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Hedgehog/Smoothened

The Hedgehog signaling pathway is a signaling pathway that transmits information to embryonic cells required for proper cell differentiation. Different parts of the embryo have different concentrations of hedgehog signaling proteins. The pathway also has roles in the adult. Diseases associated with the malfunction of this pathway include basal cell carcinoma.
Cat No. product name
T6514 Glasdegib Glasdegib (PF-04449913) is a potent, and orally bioavailable Smoothened (Smo) inhibitor with IC50 of 5 nM. Phase 2.
T3070 GANT 61 GANT 61 is an inhibitor for Gli1 and Gli2.
T23027 MRT-10 Smoothened (Smo) receptor antagonist
T1543 Naftifine hydrochloride Naftifine Hydrochloride is the hydrochloride salt form of naftifine, an allylamine derivate with synthetic broad-spectrum antifungal activity. Although the exact...
T1779 SAG SAG is a potent Smo receptor agonist and activates the Hedgehog signaling pathway.
T6891 MK-4101 MK-4101, an effective inhibitor of the Hedgehog pathway, has anti-tumor activity through the induction of extensive apoptosis and inhibition of proliferation in ...
T3363 Jervine The biological activity of Jervine is mediated via its interaction with the 7 passes transmembrane protein Smoothened. Jervine binds with and inhibits smoothened...
T15183 Dynarrestin Dynarrestin is an inhibitor of cytoplasmic dyneins 1 and 2. Dynarrestin suppresses hedgehog (Hh)-dependent proliferation of neuronal precursors and tumor cells. ...
T22089 HPI 1 HPI 1 is a hedgehog (Hh) signaling inhibitor. Inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells (IC50 values are 1.5...
T0465 Ellagic acid Ellagic acid is a fused four ring compound isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the blood clott...
T3460 HhAntag HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway with the anti-tumor activity....
T2450 SANT-1 SANT-1 directly binds to Smoothened (Smo) receptor (Kd: 1.2 nM) and inhibits Smo agonist effects (IC50: 20 nM).
T1094 Tolnaftate Tolnaftate is a synthetic antifungal agent.
T14188 ALLO-2 ALLO-2 is a Inhibitor of Drug-Resistant Smo Mutant.It inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM.
T1926 Sonidegib LDE225 (NVP-LDE225; Erismodegib), a Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively.
T2825 Cyclopamine Cyclopamine, a Smoothened (Smo) antagonist (IC50: 46 nM in TM3Hh12 cells), belongs to the group of steroidal jerveratrum alkaloids.
T2590 Vismodegib Vismodegib is a hedgehog pathway inhibitor (IC50: 3 nM). It also inhibits P-gp (IC50: 3.0 μM), ABCG2 (IC50: 1.4 μM).
T2666 Taladegib Taladegib is an orally bioavailable small molecule antagonist of the Hedgehog (Hh)-ligand cell surface receptor smoothened (Smo) with potential antineoplastic ac...
T1810 Purmorphamine Purmorphamine, which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo. It also is an inducer of osteoblast differentiation.
T2299 BMS-833923 BMS-833923, an orally bioavailable Smoothened antagonist, inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner (IC50: 21 nM).
T1011 Itraconazole Itraconazole is a triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.
T14965 Ciliobrevin D Ciliobrevin D is a AAA+ ATPase motor cytoplasmic dynein inhibitor. Ciliobrevin D inhibits Hedgehog (Hh) signaling and primary cilia formation and it also inhibit...
T4211 SAG hydrochloride (912545-86-9(free base)) SAG hydrochloride is a chlorobenzothiophene-containing compound which acts as a SMO agonist.
T3156 Ciliobrevin A Ciliobrevin A 是一种 hedgehog 信号通路抑制剂,IC50 值 <10 μM。
T3588 JK184 JK184 is a potent Hedgehog (Hh) pathway inhibitor.
T15370 GANT 58 GANT 58 is a potent antagonist of Gli. Which inhibits GLI1-induced transcription (IC50: 5 μM).
