SGLT

Sodium-dependent glucose cotransporters (or sodium-glucose linked transporter, SGLT) are a family of glucose transporter found in the intestinal mucosa (enterocytes) of the small intestine (SGLT1) and the proximal tubule of the nephron (SGLT2 in PCT and SGLT1 in PST). They contribute to renal glucose reabsorption. In the kidneys, 100% of the filtered glucose in the glomerulus has to be reabsorbed along the nephron (98% in PCT, via SGLT2). If the plasma glucose concentration is too high (hyperglycemia), glucose is excreted in urine (glucosuria) because SGLT are saturated with the filtered glucose. Glucose is never secreted by a healthy nephron.

Cat. No.	Product name	CAS No.	Purity
T17221	Velagliflozin	946525-65-1	98%
T17221	Velagliflozin is an orally available inhibitor of sodium-glucose cotransporter 2.
TN4784	Picraline	2671-32-1	98%
TN4784	A series of a hydroxy substituted derivatives 21-28 at C-17 of the Picraline-type alkaloids have been derived as having potent SGLT inhibitory activity.
T12892	SGL5213	1240305-17-2	98%
T12892	SGL5213 is an oral active and low-absorbable inhibitor of sodium-dependent glucose cotransporter 1 (SGLT1)(hSGLT1 and hSGLT2 with IC50 values of 29 nM and 20 nM ...
T11671	IRAK inhibitor 4 trans	T11671	98%
T11671	IRAK inhibitor 4 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor. IRAK inhibitor 4 (trans) is the trans form of IRAK inhibitor 4.
TN4399	Kushenol C	99119-73-0	98%
TN4399	Kushenol C is a good 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenger, and it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2)....
T12893	SGLT inhibitor-1	2247314-23-2	98%
T12893	SGLT inhibitor-1 is a potentsodium glucose co-transporter proteins (SGLTs) dual inhibitor(hSGLT1 and hSGLT2 with IC50s of 43 nM and 9 nM, respectively).
T15752	Licogliflozin	1291094-73-9	98%
T15752	Licogliflozin is an inhibitor of sodium-glucose cotransporter (SGLT1 and SGLT2).
T67849	O-Desethyl Dapagliflozin	864070-37-1	98%
T67849	O-Desethyl Dapagliflozin is a SGLT2 inhibitor, IC50=33nM.
T34286	Remogliflozin etabonate	442201-24-3	98%
T34286	Remogliflozin etabonate is a prodrug of regaliflozin and an inhibitor SGLT2 with Ki values of 1.95, 2.14, 8.57, and 43.1μM for hSGLT2, rSGLT2, rSGLT1, and hSGLT1...
T15807	LY2794193	2173037-97-1	98%
T15807	LY2794193 is a highly effective and selective agonist of the mGlu3 receptor (hmGlu3 Ki=0.927 nM,EC50=0.47 nM; hmGlu2 Ki=412 nM,EC50=47.5 nM).
T15505	HSK0935	1638851-44-1	98%
T15505	HSK0935 is a highly selective and orally available SGLT2 inhibitor (IC50: 1.3 nM). It has antihyperglycemic activities.
T7217	Bexagliflozin	1118567-05-7
T7217	EGT1442 is a potent, selective sodium glucose co-transporter 2 (SGLT2) inhibitor with IC50 values of 5.6 µM and 2 nM for human SGLT1 and SGLT2, respectively
T28757	Sergliflozin etabonate	408504-26-7	95.59%
T28757	Sergliflozin etabonate is an inhibitor of SGLT2 and can be used in studies about type 2 diabetes and obesity.
T2S0731	Trilobatin	4192-90-9	97.75%
T2S0731	Trilobatin has anti-oxidant effect, can increase superoxide dismutase (SOD) activity.Trilobatin has anti-inflammatory effect, it potentially inhibits the lipopol...
T38843	Enavogliflozin	1415472-28-4	97.81%
T38843	Enavogliflozin is an orally available small molecule and sodium glucose transporter 2 inhibitor.
T16083	Mizagliflozin	666843-10-3	98.66%
T16083	Mizagliflozin is a sodium-glucose transporter inhibitor( Ki of 27 nM for human SGLT1). Mizagliflozin displays 303-fold selectivity over SGLT2. Mizagliflozin is u...
T15244	Ertugliflozin L-pyroglutamic acid	1210344-83-4	98.71%
T15244	Ertugliflozin L-pyroglutamic acid is a selective and orally active hSGLT2 inhibitor with an IC50 of 0.877 nM. Ertugliflozin L-pyroglutamic acid can be used for s...
T5016	Tofogliflozin (hydrate)	1201913-82-7	98.78%
T5016	Tofogliflozin hydrate is a potent and highly specific inhibitor of SGLT2(IC50 of 2.9 nM and Ki values of 2.9 nM, 14.9 nM, and 6.4 nM for human, rat, and mouse SG...
T15656	KGA-2727	666842-36-0	98.95%
T15656	KGA-2727 is a potent and selective SGLT1 inhibitor, with Kis of 97.4 nM and 43.5 nM for human and rat SGLT1, respectively. The selectivity ratios (Ki for SGLT2/K...
T3547	Sotagliflozin	1018899-04-1	99.37%
T3547	LX-4211 is an orally bioavailable inhibitor of the sodium-glucose co-transporter subtype 1 (SGLT1) and 2 (SGLT2), with potential antihyperglycemic activity.