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Search Result

Search Results for " lyase "

Targets

ATP Citrate Lyase Others

45

Compounds

17

Natural Products

39

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T64354 Cystathionine-γ-lyase-IN-1 SHIP-2a Others
Cystathionine-γ-lyase-IN-1 (SHIP-2a) is a selective inhibitor of cystathionine γ-lyase (CSE) enzyme (IC50= 6.3 μM).
T79929 L-Methionine γ-lyase Methionine lyase
L-Methionine γ-lyase (Methionine lyase), a multifaceted enzyme in the γ-family of pyridoxal-5’-phosphate (PLP)-dependent enzymes, catalyzes the α, γ-elimination of L-methionine and homocysteine. This enzyme exhibits anti...
T79927 Pectate Lyase
Pectate Lyase, an enzyme secreted by plant pathogens, is essential for pectin degradation and plays a vital role in fungal virulence. Additionally, it triggers plant immune responses, further contributing to its virulenc...
T78355 Cystathionine β-lyase
Cystathionine β-lyase, an enzyme crucial for bacterial virulence [1], catalyzes the conversion of cystathionine into homocysteine, representing the penultimate step in the biosynthesis of methionine.
T76165 N-Acetylneuraminate lyase (CgNal)
N-Acetylneuraminate lyase (CgNal) (Sialic acid aldolase (CgNal)), a class I aldolase frequently utilized in biochemical research, catalyzes the reversible condensation of pyruvate and N-acetyl-d-mannosamine (ManNAc), pro...
T83910 S1PL-IN-31 Sphingosine-1-Phosphate Lyase Inhibitor 31,S1PL Inhibitor 31,S1P Lyase Inhibitor 31
S1PL-IN-31 is a dual-function chemical compound acting as an inhibitor of sphingosine-1-phosphate (S1P) lyase with an IC50 value of 210 nM and as an antagonist of the Smoothened (Smo) receptor with an IC50 of 440 nM. Dem...
T2337 BMS-303141 BMS 303141 ATP Citrate Lyase
BMS-303141 is a potent ATP-citrate lyase (ACL) inhibitor (IC50: 0.13 uM, human recombinant ACL).
T7424 NDI-091143 ATP Citrate Lyase
NDI-091143 is a potent and high-affinity human ATP-citrate lyase (ACLY) inhibitor with an IC50 of 2.1 nM (ADP-Glo assay),indirectly disrupting citrate binding via an unexpected mechanism of inhibition.
T16861 SB 204990 ATP Citrate Lyase
SB 204990 is an effective and specific ATP citrate lyase enzyme inhibitor.
T22967 MEDICA16 MEDICA 16 GPR , Others , ATP Citrate Lyase
MEDICA16 is a selective agonist for GPR40 as well as a partial agonist for GPR120. MEDICA16, an ATP-citrate lyase inhibitor, significantly reduces intracellular TG content in gastrocnemius muscle with an increase in insu...
T8336 OGG1-IN-08 OGG1-IN-O8 Others
OGG1-IN-08 (OGG1-IN-O8) is an inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1;IC50 : 0.35 μM)
T3625 Bempedoic acid ETC1002,ESP-55016,ETC 1002,ETC-1002 ATP Citrate Lyase , AMPK
Bempedoic acid (ETC1002) is an orally available, once-daily LDL-C lowering small molecule designed to lower elevated levels of LDL-C and to avoid side effects associated with existing LDL-C lowering therapies. Bempedoic ...
T13312L Seviteronel VT-464 Others
Seviteronel is an effective CYP17 lyase inhibitor (h-Lyase IC50=69 nM). In a hamster model of androgen biosynthesis inhibition, it demonstrated both exceptional in vitro lyase/hydroxylase selectivity (~10-fold) and oral...
T6050 TAK-700 (S/R)-Orteronel,Orteronel P450
TAK-700 (Orteronel) (Orteronel) is a potent and highly selective human 17, 20-lyase inhibitor with IC50 of 38 nM, exhibits >1000-fold selectivity over other CYPs (e.g. 11-hydroxylase and CYP3A4). Phase 3.
T77627 Opevesostat ODM208,ODM-208 P450
Opevesostat (ODM-208) is an inhibitor of lyase (CYP11A1) (the enzyme cleavage cholesterol side chain).
T6216 Abiraterone CB-7598 P450
Abiraterone (CB-7598) (CB-7598) is an effective steroidal cytochrome P450 17alpha-hydroxylase-17, 20-lyase (CYP17) inhibitor (IC50: 4 nM).
T6509 Galeterone VN-124-1,TOK-001,VN/124-1,VN 124 P450 , Androgen Receptor
Galeterone (VN 124) is an orally bioavailable small-molecule androgen receptor modulator and CYP17 lyase inhibitor with potential antiandrogen activity. Galeterone exhibits three distinct mechanisms of action: 1) as an a...
T38294 4-Deoxypyridoxine hydrochloride S1P Receptor
4-Deoxypyridoxine (4-DPD) is a vitamin B6 antimetabolite with diverse biological activities. It inhibits transport of pyridoxine , pyridoxal, and pyridoxamine in and reduces growth of S. carlsbergensis cells. 4-DPD inhib...
T11847L Liarozole R75251 dihydrochloride P450 , Retinoid Receptor
Liarozole (R75251 dihydrochloride) is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular androgen synthesis (inhibition of 1...
T13313 Seviteronel racemate VT-464 (racemate) Others
Seviteronel racemate is the racemate form of Seviteronel and is a potent inhibitor of CYP17 lyase.
T20607 3-Oxo-3-phenylpropene Phenylvinylketone,Phenyl vinyl ketone,Phenylvinyl ketone,3 Oxo 3 phenylpropene
3-Oxo-3-phenylpropene is an active-site directed irreversible inhibitor of hydroxynitrile lyase.
T36833 A6770
A6770 is an inhibitor of sphingosine-1-phosphate (S1P) lyase.1It induces accumulation of [3H]sphinganine-1-phosphate ([3H]dhS1P), an S1P lyase substrate, in IT-79MTNC3 cells that endogenously express high levels of S1P l...