T15019L CUR61414 hydrochloride (334998-36-6 Free base) CUR61414是一种新型的Hedgehog信号通路机制剂,可渗透细胞,可诱导癌细胞凋亡而不影响邻近的非肿瘤细胞。
Glasdegib
T6514
Glasdegib (PF-04449913) is a potent, and orally bioavailable Smoothened (Smo) inhibitor with IC50 of 5 nM. Phase 2.
GANT 61
T3070
GANT 61 is an inhibitor for Gli1 and Gli2.
MRT-10
T23027
Smoothened (Smo) receptor antagonist
Naftifine hydrochloride
T1543
Naftifine Hydrochloride is the hydrochloride salt form of naftifine, an allylamine derivate with synthetic broad-spectrum antifungal activity. Although the exact...
SAG
T1779
SAG is a potent Smo receptor agonist and activates the Hedgehog signaling pathway.
MK-4101
T6891
MK-4101, an effective inhibitor of the Hedgehog pathway, has anti-tumor activity through the induction of extensive apoptosis and inhibition of proliferation in ...
Jervine
T3363
The biological activity of Jervine is mediated via its interaction with the 7 passes transmembrane protein Smoothened. Jervine binds with and inhibits smoothened...
Dynarrestin
T15183
Dynarrestin is an inhibitor of cytoplasmic dyneins 1 and 2. Dynarrestin suppresses hedgehog (Hh)-dependent proliferation of neuronal precursors and tumor cells. ...
HPI 1
T22089
HPI 1 is a hedgehog (Hh) signaling inhibitor. Inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells (IC50 values are 1.5...
Ellagic acid
T0465
Ellagic acid is a fused four ring compound isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the blood clott...
HhAntag
T3460
HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway with the anti-tumor activity....
SANT-1
T2450
SANT-1 directly binds to Smoothened (Smo) receptor (Kd: 1.2 nM) and inhibits Smo agonist effects (IC50: 20 nM).
Tolnaftate
T1094
Tolnaftate is a synthetic antifungal agent.
ALLO-2
T14188
ALLO-2 is a Inhibitor of Drug-Resistant Smo Mutant.It inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM.
Sonidegib
T1926
LDE225 (NVP-LDE225; Erismodegib), a Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively.
Cyclopamine
T2825
Cyclopamine, a Smoothened (Smo) antagonist (IC50: 46 nM in TM3Hh12 cells), belongs to the group of steroidal jerveratrum alkaloids.
Vismodegib
T2590
Vismodegib is a hedgehog pathway inhibitor (IC50: 3 nM). It also inhibits P-gp (IC50: 3.0 μM), ABCG2 (IC50: 1.4 μM).
Taladegib
T2666
Taladegib is an orally bioavailable small molecule antagonist of the Hedgehog (Hh)-ligand cell surface receptor smoothened (Smo) with potential antineoplastic ac...
Purmorphamine
T1810
Purmorphamine, which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo. It also is an inducer of osteoblast differentiation.
BMS-833923
T2299
BMS-833923, an orally bioavailable Smoothened antagonist, inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner (IC50: 21 nM).
Itraconazole
T1011
Itraconazole is a triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.
Ciliobrevin D
T14965
Ciliobrevin D is a AAA+ ATPase motor cytoplasmic dynein inhibitor. Ciliobrevin D inhibits Hedgehog (Hh) signaling and primary cilia formation and it also inhibit...
SAG hydrochloride (912545-86-9(free base))
T4211
SAG hydrochloride is a chlorobenzothiophene-containing compound which acts as a SMO agonist.
Ciliobrevin A
T3156
Ciliobrevin A 是一种 hedgehog 信号通路抑制剂,IC50 值 <10 μM。
JK184
T3588
JK184 is a potent Hedgehog (Hh) pathway inhibitor.
GANT 58
T15370
GANT 58 is a potent antagonist of Gli. Which inhibits GLI1-induced transcription (IC50: 5 μM).
CUR61414 hydrochloride (334998-36-6 Free base)
T15019L
CUR61414是一种新型的Hedgehog信号通路机制剂,可渗透细胞,可诱导癌细胞凋亡而不影响邻近的非肿瘤细胞。