Lysyl-serine is a bioactive chemical.

Lysyl threonine is a dipeptide composed of lysine and threonine. It is an incomplete breakdown product of protein digestion or protein catabolism.

Lysyl ornithine monohydrochloride is a bioactive chemical.

Lysyllysyllysine is a cationic moiety. It may be used in the construction of gene delivery vectors and DNA nanoparticles.

Lysyl-alanyl-alanine is a bioactive chemical.

Lysyl Hydroxylase 2-IN-1 (compound 12) is a selective inhibitor of lysyl hydroxylase 2 (LH2) with an IC50 of approximately 300 nM and demonstrates specificity for LH2 over LH1 and LH3 [1].

L-Lysyl-L-lysine dihydrochloride (Lysyllysine dihydrochloride) is an enzyme cleavable linker. L-Lysyl-L-lysine dihydrochloride can be used as facile linker for delivering multiple biologically active peptides.

o-Nitrophenylsulfenyl-lysyl-tryptophan is a bioactive chemical.

Lysyl-tyrosyl-serine acetate is a bioactive chemical.

L-Threonyl-L-lysyl-L-prolyl-L-arginyl-L-prolylglycyl-L-proline acetate is a useful organic compound for research related to life sciences and the catalog number is T64693.

Methionyl-Lysyl-Bradykinin (Met-Lys-Bradykinin), a Bradykinin analogue, is a kinin [1] [2] .

L-Lysyl-L-lysinamide is a bioactive chemical.

Lysyl-aspartyl-glutamyl-leucine maintains type II surface membrane proteins in the endoplasmic reticulum.

Lysylcysteine is a dipeptide composed of lysine and cysteine. It is an incomplete breakdown product of protein digestion or protein catabolism. Some dipeptides are known to have physiological or cell-signaling effects although most are simply short-lived

Lysyl-histidyl-phenylalanyl-arginyl-tryptophyl-glycinamide is an ACTH fragment; cyclic analog evoked excessive grooming behavior in rabbits when administered intracerebroventricularly.

O-tert-Butyl lysyl-tryptophyl-glycyl-lysinate is a bioactive chemical.

Lysyl ornithine is a bioactive chemical.

Lysyl-alanyl-beta-naphthylamide is a bioactive chemical.

Lysyl-tyrosyl-lysine is a bioactive chemical.

Lysyl Hydroxylase 2-IN-2 (compound 13) is a potent inhibitor of Lysyl Hydroxylase 2 (LH2), exhibiting an IC50 of approximately 500 nM. It effectively inhibits cell migration in 344SQ WT cells without affecting the migration of LH2 knockout cells [1].

Lysyl-5-fluorotryptophyl-lysine is a bioactive chemical.

Seryl-lysyl-leucine is a bioactive chemical.

Lysyl aspartyl isoleucine (Tripeptide-10) is a bioactive peptide with anti-wrinkle effects and has been reported as a cosmetic ingredient.

Lysyl-phenylalanyl-lysine is a bioactive chemical.

Lysyl-prolyl-glycyl-glutamyl-prolyl-glycyl-prolyl-lysine is a bioactive chemical.

Lysyl-prolyl-isoleucyl-glutamyl-phenylalanyl-4-nitrophenylalanyl-arginyl-leucine is a bioactive chemical.

NNK (Nicotine-derived nitrosamine ketone) is a procarcinogen and a major tobacco-specific toxicant. It inhibits the expression of lysyl oxidase which is a tumor suppressor.

Lysylproline Third & fourth amino acid in substance P sequence.

L-Lysylpradimicin A is a bioactive chemical.

Lysyllysine is a dipeptide composed of two lysine residues. It is an incomplete breakdown product of protein digestion or protein catabolism. Some dipeptides are known to have physiological or cell-signaling effects although most are simply short-lived in

N-Acetyl lysyltyrosylcysteine amide acetate is an effective and selective tripeptide inhibitor of myeloperoxidase (MPO). N-Acetyl lysyltyrosylcysteine amide acetate inhibits MPO-dependent hypochlorous acid (HOCl) generation, protein nitration, and LDL ox

N-Acetyl lysyltyrosylcysteine amide is a non-toxic myeloperoxidase (MPO) tripeptide inhibitor that is potent, reversible, and specific.N-Acetyl lysyltyrosylcysteine amide effectively inhibits MPO production in vivo. N-Acetyl lysyltyrosylcysteine amide attenuates neuronal damage and preserves brain tissue and neurological function in the post-stroke brain.N-Acetyl lysyltyrosylcysteine amide inhibits MPO-dependent hypochlorite (HOCl) production, protein nitration and LDL oxidation.N-Acetyl lysyltyrosylcysteine amide is a potent, reversible, and specific agent. N-Acetyl lysyltyrosylcysteine amide is used in the study of bronchial dysplasia.