T13312 Seviteronel R enantiomer VT-464 (R enantiomer) Others
Seviteronel R enantiomer is the R enantiomer of Seviteronel and is a potent inhibitor of CYP17 lyase (IC50: 69 nM for h-Lyase).
T40535 L-2-Aminooxy-3-phenylpropanoic acid
L-2-Aminooxy-3-phenylpropanoic acid acts as a potent inhibitor of the enzyme L-phenylalanine ammonia-lyase.
T28770 SHIP-2a SHIP 2a
SHIP-2a is a cystathione γ lyase (CSE) inhibitor with IC50 value of 6.3 μM.
T70466 SB-201076
SB-201076 is a potent ATP citrate-lyase inhibitor. SB-204990 is the prodrug of SB-201076.
T40841 L-2-Aminooxy-3-phenylpropanoic acid hydrobromide
L-2-Aminooxy-3-phenylpropanoic acid hydrobromide is a powerful inhibitor of L-phenylalanine ammonia-lyase, an enzyme responsible for catalyzing the conversion of L-phenylalanine to trans-cinnamic acid.
T61406 RBM10-8
RBM10-8 irreversibly inhibits human sphingosine-1- phosphate lyase (hS1PL) while behaving also as an enzyme substrate.
T64074 BACE1-IN-8
BACE1-IN-8 is a potent inhibitor of BACE1 (β-site APP lyase 1) (IC50: 3.9 μM).
T19292 DL-threo-2-methylisocitrate Others
dl-threo-2-methylisocitrate is a substrate of isocitrate lyase 1 (ICL1). IC50 value: target: using michael-menten nonlinear least squares fitting to determine the purified recombinant ICL1's Km for threo-D(s)L(s)-isocitr...
T6051 Orteronel TAK-700,(S)-Orteronel P450
Orteronel ((S)-Orteronel)(TAK-700) was selected as a candidate for clinical evaluation. orteronel (TAK-700) is currently in phase III clinical trials for the treatment of castration-resistant prostate cancer.
T70847 BMS-351
BMS-351 is a potent and selective, nonsteroidal CYP17A1 lyase inhibitor with robust selectivity over steroidogenic CYPs 21A2 and 11B1. BMS-351 emerges as an outstanding preclinical candidate to treat CRPC and is likely t...
T19291 DL-threo-2-methylisocitrate sodium Others
DL-threo-2-methylisocitrate is a substrate of isocitrate lyase 1 (ICL1). Using Michaelis-Menten nonlinear least squares fitting, kcat value was 5.24 s-1, the Km of the purified recombinant ICL1 of threonine-D(s)L(s)-isoc...
T11847 Liarozole dihydrochloride R75251 dihydrochloride Others
Liarozole dihydrochloride is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular androgen synthesis (inhibition of 17 ,20-lya...
T16322 Nicodicosapent Others
Nicodicosapent is a fatty acid niacin conjugate. It is also an inhibitor of the sterol regulatory element-binding protein (SREBP). The sterol regulatory element-binding protein (SREBP) is a key regulator of cholesterol m...
T37790 TAK-700 salt TAK700 (salt),TAK 700 (salt),TAK-700 salt
TAK-700 salt is a potent and highly selective inhibitor of human 17,20-lyase with an IC50 of 38 nM and is over 1000-fold more selective than other CYPs such as 11-hydroxylase and CYP3A4.
T71102 CFG920
CFG920 is a CYP17 inhibitor, is also an orally available inhibitor of the steroid 17-alpha-hydroxylase/C17,20 lyase (CYP17A1 or CYP17), with potential antiandrogen and antineoplastic activities. Upon oral administration,...
T14129 Adenylosuccinic acid Aspartyl adenylate,Adenylosuccinate Others
Adenylosuccinic acid (Adenylosuccinate; Aspartyl adenylate) is a purine ribonucleoside monophosphate and plays a role in nucleotide cycle metabolite. Adenylosuccinic acid has the potential for the study of duchenne muscu...
T73919 Adenylosuccinic acid tetraammonium
Adenylosuccinic Acid Tetraammonium (also known as Adenylosuccinate or Aspartyl Adenylate) is an orally active compound that functions as a purine ribonucleoside monophosphate and is involved in nucleotide cycle metabolis...
T73734 Acetoacetic acid
Acetoacetic acid, an endogenous metabolite found in cerebrospinal fluid and blood, is valuable for researching conditions such as meningitis, pregnancy, 3-hydroxy-3-methylglutaryl-CoA lyase deficiency, preeclampsia/eclam...
T81677 N-Formyl-L-histidine Formyl-L-histidine
N-Formyl-L-histidine demonstrates a binding affinity for histidyl-tRNA synthetase, featuring a K i value of 4.6 μM. Additionally, it acts as a competitive inhibitor against L-histidine ammonia-lyase, suppressing urocanic...
T37394 13(S)-HpOTrE
13(S)-HpOTrE is a monohydroperoxy polyunsaturated fatty acid produced in soybeans by the action of soybean LO-2 on esterified α-linolenic acid.[1] Incubation of soybean seedling biomembranes with soybean LO-2 catalyzes t...
T83761 12-oxo-9(Z)-Dodecenoic Acid 12-oxo-9-cis-Dodecenoic Acid,12-keto-9Z-Dodecenoic Acid
12-oxo-9(Z)-Dodecenoic acid, an ω-oxoacid metabolite derived from the ω-6 PUFA linoleic acid and the ω-3 PUFA α-linolenic acid, is synthesized in plants through the action of lipoxygenase on these PUFAs, forming 13-hydro...
T82972 Argininosuccinic acid disodium Reactive Oxygen Species
Argininosuccinic acid disodium, involved in the urea cycle's fourth step, is cleaved by argininosuccinate lyase (ASL) into arginine and fumarate. It diminishes reduced glutathione (GSH) levels and elevates reactive oxyge...
T37498 Antimycin A4
Antimycin A4 is an active component of the antimycin A antibiotic complex that is more polar than antimycin A1 , antimycin A2 , and antimycin A3 . Antimycin A4 inhibits ATP-citrate lyase with a Ki value of 64.8 μM. The a...

