α-adrenoceptor

α1 adrenoceptor-MO-1 (S enantiomer) has affinity at alpha 1 adrenergic receptor with alphalytic activity and analgesic action. It has more active than R enantiomer.

Bunazosin Hydrochloride (E 1015) is an alpha(1)-adrenoceptor antagonist used as a systemic antihypertensive and an ocular hypotensive drug.

Arbutamine (GP 21213) is a novel potent non-selective beta-adrenoceptor agonist with alpha-1-sympathomimetic activity.Arbutamine promotes cardiac stress and increases heart rate, cardiac contractility.Arbutamine can be used to study cardiac stress and coronary artery disease

Ridazolol HCl (CAS 413) is a novel β-adrenoceptor (β-AR) blocker with α-adrenerolytic activity.

Clonidine hydrochloride (Catapres) is a centrally active α-adrenergic agonist used predominantly as an antihypertensive agent.

Dicentrine, a selective α±(1)-adrenoceptor antagonist with potent antiarrhythmic and antihypertensive activities, it also has antinociception in different models of chemical pain.

Indoramin, an orally active antihypertensive agent, exhibits selectivity for the α 1A -adrenoceptor [1].

Amosulalol is a combined alpha and beta adrenoceptor antagonist.

Dextromilnacipran (Levomilnacipran) is a selective serotonin and norepinephrine reuptake inhibitor.

Acepromazine-d6 maleate is a deuterated compound of Acepromazine maleate. Acepromazine maleate has a CAS number of 3598-37-6. ACEPROMAZINE MALEATE is a dopamine receptor antagonist

ST-91 is an agonist of α2-adrenoceptor with a mixed α-adrenergic receptor type/subtype selection profile.

Phenoxybenzamine hydrochloride (NCI-c01661) is the hydrochloride salt form of phenoxybenzamine, a synthetic, dibenzamine alpha-adrenergic antagonist with antihypertensive and vasodilatory properties. Phenoxybenzamine non-selectively and irreversibly blocks the postsynaptic alpha-adrenergic receptor in smooth muscle, thereby preventing vasoconstriction, relieving vasospasms, and decreasing peripheral resistance. Reflex tachycardia may occur and may be enhanced by blockade of alpha-2 receptors which enhances norepinephrine release. Phenoxybenzamine is reasonably anticipated to be a human carcinogen.

Azepexole dihydrochloride (B-HT 933), a potent and selective alpha 2-adrenoceptor agonist, exhibits affinity for α2A-, α2B-, and α2C-adrenoceptor subtypes with pKis of 8.3, 7.6, and 7.5, respectively [1]. It elicits a concentration-dependent inhibition of peristaltic contractions, evidenced by an IC50 of 78.72 nM.

Meranzin hydrate exhibits antidepressive and prokinetic-like effects through the regulation of the common mediator, the alpha 2-adrenoceptor , and α±-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors; it produces a rapid effect mediated by AMPA

OxyMetazoline is an α-adrenoceptor agonist that acts on α1A (IC50: 0.02 μM), α1B (IC50: 0.25 μM), α2A (IC50: 0.58 μM) and α2C (IC50: 0.13 μM). OxyMetazoline can be used in studies to relieve nasal mucosal congestion.

(S)-Terazosin is an active S-enantiomer of Terazosin. (S)-Terazosin is a potent and high-affinity antagonist of α-adrenoceptor(α1a, α1b and α1d-adrenoceptor with Ki values of 3.91 nM, 0.79 nM and 1.16 nM, respectively).

Saterinone is a potent and selective phosphodiesterase III inhibitor and a potent antagonist of the vascular α-1-adrenoceptor. Saterinone has vasodilatory properties and can be used in the acute treatment of chronic heart failure. Saterinone inhibited crude cAMP phosphodiesterase (PDE) activity in guinea pig right ventricular homogenates The ic50 value is 2.3 × 10(-5) mol/l.

Fluparoxan is a highly selective and potent alpha 2-adrenoceptor antagonist.

Naftopidil (KT-611) (INN, marketed under the brand name Flivas), an antihypertensive medicine, is used as a selective α1-adrenergic receptor antagonist or α-blocker.

Glaucine has antitussive, antioxidative potential and antiviral activities, it may be an anti-arthritic agent, it can enhance LPS and zymosan-induced IL-10 production. Glaucine can inhibit the migration and invasion of human breast cancer cells by MMP-9 i

Xylometazoline hydrochloride (Xylometazoline HCl) is an α-adrenoceptor agonist usually used as nasal decongestant.

ACEPROMAZINE MALEATE is a dopamine receptor antagonist

Phentolamine mesylate (Phentolamine methanesulfonate) is a nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.

Tolnapersine is a mixed dopamine agonist and alpha-adrenoceptor antagonist.