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Adenylyl cyclase

Adenylyl cyclase (also commonly known as adenyl cyclase and adenylate cyclase, abbreviated AC) is an enzyme with key regulatory roles in essentially all cells. It is the most polyphyletic known enzyme: six distinct classes have been described, all catalyzing the same reaction but representing unrelated gene families with no known sequence or structural homology. The best known class of adenylyl cyclases is class III or AC-III (Roman numerals are used for classes). AC-III occurs widely in eukaryotes and has important roles in many human tissues. All classes of adenylyl cyclase catalyse the conversion of adenosine triphosphate (ATP) to 3',5'-cyclic AMP (cAMP) and pyrophosphate. Magnesium ions are generally required and appear to be closely involved in the enzymatic mechanism. The cAMP produced by AC then serves as a regulatory signal via specific cAMP-binding proteins, either transcription factors, enzymes (e.g., cAMP-dependent kinases), or ion transporters.

Cat. No.	Product name	CAS No.	Purity
T60003	AC1-IN-1	2762422-55-7	98%
T60003	AC1-IN-1 is a selective inhibitor of adenylyl cyclase type 1 (AC1, IC50 = 0.54 µM).
T16938	ST034307	133406-29-8	98%
T16938	ST034307 is an effective and selective inhibitor of adenylyl cyclase 1 (IC50: 2.3 μM).
T16333	NKY80	299442-43-6	100%
T16333	NKY80 regulates the adenylyl cyclase catalytic activity in heart and lung tissues. NKY80 is a non-competitive inhibitor of adenylyl cyclase type V isoform (IC50...
T7813	α-MSH	581-05-5	100%
T7813	α-MSH is amide stimulates melanocortin 1 receptor that results in the activation of adenylyl cyclase.
T15787	LRE1	1252362-53-0	100%
T15787	LRE1 is a specific and allosteric soluble adenylyl cyclase inhibitor.
T16275	NB001	686301-48-4	98.43%
T16275	NB001 is an inhibitor of adenyl cyclase 1 exhibiting effects on neural and non-neural pain.
T10066	2',5'-Dideoxyadenosine	6698-26-6	98.66%
T10066	2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor via binding the P-site (IC50: 3 µM).
T2939	Forskolin	66575-29-9	99.86%
T2939	Forskolin, a potent activator of the adenylate cyclase (EC50: 0.5 μM), can increase the cAMP level. It is extracted from the plant Coleus forskohlii.