Compounds

Cystathionine-γ-lyase-IN-1
T64354
Synonym: SHIP-2a
Target: Others
L-Methionine γ-lyase
T79929
Synonym: Methionine lyase
Target:
Pectate Lyase
T79927
Synonym:
Target:
Cystathionine β-lyase
T78355
Synonym:
Target:
N-Acetylneuraminate lyase (CgNal)
T76165
Synonym:
Target:
S1PL-IN-31
T83910
Synonym: Sphingosine-1-Phosphate Lyase Inhibitor 31,S1PL Inhibitor 31,S1P Lyase Inhibitor 31
Target:
BMS-303141
T2337
Synonym: BMS 303141
Target: ATP Citrate Lyase
NDI-091143
T7424
Synonym:
Target: ATP Citrate Lyase
SB 204990
T16861
Synonym:
Target: ATP Citrate Lyase
MEDICA16
T22967
Synonym: MEDICA 16
Target: GPR, Others, ATP Citrate Lyase
OGG1-IN-08
T8336
Synonym: OGG1-IN-O8
Target: Others
Bempedoic acid
T3625
Synonym: ETC1002,ESP-55016,ETC 1002,ETC-1002
Target: ATP Citrate Lyase, AMPK
Seviteronel
T13312L
Synonym: VT-464
Target: Others
TAK-700
T6050
Synonym: (S/R)-Orteronel,Orteronel
Target: P450
Opevesostat
T77627
Synonym: ODM208,ODM-208
Target: P450
Abiraterone
T6216
Synonym: CB-7598
Target: P450
Galeterone
T6509
Synonym: VN-124-1,TOK-001,VN/124-1,VN 124
Target: P450, Androgen Receptor
4-Deoxypyridoxine hydrochloride
T38294
Synonym:
Target: S1P Receptor
Liarozole
T11847L
Synonym: R75251 dihydrochloride
Target: P450, Retinoid Receptor
Seviteronel racemate
T13313
Synonym: VT-464 (racemate)
Target: Others
3-Oxo-3-phenylpropene
T20607
Synonym: Phenylvinylketone,Phenyl vinyl ketone,Phenylvinyl ketone,3 Oxo 3 phenylpropene
Target:
A6770
T36833
Synonym:
Target:
Seviteronel R enantiomer
T13312
Synonym: VT-464 (R enantiomer)
Target: Others
L-2-Aminooxy-3-phenylpropanoic acid
T40535
Synonym:
Target:
SHIP-2a
T28770
Synonym: SHIP 2a
Target:
SB-201076
T70466
Synonym:
Target:
L-2-Aminooxy-3-phenylpropanoic acid hydrobromide
T40841
Synonym:
Target:
RBM10-8
T61406
Synonym:
Target:
BACE1-IN-8
T64074
Synonym:
Target:
DL-threo-2-methylisocitrate
T19292
Synonym:
Target: Others
Orteronel
T6051
Synonym: TAK-700,(S)-Orteronel
Target: P450
BMS-351
T70847
Synonym:
Target:
DL-threo-2-methylisocitrate sodium
T19291
Synonym:
Target: Others
Liarozole dihydrochloride
T11847
Synonym: R75251 dihydrochloride
Target: Others
Nicodicosapent
T16322
Synonym:
Target: Others
TAK-700 salt
T37790
Synonym: TAK700 (salt),TAK 700 (salt),TAK-700 salt
Target:
CFG920
T71102
Synonym:
Target:
Adenylosuccinic acid
T14129
Synonym: Aspartyl adenylate,Adenylosuccinate
Target: Others
Adenylosuccinic acid tetraammonium
T73919
Synonym:
Target:
Acetoacetic acid
T73734
Synonym:
Target:
N-Formyl-L-histidine
T81677
Synonym: Formyl-L-histidine
Target:
13(S)-HpOTrE
T37394
Synonym:
Target:
12-oxo-9(Z)-Dodecenoic Acid
T83761
Synonym: 12-oxo-9-cis-Dodecenoic Acid,12-keto-9Z-Dodecenoic Acid
Target:
Argininosuccinic acid disodium
T82972
Synonym:
Target: Reactive Oxygen Species
Antimycin A4
T37498
Synonym:
Target:
Cat No. Product Name Synonyms Targets
T11590 (-)-Hydroxycitric acid Garcinia acid ATP Citrate Lyase
(-)-Hydroxycitric acid (Garcinia acid) (Garcinia acid) is the principal acid of fruit rinds of Garcinia cambogia. It is a potent and competitive inhibitor of ATP citrate lyase. (-)-Hydroxycitric acid suppresses fatty aci...
T12045 (-)-Hydroxycitric acid lactone Garcinia lactone ATP Citrate Lyase
(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent.(-)-Hydroxycitric acid lactone was a potent inhibitor of ATP citrate lyase, which catalyzes the extramitochondrial cleavage of citrate to oxaloac...
T5544 2-Furoic acid Furan-2-carboxylic acid Anti-infection , ATP Citrate Lyase , Endogenous Metabolite , Acyltransferase
