Enbucrilate (Butyl cyanoacrylate) is a cyanoacrylate ester that has been used as surgical tissue adhesive. Enbucrilate is a tissue adhesive, forming polymer films at oil-water interfaces and revealing films of diverse morphology.

Siramesine (Lu 28-179)(Lu 28-179) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of cancer cells and to exhibit a potent anticancer activity in vivo.lysosome-destabilizing agent siramesine can induce rapid cell death in a number of cell lines at concentrations above 20 μM. In HaCaT cells, cell death was accompanied by caspase activation, rapid loss of mitochondrial membrane potential (MMP), cytochrome c release, cardiolipin peroxidation and typical apoptotic morphology, whereas in U-87MG cells most apoptotic hallmarks were not notable, although MMP was rapidly lost

Rocaglaol is a potent anticancer drug that induces apoptosis of LNCaP cells through the mitochondrial pathway and its G2/M-phase cell cycle arrest is associated with the down-regulation of Cdc25C and the dephosphorylation of Cdc2. Rocaglaol can reduce tis

NEP(1-40) TFA is a peptide antagonist of the Nogo-66 receptor (NgR), which mitigates the shift in microglial morphology distributions due to injury by attenuating myelin-derived inhibition [1].

KGP591, a tubulin polymerization inhibitor with an IC50 of 0.57 µM, effectively induces G2/M arrest, inhibits cell migration, and disrupts microtubule structure and cell morphology in MDA-MB-231 cells. Additionally, it demonstrates antitumor activity in an orthotopic kidney cancer model (RENCA) [1].

AGN 193109 is a potent antagonist of retinoic acid receptors (RARs; Kd= 2, 2, and 3 nM for RARα, β, and γ, respectively), exhibiting selectivity for RARs over retinoid X receptors (RXRs; Kd= >10,000 nM for human RXRα, β, and γ receptors). This compound effectively reverses cellular morphology changes and growth suppression induced by RAR agonists such as all-trans-RA, 13-cis-RA, and 9-cis-RA in ECE16-1 human endometrial ectocervical epithelial cells, particularly when used at a 10-fold molar excess. Furthermore, AGN 193109 downregulates the expression of cytokeratin K5-8, 13, 14, 16, 17, and 19 genes, indicating inhibition of retinoid action, specifically when co-administered with TTNPB but not as a standalone treatment. In vivo studies demonstrate teratogenic effects, including cleft palate, frontonasal dysplasia, and eye malformations in mouse fetuses following a single oral dose of 1 mg/kg.

LtaS-IN-1 is an effective inhibitor of Lipoteichoic acid synthesis in multidrug-resistant (MDR) E. faecium and by altering the cell wall morphology. LtaS-IN-1 is against Enterococcus spp 28 strains with varying MIC values ranging from 0.5 μg/mL to 64 μg/mL. LtaS-IN-1 inhibits strain E1630 and E1590 with MIC values of 0.5 μg/mL.

BDS-I, a marine toxin derived from Anemonia sulcata, functions as a selective inhibitor of the potassium channel, specifically targeting Kv3.4. It impedes the Aβ1-42-induced augmentation of Kv3.4 activity, caspase-3 activation, and distortion of nuclear morphology in NGF-differentiated PC-12 cells. Moreover, BDS-I effectively counteracts the cell death induced by the Aβ peptide [1].

RAD16-I hydrochloride is a self-assembling peptide with nanofibrous morphology that provides an optimal microenvironment for the proliferation and differentiation of human mesenchymal stem cells (hMSC) into chondrocytes. This peptide, known as RAD16-I, has been extensively studied and serves as a model to assess the amyloid-like staining properties of self-assembling peptide nanofibers (SAPNFs).

PI3K/Akt/CREB Activator 1 is a potent, orally active compound that acts as an activator for the PI3K/Akt/CREB pathway. It enhances neuronal proliferation, induces differentiation of Neuro-2a cells into neuron-like morphology, and accelerates axon-dendrite polarization in primary hippocampal neurons by upregulating brain-derived neurotrophic factor. This compound is utilized in vascular dementia (VaD) research.

Solidagonic acid, by inhibiting HSET motor activity, promotes the conversion of abnormal monopolar spindles to bipolar configurations, effectively suppressing fission yeast cell death and facilitating the mitotic spindles' reversion from monopolar to bipolar morphology. Additionally, this compound demonstrates growth inhibitory effects on the seedlings of Lactuca sativa L. and Lolium multiflorum Lam [1] [2].

