antimicrobial compound 1

Antimicrobial Compound 1 is an alkyl pyridinium compound with Tail 12C, Head 4-carboxyl. Antimicrobial Compound 1 exhibits antimicrobial activities against B. subtilis and E. coli.

NPS ALX Compound 4a hydrochloride(1:1) is a potent and selective 5-hydroxytryptamine6 (5-HT6) receptor antagonist, with an IC50 of 7.2 nM and a Ki of 0.2 nM.

Itch-Targeting Compound 1 is an anti-itch agent effective in preventing or treating reactions from insect bites, environmental allergens, skin infections, external vermination, or itching in renal dialysis patients.

Antiasthmatic Compound 1 is an antiasthmatic agent.

Cancer-Targeting Compound 1 can be used in the study of hormone-related cancers, including the treatment or prevention of fibroids, uterine leiomyomas, polycystic ovarian syndrome, or hormone-dependent Cancer, among others.

Antibacterial compound 1 is an antibacterial compound.

VPS34 inhibitor 1 (Compound 19, PIK-III analogue) (PIK-III analogue) is a potent and selective inhibitor of VPS34( IC50 : 15 nM)

Compound SC-1 is a a derivative of the multiple tyrosine kinase inhibitor sorafenib. Compound SC-1 potently inhibits the phosphorylation of STAT3 by blocking STAT3 phosphorylation and activation, and induces apoptosis in hepatocellular carcinoma cell lines[1].

Antimicrobial Agent-1 (compound 6C) shows strong activity (MIC = 2 μg/mL) against TolC mutant E. coli. Additionally, it synergistically interacts with Colistin to exhibit enhanced activity against Gram-negative bacteria. Importantly, Antimicrobial Agent-1 exhibits no cytotoxic effects on mammalian cell lines. Its MIC values on Caco-2 and Vero cell lines are greater than 128 μg/mL [1].

(Rac)-Neurodegenerative Disorder-Targeting Compound 1 is a calpain inhibitor.

Urinary Incontinence-Targeting Compound 1, used in the research of urinary incontinence, is a sulfonanilide derivative.

Antimicrobial Photosensitizer-1 demonstrates significant potential as an effective agent for treating infections caused by pathogenic microorganisms, with notable antimicrobial efficacy observed in S. aureus-infected mouse wound models [1].

Arrhythmias-Targeting Compound 1 is a compound. It is used in the research of arrhythmias.

Neurodegenerative Disorder-Targeting Compound 1 is a calpain inhibitor [1].

Arrhythmic-Targeting Compound 1, used for arrhythmic disease, contains nitrogen-containing spirocycles.

Neuromuscular Disorder-Targeting Compound 1 is utilized in research for neuromuscular disorders, including chronic fatigue syndrome and fibromyalgia syndrome symptoms.

Neuromuscular-targeting compound 1 can be used to study muscular dystrophy and neuromuscular-related diseases.

Asthma relating compound 1 is a potential anti-asthma compound.

1. Linalool (Linalol), a natural compound of the essential oils, has been shown to have antinociceptive, antimicrobial, and anti-inflammatory properties. 2. Linalool was protected against LPS GalN-induced liver injury through induction of antioxidant defense via Nrf2 activating and reduction inflammatory response via NF-κB inhibition. 3. Linalool biosynthesis and accumulation might be involved in plant defense against bacterial and fungal pathogens and be associated with field resistance to citrus canker. 4. Linalool significantly increased the expression of antioxidant enzymes regulated by Nrf-2 and diminished lung tissue levels of several pro-inflammatory cytokines, including tumor necrosis factor α (TNF-α) and interleukin (IL)-6.

Chlamydia pneumoniae-IN-1 (compound 55), a benzimidazole derivative, exhibits potent antibacterial activity, inhibiting 99% of C. pneumoniae growth at a concentration of 10 μM while maintaining 95% viability of host cells. It effectively inhibits the CV-6 strain of C. pneumoniae with a minimum inhibitory concentration (MIC) of 12.6 μM, demonstrating its antichlamydial efficacy [1].

Antimicrobial Agent-29 (Compound C35) influences the interaction between human hemoglobin and the Staphylococcus aureus IsdB hemophore. This compound facilitates the identification of IsdB:Hb PPI inhibitors [1].

Cyclopeptide 1 (Compound 1) is an antimicrobial peptide exhibiting moderate efficacy in inhibiting B. subtilis, presenting a minimum inhibitory concentration (MIC) of 25 μg/mL [1].

Desacetylcefotaxime, an in vivo metabolite of Cefotaxime (CTX), exhibits noteworthy in vitro antimicrobial efficacy, akin to its parent compound, against a broad spectrum of aerobic and anaerobic bacteria [1].