2-Furoic acid (Furan-2-carboxylic acid) 2-Furoic acid can reduce serum cholesterol and triglyceride levels and has anti-lipidemic effects.
T11589 Hydroxycitric acid tripotassium hydrate Potassium citrate monohydrate ATP Citrate Lyase , HIF/HIF Prolyl-Hydroxylase , HIF
Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) effectively inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation, and anti-tumor effects. Hydroxycitric acid tr...
T0256 Citric acid trilithium salt tetrahydrate Lithium citrate tribasic tetrahydrate,Trilithium citrate tetrahydrate Dehydrogenase , GSK-3 , HIF/HIF Prolyl-Hydroxylase , Antibacterial , GluR
Citric acid trilithium salt tetrahydrate (Lithium citrate tribasic tetrahydrate) , the active component of Lithium, is a medicine used in the therapy of psychiatric disease. It has shown the effects of signaling pathways...
TN7125 2-Propen-1-one, 1-(2,6-dimethoxyphenyl)-3-(4-hydroxyphenyl)- Others
2-Propen-1-one, 1-(2,6-dimethoxyphenyl)-3-(4-hydroxyphenyl)- can be used in studies about the inhibition against L-phenylalanine ammonia-lyase.
T19778 2-ATHBI Others
2-ATHBI is a S1P lyase inhibitor.
T60237 L-Cysteine S-sulfate S-Sulfo-L-cysteine NMDAR
L-Cysteine S-sulfate (S-Sulfo-L-cysteine) is an effective N-methyl-d-aspartate (NMDA) glutamatergic receptors agonist. L-Cysteine S-sulfate is the substrate for cystine lyase [1].
T4454 Traumatic Acid Dodec-2-Enedioic Acid,2E-Dodecenedioic Acid,Trans-2-Dodecenedioic Acid Antioxidant
Traumatic Acid (Dodec-2-Enedioic Acid) is a product of the hydroperoxide lyase pathway in plants. Potential as a wound healing agent that stimulates cell division near a wound site to form a protective callus.
T0603 Phthalic acid mono-2-ethylhexyl ester Phthalic Acid Monooctyl Ester P450 , Endogenous Metabolite
Phthalic acid mono-2-ethylhexyl ester (Phthalic Acid Monooctyl Ester is a major bioactive metabolite of diethylhexyl phthalate (DEHP), which inhibits the 17, 20 lyase activity of CYP17. Cyp17a1 gene is a specific target ...
T4766 3-Methylglutaric acid Endogenous Metabolite
Methylglutaric acid is a leucine metabolite. A large amount of methylglutaric acid is identified in urine of patients with deficiency of 3-methylglutaconyl coenzyme A hydratase (PMID 6181239 ). Methylglutaric acid is als...
T4826 L-Histidine monohydrochloride monohydrat Others , Endogenous Metabolite
Histidine (abbreviated as His or H) is an alpha-amino acid. The L-isomer is one of the 22 proteinogenic amino acids, i.e., the building blocks of proteins. It is classified as a charged, polar because of the hydrophilic ...
T79936 Forrestiacids K ATP Citrate Lyase
Forrestiacid K, a terpenoid derived from Pseudotsuga forrestii, functions as an inhibitor of ATP-citrate lyase (ACL) [1].
T79935 Forrestiacids J ATP Citrate Lyase
Forrestiacid J is an inhibitor of ATP-citrate lyase (ACL), exhibiting an IC50 value of 2.6 μM [1].
TN5879 Edgeworin
Edgeworin is a DNA polymerase beta (pol beta) inhibitor, it inhibits both the lyase and polymerase activities of DNA polymerase beta; it can potentiate the inhibitory action of the anticancer drug bleomycin in cultured A...
T82274 Gnetuhainin I
Gnetuhainin I (Compound 5), a lignin sourced from Pouzolzia zeylanica, exhibits potent inhibition of ATP citrate lyase (ACLY) with an IC50 value of 2.63 μM [1].
TN1751 Hydroxycitric acid ERK , p38 MAPK , Fatty Acid Synthase
(-)-Hydroxycitric acid (HCA) can inhibit fat synthesis and reduces food intake, the primary mechanism of action of HCA appears to be related to its ability to act as a competitive inhibitor of the enzyme ATP-citrate lyas...

