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MAGL

Monoacylglycerol lipase, also known as MAG lipase, acylglycerol lipase, MAGL, MGL or MGLL is an enzyme that, in humans, is encoded by the MGLL gene. MAGL is a 33-kDa, membrane-associated member of the serine hydrolase superfamily and contains the classical GXSXG consensus sequence common to most serine hydrolases. The catalytic triad has been identified as Ser122, His269, and Asp239.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T81878 MAGL-IN-9 98%
MAGL-IN-9
MAGL-IN-9, also referred to as compound 16, is a reversible inhibitor of monoacylglycerol lipase (MAGL) with a potent IC50 value of 2.7 nM [1].
T81879 MAGL-IN-8 98%
MAGL-IN-8
MAGL-IN-8 (compound 13) serves as a reversible inhibitor of monoacylglycerol lipase (MAGL), exhibiting an inhibitory concentration half-maximal (IC50) value of 2...
T81880 MAGL-IN-11 98%
MAGL-IN-11
MAGL-IN-11 (compound 29) is a selective, reversible inhibitor of monoacylglycerol lipase (MAGL), with potential in researching inflammation, cancer, and antioxid...
T81881 MAGL-IN-10 98%
MAGL-IN-10
MAGL-IN-10, a reversible monoacylglycerol lipase (MAGL) inhibitor, exhibits favorable ADME properties and low in vivo toxicity. It is applicable in the study of ...
T9374 AA38-3 65815-76-1 99.70%
AA38-3
AA38-3 (1-Piperidinecarboxylic acid, 4-nitrophenyl ester) inhibites three SHs (ABHD6, ABHD11, and FAAH)
T8994 ML-​226 2055172-43-3 99.61%
ML-​226
ML226 is a α/β hydrolase domain-containing protein 11 (ABHD11) inhibitor that inhibits ABHD11 in vitro and in situ.
T22171 WWL123 1338575-41-9 99.44%
WWL123
WWL123 is a potent and selective ABHD6 inhibitor (IC50=430 nM). WWL123 crosses the blood-brain-barrier and inhibits ABHD6 in brain parenchyma. ABHD6 blockade by ...
T11785 KT203 1402612-64-9 98.88%
KT203
KT203 is a selective and potent structural domain 6 (ABHD6) inhibitor of alpha/beta hydrolytic enzymes with potential antiviral and anti-inflammatory activity fo...
T15635 JZP-430 1672691-74-5 98.31%
JZP-430
JZP-430 is an effective, highly selective, irreversible inhibitor of α/β-hydrolase domain 6 (ABHD6) (IC50: 44 nM). It also shows ~230-fold selectivity over fatty...
T17260 WWL70 947669-91-2 98.25%
WWL70
WWL70 is a selective alpha/beta hydrolase domain 6 inhibitors (IC50: 70 nM).
T11784 KT182 1402612-62-7 100%
KT182
KT182 is a selective and  potent inhibitor of α/β-hydrolase domain containing 6 (ABHD6), with an IC50 of 0.24 nM in Neuro2A cells.
MAGL-IN-9
T81878
MAGL-IN-9, also referred to as compound 16, is a reversible inhibitor of monoacylglycerol lipase (MAGL) with a potent IC50 value of 2.7 nM [1].
MAGL-IN-8
T81879
MAGL-IN-8 (compound 13) serves as a reversible inhibitor of monoacylglycerol lipase (MAGL), exhibiting an inhibitory concentration half-maximal (IC50) value of 2...
MAGL-IN-11
T81880
MAGL-IN-11 (compound 29) is a selective, reversible inhibitor of monoacylglycerol lipase (MAGL), with potential in researching inflammation, cancer, and antioxid...
MAGL-IN-10
T81881
MAGL-IN-10, a reversible monoacylglycerol lipase (MAGL) inhibitor, exhibits favorable ADME properties and low in vivo toxicity. It is applicable in the study of ...
AA38-3
T9374
AA38-3 (1-Piperidinecarboxylic acid, 4-nitrophenyl ester) inhibites three SHs (ABHD6, ABHD11, and FAAH)
ML-​226
T8994
ML226 is a α/β hydrolase domain-containing protein 11 (ABHD11) inhibitor that inhibits ABHD11 in vitro and in situ.
WWL123
T22171
WWL123 is a potent and selective ABHD6 inhibitor (IC50=430 nM). WWL123 crosses the blood-brain-barrier and inhibits ABHD6 in brain parenchyma. ABHD6 blockade by ...
KT203
T11785
KT203 is a selective and potent structural domain 6 (ABHD6) inhibitor of alpha/beta hydrolytic enzymes with potential antiviral and anti-inflammatory activity fo...
JZP-430
T15635
JZP-430 is an effective, highly selective, irreversible inhibitor of α/β-hydrolase domain 6 (ABHD6) (IC50: 44 nM). It also shows ~230-fold selectivity over fatty...
WWL70
T17260
WWL70 is a selective alpha/beta hydrolase domain 6 inhibitors (IC50: 70 nM).
KT182
T11784
KT182 is a selective and  potent inhibitor of α/β-hydrolase domain containing 6 (ABHD6), with an IC50 of 0.24 nM in Neuro2A cells.
TargetMol