Pulcherriminic acid, a cyclic dipeptide antimicrobial compound predominantly found in Bacillus and yeast, exhibits a strong affinity for Fe3+. It chelates iron ions via a non-enzymatic reaction, forming the extracellular red pigment pulcherrimin. This pigment competes for iron nutrition, thereby exerting an antibacterial effect. Pulcherriminic acid holds significant potential for applications in the food, agriculture, and medical industries [1] [2].

FabH-IN-1 (compound 3f) is an effective inhibitor of bacterial 3-oxoacyl-[acyl-carrier-protein] synthase 3 (FabH), a broad-spectrum antimicrobial target, demonstrating efficacy against both gram-positive and gram-negative bacteria, and exhibiting strong antioxidant properties [1].

Complestatin is a compound extracted from Streptomyces lavendulae mycelia; on acid hydrolysis yields D-4-hydroxyphenylglycine & D-3,5-dichloro-4-hydroxyphenylglycine & acidic chromophore; inhibits gp120-CD4 binding. It is isolated from the culture broth of Streptomyces and has anti-HIV-1 activity. It has a role as a metabolite, an antimicrobial agent and an anti-HIV-1 agent.

NusB-IN-1 (Compound 22r) is a highly effective, orally administered bacterial rRNA synthesis inhibitor with potent antimicrobial activity against MRSA and VRSA [1].

Piperacillin-d5 is a deuterated compound of Piperacillin. Piperacillin has a CAS number of 61477-96-1. Piperacillin is a semisynthetic penicillin with wide spectrum of antimicrobial activity(particularly pseudomonas strains)

Maximin 78 is an antimicrobial peptide with antibacterial activity against C. albicans, S. aureus, and B. subtilis, exhibiting minimum inhibitory concentrations (MIC) of 37.5, 4.7, and 37.5 μg/mL, respectively. Additionally, this compound has hemolytic activities against human and rabbit red cells [1].

Des(8-14)brevinin-1PMa is a host-defense peptide with potent antimicrobial properties, especially against Staphylococcus aureus and Echerichia coli, and also demonstrates hemolytic activity [1].

Cyclo(Gly-His) is a cyclic dipeptide encompassed within liposomes, exhibiting antimicrobial and anticancer properties with cytotoxic effects on HeLa and MCF-7 cells, demonstrating IC50 values of 1.699 mM and 0.358 mM, respectively. This compound is relevant for drug delivery system research [1].

Kigamicins are natural antitumor antibiotics that selectively kill pancreatic cancer PANC-1 cells only under nutrient-starved conditions. They also show antimicrobial activity against Gram-positive bacteria, including methicillin-resistant S. aureus. Kigamicin C inhibits PANC-1 cell survival in nutrient-deprived media at a 100-fold lower concentration than that required for cells maintained in nutrient-rich media. A related compound, kigamicin D, is active in vivo, suppressing the tumor growth of several pancreatic cancer cell lines in nude mice. It blocks the activation of Akt induced in PANC-1 cells placed in nutrient-deprived media. Kigamicin can also induce necrosis in human myeloma cells, but not normal lymphocytes, maintained in nutrient-rich media (CC50 = 100 nM).

Bombinin H4, an antimicrobial peptide from the skin of the moth species Bombina variegata, exhibits potent bactericidal activity with lethal concentrations of 4.8 μM against Escherichia coli D21 and 3.3 μM against Staphylococcus aureus Cowan 1 [1].

C16-K-cBB1 is a potent, selective antimicrobial agent effective against Methicillin-resistant Staphylococcus aureus (MRSA), demonstrated by its minimal inhibitory concentration (MIC) of 1 µg/mL. This compound exhibits excellent selectivity with minimal hemolytic activity, and can eradicate MRSA cells within 120 minutes when applied at a concentration of 12.5 μg/mL.

Diallyl tetrasulfide is an organosulfur compound that has been found in A. sativum and has diverse biological activities, including antimicrobial, antioxidant, and anticancer properties.[1],[2],[3],[4] It is active against the bacteria S. aureus and methicillin-resistant S. aureus (MRSA; MICs = 0.5 and 2 mg/L, respectively), as well as the fungi C. albicans, C. krusei, C. glabrata, A. niger, A. flavus, and A. fumigatus (MICs = 0.5, 4, 2, 1, 2, and 4 mg/L, respectively).[1] It reduces cadmium-induced increases in hepatic levels of thiobarbituric acid reactive substances (TBARS) and increases cadmium-induced decreases in the hepatic activity of superoxide dismutase (SOD1), catalase, GST, and glucose-6-phosphate dehydrogenase (G6PDH) in rats when administered at a dose of 40 mg/kg.[2] Diallyl tetrasulfide is cytotoxic to MCF-7 breast cancer cells (IC50 = 92 μM) and reduces tumor growth in a BGC-823 mouse xenograft model when administered at doses of 20, 30, and 40 mg/kg for 32 days.[3],[4]

