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Aminopeptidase

Aminopeptidases are enzymes that catalyze the cleavage of amino acids from the amino terminus (N-terminus) of proteins or peptides (exopeptidases).They are widely distributed throughout the animal and plant kingdoms and are found in many subcellular organelles, in cytosol, and as membrane components. Aminopeptidases are used in essential cellular functions. Many, but not all, of these peptidases are zinc metalloenzymes.Some aminopeptidases are monomeric, and others are assemblies of relatively high mass (50 kDa) subunits. cDNA sequences are available for several aminopeptidases and a crystal structure of the open state of human endoplasmic reticulum Aminopeptidase 1 ERAP1 is presented here. Amino acid sequences determined directly or deduced from cDNAs indicate some amino acid sequence homologies in organisms as diverse as Escherichia coli and mammals, particularly in catalytically important residues or in residues involved in metal ion binding.
Cat No. product name
T7958 Methyl arachidate Methyl Icosanoate is an esterified form of arachidic acid
T2830 Betulinic acid Betulinic acid is a pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba, the common white birch) which has antiretrov...
T6301 Tosedostat CHR-2797 is an orally bioavailable inhibitor of the M1 family of aminopeptidases with potential antineoplastic activity. CHR-2797 is converted intracellularly in...
T28482 Firibastat QGC-001 is a glutamyl aminopeptidase antagonist.
T16684 Puromycin aminonucleoside Puromycin aminonucleoside increases podocyte permeability by modulating ZO-1 in an oxidative stress-dependent manner.
T21859 ARM1 ARM1 is a potent inhibitor of aminopeptidase and epoxide hydrolase. The IC50 values are 7.61 µM for aminopeptidase and 12.4 µM for epoxide hydrolase.
T1257 Bestatin Ubenimex competitively inhibits many aminopeptidases, including B, N and leucine aminopeptidases. Ubenimex is a microbial metabolite and dipeptide with potential...
T3529 Bestatin hydrochloride Bestatin (Ubenimex) hydrochlorideis an inhibitor of aminopeptidase N (APN)/CD13 and aminopeptidase B.
T3715 Acebilustat Acebilustat (ZK322) is an effective and specific leukotriene B4 hydrolase inhibitor.
T21696 SC-57461A SC 57461A is a potent and specific leukotriene A4 hydrolase (LTA4H) inhibitor.
TQ0047 DG051 DG051 is a potent leukotriene A4 hydrolase (LTA4H) inhibitor (IC50: 47 nM).
T5652 L(+)-Leucinol L(+)-Leucinol is a potent inhibitor of leucine aminopeptidase.
T14121 Actinonin Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces and a potent reversible peptide deformylase (PDF) inhibitor with a...
Methyl arachidate
T7958
Methyl Icosanoate is an esterified form of arachidic acid
Betulinic acid
T2830
Betulinic acid is a pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba, the common white birch) which has antiretrov...
Tosedostat
T6301
CHR-2797 is an orally bioavailable inhibitor of the M1 family of aminopeptidases with potential antineoplastic activity. CHR-2797 is converted intracellularly in...
Firibastat
T28482
QGC-001 is a glutamyl aminopeptidase antagonist.
Puromycin aminonucleoside
T16684
Puromycin aminonucleoside increases podocyte permeability by modulating ZO-1 in an oxidative stress-dependent manner.
ARM1
T21859
ARM1 is a potent inhibitor of aminopeptidase and epoxide hydrolase. The IC50 values are 7.61 µM for aminopeptidase and 12.4 µM for epoxide hydrolase.
Bestatin
T1257
Ubenimex competitively inhibits many aminopeptidases, including B, N and leucine aminopeptidases. Ubenimex is a microbial metabolite and dipeptide with potential...
Bestatin hydrochloride
T3529
Bestatin (Ubenimex) hydrochlorideis an inhibitor of aminopeptidase N (APN)/CD13 and aminopeptidase B.
Acebilustat
T3715
Acebilustat (ZK322) is an effective and specific leukotriene B4 hydrolase inhibitor.
SC-57461A
T21696
SC 57461A is a potent and specific leukotriene A4 hydrolase (LTA4H) inhibitor.
DG051
TQ0047
DG051 is a potent leukotriene A4 hydrolase (LTA4H) inhibitor (IC50: 47 nM).
L(+)-Leucinol
T5652
L(+)-Leucinol is a potent inhibitor of leucine aminopeptidase.
Actinonin
T14121
Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces and a potent reversible peptide deformylase (PDF) inhibitor with a...