compound-52

NG 52 (NG-52) is a cell-permeable, reversible, and ATP-compatible inhibitor of the cell cycle-regulating kinase Cdc28p and the related Pho85p kinase.

Dibutyl carbonate is a useful organic compound for research related to life sciences. The catalog number is T2152 and the CAS number is 542-52-9.

BRK inhibitor P21d hydrochloride is a highly potent inhibitor of breast tumor kinase (BRK PTK6), displaying an IC50 of 30 nM, and effectively suppresses p-SAM68 with an IC50 of 52 nM. This compound serves as a valuable tool for evaluating BRK inhibitors' efficacy in xenograft breast tumor models, enabling in vivo activity assessment.

Unifiram is a nootropic agent.1It increases acetylcholine (ACh) release in the rat cerebral cortexin vivoand induces a long-lasting increase in the amplitude of field excitatory postsynaptic potentials (fEPSPs) in the rat hippocampal CA1 region (EC50= 27 nM). It does not bind to serotonin (5-HT), dopamine, muscarinic, nicotinic, adrenergic, glutamate, histamine, opioid, or GABA receptors at 1 μM. Unifiram (0.1 mg kg) improves memory in non-memory-impaired rats in a social learning test.2It also prevents memory deficits induced by the anticholinergic agent scopolamine, nicotinic receptor antagonist mecamylamine, GABABreceptor agonist baclofen, or α2-adrenergic receptor agonist clonidine in the passive avoidance test in mice when administered at a dose of 0.01 mg kg and prevents memory deficits induced by the AMPA kainate glutamate receptor antagonist NBQX at 0.1 mg kg.1 1.Romanelli, M.N., Galeotti, N., Ghelardini, C., et al.Pharmacological characterization of DM232 (unifiram) and DM235 (sunifiram), new potent cognition enhancersCNS Drug Rev.12(1)39-52(2006) 2.Ghelardini, C., Galeotti, N., Gualtieri, F., et al.The novel nootropic compound DM232 (unifiram) ameliorates memory impairment in mice and ratsDrug Develop. Res.56(1)23-32(2002)

(R)-2-(((Benzyloxy)carbonyl)amino)-2-phenylacetic acid is a useful organic compound for research related to life sciences. The catalog number is T65810 and the CAS number is 17609-52-8.

Boc-Gly-Gly-OH, catalog number T66761 (CAS number: 31972-52-8), is a valuable organic compound for life sciences research.

4-Hydrazinylbenzenesulfonamide hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T65814 and the CAS number is 17852-52-7.

Anti-inflammatory agent 52 (compound 7c) is an orally active, selective COX-2 inhibitor with demonstrated anti-HT29 metastatic activity, causing periodic arrest in the S phase and G2 M phase. This agent exhibits moderate anti-inflammatory efficacy alongside a notable safety profile. Additionally, it possesses the uncommon capability of inhibiting tumor development in a mouse model, indicative of anti-cancer properties [1].

Ethane-1,2-diyl bis(4-methylbenzenesulfonate) is a useful organic compound for research related to life sciences. The catalog number is T67068 and the CAS number is 6315-52-2.

2-(4-Bromophenyl)quinoline-4-carboxylic acid is a useful organic compound for research related to life sciences. The catalog number is T65561 and the CAS number is 103914-52-9.

Decyl Glucose Neopentyl Glycol is a useful organic compound for research related to life sciences. The catalog number is TF0079 and the CAS number is 1423314-52-6.

Multiflorin B (compound 5), a kaempferol glycoside, can be extracted from the root of Neocheiropteris palmatopedata. This compound demonstrates the ability to inhibit nitric oxide production, achieving a 52% inhibition at a concentration of 20 μg/ml [1].

7,8-Dihydroyangonin is a useful organic compound for research related to life sciences. The catalog number is T125064 and the CAS number is 3155-52-0.

2-Amino -7-propargyl-7,8-dihydro-8-oxo-9-(beta-D-2,3,5-tri-O-actyl-xylofuranosyl)purine is a useful organic compound for research related to life sciences. The catalog number is TNU1331 and the CAS number is 2389988-52-5.

COX-2-IN-39 (compound 44) potently inhibits COX-2, exhibiting an IC50 of 0.4 nM [1].

HSD17B13-IN-52 (Compound 84), an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), exhibits potent activity with an IC50 value of ≤ 0.1 μM against estradiol. This compound is applicable in the research of various health conditions including liver, metabolic, and cardiovascular diseases, specifically NAFLD, NASH, and drug-induced liver injury (DILI) [1].

XY-52 (Compound 32), an ST2 (Stimulation-2) inhibitor, exhibits IC50 values of 5.68 μM and 4.59 μM in the AlphaLISA and HEK-Blue assays, respectively. It promotes proinflammatory T-cell proliferation and diminishes plasma sST2 and IFNγ biomarkers in a graft versus host disease (GVHD) mouse model [1].

Irinotecan Impurity 52-d5 is a deuterated compound of Irinotecan Impurity 52.Irinotecan Impurity 52 has a CAS number of 1026078-50-1.

Ac-D-Ala-OH is a useful organic compound for research related to life sciences. The catalog number is T64967 and the CAS number is 19436-52-3.

Z-Asp(OtBu)-OH is a useful organic compound for research related to life sciences. The catalog number is T66041 and the CAS number is 5545-52-8.

Melilotussaponin O1 is a useful organic compound for research related to life sciences. The catalog number is T125393 and the CAS number is 205441-52-7.