YW3-56 is a potent peptidylarginine deiminase (PAD) inhibitor, with an IC50 of 1-5 μM for PAD4. Compared with Cl-amidine, YW3-56 shows >60-fold increase in cell growth inhibition efficacy (IC50 about 2.5 μM) but only 5-fold increase in PAD4 inhibition (IC sub>50 about 1-5 μM). At 2-4 μM concentrations, YW3-56 displays mainly cytostatic effects by slowing cell division, whereas at higher concentrations, it exerts cytotoxic effects by altering cell morphology and killing cells[1]. [1]. Wang Y, et al. Anticancer peptidylarginine deiminase (PAD) inhibitors regulate the autophagy flux and t he mammalian target of rapamycin complex 1 activity. J Biol Chem. 2012 Jul 27;287(31):25941-53.

SMAP-29 is a broad spectrum antibacterial and antifungal α-helical cathelicidin-derived peptide with strong potential as an antiinfective agent. It effectively permeabilizes bacterial membranes and induces significant alterations in the surface morphology of susceptible microorganisms.

AGK7 is an inactive control of AGK2, a selective SIRT2 inhibitor that selectively inhibits SIRT3 over SIRT1 and SIRT2 (IC50 = >5 μM, >50 μM and >50 μM for SIRT3, SIRT1, and SIRT2, respectively).

Batabulin (T138067) is an antitumor compound, which binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. Batabulin affects cell morphology and leads to cell-cycle arrest ultimately induce apoptotic cell death.

Laccase-IN-1 (compound 4b) is an orally active laccase inhibitor, demonstrating an IC50 of 11.3 μM. It exhibits both protective and curative effects against B. dothidea infections in apple fruits. The compound increases cell membrane permeability, disrupts mycelial surface morphology, alters cell ultrastructure, and decreases the ergosterol and exopolysaccharide levels in B. dothidea [1].

Antitumor agent-38 is a highly effective antitumor compound that exhibits antiproliferative activity towards cancer cells. It induces cell cycle arrest specifically at the late S and G2/M phase, while not impeding microtubule formation or altering cell morphology [1].

Dihydrocytochalasin B (H2CB) is a cell division inhibitor that changes the morphology of cells, similar to cytochalasin B. Does not inhibit glucose transport. Dihydrocytochalasin B (H2CB) disrupts the structure of actin and inhibits the ability of growth

Batabulin sodium (T138067 sodium) is an antitumor agent, which covalently and selectively modifies the β-tubulin isotypes, thereby disrupting microtubule polymerization. Batabulin sodium affects cell morphology and leads to cell-cycle arrest ultimately induces apoptotic cell death [1].

Ingenol 3,20-dibenzoate is a powerful activator of protein kinase C (PKC) isoforms. It effectively induces the translocation of nPKC-delta, -epsilon, and -theta as well as PKC-mu from the cytosolic fraction to the particulate fraction. Through de novo synthesis of macromolecules, it triggers apoptosis with characteristic morphology. Moreover, Ingenol 3,20-dibenzoate enhances IFN-γ production and degranulation in NK cells, particularly when stimulated by NSCLC cells[1][2].

AChE-IN-10 (Compound 24r) is a potent inhibitor of AChE with an IC50 value of 2.4 nM. AChE-IN-10 decreases amyloid aggregation in the presence of AChE. AChE-IN-10 exhibited a potent inhibitory effect on AChE, reducing tau phosphorylation of S396 residues, rescuing neuronal morphology and increasing cell viability, thereby providing neuroprotection.

RO314724 is a HDAC inhibitor. RO314724 is also a a reversible, tightly binding, MMP inhibitor with a Ki of 26 nm. Matrix metalloproteinases (MMPs) belong to the key enzymes of the proteolytic destruction of cartilage matrix during chronic rheumatic diseases. Ro314724 displayed MMP-proteoglycanase inhibitory activity both in vitro and ex vivo and proved to be not harmful to the morphology, viability and proteoglycan biosynthesis of bovine articular cartilage explants.

1-Naphthaleneacetic acid potassium salt (1-NAA Potassium Salt) is used as a plant Growth Regulator that affects conidial germination, sporulation, mycelial growth, cell surface morphology, and the viability of certain fungal plant pathogens.

Exo2 is a secretion inhibitor that hinders the trafficking of Shiga toxin from endosomes to the trans-Golgi network. It inhibits the exit of secretory cargo from the endoplasmic reticulum (ER) and disrupts the Golgi apparatus. Notably, Exo2 does not impact the morphology of the trans-Golgi network (TGN). Additionally, Exo2 has the ability to induce calcium-dependent exocytosis in permeabilized adrenal chromaffin cells [1] [2].