Natural Products

(-)-Hydroxycitric acid
T11590
Synonym: Garcinia acid
Target: ATP Citrate Lyase
(-)-Hydroxycitric acid lactone
T12045
Synonym: Garcinia lactone
Target: ATP Citrate Lyase
2-Furoic acid
T5544
Synonym: Furan-2-carboxylic acid
Target: Anti-infection, ATP Citrate Lyase, Endogenous Metabolite, Acyltransferase
Hydroxycitric acid tripotassium hydrate
T11589
Synonym: Potassium citrate monohydrate
Target: ATP Citrate Lyase, HIF/HIF Prolyl-Hydroxylase, HIF
Citric acid trilithium salt tetrahydrate
T0256
Synonym: Lithium citrate tribasic tetrahydrate,Trilithium citrate tetrahydrate
Target: Dehydrogenase, GSK-3, HIF/HIF Prolyl-Hydroxylase, Antibacterial, GluR
2-Propen-1-one, 1-(2,6-dimethoxyphenyl)-3-(4-hydroxyphenyl)-
TN7125
Synonym:
Target: Others
2-ATHBI
T19778
Synonym:
Target: Others
L-Cysteine S-sulfate
T60237
Synonym: S-Sulfo-L-cysteine
Target: NMDAR
Traumatic Acid
T4454
Synonym: Dodec-2-Enedioic Acid,2E-Dodecenedioic Acid,Trans-2-Dodecenedioic Acid
Target: Antioxidant
Phthalic acid mono-2-ethylhexyl ester
T0603
Synonym: Phthalic Acid Monooctyl Ester
Target: P450, Endogenous Metabolite
3-Methylglutaric acid
T4766
Synonym:
Target: Endogenous Metabolite
L-Histidine monohydrochloride monohydrat
T4826
Synonym:
Target: Others, Endogenous Metabolite
Forrestiacids K
T79936
Synonym:
Target: ATP Citrate Lyase
Forrestiacids J
T79935
Synonym:
Target: ATP Citrate Lyase
Edgeworin
TN5879
Synonym:
Target:
Gnetuhainin I
T82274
Synonym:
Target:
Hydroxycitric acid
TN1751
Synonym:
Target: ERK, p38 MAPK, Fatty Acid Synthase

