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Hedgehog/Smoothened

The Hedgehog signaling pathway is a signaling pathway that transmits information to embryonic cells required for proper cell differentiation. Different parts of the embryo have different concentrations of hedgehog signaling proteins. The pathway also has roles in the adult. Diseases associated with the malfunction of this pathway include basal cell carcinoma.
Cat. No. Product name CAS No. Purity Chemical Structure
T40465 SAG dihydrochloride 2702366-44-5 98%
SAG dihydrochloride is a potent Smoothened (Smo) receptor agonist ( EC 50 =3 nM; K d =59 nM). SAG dihydrochloride activates the Hedgehog signaling pathway and co...
T22814 GSA-10 300833-95-8 98%
Smoothened (Smo) receptor agonist
T1094 Tolnaftate 2398-96-1 98%
Tolnaftate is a synthetic antifungal agent.
T14965 Ciliobrevin D 1370554-01-0 98%
Ciliobrevin D is a AAA+ ATPase motor cytoplasmic dynein inhibitor. Ciliobrevin D inhibits Hedgehog (Hh) signaling and primary cilia formation and it also inhibit...
T23370 SMANT hydrochloride 1177600-74-6 98%
SMANT hydrochloride is an antagonist of Smoothened accumulation.
T22089 HPI 1 599150-20-6 98%
HPI 1 is a hedgehog (Hh) signaling inhibitor. Inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells (IC50 values are 1.5...
T15019L CUR61414 hydrochloride 98%
CUR61414 is a potent and cell permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM). CUR61414 is a small-molecule aminoproline class compound. CUR...
T3460 HhAntag 496794-70-8 98%
HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway with the anti-tumor activity....
T15019 CUR61414 334998-36-6 98%
CUR61414 is a cell-permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM) and selectively binds to smoothened (Ki = 44 nM).
T6514 Glasdegib 1095173-27-5 98%
Glasdegib (PF-04449913) is a potent, and orally bioavailable Smoothened (Smo) inhibitor with IC50 of 5 nM. Phase 2.
T3070 GANT 61 500579-04-4 98%
GANT 61 is an inhibitor for Gli1 and Gli2.
T14188 ALLO-2 1357350-60-7 98%
ALLO-2 is a Inhibitor of Drug-Resistant Smo Mutant.It inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM.
T2666 Taladegib 1258861-20-9 98%
Taladegib is an orally bioavailable small molecule antagonist of the Hedgehog (Hh)-ligand cell surface receptor smoothened (Smo) with potential antineoplastic ac...
T21325 TAK-441 1186231-83-3 98%
TAK-441 is an orally active inhibitor of Hedgehog signaling(IC50 = 4.4 nM) with potent antitumor activity. TAK-441 suppresses transcription factor Gli1 mRNA expr...
T1779 SAG 912545-86-9 98%
SAG is a potent Smo receptor agonist and activates the Hedgehog signaling pathway.
T6891 MK-4101 935273-79-3 98%
MK-4101, an effective inhibitor of the Hedgehog pathway, has anti-tumor activity through the induction of extensive apoptosis and inhibition of proliferation in ...
T4211 SAG hydrochloride (912545-86-9(free base)) 2095432-58-7 98%
SAG hydrochloride is a chlorobenzothiophene-containing compound which acts as a SMO agonist.
T3156 Ciliobrevin A 302803-72-1 98%
Ciliobrevin A is an inhibitor of hedgehog signaling pathway with an IC50 <10 μM.
T23027 MRT-10 330829-30-6 98%
Smoothened (Smo) receptor antagonist
T1810 Purmorphamine 483367-10-8 98%
Purmorphamine, which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo. It also is an inducer of osteoblast differentiation.
SAG dihydrochloride
T40465
SAG dihydrochloride is a potent Smoothened (Smo) receptor agonist ( EC 50 =3 nM; K d =59 nM). SAG dihydrochloride activates the Hedgehog signaling pathway and co...
GSA-10
T22814
Smoothened (Smo) receptor agonist
Tolnaftate
T1094
Tolnaftate is a synthetic antifungal agent.
Ciliobrevin D
T14965
Ciliobrevin D is a AAA+ ATPase motor cytoplasmic dynein inhibitor. Ciliobrevin D inhibits Hedgehog (Hh) signaling and primary cilia formation and it also inhibit...
SMANT hydrochloride
T23370
SMANT hydrochloride is an antagonist of Smoothened accumulation.
HPI 1
T22089
HPI 1 is a hedgehog (Hh) signaling inhibitor. Inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells (IC50 values are 1.5...
CUR61414 hydrochloride
T15019L
CUR61414 is a potent and cell permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM). CUR61414 is a small-molecule aminoproline class compound. CUR...
HhAntag
T3460
HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway with the anti-tumor activity....
CUR61414
T15019
CUR61414 is a cell-permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM) and selectively binds to smoothened (Ki = 44 nM).
Glasdegib
T6514
Glasdegib (PF-04449913) is a potent, and orally bioavailable Smoothened (Smo) inhibitor with IC50 of 5 nM. Phase 2.
GANT 61
T3070
GANT 61 is an inhibitor for Gli1 and Gli2.
ALLO-2
T14188
ALLO-2 is a Inhibitor of Drug-Resistant Smo Mutant.It inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM.
Taladegib
T2666
Taladegib is an orally bioavailable small molecule antagonist of the Hedgehog (Hh)-ligand cell surface receptor smoothened (Smo) with potential antineoplastic ac...
TAK-441
T21325
TAK-441 is an orally active inhibitor of Hedgehog signaling(IC50 = 4.4 nM) with potent antitumor activity. TAK-441 suppresses transcription factor Gli1 mRNA expr...
SAG
T1779
SAG is a potent Smo receptor agonist and activates the Hedgehog signaling pathway.
MK-4101
T6891
MK-4101, an effective inhibitor of the Hedgehog pathway, has anti-tumor activity through the induction of extensive apoptosis and inhibition of proliferation in ...
SAG hydrochloride (912545-86-9(free base))
T4211
SAG hydrochloride is a chlorobenzothiophene-containing compound which acts as a SMO agonist.
Ciliobrevin A
T3156
Ciliobrevin A is an inhibitor of hedgehog signaling pathway with an IC50 <10 μM.
MRT-10
T23027
Smoothened (Smo) receptor antagonist
Purmorphamine
T1810
Purmorphamine, which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo. It also is an inducer of osteoblast differentiation.
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