T2590 |
Vismodegib
|
879085-55-9
|
99.99%
|
|
Vismodegib (GDC-0449) is a hedgehog pathway inhibitor (IC50: 3 nM). It also inhibits P-gp (IC50: 3.0 μM), ABCG2 (IC50: 1.4 μM).
|
T1926 |
Sonidegib
|
956697-53-3
|
99.91%
|
|
Sonidegib (Erismodegib), a Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively.
|
T3588 |
JK184
|
315703-52-7
|
99.89%
|
|
JK184 is a potent Hedgehog (Hh) pathway inhibitor.
|
T2450 |
SANT-1
|
304909-07-7
|
99.84%
|
|
SANT-1 directly binds to Smoothened (Smo) receptor (Kd: 1.2 nM) and inhibits Smo agonist effects (IC50: 20 nM).
|
T12797 |
RU-SKI 43
|
1043797-53-0
|
99.78%
|
|
RU-SKI 43 is a potent and selective hedgehog acyltransferase (Hhat) inhibitor with an IC50 of 850 nM.RU-SKI 43 has anticancer activity and is a potential compoun...
|
T0465 |
Ellagic acid
|
476-66-4
|
99.76%
|
|
Ellagic acid (Gallogen) is a fused four ring compound isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the ...
|
T26296 |
Triparanol
|
78-41-1
|
99.73%
|
|
Triparanol (NSC-65345) interferes with posttranslational modification of Hedgehog signaling molecules as well as the sterol sensing domain of its receptor PTCH1,...
|
T2299 |
BMS-833923
|
1059734-66-5
|
99.61%
|
|
BMS-833923 (XL-139), an orally bioavailable Smoothened antagonist, inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner (IC50: 21 nM).
|
T3363 |
Jervine
|
469-59-0
|
99.57%
|
|
The biological activity of Jervine (Jerwiny) is mediated via its interaction with the 7 passes transmembrane protein Smoothened. Jervine binds with and inhibits ...
|
T35559 |
SAG 21k
|
946002-48-8
|
99.51%
|
|
SAG 21k is an orally bioactive and potent Hedgehog signaling activator that crosses the blood-brain barrier for the study of cartilage regeneration.
|
T15183 |
Dynarrestin
|
2222768-84-3
|
99.49%
|
|
Dynarrestin is an inhibitor of cytoplasmic dyneins 1 and 2. Dynarrestin suppresses hedgehog (Hh)-dependent proliferation of neuronal precursors and tumor cells. ...
|
T23027 |
MRT-10
|
330829-30-6
|
99.47%
|
|
MRT-10 is a Smoothened (Smo) receptor antagonist.
|
T6891 |
MK-4101
|
935273-79-3
|
98.91%
|
|
MK-4101, an effective inhibitor of the Hedgehog pathway, has anti-tumor activity through the induction of extensive apoptosis and inhibition of proliferation in ...
|
T21325 |
TAK-441
|
1186231-83-3
|
98.79%
|
|
TAK-441 is an orally active inhibitor of Hedgehog signaling(IC50 = 4.4 nM) with potent antitumor activity. TAK-441 suppresses transcription factor Gli1 mRNA expr...
|
T14188 |
ALLO-2
|
1357350-60-7
|
98.67%
|
|
ALLO-2 is a Inhibitor of Drug-Resistant Smo Mutant.It inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM.
|
T63429 |
SMO-IN-2
|
1822355-27-0
|
98.64%
|
|
SMO-IN-2 is a potent smoothened (SMO) inhibitor of hedgehog (Hh) signaling.SMO-IN-2 shows antiproliferative activity and anticancer activity against human medull...
|
T24754 |
Hh-Ag1.5
|
612542-14-0
|
98.61%
|
|
Hh-Ag1.5 (SAG-1.5) is a potent Hedgehog (Hh) agonist (EC50: 1 nM) and Smoothened (Smo) receptor agonist, with an EC50 of 1 nM and Ki values between 0.5 and 2.3 n...
|
T1779 |
SAG
|
912545-86-9
|
98.16%
|
|
SAG (Smoothened Agonist) is a potent Smo receptor agonist and activates the Hedgehog signaling pathway.
|
T1810 |
Purmorphamine
|
483367-10-8
|
98.11%
|
|
Purmorphamine (Shh Signaling Antagonist VI), which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo. It also is an inducer of os...
|
T6514 |
Glasdegib
|
1095173-27-5
|
98%
|
|
Glasdegib (PF-04449913) (PF-04449913) is a potent, and orally bioavailable Smoothened (Smo) inhibitor with IC50 of 5 nM. Phase 2.
|