Metallo-β-lactamase-IN-5 (compound 5c) is a potent inhibitor of metallo-β-lactamases (MBLs), demonstrating inhibitory activity against MBLs NDM-1 and VIM-1. It effectively inhibits HUVECs with an IC50 value of 45 μg mL. Additionally, when combined with Imipenem, Metallo-β-lactamase-IN-5 exhibits synergistic antimicrobial activity [1].

NDM-1 Inhibitor-4 (compound 27) is an antimicrobial agent that inhibits NDM-1 with a K_i of 1.7 μM [1].

Garvicin KS is a 32-amino-acid peptide that, in collaboration with two other peptides, GakA and GakB, constitutes the bacteriocin GarKS. This compound impairs fibroblast viability and proliferation and exhibits antimicrobial activity against MSSA, demonstrating minimum inhibitory concentration (MIC) values ranked as GakB > GakC > GakA [1].

Brevianamide M (compound 4), a metabolite of the endophytic fungus Aspergillus versicolor isolated from the marine brown alga Sargassum, exhibits antimicrobial activity against Escherichia coli and Staphylococcus aureus [1].

Oleanolic aldehyde, an antimicrobial agent, effectively hinders the growth of oral pathogens Streptococcus mutans and Porphyromonas gingivalis, implicated in dental caries and periodontal disease. The compound exhibits minimum inhibitory concentrations (MICs) of 488 µg/mL and 250 µg/mL against these bacteria respectively [1].

Magainin 2, a cationic peptide derived from the African clawed frog (X. laevis) skin, exhibits host defense and antimicrobial properties. This compound effectively inhibits a range of pathogens, including E. coli, K. pneumoniae, S. epidermidis, S. aureus bacteria, and C. albicans fungus, with minimum inhibitory concentrations (MICs) of 5, 10, 10, 50, and 80 µg/ml, respectively. Additionally, at a concentration of 20 µM, Magainin 2 significantly reduces the germination and tube elongation in kiwi fruit pollen. It also curtails viral replication in Vero cells infected by herpes simplex virus 1 (HSV-1) or HSV-2, with half-maximal effective concentrations (EC50s) of 22.16 and 19.8 µM, respectively, while demonstrating low toxicity to these cells, shown by a 50% cytotoxic concentration (CC50) greater than 100 µM.

Clindamycin phosphate hydrochloride (Clindamycin 2-phosphate), a broad-spectrum bacteriostatic lincosamide antibiotic, serves as a prodrug of Clindamycin. It lacks antimicrobial activity in vitro; however, through phosphatase ester hydrolysis, it is rapidly converted to the active form, Clindamycin, in vivo. This compound is utilized in the research of acne and bacterial vaginosis [1] [2] [3].

Antimicrobial agent-12 serves as a powerful antibacterial compound that also exhibits inhibitory activity against SARS-CoV-2 [1].

Antimicrobial Agent-7 (Compound 12) serves as a potent antimicrobial with an MIC range of 2-8 μg/mL effective against both Gram-positive and Gram-negative bacteria. Additionally, it demonstrates anti-inflammatory properties in combating lipopolysaccharide-induced inflammation [1].

GlcN-6-P Synthase-IN-1 (Compound 4d) is a potent inhibitor of Glucosamine-6-phosphate (GlcN-6-P) synthase with an IC50 of 3.47 μM. This compound exhibits remarkable antimicrobial activity, excellent central nervous system penetration, and inhibits cytochrome P450, specifically the CYP3A4 isoform [1].

MraY-IN-1 (compound 12a) is a potent inhibitor (IC50: 140 μM) of the bacterial translocase MraY. MraY-IN-1 has antibacterial activity against Escherichia coli K12 (MIC50: 7 μg/ml), Bacillus subtilis W23 (MIC50: 12 μg/ml) and Pseudomonas fluorescens Pf-5 (MIC50: 46 μg/ml). /MraY-IN-1 can be used for antimicrobial studies.

Variculanol, a compound with antimicrobial, anticancer, and anti-HCV NS3/4A protease properties, is derived from the marine fungus Aspergillus versicolor [1].

Daldinone A (Compound 4), isolated from Nigrospora oryzae, exhibits antibacterial properties, specifically demonstrating antimicrobial potential against P. aeruginosa [1].