7-10 days
    Size
    QTY
  • FGFR2 alpha (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated
    TMPK-00396
    FGFR2 alpha (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 42.5 kDa and the accession number is P21802-1.
    • $814
    7-10 days
    Size
    QTY
  • FGFR2 beta (IIIb) Protein, Human, Recombinant (His & Avi), Biotinylated
    TMPK-00400
    FGFR2 beta (IIIb) Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 28.3 kDa and the accession number is P21802-3.
    • $814
    7-10 days
    Size
    QTY
  • FGFR2 beta (IIIb) Domain Protein, Human, Recombinant (Avi), Biotinylated
    TMPK-00399
    FGFR2 beta (IIIb) Domain Protein, Human, Recombinant (Avi), Biotinylated is expressed in HEK293 mammalian cells with C-Avi tag. The predicted molecular weight is 15.49 kDa and the accession number is P21802-3.
    • $814
    7-10 days
    Size
    QTY
  • FGFR2 Protein, Human, Recombinant (aa 1-377, His)
    TMPY-01228
    FGFR2 Protein, Human, Recombinant (aa 1-377, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 41 kDa and the accession number is P21802-1.
    • $600
    7-10 days
    Size
    QTY
  • FGFR4 Protein, Rhesus, Recombinant (His)
    TMPY-03683
    FGFR4 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 61.8 kDa and the accession number is XP_001087243.1.
    • $600
    7-10 days
    Size
    QTY
  • FGFR1 Protein, Rhesus, Recombinant (His)
    TMPY-03926
    FGFR1 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 30.6 kDa and the accession number is H9FRD4.
    • $600
    7-10 days
    Size
    QTY
  • FGFR3 Protein, Human, Recombinant (hFc)
    TMPY-04200
    FGFR3 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 64.9 kDa and the accession number is P22607-1.
    • $904
    7-10 days
    Size
    QTY
  • FGFR1 Protein, Human, Recombinant (His & GST)
    TMPY-04371
    FGFR1 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 75 kDa and the accession number is H9FRD4.
    • $498
    7-10 days
    Size
    QTY
  • FGFR1 Protein, Human, Recombinant (hFc)
    TMPY-05777
    FGFR1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 56.15 kDa and the accession number is NP_001341297.1.
    • $357
    7-10 days
    Size
    QTY
  • FGFR1 Protein, Human, Recombinant (His), Biotinylated
    TMPY-05761
    FGFR1 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31 kDa and the accession number is H9FRD4.
    • $306
    7-10 days
    Size
    QTY
  • FGFR1 Protein, Human, Recombinant (alpha (IIIb), hFc)
    TMPY-06035
    FGFR1 Protein, Human, Recombinant (alpha (IIIb), hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 65.7 kDa and the accession number is P11362-7.
    • $904
    7-10 days
    Size
    QTY
  • FGFR2 alpha (IIIc) Protein, Human, Recombinant (hFc)
    TMPJ-00389
    FGFR2 alpha (IIIc) Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 72-95 KDa and the accession number is P21802.
    • $86
    7-10 days
    Size
    QTY
  • FGFR4 beta Protein, Human, Recombinant (His & Avi)
    TMPK-00378
    FGFR4 beta Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 26.90 kDa and the accession number is P22455-1.
    • $487
    7-10 days
    Size
    QTY
  • FGFR2 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated
    TMPK-00397
    FGFR2 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 28.2 kDa and the accession number is P21802-1.
    • $814
    7-10 days
    Size
    QTY
  • FGFR3 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated
    TMPK-00387
    Four distinct genes encoding closely related FGF receptors, FGF R1-4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid‑box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain.FGFR3 is tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts..
    • $814
    7-10 days
    Size
    QTY
  • FGFR2 beta (IIIb) Protein, Cynomolgus, Recombinant (His)
    TMPK-00475
    FGFR2 beta (IIIb) Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 26.2 kDa and the accession number is A0A2K5TL84-1.
    • $487
    7-10 days
    Size
    QTY