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GPCR/G Protein SGLT

SGLT

Sodium-dependent glucose cotransporters (or sodium-glucose linked transporter, SGLT) are a family of glucose transporter found in the intestinal mucosa (enterocytes) of the small intestine (SGLT1) and the proximal tubule of the nephron (SGLT2 in PCT and SGLT1 in PST). They contribute to renal glucose reabsorption. In the kidneys, 100% of the filtered glucose in the glomerulus has to be reabsorbed along the nephron (98% in PCT, via SGLT2). If the plasma glucose concentration is too high (hyperglycemia), glucose is excreted in urine (glucosuria) because SGLT are saturated with the filtered glucose. Glucose is never secreted by a healthy nephron.
Cat No. product name
T1766 Empagliflozin Empagliflozin is a Sodium-Glucose Cotransporter 2 Inhibitor. The mechanism of action of empagliflozin is as a Sodium-Glucose Transporter 2 Inhibitor.
T1782 Canagliflozin Canagliflozin, a sodium-glucose transporter 2( SGLT2) and P-Glycoprotein inhibitor, is used in type 2 diabetes.
T2385 Ipragliflozin Ipragliflozin is under investigation in Type 2 Diabetes and Diabetes Mellitus, Type 2.
T2389 Dapagliflozin Dapagliflozin is a selective sodium-glucose co-transporter subtype 2 (SGLT2) inhibitor with antihyperglycemic activity.
T2922 Phlorizin Phlorizin is a non-selective SGLT inhibitor found in apple, for hSGLT1( Ki=300 nM) and hSGLT2( Ki=39 nM) .
T2924 Phloretin Phloretin is a well-known inhibitor of eukaryotic urea transporters, blocks VacA-mediated urea and ion transport. Phloretin is a dihydrochalcone, a type of natu...
T3547 Sotagliflozin LX-4211 is an orally bioavailable inhibitor of the sodium-glucose co-transporter subtype 1 (SGLT1) and 2 (SGLT2), with potential antihyperglycemic activity.
T4999 Ertugliflozin PF-04971729 (Ertugliflozin) is a potent and selective inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2).
T7217 EGT1442 EGT1442 is a potent, selective sodium glucose co-transporter 2 (SGLT2) inhibitor with IC50 values of 5.6 μM and 2 nM for human SGLT1 and SGLT2, respectively
TN1856 Leachianone A Leachianone A is a potential antitoxic agent, it shows inhibitory effects on cadmium- Induced cytotoxicity.
T12892 SGL5213 SGL5213 is an oral active and low-absorbable inhibitor of sodium-dependent glucose cotransporter 1 (SGLT1)(hSGLT1 and hSGLT2 with IC50 values of 29 nM and 20 nM...
T12893 SGLT inhibitor-1 SGLT inhibitor-1 is a potentsodium glucose co-transporter proteins (SGLTs) dual inhibitor(hSGLT1 and hSGLT2 with IC50s of 43 nM and 9 nM, respectively).
T15505 HSK0935 HSK0935 is a highly selective and orally available SGLT2 inhibitor (IC50: 1.3 nM). It has antihyperglycemic activities.
T15656 KGA-2727 KGA-2727 is a first selective and high-affinity inhibitor of SGLT1 (Kis: 97.4 nM and 43.5 nM for human and rat SGLT1, respectively). KGA-2727 has antidiabetic e...
T15752 Licogliflozin Licogliflozin is an inhibitor of sodium-glucose cotransporter (SGLT1 and SGLT2).
T11671 IRAK inhibitor 4 trans IRAK inhibitor 4 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor. IRAK inhibitor 4 (trans) is the trans form of IRAK inhibitor 4.
T15807 LY2794193 LY2794193 is a highly effective and selective agonist of the mGlu3 receptor (hmGlu3 Ki=0.927 nM,EC50=0.47 nM; hmGlu2 Ki=412 nM,EC50=47.5 nM).
T16098 Islatravir Islatravir is an effective anti-HIV-1 agent. It acting as a nucleoside reverse transcriptase inhibitor (EC50s: 0.068 nM, 3.1 nM, and 0.15 nM for HIV-1 (WT), HIV...
T17221 Velagliflozin Velagliflozin is an orally available inhibitor of sodium-glucose cotransporter 2.
TN4399 Kushenol C Kushenol C is a good 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenger, and it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2)...
TN4784 Picraline A series of a hydroxy substituted derivatives 21-28 at C-17 of the Picraline-type alkaloids have been derived as having potent SGLT inhibitory activity.
