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CGRP Receptor

CGRP receptor is found in myelinated A-fibers axon which is required for ligand specificity and function of the receptor. The CGRP receptor has three subunits: receptor activity-modifying protein 1 (RAMP1), calcitonin-like receptor (CLR) and receptor component protein (RCP).[17] The complex central receptor is the G protein-coupled receptor calcitonin receptor-like receptor (CALCRL) which is necessary for CGRP and adrenomedullin (AM receptors). For function CGRP, CALCRL must coincide with RAMP1 where the ligand-binding domain of CGRP is located.
Cat No. product name
TP2167 β-CGRP, human acetate β-CGRP, human acetate is one of calcitonin peptides and acts via the complex of receptor-activity-modifying protein (RAMP) and calcitonin-receptor-like receptor ...
T8682 Vazegepant hydrochloride Vazegepant is the first intranasal gepant for the acute treatment of migraine and has announced a positive phase II/III study.
T12293L Olcegepant Olcegepant is an effective and selective non-peptide calcitonin gene-related peptide 1 (CGRP1) receptor antagonist (IC50 of 0.03 nM and Ki of 14.4 pM for human C...
TP1040L Calcitonin(salmon) Acetate(47931-85-1(free base)) Calcitonin(salmon) Acetate, a calcium regulating hormone, is used to treat osteoporosis in women who are at least 5 years past menopause.
TP1040 Calcitonin (salmon) Calcitonin salmon, a calcium regulating hormone, is used to treat osteoporosis in women who are at least 5 years past menopause.
TP1134L HCGRP-(8-37) acetate HCGRP-(8-37) acetate is a human calcitonin gene-related peptide (hCGRP) fragment acetate and also an antagonist of CGRP receptor.
T4610 Rimegepant BMS-927711 is a highly potent, oral calcitonin gene-related peptide (CGRP) receptor antagonist with a Ki value of 0.027 nM.
T6590 MK-3207 Hydrochloride MK-3207 is a potent CGRP receptor antagonist with IC50 and Kiof 0.12 nM and 0.022 nM, highly selective versus human AM1, AM2, CTR, and AMY3. Phase 2.
T16107 ML230 ML230 is a selective ATP-binding cassette (ABC) transporter ABCG2 inhibitor. It 36-fold selective for ABCG2 over ABCB1 (EC50s: 0.13 μM and 4.65 μM, respectively)...
β-CGRP, human acetate
TP2167
β-CGRP, human acetate is one of calcitonin peptides and acts via the complex of receptor-activity-modifying protein (RAMP) and calcitonin-receptor-like receptor...
Vazegepant hydrochloride
T8682
Vazegepant is the first intranasal gepant for the acute treatment of migraine and has announced a positive phase II/III study.
Olcegepant
T12293L
Olcegepant is an effective and selective non-peptide calcitonin gene-related peptide 1 (CGRP1) receptor antagonist (IC50 of 0.03 nM and Ki of 14.4 pM for human C...
Calcitonin(salmon) Acetate(47931-85-1(free base))
TP1040L
Calcitonin(salmon) Acetate, a calcium regulating hormone, is used to treat osteoporosis in women who are at least 5 years past menopause.
Calcitonin (salmon)
TP1040
Calcitonin salmon, a calcium regulating hormone, is used to treat osteoporosis in women who are at least 5 years past menopause.
HCGRP-(8-37) acetate
TP1134L
HCGRP-(8-37) acetate is a human calcitonin gene-related peptide (hCGRP) fragment acetate and also an antagonist of CGRP receptor.
Rimegepant
T4610
BMS-927711 is a highly potent, oral calcitonin gene-related peptide (CGRP) receptor antagonist with a Ki value of 0.027 nM.
MK-3207 Hydrochloride
T6590
MK-3207 is a potent CGRP receptor antagonist with IC50 and Kiof 0.12 nM and 0.022 nM, highly selective versus human AM1, AM2, CTR, and AMY3. Phase 2.
ML230
T16107
ML230 is a selective ATP-binding cassette (ABC) transporter ABCG2 inhibitor. It 36-fold selective for ABCG2 over ABCB1 (EC50s: 0.13 μM and 4.65 μM, respectivel...