Recombinant Proteins

Species：
Human (21)
Mouse (5)
Ambrosia artemisiifolia (3)
Azotobacter vinelandii (1)
Chamaecyparis obtusa (1)
Dechloromonas aromatica (1)
E. coli (1)
Geobacillus stearothermophilus (1)
Hesperocyparis arizonica (1)
Juniperus ashei (1)
Expression System：
E. coli (28)
Baculovirus-Insect Cells (4)
Yeast (3)
Baculovirus (2)
in vitro E. coli expression system (2)
Tag：
N-terminal 6xHis-tagged (10)
His (7)
N-terminal 10xHis-tagged and C-terminal Myc-tagged (5)
N-terminal 6xHis-SUMO-tagged (3)
C-terminal 6xHis-tagged (2)
N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged (2)
N-terminal GST-tagged (2)
None (2)
C-6His (1)
His,GST (1)
Cat No. Product Name Species Expression System
TMPY-02483 ATP citrate lyase/ACLY Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
ATP citrate lyase, also known as Acly or Acl, is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is composed of two polymer chains which are polypeptides in human. ATP...
TMPY-03172 Argininosuccinate lyase Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
The recycling of citrulline by argininosuccinate synthase 1 (ASS1) and argininosuccinate lyase (ASL) is crucial to maintain arginine availability and nitric oxide (NO) production. Nitric oxide (NO) plays an established r...
TMPY-02552 Adenylosuccinate Lyase Protein, Human, Recombinant (His) Human E. coli
Adenylosuccinate lyase, also known as adenylosuccinase, ADSL or ASL, is an enzyme implicated in the reaction of adenylosuccinat converting to AMP and fumarate as part of the purine nucleotide cycle. The two substates of ...
TMPH-03183 Alginate lyase Protein, Pseudomonas fluorescens, Recombinant (His & Myc) Pseudomonas fluorescens E. coli
Catalyzes the depolymerization of alginate by cleaving the beta-1,4 glycosidic bond between two adjacent sugar residues via a beta-elimination mechanism. May serve to degrade mislocalized alginate that is trapped in the ...
TMPH-03739 Alginate lyase Protein, Azotobacter vinelandii, Recombinant (His & Myc & SUMO) Azotobacter vinelandii E. coli
Catalyzes the depolymerization of alginate by cleaving the beta-1,4 glycosidic bond between two adjacent sugar residues via a beta-elimination mechanism. Splits ManA-ManA and ManA-GulA bonds, but not GulA-ManA or GulA-Gu...
TMPY-03754 SCLY Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
SCLY, also known as selenocysteine lyase, belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. It is a novel enzyme that exclusively decomposes L-selenocysteine into L-alanine and H2Se in various...
TMPJ-00457 OGG1 Protein, Human, Recombinant Human E. coli
Human N-Glycosylase/DNA Lyase(OOG1) is a DNA repair enzyme, which belongs to the type-1 OGG1 family. OOG1 incises DNA at 8-oxoG residues, and excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamido...
TMPJ-00939 CTH Protein, Human, Recombinant Human E. coli
Cystathionine Gamma-Lyase (CTH) belongs to the trans-sulfuration enzymes family. CTH exists as a homotetramer and interacts with CALM in a calcium-dependent manner. CTH breaks down cystathionine into cysteine, ammonia an...
TMPH-00767 Gellan lyase Protein, Geobacillus stearothermophilus, Recombinant (His) Geobacillus stearothermophilus E. coli
Cleaves the glycosidic bonds of gellan backbone and releases tetrasaccharide units of glucuronyl-glucosyl-rhamnosyl-glucose with unsaturated glucuronic acid at the non-reducing terminal. The enzyme is highly specific to ...
TMPH-01601 Lactoylglutathione lyase/GLO1 Protein, Human, Recombinant (GST) Human E. coli
Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B. Required for normal osteocl...
TMPH-00048 Pectate lyase 1 Protein, Ambrosia artemisiifolia, Recombinant (His) Ambrosia artemisiifolia E. coli
Has pectate lyase activity.
TMPH-00049 Pectate lyase 5 Protein, Ambrosia artemisiifolia, Recombinant (His) Ambrosia artemisiifolia Yeast
Has pectate lyase activity.
TMPH-02367 Pectate lyase 1 Protein, Juniperus ashei, Recombinant (His) Juniperus ashei Yeast
Has low pectate lyase activity.
TMPJ-01147 Cld Protein, Dechloromonas aromatica, Recombinant (His) Dechloromonas aromatica E. coli
Chlorite dismutase (Cld) found in prokaryotic organisms, also known as Chlorite O2-lyase, is a b-type heme containing enzyme that catalyzes the reduction of chlorite into chloride plus dioxygen. The subunit of chlorite d...
TMPH-03614 DNA photolyase Protein, Synechococcus sp., Recombinant (His & Myc & SUMO) Synechococcus sp. E. coli
DNA photolyase Protein, Synechococcus sp., Recombinant (His & Myc & SUMO) is expressed in E. coli.
