antinociception — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T21946	BIMU 8		5-HT Receptor
	BIMU 8 is a selective agonist of 5-HT4 with EC50s of 18 nM, 77 nM, and 540 nM for wild-type 5HT4 receptor, T3.36A, and W6.48A mutant 5-HT4.		5-HT Receptor
T6888	Methylene Blue	methylthioninium chloride,CI-52015,Tetramethylthionine chloride,Basic Blue 9	Guanylate cyclase , Microtubule Associated , NO Synthase , Parasite , Monoamine Oxidase
	Methylene Blue (Tetramethylthionine chloride) (IC50 of 1.9 μM) inhibits tau filament formation. And it inhibits soluble guanylyl cyclase. It is also used as a dye in chromoendoscopy.
T0006	Methylene Blue trihydrate	Methylthionine chloride,Basic blue 9,Methylene Blue	Guanylate cyclase , Microtubule Associated , NO Synthase , Parasite , Monoamine Oxidase
	Methylene Blue trihydrate (Basic blue 9) is a compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue color. Methylene Blue trihydrate...
T14127	Adenosine A1 receptor activator T62		Adenosine Receptor
	Adenosine A1 receptor activator T62 is an allosteric enhancer of adenosine A1 receptor, and it produces antinociception in animal models of acute pain and also reduces hypersensitivity in models of inflammatory and nerve...		Adenosine Receptor
T38193L	β-Endorphin (1-27) (human) acetate	β-Endorphin (1-27) (human) acetate(76622-84-9 Free base)	Opioid Receptor
	β-Endorphin (1-27) (human) acetate, existing in the hypophysis cerebri and hypothalamus, exhibits antinociception activity. β-Endorphin (1-27) (human) acetate is an agonist of opioid receptor, showing preferred affinity ...		Opioid Receptor
T25684	Leucylarginine	Leu-arg,Leucyl-arginine
	Leucylarginine hinders antinociception induced by L-arginine.
T10361	AR-C102222 hydrochloride		Others
	AR-C102222 hydrochloride is a competitive, orally active, and highly selective inducible nitric oxide synthase (iNOS) inhibitor (IC50: 37 nM). It has antinociception and anti-inflammatory activities.		Others
T29206	ZCZ011	ZCZ 011,ZCZ-011
	ZCZ011 is a positive allosteric modulator of the cannabinoid CB1 receptor. ZCZ011 is brain penetrant, increased the potency of orthosteric agonists in mouse behavioral assays indicative of cannabimimetic activity, includ...
T14070	A-317567		Others
	A-317567 is a potent acid-sensing ion channel 3 (ASIC-3) inhibitor with an IC50 of 1.025 μM, and it has antidepressant and antinociception effects[1][2].		Others
T62722	SC13
	SC13, a novel mitragynine analog, exhibits low-efficacy agonism at Mu opioid receptors and provides antinociception while minimizing adverse effects.
T28247	ONO-1714 HCl	ONO-1714,ONO1714,ONO-1714 hydrochloride,ONO 1714
	ONO-1714 is a inducible nitric oxide synthase (NOS-2) inhibitor. ONO-1714 reduces hyperoxic lung injury in mice. ONO-1714 attenuates inflammation-related large bowel carcinogenesis in male Apc(Min/+) mice. ONO-1714 also ...
T38030	(R)-AM1241	(R)-AM1241
	(R)-AM1241 binds to cannabinoid (CB) receptors and has greater than 100-fold selectivity for the CB2 over the CB1 receptor (Kis = 15 and 5,000 nM, respectively, in a membrane assay using human receptors). (R)-AM1241 acts...
T38147	(S)-AM1241	(S)-AM1241
	(S)-AM1241 binds to cannabinoid (CB) receptors and is selective for the CB2 over the CB1 receptor (Kis = 658 and >10,000 nM, respectively, in a membrane assay using human receptors). (S)-1241 acts as an agonist at human,...
T11721L	JDTic dihydrochloride		JAK
	JDTic is a powerful antagonist of kappa-opioid receptors (KOR), effectively inhibiting the antinociceptive effects induced by the κ-agonist U50, 488.		JAK
T38193	β-Endorphin (1-27) (human) (trifluoroacetate salt)
	β-Endorphin (1-27) is an endogenous peptide that binds to μ-, δ-, and κ-opioid receptors (Kis = 5.31, 6.17, and 39.82 nM, respectively, in COS-1 cells expressing rat receptors). It binds to rat and mouse brain membrane p...

Compounds

BIMU 8

T21946

Synonym:

Target: 5-HT Receptor

Methylene Blue

T6888

Synonym: methylthioninium chloride,CI-52015,Tetramethylthionine chloride,Basic Blue 9

Target: Guanylate cyclase, Microtubule Associated, NO Synthase, Parasite, Monoamine Oxidase

Methylene Blue trihydrate

T0006

Synonym: Methylthionine chloride,Basic blue 9,Methylene Blue

Target: Guanylate cyclase, Microtubule Associated, NO Synthase, Parasite, Monoamine Oxidase

Adenosine A1 receptor activator T62

T14127

Synonym:

Target: Adenosine Receptor

β-Endorphin (1-27) (human) acetate

T38193L

Synonym: β-Endorphin (1-27) (human) acetate(76622-84-9 Free base)

Target: Opioid Receptor

Leucylarginine

T25684

Synonym: Leu-arg,Leucyl-arginine

Target:

AR-C102222 hydrochloride

Synonym: ZCZ 011,ZCZ-011

Synonym: ONO-1714,ONO1714,ONO-1714 hydrochloride,ONO 1714

JDTic dihydrochloride

T11721L

Synonym:

Target: JAK

β-Endorphin (1-27) (human) (trifluoroacetate salt)

T38193

Synonym:

Target:

Cat No.	Product Name	Synonyms	Targets
TN7059	Deoxylimonin	NSC 314317,desoxylimonin	Others
	Deoxylimonin (NSC 314317) is a triterpenoid isolated from grapefruit seeds.		Others
T3S0870	Paederosidic acid methyl ester		ATPase , Potassium Channel , NO Synthase
	Paederosidic acid methyl ester has antinociception, is possibly related to the pathway of NO-cGMP-ATP sensitive K(+) channels.		ATPase , Potassium Channel , NO Synthase
T5S0662	Gelsemine	Gelsemin	Antioxidant
	1. Gelsemine (Gelsemin) has antitumor activity. 2. Gelsemine has anti-oxidative activity. 3. Gelsemine has anti-hyperlipidemic activity. 4. Gelsemine has marked antinociception in inflammatory, neuropathic and bone cance...		Antioxidant
T7033	Rosmanol		Antioxidant , COX
	Rosmanol has antioxidant activity, it can activate the antioxidant response element. Rosmanol has biphasic modulation of GABAA receptors, demonstrates CNS activity in mouse models of antinociception, antidepressant and a...		Antioxidant , COX
T24884	Tingenone	Maytenin,Maitenin,Tingenin A,Tingenon
	Tingenone is a pentacyclic triterpene. It induces peripheral antinociception due to opioidergic activation.
TN1577	Dicentrine		Others
	Dicentrine, a selective α±(1)-adrenoceptor antagonist with potent antiarrhythmic and antihypertensive activities, it also has antinociception in different models of chemical pain.		Others