excipient

mRNA-Encapsulating Lipid Excipient 1 (Compound 2), a thiocarbamate-based ionizable lipid, serves as an excipient in the formulation of mRNA-encapsulating lipid nanoparticles [1].

Sorbitan monooleate is a pharmaceutical excipient, a lipophilic nonionic surfactant, and is often used as an emulsifier in cosmetics, food and pharmaceuticals.

Citric Acid Monohydrate is a tricarboxylic acid found in citrus fruits. Citric acid is used as an excipient in pharmaceutical preparations due to its antioxidant properties. It maintains stability of active ingredients and is used as a preservative.

Sodium dodecyl sulfate(Sodium lauryl sulfate) is a pharmaceutical excipient that is biologically inactive and improves the stability, solubility and processability of pharmaceutical preparations.

Castor oil (Xenaderm) is a vegetable oil pressed from the seeds of the castor bean, Ricinus communis, used as a laxative and as an excipient in medicinally.

Gelucire 44 14 (Gelucire 14 44) acts as a nonionic surface-active excipient and improves fat absorption in rats with impaired lipolysis.

DMG-PEG 2000 (DMG-PEG2000) is a lipid excipient that has been used in combination with other lipids in the formation of lipid nanoparticles. Formulations containing DMG-PEG 2000 have been used in the development of lipid nanoparticles for the delivery of mRNA-based vaccines.

Poly(acrylic acid) serves as an effective corrosion inhibitor for pure cast aluminium in acidic environments through its adsorption onto the metal's surface. Additionally, this compound functions as an excipient within the pharmaceutical industry, utilized in roles such as a coating material and release blocker. Pharmaceutical excipients, also known as pharmaceutical auxiliaries, are chemical substances employed in drug formulation alongside the active pharmaceutical ingredients to enhance the stability, solubility, and manufacturability of the products. These excipients also influence the absorption, distribution, metabolism, and elimination (ADME) processes of drugs [1] [2].

Polyoxyethylene Sorbitan Monostearate, an ester derived from the saturated fatty acid stearic acid (C18:0), serves multiple roles in pharmaceutical formulations, including as a surfactant, emulsifier, solubilizer, and wetting agent. As a pharmaceutical excipient—an inert substance that enhances the stability, solubility, and processability of drug formulations—it plays a crucial role in affecting the absorption, distribution, metabolism, and elimination (ADME) processes of drugs [1] [2].

Fazirsiran sodium, a second-generation RNAi agent, contains a cholesterol-conjugated RNAi trigger (chol-RNAi) that selectively degrades Alpha1-antitrypsin (AAT) mRNA via RNAi. It includes a melittin-derived peptide linked to N-acetylgalactosamine (NAG), formulated as the excipient EX1, to facilitate endosomal escape of the chol-RNAi in hepatocytes [1]. Fazirsiran sodium is useful for studying Alpha-1 Antitrypsin Deficiency (AATD) liver disease.

Cholesterol-PEG-Folate (MW 2000), an excipient, facilitates the preparation of folate-conjugated PEG-liposomes [1].

Fazirsiran (ARO-AAT), a second-generation RNAi agent, comprises a cholesterol-conjugated RNAi trigger (chol-RNAi) that selectively degrades AAT mRNA via RNAi, and a melittin-derived peptide conjugated to N-acetylgalactosamine (NAG) as the excipient EX1 to enhance endosomal escape of chol-RNAi in hepatocytes [1].

Triton X-100 is a non-denaturing detergent that solubilizes lipid membranes. Triton X-100 is commonly used in laboratories and is applied to vaccines at different stages of the manufacturing process. Triton X-100 is listed as an excipient in certain vaccines including split virus influenza vaccines. Triton X-100 is a nonionic surfactant [1] [2].

ALC-0159 is a polyethylene glycol (PEG) lipid conjugate that could be used as a vaccine excipient[1].

Cellulose can be used as an excipient. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs [1] .

Maltodextrin (dextrose equivalent 16.5-19.5) serves as an excipient in pharmaceutical applications. Excipients, also known as pharmaceutical auxiliaries, are chemical substances utilized in drug formulation alongside active pharmaceutical ingredients. They primarily enhance the stability, solubility, and processability of drug preparations, while also influencing the absorption, distribution, metabolism, and elimination (ADME) of co-administered drugs [1].

Trisodium phosphate dodecahydrate serves as a corrosion inhibitor for iron in 0.1 M NaClO4 solutions, effective under both aerated and deaerated conditions. Additionally, it acts as an excipient in pharmaceutical formulations, functioning primarily as a pH regulator and buffer. These excipients, also known as pharmaceutical auxiliaries, are substances utilized in the pharmaceutical manufacturing process besides the active pharmaceutical ingredients. They are crucial for enhancing the stability, solubility, and processability of pharmaceutical products. Moreover, pharmaceutical excipients play a significant role in influencing the absorption, distribution, metabolism, and elimination (ADME) of co-administered drugs, thereby affecting their efficacy and safety [1] [2].