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Adenylyl cyclase

Adenylyl cyclase (also commonly known as adenyl cyclase and adenylate cyclase, abbreviated AC) is an enzyme with key regulatory roles in essentially all cells. It is the most polyphyletic known enzyme: six distinct classes have been described, all catalyzing the same reaction but representing unrelated gene families with no known sequence or structural homology. The best known class of adenylyl cyclases is class III or AC-III (Roman numerals are used for classes). AC-III occurs widely in eukaryotes and has important roles in many human tissues. All classes of adenylyl cyclase catalyse the conversion of adenosine triphosphate (ATP) to 3',5'-cyclic AMP (cAMP) and pyrophosphate. Magnesium ions are generally required and appear to be closely involved in the enzymatic mechanism. The cAMP produced by AC then serves as a regulatory signal via specific cAMP-binding proteins, either transcription factors, enzymes (e.g., cAMP-dependent kinases), or ion transporters.
Cat No. product name
T2939 Forskolin Forskolin, a potent activator of the adenylate cyclase (EC50: 0.5 μM), can increase the cAMP level. It is extracted from the plant Coleus forskohlii.
T7813 α-MSH α-MSH is amide stimulates melanocortin 1 receptor that results in the activation of adenylyl cyclase.
T10066 2',5'-Dideoxyadenosine 2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor via binding the P-site (IC50: 3 µM).
T16938 ST034307 ST034307 is an effective and selective inhibitor of adenylyl cyclase 1 (IC50: 2.3 μM).
Forskolin
T2939
Forskolin, a potent activator of the adenylate cyclase (EC50: 0.5 μM), can increase the cAMP level. It is extracted from the plant Coleus forskohlii.
α-MSH
T7813
α-MSH is amide stimulates melanocortin 1 receptor that results in the activation of adenylyl cyclase.
2',5'-Dideoxyadenosine
T10066
2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor via binding the P-site (IC50: 3 µM).
ST034307
T16938
ST034307 is an effective and selective inhibitor of adenylyl cyclase 1 (IC50: 2.3 μM).