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Antifolate

Antifolates are a class of antimetabolite medications that antagonise (that is, block) the actions of folic acid (vitamin B9). Folic acid's primary function in the body is as a cofactor to various methyltransferases involved in serine, methionine, thymidine and purine biosynthesis. Consequently, antifolates inhibit cell division, DNA/RNA synthesis and repair and protein synthesis. Some such as proguanil, pyrimethamine and trimethoprim selectively inhibit folate's actions in microbial organisms such as bacteria, protozoa and fungi. The majority of antifolates work by inhibiting dihydrofolate reductase (DHFR).
Cat. No. Product name CAS No. Purity Chemical Structure
T17257 WR99210 47326-86-3 98%
WR99210 is a potent, orally available and less toxic dihydrofolate reductase (DHFR) inhibitor (IC50<0.075 nM). WR99210 has good antiparasitic activity against P....
T0189L Pemetrexed disodium 150399-23-8 98%
Pemetrexed is a parenterally administered folate antagonist and antineoplastic agent, used in the treatment of non-small cell lung cancer and malignant mesotheli...
T1153 Trimethoprim 738-70-5 98%
Trimethoprim is a Dihydrofolate Reductase Inhibitor Antibacterial. The mechanism of action of trimethoprim is as a Dihydrofolate Reductase Inhibitor, and Cytochr...
T8003 Methotrexate disodium 7413-34-5 98%
Methotrexate disodium is an tetrahydrofolate dehydrogenase inhibitor
T1485 Methotrexate 59-05-2 98%
Methotrexate is a folate analog metabolic inhibitor with immunosuppressant and antineoplastic properties.
T0148 Folinic acid calcium 1492-18-8 98%
Leucovorin calcium is the active metabolite of folic acid. Leucovorin is used principally as an antidote to folic acid antagonists.
T2204 Diaveridine 5355-16-8 98%
Diaveridine (DVD) is a popular antibacterial synergist that is widely used in combination with sulfonamide. It has been reported to be genotoxic to mammalian cel...
T6226 Pemetrexed disodium hemipenta hydrate 357166-30-4 98%
Pemetrexed Disodium Hydrate is a new-type antifolate and antimetabolite for TS, DHFR, and GARFT. The Ki of Pemetrexed Disodium Hydrate for TS, DHFR and GARFT is ...
T8548 Metoprine 7761-45-7 98%
Metoprine is a potent inhibitor of histamine N-methyltransferase (HMT), with potential antineoplastic activity.
T6431 Levoleucovorin Calcium 80433-71-2 98%
Calcium Levofolinate, a calcium salt of the folinic acid, is used in cancer chemotherapy as an adjuvant.
T4382 Proguanil hydrochloride 637-32-1 98%
Proguanil Hydrochloride is a biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.Upon hydrolysis, proguanil is converted ...
T7730 Aminopterin 54-62-6 98%
Aminopterin is a synthetic folic acid derivative whose metabolite is a competitive inhibitor of dihydrofolate reductase
T7593 Levomefolate calcium 151533-22-1 98%
Levomefolate calcium is an artificial form of folate. It is a coenzymated form of folic acid and a more bioavailable alternative in dietary supplements.
T16045 Methotrexate metabolite 19741-14-1 98%
Methotrexate metabolite (DAMPA) is the active metabolite of Methotrexate. Methotrexate is a folic acid antagonist. Methotrexate is used as a chemotherapeutic age...
T0148L Folinic Acid Calcium Salt Pentahydrate 6035-45-6 98%
Folinic Acid, a reduced folic acid, is used in combination with other chemotherapeutics.
T0189 Pemetrexed 137281-23-3 98%
Pemetrexed, a guanine-derived antineoplastic agent, binds to and inhibits the enzyme thymidylate synthase (TS).
T7598 Calcium N5-methyltetrahydrofolate 26560-38-3 98%
Calcium N5-methyltetrahydrofolate is the calcium salt of levomefolic acid, which has been proposed for treatment of cardiovascular disease and advanced cancers s...
T6120 Pralatrexate 146464-95-1 98%
Pralatrexate is a folate analogue inhibitor of dihydrofolate reductase (DHFR) exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic a...
T0849 Pyrimethamine 58-14-0 98%
Pyrimethamine is a competitive inhibitor of dihydrofolate reductase (DHFR), used as an antimalarial drug.
WR99210
T17257
WR99210 is a potent, orally available and less toxic dihydrofolate reductase (DHFR) inhibitor (IC50<0.075 nM). WR99210 has good antiparasitic activity against P....
Pemetrexed disodium
T0189L
Pemetrexed is a parenterally administered folate antagonist and antineoplastic agent, used in the treatment of non-small cell lung cancer and malignant mesotheli...
Trimethoprim
T1153
Trimethoprim is a Dihydrofolate Reductase Inhibitor Antibacterial. The mechanism of action of trimethoprim is as a Dihydrofolate Reductase Inhibitor, and Cytochr...
Methotrexate disodium
T8003
Methotrexate disodium is an tetrahydrofolate dehydrogenase inhibitor
Methotrexate
T1485
Methotrexate is a folate analog metabolic inhibitor with immunosuppressant and antineoplastic properties.
Folinic acid calcium
T0148
Leucovorin calcium is the active metabolite of folic acid. Leucovorin is used principally as an antidote to folic acid antagonists.
Diaveridine
T2204
Diaveridine (DVD) is a popular antibacterial synergist that is widely used in combination with sulfonamide. It has been reported to be genotoxic to mammalian cel...
Pemetrexed disodium hemipenta hydrate
T6226
Pemetrexed Disodium Hydrate is a new-type antifolate and antimetabolite for TS, DHFR, and GARFT. The Ki of Pemetrexed Disodium Hydrate for TS, DHFR and GARFT is ...
Metoprine
T8548
Metoprine is a potent inhibitor of histamine N-methyltransferase (HMT), with potential antineoplastic activity.
Levoleucovorin Calcium
T6431
Calcium Levofolinate, a calcium salt of the folinic acid, is used in cancer chemotherapy as an adjuvant.
Proguanil hydrochloride
T4382
Proguanil Hydrochloride is a biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.Upon hydrolysis, proguanil is converted ...
Aminopterin
T7730
Aminopterin is a synthetic folic acid derivative whose metabolite is a competitive inhibitor of dihydrofolate reductase
Levomefolate calcium
T7593
Levomefolate calcium is an artificial form of folate. It is a coenzymated form of folic acid and a more bioavailable alternative in dietary supplements.
Methotrexate metabolite
T16045
Methotrexate metabolite (DAMPA) is the active metabolite of Methotrexate. Methotrexate is a folic acid antagonist. Methotrexate is used as a chemotherapeutic age...
Folinic Acid Calcium Salt Pentahydrate
T0148L
Folinic Acid, a reduced folic acid, is used in combination with other chemotherapeutics.
Pemetrexed
T0189
Pemetrexed, a guanine-derived antineoplastic agent, binds to and inhibits the enzyme thymidylate synthase (TS).
Calcium N5-methyltetrahydrofolate
T7598
Calcium N5-methyltetrahydrofolate is the calcium salt of levomefolic acid, which has been proposed for treatment of cardiovascular disease and advanced cancers s...
Pralatrexate
T6120
Pralatrexate is a folate analogue inhibitor of dihydrofolate reductase (DHFR) exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic a...
Pyrimethamine
T0849
Pyrimethamine is a competitive inhibitor of dihydrofolate reductase (DHFR), used as an antimalarial drug.