CGRP Receptor

CGRP receptor is found in myelinated A-fibers axon which is required for ligand specificity and function of the receptor. The CGRP receptor has three subunits: receptor activity-modifying protein 1 (RAMP1), calcitonin-like receptor (CLR) and receptor component protein (RCP).[17] The complex central receptor is the G protein-coupled receptor calcitonin receptor-like receptor (CALCRL) which is necessary for CGRP and adrenomedullin (AM receptors). For function CGRP, CALCRL must coincide with RAMP1 where the ligand-binding domain of CGRP is located.

Cat. No.	Product name	CAS No.	Purity	Chemical Structure
TP1323	CGRP 8-37 (rat)	129121-73-9	99.28%
TP1323	CGRP 8-37 (rat) is a CGRP receptor antagonist, a CGRP fragment with potential anti-injury effects that induces arterial relaxation.
T78540	α-CGRP (mouse, rat) TFA		98%
T78540	α-CGRP (mouse, rat) TFA, a neuropeptide belonging to the calcitonin gene-related peptide (CGRP) family, is predominantly located at neuromuscular junctions and f...
T6590	MK-3207 Hydrochloride	957116-20-0	98%
T6590	MK-3207 Hydrochloride (MK-3207 HCl) is a potent CGRP receptor antagonist with IC50 and Kiof 0.12 nM and 0.022 nM, highly selective versus human AM1, AM2, CTR, an...
T16107	ML230	1776055-05-0	98%
T16107	ML230 is a selective ATP-binding cassette (ABC) transporter ABCG2 inhibitor. It 36-fold selective for ABCG2 over ABCB1 (EC50s: 0.13 μM and 4.65 μM, respectively)...
T8682	Vazegepant hydrochloride	1414976-20-7	99.56%
T8682	Vazegepant hydrochloride (Vazegepant HCl) is the first intranasal gepant for the acute treatment of migraine and has announced a positive phase II/III study.
TP1257L	Adrenomedullin (AM) (22-52), human acetate		99.42%
TP1257L	Adrenomedullin (AM) (22-52), human acetate is an antagonist of calcitonin generelated peptide receptor in the hindlimb vascular bed of the cat and an adrenomedul...
TP2167	β-CGRP, human acetate	TP2167	99.35%
TP2167	β-CGRP, human acetate is one of calcitonin peptides and acts via the complex of receptor-activity-modifying protein (RAMP) and calcitonin-receptor-like receptor ...
T4610	Rimegepant	1289023-67-1	99.33%
T4610	Rimegepant (BMS 927711) is a highly potent, oral calcitonin gene-related peptide (CGRP) receptor antagonist with a Ki value of 0.027 nM.
TP1040L	Calcitonin（salmon） Acetate(47931-85-1(free base))	TP1040L	99.29%
TP1040L	Calcitonin(salmon)Acetate(47931-85-1(free base))(Salmon calcitonin) , a calcium regulating hormone, is used to treat osteoporosis in women who are at least 5 yea...
TP1134L	HCGRP-(8-37) acetate	TP1134L	99.29%
TP1134L	HCGRP-(8-37) acetate is a human calcitonin gene-related peptide (hCGRP) fragment acetate and also an antagonist of CGRP receptor.
T12293L	Olcegepant	204697-65-4	96.08%
T12293L	Olcegepant (BIBN-4096) is an effective and selective non-peptide calcitonin gene-related peptide 1 (CGRP1) receptor antagonist (IC50 of 0.03 nM and Ki of 14.4 pM...
T13453	CGRP antagonist 1	1123757-49-2	100%
T13453	CGRP antagonist 1 is a potent CGRP receptor antagonist with Ki values of 35 nM and IC50 values of 57 nM, respectively.CGRP antagonist 1 can be used for the study...
T17194	Ubrogepant	1374248-77-7
T17194	Ubrogepant (MK-1602) is an antagonist of calcitonin gene-related peptide receptor that can be used in the acute treatment of migraine studies.
T76682	Galcanezumab	1578199-75-3	98%	Galcanezumab
T76682	Galcanezumab is a humanized IgG4 monoclonal antibody targeting the CGRP ligand, which binds to the ligand calcitonin gene-related peptide. Galcanezumab can be us...			Galcanezumab
T76874	Erenumab	1582205-90-0	98%	Erenumab
T76874	Erenumab is a whole-human monoclonal antibody. Erenumab inhibits calcitonin gene-related peptide (CGRP) receptors. Erenumab can be used to prevent migraine attac...			Erenumab
TP1040	Calcitonin (salmon)	47931-85-1	98%
TP1040	Calcitonin (salmon), a calcium regulating hormone, is used to treat osteoporosis in women who are at least 5 years past menopause.