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Syk

Tyrosine-protein kinase SYK, also known as spleen tyrosine kinase, is an enzyme which in humans is encoded by the SYK gene.
Cat. No. Product name CAS No. Purity Chemical Structure
TN1549 Damnacanthal 477-84-9 98%
Damnacanthal possesses anti-cancer, immunomodulatory, antinociceptive and anti-inflammatory actions, it can treat or prevent hepatocellular carcinoma through its...
T11824L Lanraplenib monosuccinate 1800046-97-2 98%
Lanraplenib monosuccinate inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans. ...
T11824 Lanraplenib succinate 1800047-00-0 98%
Lanraplenib succinate inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans. Lanr...
T16995 TAS05567 1429038-15-2 98%
TAS05567 is a potent, highly selective, and ATP-competitive Syk inhibitor (IC50: 0.37 nM). TAS05567 only shows >70% inhibition of Syk and 4 other kinases (FLT3, ...
T9789 Cevidoplenib dimesylate hydrochloride 269062-93-3 98%
Cevidoplenib dimesylate hydrochloride is a spleen tyrosine kinase (Syk) inhibitor showing potential immunomodulating and anti-inflammatory properties.
T6003 GSK1904529A 1089283-49-7 98%
GSK1904529A is a specific inhibitor of IGF-1R (IC50=27 nM) and IR(IC50=25 nM) .
T39437 Cevidoplenib dimesylate 2043659-93-2 98%
Cevidoplenib dimesylate is an inhibitor of spleen tyrosine kinase (Syk), possessing anti-inflammatory and immunomodulating properties.
T16776 RO9021 1446790-62-0 98%
RO9021 is an orally bioavailable, novel ATP-competitive SYK inhibitor (average IC50: 5.6 nM).
T22430 SRX3207 2254693-15-5 98%
SRX3207 is an inhibitor of Syk and PI3K and relieves tumor immunosuppression.
T6115 Fostamatinib 901119-35-5 98%
Fostamatinib(IC50 of 41 nM), which is a prodrug of the active metabolite R406, is a Syk inhibitor. It does not work on Lyn.
T6594 MNS 1485-00-3 98%
MNS is a tyrosine kinases inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively.
T4263 BAY 61-3606 732983-37-8 98%
BAY 61-3606 is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (Ki= 7.5 nM), exhibiting no inhibitory effec...
T6957 PRT-060318 1194961-19-7 98%
PRT-060318 (PRT318) is a novel selective inhibitor of the Syk tyrosine kinase, as an approach to HIT treatment.
T6174 R406 841290-81-1 98%
R406 is an effective Syk inhibitor (IC50: 41 nM) and shows no effects on Lyn.
T2605 Fostamatinib Disodium 1025687-58-4 98%
Fostamatinib Disodium is an orally available Syk kinase inhibitor with potential anti-inflammatory and immunomodulating activities.
T6104 Cerdulatinib hydrochloride 1369761-01-2 98%
Cerdulatinib (PRT-062070) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and S...
T2467 R406 free base 841290-80-0 98%
R406 (free base) is a potent Syk inhibitor.
T6057 URMC-099 1229582-33-5 98%
URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM)...
T0610 Piceatannol 10083-24-6 98%
Piceatannol is an anti-inflammatory, immunomodulatory and antiproliferative agent. It inhibits p56lck and syk protein tyrosine kinases and inhibits NF-κB activat...
T11824LL Lanraplenib 1800046-95-0 98%
Lanraplenib is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) in development for the treatment of inflammatory diseases. Lanraplenib inhibits S...
Damnacanthal
TN1549
Damnacanthal possesses anti-cancer, immunomodulatory, antinociceptive and anti-inflammatory actions, it can treat or prevent hepatocellular carcinoma through its...
Lanraplenib monosuccinate
T11824L
Lanraplenib monosuccinate inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans. ...
Lanraplenib succinate
T11824
Lanraplenib succinate inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans. Lanr...
TAS05567
T16995
TAS05567 is a potent, highly selective, and ATP-competitive Syk inhibitor (IC50: 0.37 nM). TAS05567 only shows >70% inhibition of Syk and 4 other kinases (FLT3, ...
Cevidoplenib dimesylate hydrochloride
T9789
Cevidoplenib dimesylate hydrochloride is a spleen tyrosine kinase (Syk) inhibitor showing potential immunomodulating and anti-inflammatory properties.
GSK1904529A
T6003
GSK1904529A is a specific inhibitor of IGF-1R (IC50=27 nM) and IR(IC50=25 nM) .
Cevidoplenib dimesylate
T39437
Cevidoplenib dimesylate is an inhibitor of spleen tyrosine kinase (Syk), possessing anti-inflammatory and immunomodulating properties.
RO9021
T16776
RO9021 is an orally bioavailable, novel ATP-competitive SYK inhibitor (average IC50: 5.6 nM).
SRX3207
T22430
SRX3207 is an inhibitor of Syk and PI3K and relieves tumor immunosuppression.
Fostamatinib
T6115
Fostamatinib(IC50 of 41 nM), which is a prodrug of the active metabolite R406, is a Syk inhibitor. It does not work on Lyn.
MNS
T6594
MNS is a tyrosine kinases inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively.
BAY 61-3606
T4263
BAY 61-3606 is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (Ki= 7.5 nM), exhibiting no inhibitory effec...
PRT-060318
T6957
PRT-060318 (PRT318) is a novel selective inhibitor of the Syk tyrosine kinase, as an approach to HIT treatment.
R406
T6174
R406 is an effective Syk inhibitor (IC50: 41 nM) and shows no effects on Lyn.
Fostamatinib Disodium
T2605
Fostamatinib Disodium is an orally available Syk kinase inhibitor with potential anti-inflammatory and immunomodulating activities.
Cerdulatinib hydrochloride
T6104
Cerdulatinib (PRT-062070) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and S...
R406 free base
T2467
R406 (free base) is a potent Syk inhibitor.
URMC-099
T6057
URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM)...
Piceatannol
T0610
Piceatannol is an anti-inflammatory, immunomodulatory and antiproliferative agent. It inhibits p56lck and syk protein tyrosine kinases and inhibits NF-κB activat...
Lanraplenib
T11824LL
Lanraplenib is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) in development for the treatment of inflammatory diseases. Lanraplenib inhibits S...
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