3-Fluorocatechol is a useful organic compound for research related to life sciences. The catalog number is T67684 and the CAS number is 363-52-0.

Silenorubicoside A is a useful organic compound for research related to life sciences. The catalog number is T124083 and the CAS number is 857411-52-0.

Gleditsioside J is a useful organic compound for research related to life sciences. The catalog number is T125199 and the CAS number is 253123-52-3.

Tubulin polymerization-IN-52 (compound SC23) effectively inhibits tubulin polymerization with an IC50 value of 2.9 μM [1].

4'-O-Glucopyranosylsinapic acid is a useful organic compound for research related to life sciences. The catalog number is T126287 and the CAS number is 117405-52-4.

Madurastatin B2 is a useful organic compound for research related to life sciences. The catalog number is T124249 and the CAS number is 768384-52-7.

LIMK-IN-2 (Compound 52), an LIMK inhibitor, has demonstrated potential anti-angiogenic activity by suppressing the cell migration of osteosarcoma and cervical cancer cells [1].

CDK4 6-IN-21 (compound I-52) is a CDK4 6 inhibitor with IC50 values of 3.88 nM for CDK4 and 3.31 nM for CDK6, exhibiting antitumor activity.

Fmoc-Asp-OMe is a useful organic compound for research related to life sciences. The catalog number is T65757 and the CAS number is 145038-52-4.

Anti-inflammatory agent 52 (compound 7j) is an orally active, selective COX-2 inhibitor that induces G2 M phase arrest and exhibits anti-HT29 transfer activity. It demonstrates moderate anti-inflammatory efficacy and a notable safety profile, and uniquely inhibits tumor growth in mouse models, indicative of its anticancer properties [1].

3-Ethoxy-4-methoxybenzaldehyde is a useful organic compound for research related to life sciences. The catalog number is T67175 and the CAS number is 1131-52-8.

EGFR-IN-52 (Compound 4) is a highly effective inhibitor of the epidermal growth factor receptor (EGFR) with IC50 values of 0.358, 86.02, and 432.67 μM against EGFR, EGFR L858R-TK, and EGFR T790M-TK, respectively. Additionally, it demonstrates potent cytotoxic effects on cancer cell lines and triggers apoptosis [1].

Pyridin-3-ylmethanamine-d2 is a deuterated compound of Pyridin-3-ylmethanamine. Pyridin-3-ylmethanamine has a CAS number of 3731-52-0. Picolamine acts as a potential inhibitor of DPP-4.

2-(9-Decenyl)glutaconic acid is a useful organic compound for research related to life sciences. The catalog number is T123835 and the CAS number is 97207-52-8.

Zevotrelvir (Compound 52) serves as an inhibitor of coronavirus, demonstrating IC50 values below 0.1 μM for 229E hCoV protease and below 0.1 mM for SARS-CoV-3C-like (3CL) protease, suggesting its potential for researching viral infections [1].

2',4'-Dihydroxy-3,7':4,8'-diepoxylign-7-ene is a natural compound used in life sciences research, catalog number TN2716, CAS number [666250-52-8].

3,5-Di-O-galloylshikimic acid is a useful organic compound for research related to life sciences. The catalog number is T123852 and the CAS number is 95753-52-9.

Aromadendrin 4'-glucoside is a useful organic compound for research related to life sciences. The catalog number is T124038 and the CAS number is 87314-52-1.

Spironolactone-d3 is a deuterated compound of Spironolactone. Spironolactone has a CAS number of 52-01-7. Spironolactone is an Aldosterone Antagonist. The mechanism of action of spironolactone is as an Aldosterone Antagonist.

Compound I-52 (AChE-IN-53) is a potent inhibitor of NMDAR, exhibiting favorable behavioral and neuroprotective effects [1].

L-Cysteine-d3 is a deuterated compound of L-Cysteine. L-Cysteine has a CAS number of 52-90-4. L-Cysteine is a non-essential sulfur-containing amino acid in humans. L-Cysteine is important for protein synthesis, detoxification, and diverse metabolic functions. Found in beta-keratin, the main protein in nails, skin, and hair, L-Cysteine is important in collagen production, as well as skin elasticity and texture. Also required in the manufacture of amino acid taurine, L-Cysteine is a component of the antioxidant glutathione, and plays a role in the metabolism of essential biochemicals such as coenzyme A, heparin, and biotin.

Antiproliferative agent-52 (Compound 4a) exhibits significant antiproliferative activity against four human tumor cell lines (A549, A2780, SKOV3, HCC827), with IC50 values ranging from 5.83 to 8.63 nM. This compound is useful for cancer research.

ICMT-IN-52 (compound 44) is an ICMT inhibitor with an IC50 value of 0.052 μM [1].

Crizotinib-d5 is a deuterated compound of Crizotinib. Crizotinib has a CAS number of 877399-52-5. Crizotinib is an ATP-competitive small-molecule tyrosine kinases inhibitor of c-MET (IC50: 8 nM) and ALK (IC50: 20 nM) receptor.

Biphenyl-d10 is a deuterated compound of Biphenyl. Biphenyl has a CAS number of 92-52-4.

5-Bromoindan-2-ylamine hydrobromide is a useful organic compound for research related to life sciences. The catalog number is T66520 and the CAS number is 321352-52-7.

1-methyl-4-piperidin-1-iumol is a useful organic compound for research related to life sciences. The catalog number is T65669 and the CAS number is 106-52-5.