TMPH-00050 Pectate lyase 5 Protein, Ambrosia artemisiifolia, Recombinant (His & SUMO) Ambrosia artemisiifolia E. coli
Has pectate lyase activity.
TMPH-00364 Pectate lyase 1 Protein, Chamaecyparis obtusa, Recombinant (His & SUMO) Chamaecyparis obtusa E. coli
Has pectate lyase activity.
TMPH-00817 Pectate lyase 1 Protein, Hesperocyparis arizonica, Recombinant (His & Myc) Hesperocyparis arizonica E. coli
Has pectate lyase activity.
TMPH-00574 Adenylate cyclase Protein, E. coli, Recombinant (His) E. coli in vitro E. coli expression system
Catalyzes the formation of the second messenger cAMP from ATP. Its transcript is probably degraded by endoribonuclease LS (rnlA), decreasing cAMP levels and the negative regulator Crp-cAMP, which then induces its own tra...
TMPH-03052 EnoA Protein, Neosartorya fumigata, Recombinant (His) Neosartorya fumigata E. coli
EnoA Protein, Neosartorya fumigata, Recombinant (His) is expressed in E. coli.
TMPH-02547 ENO3 Protein, Mouse, Recombinant (His & Myc) Mouse E. coli
Appears to have a function in striated muscle development and regeneration.
TMPH-02505 ENO1 Protein, Mouse, Recombinant (His) Mouse E. coli
Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate. In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses. May ...
TMPH-02546 ENO3 Protein, Mouse, Recombinant (His) Mouse Yeast
Appears to have a function in striated muscle development and regeneration.
TMPH-02139 CYP17A1 Protein, Human, Recombinant (GST) Human E. coli
A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen sy...
TMPH-01598 CCBL2 Protein, Human, Recombinant (His & SUMO) Human E. coli
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the thre...
TMPJ-00464 APE Protein, Human, Recombinant Human E. coli
Apurinic-Apyrimidinic Endonuclease 1 (APE1) is required for efficient DNA base excision repair. When the DNA glycosylase remove the damaged bases, APE1 cleaves the AP site to allow resynthesis and ligation to complete re...
TMPY-02287 Ku70 & Ku80 Heterodimer Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
X-ray repair cross-complementing protein 5, also known as 86 kDa subunit of Ku antigen, ATP-dependent DNA helicase 2 subunit 2, ATP-dependent DNA helicase II 8 kDa subunit, CTC box-binding factor 85 kDa subunit, DNA repa...
TMPH-01206 DDTL Protein, Human, Recombinant (His & Myc) Human E. coli
May have lyase activity.
TMPH-01774 OGG1 Protein, Human, Recombinant (His) Human E. coli
DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the ...
TMPH-00870 ILVBL Protein, Human, Recombinant (His) Human in vitro E. coli expression system
Endoplasmic reticulum 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner. Involved in the phytosphingosine degradation ...
TMPJ-00792 DNA PolymeraseBeta Protein, Human, Recombinant (His) Human E. coli
Human DNA polymerase β is constitutively expressed in cells. It fills in gaps in DNA that are formed following base excision repair. Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-p...
TMPH-02615 CBS Protein, Mouse, Recombinant (His) Mouse E. coli
Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cystei...
TMPY-01618 GLO1 Protein, Mouse, Recombinant (His) Mouse E. coli
Lactoylglutathione lyase, also known as Methylglyoxalase, Aldoketomutase, Glyoxalase I, Ketone-aldehyde mutase, S-D-lactoylglutathione methylglyoxal lyase and GLO1, is a member of the glyoxalase I family. GLO1 / Glyox...
TMPH-02315 XRCC5 Protein, Human, Recombinant (His & Myc) Human E. coli
Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a...
TMPY-02002 PHPT1 Protein, Human, Recombinant (His) Human E. coli
PHPT1, also known as 14 kDa phosphohistidine phosphatase, phosphohistidine phosphatase 1, protein janus-A homolog, PHP14, is a cytoplasm protein which belongs to the janus family. PHPT1 / PHP14 is expressed abundantly in...
TMPH-02314 XRCC5 Protein, Human, Recombinant (His & MBP) Human Baculovirus
Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a...
TMPY-02798 NEIL1 Protein, Human, Recombinant (His) Human E. coli
NEIL1 is a member of DNA glycosylases. DNA glycosylases are a family homologous to the bacterial Fpg/Nei family. They play a role in base excision repair which is the mechanism by which damaged bases in DNA are removed a...
TMPH-01237 POLQ Protein, Human, Recombinant (E. coli, His) Human E. coli
DNA polymerase that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks in DNA. MMEJ is an error-prone repair pathw...
TMPH-01238 POLQ Protein, Human, Recombinant (His) Human Baculovirus