PXS-5153A is an effective, selective, and fast-acting inhibitor of lysyl oxidase like 2/3 enzymes with enzymatic activity almost entirely blocked within 15 minutes. PXS-5153A could reduce crosslinks and ameliorates fibrosis.

Lenumlostat is an orally available, selective and potent lysyl oxidase-like protein 2 (LOXL2) inhibitor with inhibitory effects on hLOXL2, hLOXL3 and LOXL2 for the study of fibrotic diseases.

CCT365623 is an orally bioavailable Lysyl Oxidase inhibitor with good anti-LOX potency, selectivity, pharmacokinetic properties, as well as anti-metastatic efficacy.

LysRs-IN-1 is an inhibitor of Lysyl-tRNA synthetase (LysRs).

7-Lysylalanyl-4-methylcoumarinamide is a Fluorogenic substrate for dipeptidyl aminopeptidase.

Lysylphenylalanine is a cell sickling and a gelatin inhibitor of hemoglobin S.

Lysyllysyllysine acetate is a bioactive chemical.

Lysylglutamic acid dihydrate is a bioactive chemical.

Dehydrolysylnorleucine is a bioactive chemical.

Lysylphosphatidylglycerol is glycerol with two fatty acids plus a lysine-glycerol-phosphate, a major membrane phospholipid of Staphylococcus and the lysine positive charge repels DEFENSINS.

β-Aminopropionitrile (3-Aminopropionitrile) is a selective inhibitor of lysyl oxidase.

Jump to search UTS2 Identifiers Aliases UTS2, PRO1068, U-II, UCN2, UII, urotensin 2 External IDs OMIM: 604097 MGI: 1346329 HomoloGene: 4939 GeneCards: UTS2 hide Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.23 Start 7,843,083 bp[1] En

Simtuzumab is a monoclonal antibody against lysyl oxidase-like protein 2 (LOXL2). Simtuzumab can be used to treat primary sclerosing cholangitis (PSC) and is not effective in patients with bridging fibrosis or compensatory cirrhosis caused by non-alcoholic steatohepatitis.

Sirtuins (SIRTs) represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs). Human SIRT1 is the homolog of yeast silent information regulator 2 (Sir2) and has been shown to regulate the activity of the p53 tumor suppressor and inhibit apoptosis. Small molecule activators of SIRT1, such as resveratrol, extend lifespan in yeast and C. elegans in a manner that resembles caloric restriction. CAY10591 has been identified as an activator of the enzyme SIRT1. This compound increases fluorescence by 233% in a SIRT1 activity assay. [Activator activity was defined as the percentage of signal increase relative to signal window in the following formula: 100 x (Sample - Signallow)/(Signalhigh - Signallow)]. CAY10591 suppresses TNF-α in a dose-dependent manner. In THP-1 cells, TNF-α levels decreased from 325 pg/ml (control) to 104 and 53 pg/ml with 20 and 60 µM CAY10591, respectively. This activator also has a significant dose-dependent effect on fat mobilization in differentiated adipocytes, which would indicate the potential of SIRT1 activators for anti-obesity or anti-diabetic purposes.

PXS-5153A monohydrochloride is a potent, selective, orally active and fast-acting lysyl oxidase like 2/3 enzymatic (LOXL2/LOXL3) inhibitor, with an IC 50 of <40 nM for LOXL2 across all mammalian species and an IC 50 of 63 nM for human LOXL3. PXS-5153A monohydrochloride dose-dependently reduced LOXL2-mediated collagen oxidation and collagen crosslinking in vitro which may represent an innovative therapeutic approach for the treatment of fibrosis

PAT-1251 Hydrochloride is a potent, selective and oral inhibitor of lysyl oxidase-like 2 (LOXL2)(hLOXL2 and hLOXL3 with IC50s of 0.71 and 1.17 μM , respectively),

PXS-6302 is an irreversible inhibitor of lysyl oxidase with IC50s of 3.7 μM for Bovine LOX, 3.4 μM for rh LOXL1, 0.4 μM for rh LOXL2, 1.5 μM for rh LOXL3, 0.3 μM for rh LOXL4, respectively. PXS-6302 can readily penetrate the skin, reduces collagen deposition and cross-linking, and significantly improves scar appearance without reducing tissue strength. PXS-6302 also has potentially broader applications in other fibrotic diseases.

PXS-5120A is an irreversible fluoroallylamine Lysyl Oxidase-like 2/3 (LOXL2/3) inhibitor with anti-fibrotic activity.