Empagliflozin
T1766CAS 864070-44-0
Empagliflozin is a Sodium-Glucose Cotransporter 2 Inhibitor. The mechanism of action of empagliflozin is as a Sodium-Glucose Transporter 2 Inhibitor.
Canagliflozin
T1782CAS 842133-18-0
Canagliflozin, a sodium-glucose transporter 2( SGLT2) and P-Glycoprotein inhibitor, is used in type 2 diabetes.
Ipragliflozin
T2385CAS 761423-87-4
Ipragliflozin is under investigation in Type 2 Diabetes and Diabetes Mellitus, Type 2.
Dapagliflozin
T2389CAS 461432-26-8
Dapagliflozin is a selective sodium-glucose co-transporter subtype 2 (SGLT2) inhibitor with antihyperglycemic activity.
Phlorizin
T2922CAS 60-81-1
Phlorizin is a non-selective SGLT inhibitor found in apple, for hSGLT1( Ki=300 nM) and hSGLT2( Ki=39 nM) .
Phloretin
T2924CAS 60-82-2
Phloretin is a well-known inhibitor of eukaryotic urea transporters, blocks VacA-mediated urea and ion transport. Phloretin is a dihydrochalcone, a type of natu...
Sotagliflozin
T3547CAS 1018899-04-1
LX-4211 is an orally bioavailable inhibitor of the sodium-glucose co-transporter subtype 1 (SGLT1) and 2 (SGLT2), with potential antihyperglycemic activity.
Ertugliflozin
T4999CAS 1210344-57-2
PF-04971729 (Ertugliflozin) is a potent and selective inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2).
EGT1442
T7217CAS 1118567-05-7
EGT1442 is a potent, selective sodium glucose co-transporter 2 (SGLT2) inhibitor with IC50 values of 5.6 μM and 2 nM for human SGLT1 and SGLT2, respectively
Leachianone A
TN1856CAS 97938-31-3
Leachianone A is a potential antitoxic agent, it shows inhibitory effects on cadmium- Induced cytotoxicity.
SGL5213
T12892CAS 1240305-17-2
SGL5213 is an oral active and low-absorbable inhibitor of sodium-dependent glucose cotransporter 1 (SGLT1)(hSGLT1 and hSGLT2 with IC50 values of 29 nM and 20 nM...
SGLT inhibitor-1
T12893CAS 2247314-23-2
SGLT inhibitor-1 is a potentsodium glucose co-transporter proteins (SGLTs) dual inhibitor(hSGLT1 and hSGLT2 with IC50s of 43 nM and 9 nM, respectively).
HSK0935
T15505CAS 1638851-44-1
HSK0935 is a highly selective and orally available SGLT2 inhibitor (IC50: 1.3 nM). It has antihyperglycemic activities.
KGA-2727
T15656CAS 666842-36-0
KGA-2727 is a first selective and high-affinity inhibitor of SGLT1 (Kis: 97.4 nM and 43.5 nM for human and rat SGLT1, respectively). KGA-2727 has antidiabetic e...
Licogliflozin
T15752CAS 1291094-73-9
Licogliflozin is an inhibitor of sodium-glucose cotransporter (SGLT1 and SGLT2).
IRAK inhibitor 4 trans
T11671CAS NA
IRAK inhibitor 4 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor. IRAK inhibitor 4 (trans) is the trans form of IRAK inhibitor 4.
LY2794193
T15807CAS 2173037-97-1
LY2794193 is a highly effective and selective agonist of the mGlu3 receptor (hmGlu3 Ki=0.927 nM,EC50=0.47 nM; hmGlu2 Ki=412 nM,EC50=47.5 nM).
Islatravir
T16098CAS 865363-93-5
Islatravir is an effective anti-HIV-1 agent. It acting as a nucleoside reverse transcriptase inhibitor (EC50s: 0.068 nM, 3.1 nM, and 0.15 nM for HIV-1 (WT), HIV...
Velagliflozin
T17221CAS 946525-65-1
Velagliflozin is an orally available inhibitor of sodium-glucose cotransporter 2.
Kushenol C
TN4399CAS 99119-73-0
Kushenol C is a good 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenger, and it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2)...
Picraline
TN4784CAS 2671-32-1
A series of a hydroxy substituted derivatives 21-28 at C-17 of the Picraline-type alkaloids have been derived as having potent SGLT inhibitory activity.