DNA polymerase that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks in DNA. MMEJ is an error-prone repair pathw...
ATP citrate lyase/ACLY Protein, Human, Recombinant (His)
TMPY-02483
Species: Human
Expression System: Baculovirus-Insect Cells
Argininosuccinate lyase Protein, Human, Recombinant (His & GST)
TMPY-03172
Species: Human
Expression System: Baculovirus-Insect Cells
Adenylosuccinate Lyase Protein, Human, Recombinant (His)
TMPY-02552
Species: Human
Expression System: E. coli
Alginate lyase Protein, Pseudomonas fluorescens, Recombinant (His & Myc)
TMPH-03183
Species: Pseudomonas fluorescens
Expression System: E. coli
Alginate lyase Protein, Azotobacter vinelandii, Recombinant (His & Myc & SUMO)
TMPH-03739
Species: Azotobacter vinelandii
Expression System: E. coli
SCLY Protein, Human, Recombinant (His)
TMPY-03754
Species: Human
Expression System: Baculovirus-Insect Cells
OGG1 Protein, Human, Recombinant
TMPJ-00457
Species: Human
Expression System: E. coli
CTH Protein, Human, Recombinant
TMPJ-00939
Species: Human
Expression System: E. coli
Gellan lyase Protein, Geobacillus stearothermophilus, Recombinant (His)
TMPH-00767
Species: Geobacillus stearothermophilus
Expression System: E. coli
Lactoylglutathione lyase/GLO1 Protein, Human, Recombinant (GST)
TMPH-01601
Species: Human
Expression System: E. coli
Pectate lyase 1 Protein, Ambrosia artemisiifolia, Recombinant (His)
TMPH-00048
Species: Ambrosia artemisiifolia
Expression System: E. coli
Pectate lyase 5 Protein, Ambrosia artemisiifolia, Recombinant (His)
TMPH-00049
Species: Ambrosia artemisiifolia
Expression System: Yeast
Pectate lyase 1 Protein, Juniperus ashei, Recombinant (His)
TMPH-02367
Species: Juniperus ashei
Expression System: Yeast
Cld Protein, Dechloromonas aromatica, Recombinant (His)
TMPJ-01147
Species: Dechloromonas aromatica
Expression System: E. coli
DNA photolyase Protein, Synechococcus sp., Recombinant (His & Myc & SUMO)
TMPH-03614
Species: Synechococcus sp.
Expression System: E. coli
Pectate lyase 5 Protein, Ambrosia artemisiifolia, Recombinant (His & SUMO)
TMPH-00050
Species: Ambrosia artemisiifolia
Expression System: E. coli
Pectate lyase 1 Protein, Chamaecyparis obtusa, Recombinant (His & SUMO)
TMPH-00364
Species: Chamaecyparis obtusa
Expression System: E. coli
Pectate lyase 1 Protein, Hesperocyparis arizonica, Recombinant (His & Myc)
TMPH-00817
Species: Hesperocyparis arizonica
Expression System: E. coli
Adenylate cyclase Protein, E. coli, Recombinant (His)
TMPH-00574
Species: E. coli
Expression System: in vitro E. coli expression system
EnoA Protein, Neosartorya fumigata, Recombinant (His)
TMPH-03052
Species: Neosartorya fumigata
Expression System: E. coli
ENO3 Protein, Mouse, Recombinant (His & Myc)
TMPH-02547
Species: Mouse
Expression System: E. coli
ENO1 Protein, Mouse, Recombinant (His)
TMPH-02505
Species: Mouse
Expression System: E. coli
ENO3 Protein, Mouse, Recombinant (His)
TMPH-02546
Species: Mouse
Expression System: Yeast
CYP17A1 Protein, Human, Recombinant (GST)
TMPH-02139
Species: Human
Expression System: E. coli
CCBL2 Protein, Human, Recombinant (His & SUMO)
TMPH-01598
Species: Human
Expression System: E. coli
APE Protein, Human, Recombinant
TMPJ-00464
Species: Human
Expression System: E. coli
Ku70 & Ku80 Heterodimer Protein, Human, Recombinant (His)
TMPY-02287
Species: Human
Expression System: Baculovirus-Insect Cells
DDTL Protein, Human, Recombinant (His & Myc)
TMPH-01206
Species: Human
Expression System: E. coli
OGG1 Protein, Human, Recombinant (His)
TMPH-01774
Species: Human
Expression System: E. coli
ILVBL Protein, Human, Recombinant (His)
TMPH-00870
Species: Human
Expression System: in vitro E. coli expression system
DNA PolymeraseBeta Protein, Human, Recombinant (His)
TMPJ-00792
Species: Human
Expression System: E. coli
CBS Protein, Mouse, Recombinant (His)
TMPH-02615
Species: Mouse
Expression System: E. coli
GLO1 Protein, Mouse, Recombinant (His)
TMPY-01618
Species: Mouse
Expression System: E. coli
XRCC5 Protein, Human, Recombinant (His & Myc)
TMPH-02315
Species: Human
Expression System: E. coli
PHPT1 Protein, Human, Recombinant (His)
TMPY-02002
Species: Human
Expression System: E. coli
XRCC5 Protein, Human, Recombinant (His & MBP)
TMPH-02314
Species: Human
Expression System: Baculovirus
NEIL1 Protein, Human, Recombinant (His)
TMPY-02798
Species: Human
Expression System: E. coli
POLQ Protein, Human, Recombinant (E. coli, His)
TMPH-01237
Species: Human
Expression System: E. coli
POLQ Protein, Human, Recombinant (His)
TMPH-01238
Species: Human
Expression System: Baculovirus
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