1. Kamebakaurin (Kamebakaurine) has the ability to protect the liver from APAP-induced hepatotoxicity, presumably by both inhibiting the inflammatory response and oxidative stress. 2. Kamebakaurin inhibits the expression of hypoxia-inducible factor-1α and its target genes to confer antitumor activity. 3. Kamebakaurin has anti-cancer and anti-inflammatory activities through direct inhibition of DNA-binding activity of nuclear factor-kappa B (NF-κB) p50.4. Kamebakaurin has anti-neuroinflammatory activity via inhibition of c-Jun NH -terminal kinase and p38 mitogen-activated protein kinase pathway in activated microglial cells.
Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Foxo3a activity by inhibiting pAKT and c-Myc and activating pro-apoptotic protein Puma and Bax to
Trichokaurin is a natural product of Isodon, Lamiaceae. The catalog number is TN5172 and the CAS number is 23811-50-9. Trichokaurin can be used as a reference standard.
Sculponeatin K is a natural product of Isodon, Lamiaceae. The catalog number is TN4971 and the CAS number is 477529-70-7. Sculponeatin K can be used as a reference standard.
ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a potential anti-metastatic chemotherapeutic agent for the treatment of breast cancer. Excisanin A shows comparable inhibitory effects on the LPS-induced production of NO and PGE2, and activation of NF-kappaB without affecting cell viability.Excisanin A induces apoptosis in colon cancer cell line SW620 as determined by Annexin V staining, the cleavage of caspase-3 and the proteolytic degradation of poly (ADP-ribose) polymerase (PARP).
Pedalitin is a mixed-type inhibitor of tyrosinase. In the assay of α-glucosidase inhibition, rosmarinic acid is a competitive inhibitor, whereas both methyl rosmarinate and Pedalitin are mixed-type inhibitors.
1,10:4,5-Diepoxy-7(11)-germacren-8-one is a natural product for research related to life sciences. The catalog number is TN2476 and the CAS number is 32179-18-3.
Sculponeatic acid is a natural product of Isodon, Lamiaceae. The catalog number is TN4969 and the CAS number is 1169806-02-3. Sculponeatic acid can be used as a reference standard.
Sventenic acid is a natural product of Isodon, Lamiaceae. The catalog number is TN5081 and the CAS number is 126778-79-8. Sventenic acid can be used as a reference standard.
ent-7alpha,9-Dihydroxy-15-oxokaur-16-en-19,6bet-olide is a natural product for research related to life sciences. The catalog number is TN3954 and the CAS number is 59885-89-1.
Xerophilusin G is a natural product of Isodon, Lamiaceae. The catalog number is TMA1742 and the CAS number is 304642-94-2. Xerophilusin G can be used as a reference standard.
Effusanin E shows antibacterial and anti-cancer activities, it significantly inhibits cell proliferation and induces apoptosis in NPC cells by suppressing p50/p65 proteins to down-regulate COX-2 expression .
Hispidanin B shows significant cytotoxicities against tumor cell lines SGC7901, SMMC7721, and K562, with IC50 values of 10.7, 9.8, and 13.7 uM, respectively.
16-Acetoxy-7-O-acetylhorminone is a natural product of Isodon, Lamiaceae, with catalog number TN2643 and CAS number 269742-39-4. It can be used as a reference standard.
Effusanin A has antibacterial activity. It exhibits DNA-damaging activity in assay which employed DNA-repair deficient (RAD 52Y) and repair proficient (RAD +) yeast strains. Effusanin A shows inhibitory effects on DU145 cells with IC50 value of 3.16 micro
Epinodosin induces significant DNA damage to HepG2 cells in a time- and dose-dependent manner.Epinodosin has a biphasic, dose-dependent effect on root growth and a strong inhibitory effect on root hair development in Lactuca sativa L. seedlings.
Rabdosin B shows cytotoxic activity against three human tumour HepG2, GLC-82 and HL-60 cell lines, it induces significant DNA damage to HepG2 cells in a time- and dose-dependent manner. Rabdosin B at higher concentrations inhibits root growth by affecting
Effusanin B shows antibacterial activity. It exhibits DNA-damaging activity in assay which employes DNA-repair deficient (RAD 52Y) and repair proficient (RAD +) yeast strains.